Human protein and cdna

ABSTRACT

The present application provides a purified human protein, DNA fragment encoding the protein, expression vector for the DNA fragment, various cells transformed with the expression vector, and antibody against the protein. The purified protein in this invention is useful as a medicinal or as an antigen for manufacturing the antibody against the proteins. Further, the protein is useful as a search reagent for elucidating the intracellular protein network or as a protein source for screening such a protein as binding with a small molecule medicinal. The human cDNA of this invention is useful as a probe for gene diagnosis or as a gene source for gene therapy. Further, it can be also used as a gene source for mass production of the protein encoded by the cDNA. The expression vector being capable of translating in vitro or expressing the DNA within the host cell can be used for producing the human protein of this invention in vitro or within various host cells. The cells carrying the gene and expressing excessively it can be utilized for detecting the corresponding receptors and ligands or screening new small molecule medicinal or the like. The antibody against the protein of this invention can be used as a means for purifying the protein or for examining an expression level and localization site of the intracellular protein.

TECHNICAL FIELD

[0001] The present invention relates to a purified human protein, DNA fragment encoding the protein, expression vector of the DNA fragment, various cells transformed with the expression vector, and antibody against the protein. The protein in this invention is useful as a medicinal or as an antigen for manufacturing an antibody against the protein. Further, the protein is useful as a search reagent for elucidating the intracellular protein network or as a protein source for screening such a protein as binding with a small molecule medicinal. The human cDNA of this invention is useful as a probe for gene diagnosis or as a gene source for gene therapy. Further, it can be also used as a gene source for mass production of the protein encoded by the cDNA. The expression vector can be used for producing the protein of this invention in vitro or within various host cells. The cell carrying these genes and expressing excessively them can be utilized for detecting the corresponding receptors and ligands or screening new small molecule medicinal or the like. The antibody against the protein of this invention can be used as a means for purifying the protein or for examining an expression level and localization site of the intracellular protein.

BACKGROUND ART

[0002] Human proteins are essential components of the cells consisting of human bodies. Of them, there are (1) cytoskeleton proteins keeping the cell form or participating in the intracellular transportation of materials or cell movement, (2) metabolic enzymes participating in the intracellular metabolism of materials, (3) proteins concerning the energy production, (4) proteins transferring information on the cell proliferation and division, (5) translation-related proteins concerning the synthesis of proteins, (6) protease-related proteins concerning the protein breakdown, (7) proteins participating in replicating genome, (8) transcription factor participating in gene transcription, (9) nuclear protein participating in splicing mRNA, and so on. These proteins are not only important for elucidating the work of human cells but also useful in developing medicinals. Most of the small molecule medicinal so far known exhibit their pharmacological effects by combining with a particular protein existing in the cell and enhancing or inhibiting the action of the protein. Thus, possession of a set of human proteins becomes an effective instrument in screening these small molecule medicinals.

[0003] For getting human proteins there has so far been adopted a method of homogenizing human tissues or culture cells and purifying a single protein by combining various separating methods. Such proteins so far known as having a high content thereof and having been known to be active can be easily isolated and purified by conventional methods, but most of unknown proteins having a low content are difficult in isolation depending upon their quality. Further, most of human tissues are hardly available. Therefore, it is nearly impossible to provide every human protein in a conventional manner for isolation and purification.

[0004] On the other hand, the information on the structure of human proteins is described in human genome DNA, the primary structure of every human protein can be presumed if all of the information could be read. One of the objects of Human Genome Project consists herein. However, those obtained as a result of reading genome concern the information on DNA sequence only without proteins themselves. Within the cell, the genome information is at first transcribed into mRNA and the protein is synthesized by translating the sequence information of mRNA. Thus, if cDNA could be synthesized from the template mRNA, it is possible to synthesize the corresponding protein by using this cDNA. So, so-called EST project is going on, in which the partial base sequence of cDNA is determined by preparing cDNA from template mRNA isolated from various cells.

[0005] An essential requirement for cDNA in case of aiming at getting proteins is to involve all the translated region for the protein. That is, so-called full-length cDNA is required. However, the ratio of full-length cDNA is very low in cDNAs prepared by conventional methods, and it is also difficult to determine whether or not the cDNA is full-length. Thus, most of those known as EST are cDNA fragments containing only a part of the translated region for a protein.

[0006] On the other hand, the inventors of the present application established an original synthetic technology for full-length cDNA (Kato, S. et al., Gene 150:243-250, 1994). Then, human protein in full length can have been obtained by analyzing human full-length cDNA clone prepared by this technology. It is desirable to prepare the human protein bank by cloning all human full-length cDNA according to this technology.

[0007] Further, it has been elucidated as a result of search on human diseases seen so far that almost diseases are caused by having any disorder in the gene. For curing these diseases, the gene therapy of introducing normal gene in place of abnormal gene has been found promising. In this case, human full-length cDNA can be used as a gene source for the gene therapy.

[0008] In view of these circumstances above, the invention of the present application has been made, and its object is to provide a novel purified human protein, DNA fragments encoding the protein, expression vector for the DNA fragments, various cells transformed with the expression vector, and an antibody against the protein.

DISCLOSURE OF INVENTION

[0009] The present application provides the following invention (i)-(ix).

[0010] (i) A purified human proteins having any one of the amino acid sequences of SEQ ID No: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158 or 160.

[0011] (ii) A DNA fragment encoding the protein of the invention (i).

[0012] (iii) A DNA fragment having the base sequence of the translated region in SEQ ID No: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 30 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157 or 159, which is human cDNA encoding the protein of the invention (i).

[0013] (iv) The DNA fragment of the invention (iii), which consists of any one of the base sequences of SEQ ID No: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157 or 159.

[0014] (v) An expression vector, which is capable of expressing any one of the DNA fragments of inventions (ii) to (iv) by in vitro translation or within host cell.

[0015] (vi) The expression vector of the invention (v), which is capable of expressing a fused DNA fragment of the DNA fragment of any one of the invention (ii) to (iv) and the DNA fragment encoding a fluorescent protein.

[0016] (vii) A fluorescent protein-fused protein, which is an expression product of the expression vector of the invention (vi).

[0017] (viii) A cell transformed with the expression vector of the invention (v) or (vi), which is capable of producing the protein of the invention (i) or the fluorescent protein-fused protein of the invention (vii).

[0018] (ix) An antibody against the protein of the invention (i).

BRIEF DESCRIPTION OF DRAWINGS

[0019]FIG. 1 is a drawing wherein the human protein encoded by clone HP02573 is compared with the amino acid sequence of bacteria GTP-binding protein CgpA.

[0020]FIG. 2 is a drawing wherein the human protein encoded by clone HP02612 is compared with the amino acid sequence of Mycobacteria 50S ribosomal protein L9.

[0021]FIG. 3 is a drawing wherein the human protein encoded by clone HP10117 is compared with the amino acid sequence of brucella ribosome recycling factor.

[0022]FIG. 4 is a drawing wherein the human protein encoded by clone HP10120 is compared with the amino acid sequence of nematoda hypothetical protein F45G2.10.

[0023]FIG. 5 is a drawing wherein the human protein encoded by clone HP10421 is compared with the amino acid sequence of nematoda hypothetical protein B0261.4.

[0024]FIG. 6 is a drawing wherein the human protein encoded by clone HP10582 is compared with the amino acid sequence of nematoda hypothetical protein 108.7 kDa.

[0025]FIG. 7 is a drawing wherein the human protein encoded by clone HP10149 is compared with the amino acid sequence of nematoda hypothetical protein W02A11.2.

[0026]FIG. 8 is a drawing wherein the human protein encoded by clone HP10160 is compared with the amino acid sequence of nematoda hypothetical protein ZK1248.15.

[0027]FIG. 9 is a drawing wherein the human protein encoded by clone HP10173 is compared with the amino acid sequence of nematoda hypothetical protein C04H5.1.

[0028]FIG. 10 is a drawing wherein the human protein encoded by clone HP02644 is compared with the amino acid sequence of nematoda RNA helicase-like protein.

[0029]FIG. 11 is a drawing wherein the human protein encoded by clone HP03233 is compared with the amino acid sequence of fission yeast putative ubiquinone biosynthesis methyltransferase.

[0030]FIG. 12 is a drawing wherein the human protein encoded by clone HP10437 is compared with the amino acid sequence of human pp21 homologue.

[0031]FIG. 13 is a drawing wherein the human protein encoded by clone HP10525 is compared with the amino acid sequence of fission yeast hypothetical protein SPAC8C9.11.

[0032]FIG. 14 is a drawing wherein the human protein encoded by clone HP10543 is compared with the amino acid sequence of mouse leucine-rich domain interacting protein 1.

[0033]FIG. 15 is a drawing wherein the human protein encoded by clone HP03090 is compared with the amino acid sequence of nematoda hypothetical protein 32.0 kDa.

[0034]FIG. 16 is a drawing wherein the human protein encoded by clone HP03145 is compared with the amino acid sequence of fission yeast mitochondrial p-hydroxybenzoate polyprenyltransferase-like protein.

[0035]FIG. 17 is a drawing wherein the human protein encoded by clone HP03185 is compared with the amino acid sequence of human histone macroH2A1.2.

[0036]FIG. 18 is a drawing wherein the human protein encoded by clone HP03324 is compared with the amino acid sequence of bacterial ribosomal protein L2.

[0037]FIG. 19 is a drawing wherein the human protein encoded by clone HP10648 is compared with the amino acid sequence of nematoda hypothetical protein Y40B1B.7.

[0038]FIG. 20 is a drawing wherein the human protein encoded by clone HP10162 is compared with the amino acid sequence of rat hypothetical protein.

[0039]FIG. 21 is a drawing wherein the human protein encoded by clone HP10334 is compared with the amino acid sequence of human SH3 domain binding glutamic acid-rich-like protein.

[0040]FIG. 22 is a drawing wherein the human protein encoded by clone HP10532 is compared with the amino acid sequence of human apoptosis associated protein Bbk.

[0041]FIG. 23 is a drawing wherein the human protein encoded by clone HP10559 is compared with the amino acid sequence of human hypothetical protein KIAA0276.

[0042]FIG. 24 is a drawing wherein the human protein encoded by clone HP10562 is compared with the amino acid sequence of human basic leucine-zipper protein LZIP.

[0043]FIG. 25 is a drawing wherein the human protein encoded by clone HP10456 is compared with the amino acid sequence of nematoda BC-2 like protein.

[0044]FIG. 26 is a drawing wherein the human protein encoded by clone HP10498 is compared with the amino acid sequence of nematoda hypothetical protein C24D19.6.

[0045]FIG. 27 is a drawing wherein the human protein encoded by clone HP10505 is compared with the amino acid sequence of nematoda hypothetical protein F29B9.10.

[0046]FIG. 28 is a drawing wherein the human protein encoded by clone HP10515 is compared with the amino acid sequence of drosophila hypothetical protein 63B12.s.

[0047]FIG. 29 is a drawing wherein the human protein encoded by clone HP01124 is compared with the amino acid sequence of human acyl-CoA-binding protein.

[0048]FIG. 30 is a drawing wherein the human protein encoded by clone HP02241 is compared with the amino acid sequence of African clawed frog's ribosomal protein L24-like protein.

[0049]FIG. 31 is a drawing wherein the human protein encoded by clone HP10101 is compared with the amino acid sequence of nematoda hypothetical protein C32E8.5.

[0050]FIG. 32 is a drawing wherein the human protein encoded by clone HP10370 is compared with the amino acid sequence of drosophila hypothetical protein CG11534.

[0051]FIG. 33 is a drawing wherein the human protein encoded by clone HP10427 is compared with the amino acid sequence of nematoda hypothetical protein Y106G6H.8.

[0052]FIG. 34 is a drawing wherein the human protein encoded by clone HP10516 is compared with the amino acid sequence of drosophila hypothetical protein CG14130.

[0053]FIG. 35 is a drawing wherein the human protein encoded by clone HP10580 is compared with the amino acid sequence of drosophila hypothetical protein CG5469.

BEST MODE FOR CARRYING OUT THE INVENTION

[0054] The protein of the invention (i) can be obtained by a method of isolating it from human organs, cell line or the like, a method of preparing the peptide by chemical synthesis based on the amino acid sequence provided by the present application, a method of producing it by recombinant DNA techniques using DNA fragments of the inventions (ii)-(iv) above, and so on. Above all, the method by the recombinant DNA techniques is preferred. For example, the protein can be expressed in vitro by preparing RNA from the vector having the DNA fragment (cDNA) of the invention (iii) or (iv) above through in vitro transcription and performing in vitro translation using it as a template. Further, the protein encoded by the DNA fragment can be expressed in a large scale in prokaryotic cell such as Escherichia coli, Bacillus subtilis and the like or eukaryotic cell such as yeast, insect cell, mammalian cell, vegetable cell or the like, by subjecting the translated region to recombination in a conventional manner into an appropriate expression vector.

[0055] In case of producing the protein of the invention (i) by expressing DNA fragment through the in vitro translation, for example, the protein of the invention (i) above can be produced by subjecting the translated region of DNA fragment in the invention (iii) or (iv) above to recombination into the vector having RNA polymerase promotor and mixing it with the in vitro translation system such as rabbit reticulocyte lysate, wheat germ extract, or the like containing RNA polymerase corresponding to the promoter. The RNA polymerase promoter illustratively includes T7, T3, SP6 or the like. Examples of the vector containing these RNA polymerase promoters are pKA1, pCDM8, pT3/T7 18, pT7/3 19, pbluescipt II or the like.

[0056] In case of producing the protein of the invention (i) by expressing DNA fragment with microorganism such as E. coli, the protein desired can be produced in a large scale within a microorganism, for example, by preparing the recombinant expression vector wherein an expression vector having such an origin replicable in the microorganism, promoter, ribosome binding site, DNA cloning sites, terminator or the like is integrated with the translated region in the DNA fragment of the invention (iii) or (iv) above, transforming the host cell with this expression vector and cultivating the resultant transformant to give the protein encoded by this DNA fragment. In this case, the protein fragment containing an optional region can be obtained by expressing while adding the initiation codon and termination codon around the optional translated region. Otherwise, the protein can be also expressed as a fusion protein with other protein. Only the protein fragment encoded by this cDNA can be obtained by cutting this fusion protein with an appropriate protease. Examples of the expression vector for E. coli are pUC system, pBluescript II, pET expression system, pGEX expression system, and so on.

[0057] In case of producing the protein of the invention (i) by expressing DNA fragment with an eukaryotic cell, for example, the protein of the invention (i) above can be produced within the eukaryotic cell by recombining the translated region of DNA fragment in the invention (iii) or (iv) above within an expression vector for eukaryotic cell having promoter, splicing site, poly (A) addition site or the like and introducing it within the eukaryotic cell. Examples of the expression vector are pKA1, pCDM8, pSVK3, pMSG, pSVL, pBK-CMV, pBK-RSV, EBV vector, pRS, pYES2, and so on. Further, fusion protein added by various tags such as His tag, FLAG tag, GFP or the like can be also expressed by using pIND/V5-His, pFLAG-CMV-2, pEGFP-N1, pEGFP-C1 or the like as an expression vector. As the eukaryotic cells, mammalian cultured cells such as monkey kidney cells COS7 and Chinese hamster ovary cells CHO, budding yeasts, fission yeasts, silkworm cells and Xenopus oocytes are generally used, but insofar as the protein of the invention (1) can be expressed, any eukaryotic cells can be used. An expression vector can be induced into an eukaryotic cell in a conventional manner such as electroporation method, calcium phosphate method, liposome method, DEAE dextran method, or the like.

[0058] For isolating and purifying the protein of the invention (1) from a culture after expression of the desired protein in the prokaryotic or eukaryotic cells, separation techniques known in the art can be used in combination. Such techniques include e.g. treatment with a denaturant such as urea or a surfactant, sonication, enzymatic digestion, salting-out or solvent precipitation, dialysis, centrifugation, ultrafiltration, gel filtration, SDS-PAGE, isoelectric focusing, ion-exchange chromatography, hydrophobic chromatography, affinity chromatography and reverse phase chromatography.

[0059] The protein of the invention (i) includes also the peptide fragment (not less than 5 amino acid residues) consisting of any partial amino acid sequence in the SEQ ID No: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158 or 160. These peptide fragments can be used as an antigen for preparing an antibody. Further, most of the proteins of the invention (i) undergo various modification within the cell, after subjecting to translation. Thus, these modified proteins are also included in the scope of the protein of the invention (i). Examples of such modification after translation are elimination of N-terminal methionine, N-terminal acetylation, addition of sugar chain, limited proteolysis due to intracellular protease, myristoylation, isoprenylation, phophorylation, and so on.

[0060] The expression vector of the invention (v) is a vector that can translate in vitro the protein of the invention (i), as described above, or can express it within a host cell. Further, the expression vector of the invention (vi) is a vector that can express DNA fragment (the invention (ii), (iii) or (iv)) encoding the protein of the invention (i) and fused DNA fragment encoding the fluorescent protein. The fluorescent protein illustratively includes green fluorescent protein (GFP, EGFP), yellow fluorescent protein (EYFP), blue fluorescent protein (ECFP), red fluorescent protein (DsRed, the above-tradenames, Clontech Co.), green fluorescent protein coming from Renilla (hrGFP, Stratagene Co.) or the like. The position to fuse the fluorescent protein is either N-terminal or C-terminal of the protein. The expression vector of the invention (vi), being able to express a fusion protein of the protein of the invention (i) and the fluorescent protein (invention (vii)), is useful, for example, as a library for detecting the protein-protein interaction by using an intracellular localization site marker and 2-hybrid localization method.

[0061] DNA fragments (ii)-(iv) includes all DNA encoding the protein of the above (i). This DNA fragment can be obtained by using a chemical synthetic method, a cDNA cloning method, a method of screening human genome library, and so on.

[0062] DNA fragments (cDNA) in the invention (iii) or (iv) can be cloned, for example, cDNA library derived from human cell. The cDNA is prepared by using poly (A)⁺RNA extracted from human cell. Human cell may include those delivered from human body by means of operation or the like or those culture cells. The cDNA may be prepared by any synthetic methods such as Okayama-Berg method (Okayama, H. and Berg, P., Mol. Gell. Biol. 2: 161-170, 1982), Gubler-Hoffman method (Gubler, U. and Hoffman, J., Gene 25: 263-269, 1983) or the like, and preferably by Capping method (Kato, S. et al., Gene 150: 243-250, 1994), as shown in Example, for getting the full-length clone effectively. Further, commercially available human cDNA library can be also used. For cloning the objective cDNA from cDNA library, an oligonucleotide may be prepared on the basis of an optional part of base sequence from cDNA (SEQ ID No: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157 or 159) of the invention (iii) or (iv) provided by the present invention, and then the screening due to the colony- or plaque-hybridization method may be performed by using it as a probe. Further, cDNA fragment of the invention (iii) or (iv) can be prepared also by preparing oligonucleotides to hybridize at each ends of the objective cDNA fragment and preparing it from mRNA isolated from human cell while using the oligonucleotide as a primer according to RT-PCR method.

[0063] The DNA fragment of the invention (iii) is cDNA having the base sequence of the translated region (Open Reading Frame: ORF) in SEQ ID No: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157 or 159, and the DNA fragment of the invention (iv) is cDNA composed of any one of the base sequence of SEQ ID No: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157 or 159. Table 1 collectively shows the respective sequence number, clone No. (HP No.), cell from which cDNA clone was obtained, number of all bases of cDNA, and number of amino acid residues in the protein encoded, respectively. TABLE 1 Number of SEQ Number of Amino Acid ID No:. HP No. Cell Bases Residue 1, 2 HP02573 Stomach Carcinoma 1323 284 3, 4 HP02612 Saos-2 1120 233 5, 6 HP10021 HT-1080 528 64 7, 8 HP10117 U937 1306 262  9, 10 HP10120 HT-1080 893 102 11, 12 HP10321 KB 597 158 13, 14 HP10416 Stomach Carcinoma 760 199 15, 16 HP10421 Stomach Carcinoma 806 250 17, 18 HP10582 HT-1080 3907 614 19, 20 HP10098 U937 901 199 21, 22 HP10106 U937 1274 326 23, 24 HP10111 U937 1000 50 25, 26 HP10149 U937 1087 176 27, 28 HP10151 U-2 0S 703 51 29, 30 HP10160 U937 921 190 31, 32 HP10173 HT-1080 584 125 33, 34 HP10200 HT-1080 875 176 35, 36 HP10327 KB 470 52 37, 38 HP02644 HT-1080 2920 859 39, 40 HP03233 HT-1080 1502 327 41, 42 HP10384 KB 737 86 43, 44 HP10431 Liver 903 178 45, 46 HP10437 Stomach Carcinoma 1170 117 47, 48 HP10525 Stomach Carcinoma 404 86 49, 50 HP10543 HT-1080 752 179 51, 52 HP10565 Stomach Carcinoma 1222 189 53, 54 HP10570 HT-1080 1209 117 55, 56 HP03090 KB 1763 298 57, 58 HP03115 KB 1913 358 59, 60 HP03145 KB 1520 371 61, 62 HP03185 HT-1080 1731 372 63, 64 HP03324 U937 910 225 65, 66 HP10052 HT-1080 784 114 67, 68 HP10626 KB 984 140 69, 70 HP10633 HT-1080 864 85 71, 72 HP10637 HT-1080 2617 579 73, 74 HP10648 KB 1810 360 75, 76 HP10211 Saos-2 1620 126 77, 78 HP10332 Stomach Carcinoma 1349 285 79, 80 HP10641 KB 1355 329 81, 82 HP10650 KB 1543 233 83, 84 HP10654 KB 1436 183 85, 86 HP10657 U937 1357 380 87, 88 HP10659 U937 1399 260 89, 90 HP10681 HT-1080 1119 274 91, 92 HP10077 Stomach Carcinoma 540 101 93, 94 HP10162 Saos-2 1059 278 95, 96 HP10334 HT-1080 782 93 97, 98 HP10400 Stomach Carcinoma 417 57  99, 100 HP10410 Stomach Carcinoma 697 115 101, 102 HP10417 Stomach Carcinoma 1504 110 103, 104 HP10482 HT-1080 1046 133 105, 106 HP10499 Stomach Carcinoma 341 68 107, 108 HP10522 Stomach Carcinoma 1684 332 109, 110 HP10532 Stomach Carcinoma 727 159 111, 112 HP10552 Saos-2 1354 245 113, 114 HP10553 HT-1080 653 110 115, 116 HP10558 Saos-2 643 123 117, 118 HP10559 Saoa-2 1293 237 119, 120 HP10560 Saos-2 916 107 121, 122 HP10561 Stomach Carcinoma 1002 226 123, 124 HP10562 Saos-2 1753 395 125, 126 HP10564 Saos-2 668 22 127, 128 HP10569 KB 279 70 129, 130 HP10601 HT-1080 3367 695 131, 132 HP10456 U-2 0S 1290 199 133, 134 HP10498 Saos-2 564 118 135, 136 HP10503 Saos-2 904 114 137, 138 HP10505 Saos-2 472 87 139, 140 HP10511 Stomach Carcinoma 180 39 141, 142 HP10515 Liver 473 102 143, 144 HP01124 Liver 1664 341 145, 146 HP02241 Stomach Carcinoma 835 216 147, 148 HP10101 HT-1080 2465 396 149, 150 HP10370 KB 3600 451 151, 152 HP10427 Stomach Carcinoma 442 113 153, 154 HP10438 Stomach Carcinoma 726 222 155, 156 HP10502 HT-1080 1120 278 157, 158 HP10516 Stomach Carcinoma 747 221 159, 160 HP10580 Stomach Carcinoma 1441 441

[0064] Further, the same clone as cDNA of the invention (iii) and (iv) can be easily prepared by screening the cDNA library prepared from human cell line as shown in Table 1 or human tissue while using the oligonucleotide probe prepared on the basis of any one of the base sequence, SEQ ID No: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157 or 159.

[0065] Furthermore, polymorphisms are generally often observed in human genes. Thus, in SEQ ID No: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157 or 159, the cDNA in which one or more nucleotides are added, deleted and/or substituted by other nucleotides is included in the scope of the invention.

[0066] Similarly, the protein in which one or more amino acids are added, deleted and/or substituted by other amino acids brought about by these modifications are included in the scope of the present invention, as far as it possess the activity of the protein having the amino acid sequence in SEQ ID No: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158 or 160.

[0067] The DNA fragment (not less than 10 bp) having any partial base sequence in SEQ ID No: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157 or 159 is also included in the DNA fragment of the invention (iii) or (iv). Further, the DNA fragment composed of sense strand and anti-sense strand is also included in this scope. These DNA fragments can be used as a probe for the gene diagnosis.

[0068] The antibody of the invention (vii) can be obtained from serum after immunizing an animal by using the protein of the invention (i) as an antigen. As an antigen, the peptide prepared chemically on the basis of amino acid sequence in SEQ ID No: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158 or 160, as well as the protein expressed in eukaryotic cell or prokaryotic cell can be used as an antigen. Otherwise, the antigen can be prepared by introducing the expression vector for eukaryotic cell into animals' muscle or skin by injection or gene gun and collecting the serum (e.g. the method described in Japanese Patent Application Provisional Publication No. 7-313187). Examples of the animal are mouse, rat, rabbit, goat, chick, and so on. The monoclonal antibody corresponding to the protein of the invention (i) by preparing a hybridoma while fusing the myeloma with B cell collected from the spleen of the immunized animal.

EXAMPLES

[0069] The present invention will be described in more detail by reference to the Examples, which however are not intended to limit the scope of the present invention. Basic procedures for DNA recombination and enzymatic reaction were in accordance with those described in a literature (Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory, 1989). Unless otherwise specified, the restriction enzymes and various modifying enzymes used were products of Takara Shuzo Co., Ltd. The buffer composition in each enzymatic reaction, as well as reaction conditions, was followed instructions attached to the kits. Synthesis of cDNA was conducted according to a literature (Kato, S. et al., Gene, 150, 243-250, 1994).

Example 1 cDNA Cloning

[0070] As cDNA library, human full-length cDNA library (WO 97/33993, WO98/11217, and WO98/21328 Gazette) was used. From the individual library full-length cDNA clones were selected and the total base sequence was determined. The details of the obtained clones 1 to 80 will be described below.

[0071] 1: HP02573

[0072] As the result of determining the total base sequence of cDNA insert of clone HP02573 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 26 bp 5′ untranslated region, 855 bp ORF and 442 bp 3′ untranslated region (SEQ ID No: 1). The ORF encodes the protein consisting of 284 amino acid residues (SEQ ID No: 2), and as a result of in vitro translation, the translated product of almost the same 31 kDa as molecular weight 32,126 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was observed to be expressed in the whole cell (Example 4).

[0073] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to bacteria GTP-binding protein CgpA (Accession No. AAC69623). FIG. 1 shows the comparison of amino acid sequence between the human protein encoded by the clone 1 and the bacteria GTP-binding protein CgpA. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means the amino acid residue similar to the protein of this invention, respectively. Over the whole region except for the N-terminal region, they had a homology of 37.2%.

[0074] Further, as a result of reference to GenBank on the basis of the base sequence of clone 1 cDNA, those having a homology of not less than 90% (e.g. Accession No. AA429983) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 1 is encoded.

[0075] GTP-binding protein plays an important role in route of the intracellular signal transduction.

[0076] 2: HP02612

[0077] As the result of determining the total base sequence of cDNA insert of clone HP02612 obtained from human osteosarcoma cell line Saos-2 cDNA library, it was found that it had a structure of 17 bp 5′ untranslated region, 702 bp ORF and 401 bp 3′ untranslated region was found (SEQ ID No: 3). The ORF encoded the protein consisting of 233 amino acid residues (SEQ ID No: 4), and as a result of in vitro translation, the translated product of 29 kDa slightly larger than molecular weight 26,038 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized in the mitochondria (Example 4).

[0078] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to Mycobacterium 50S ribosomal protein L9 (Accession No. P46385). FIG. 2 shows the comparison of amino acid sequence between the human protein encoded by clone 2 and mycobacteria 50S ribosomal protein L9. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region except for the N-terminal region, they had a homology of 30.3%. In reconsidering the localization to mitochondria, it is considered that this protein is a mitochondria ribosomal protein, and the N-terminal region is a signal sequence for mitochondrial localization.

[0079] Further, as a result of reference to GenBank on the basis of the base sequence of clone 2 cDNA, those having a homology of not less than 90% (e.g. Accession No. H79400) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 2 is encoded.

[0080] The mitochondria ribosomal protein is one of the proteins constituting the mitochondria ribosome and participates in the translation system within the mitochondria.

[0081] 3: HP10021

[0082] As the result of determining the total base sequence of cDNA insert of clone HP10021 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 89 bp 5′ untranslated region, 195 bp ORF and 244 bp 3′ untranslated region (SEQ ID No: 5). The ORF encoded the protein consisting of 64 amino acid residues (SEQ ID No: 6). The fusion protein of this protein and GFP was observed to be expressed in the whole cell (Example 4).

[0083] Further, as a result of reference to GenBank on the basis of the base sequence of clone 3 cDNA, those having a homology of not less than 90% (e.g. Accession No. AA156954) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 3 is encoded.

[0084] 4: HP10117

[0085] As the result of determining the total base sequence of cDNA insert of clone HP10117 obtained from human lymphoma cell line U937 cDNA library, it was found that it had a structure of 52 bp 5′ untranslated region, 789 bp ORF and 465 bp 3′ untranslated region (SEQ ID No: 7). The ORF encoded the protein consisting of 262 amino acid residues (SEQ ID No: 8), and as a result of in vitro translation, a translated product of 30 kDa almost same as molecular weight 29,259 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized in the mitochondria (Example 4).

[0086] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to brucella ribosome recycling factor (Accession No. P94340). FIG. 3 shows the comparison of the amino acid sequence between the human protein encoded by clone 4 and the brucella ribosomal recycling factor. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region except for the N-terminal region, they had a homology of 29.0%. In reconsidering the localization to mitochondria, it is considered that this protein is a mitochondria ribosomal recycling factor, and the N-terminal region is a signal sequence for mitochondrial localization.

[0087] Further, as a result of referring to GenBank on the basis of the base sequence of clone 4 cDNA, those having a homology of not less than 90% (e.g. Accession No. H67316) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 4 is encoded.

[0088] The ribosomal recycling factor is a factor needed for removing mRNA from ribosome at the time of finishing the protein synthesis, and works for enhancing the translational efficiency on the ribosome.

[0089] 5: HP10120

[0090] As the result of determining the total base sequence of cDNA insert of clone HP10120 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 95 bp 5′ untranslated region, 309 bp ORF and 489 bp 3′ untranslated region (SEQ ID No: 9). The ORF encoded the protein consisting of 102 amino acid residues (SEQ ID No: 10), and as a result of in vitro translation, a translated product of 14 kDa slightly larger than molecular weight 11,634 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was observed to be expresses in the whole cell (Example 4).

[0091] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematode hypothetical protein F45G2.10 (Accession No. CBA07619). FIG. 4 shows the comparison of the amino acid sequence between the human protein encoded by clone 5 and the nematode hypothetical protein F45G2.10. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means the same amino acid residue as the protein of this invention, respectively. Over the C-terminal 73 amino acid residues, they had a homology of 50.7%.

[0092] Further, as a result of referring to GenBank on the basis of the base sequence of clone 5 cDNA, those having a homology of not less than 90% (e.g. Accession No. N44558) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 5 is encoded.

[0093] 6: HP10321

[0094] As the result of determining the total base sequence of cDNA insert of clone HP10321 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 20 bp 5′ untranslated region, 477 bp ORF and 100 bp 3′ untranslated region (SEQ ID No: 11). The ORF encoded the protein consisting of 158 amino acid residues (SEQ ID No:. 12), and as a result of in vitro translation, the translated product of 19 kDa slightly larger than molecular weight 16,215 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was observed to be expressed in the whole cell (Example 4).

[0095] As a result of searching GenBank on the basis of base sequence of cDNA of clone 6, those having a homologue of not less than 90% (Accession No. AA010288) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 6 is encoded.

[0096] 7: HP10416

[0097] As the result of determining all the base sequence of cDNA insert of clone HP10416 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 96 bp 5′ untranslated region, 600 bp ORF and 64 bp 3′ untranslated region (SEQ ID No: 13). The ORF encoded the protein consisting of 199 amino acid residues (SEQ ID No: 14), and as a result of in vitro translation, a translated product of 23 kDa almost same as molecular weight 22,340 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized as particles in the nucleus or cytoplasm (Example 4).

[0098] Further, as a result of referring to GenBank on the basis of the base sequence of clone 7 cDNA, those having a homology of not less than 90% (e.g. Accession No. AA218581) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 7 is encoded.

[0099] 8: HP10421

[0100] As the result of determining the total base sequence of cDNA insert of clone HP10421 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 14 bp 5′ untranslated region, 753 bp ORF and 39 bp 3′ untranslated region (SEQ ID No: 15). The ORF encoded the protein consisting of 250 amino acid residues (SEQ ID No: 16), and as a result of in vitro translation, a translated product of almost the same 30 kDa as molecular weight 29,450 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized in the mitochondria (Example 4).

[0101] As the result of searching the protein database by using the amino acid sequence of this protein, there was found to have a similarity to nematoda hypothetical protein B0261.4 (Accession No.AAB52351). FIG. 5 shows a comparison of the amino acid sequence between the human protein encoded by clone 8 and the nematoda hypothetical protein B0261.4. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means the amino acid residue similar to the protein of this invention, respectively. Over the whole region except for the N-terminal region they had a homology of 35.8%. Further, there was also found a similarity to mitochondria 60S ribosomal protein L4 in yeast. In view of localization in the mitochondria, it is considered that this protein is one of mitochondria ribosomal proteins, in which N-terminal region takes a signal sequence for mitochondrial localization.

[0102] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 8, those having a homology of not less than 90% (e.g. Accession No. AA167086) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 8 is encoded.

[0103] The mitochondria ribosomal protein is one of the proteins constituting a mitochondria ribosome and participates in the translational system within the mitochondria.

[0104] 9: HP10582

[0105] As the result of determining the total base sequence of cDNA insert of clone HP10582 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 131 bp 5′ untranslated region, 1845 bp ORF and 1931 bp 3′ untranslated region (SEQ ID No: 17). The ORF encoded the protein consisting of 614 amino acid residues (SEQ ID No: 18), and as a result of in vitro translation, a translated product of 70 kDa almost same as molecular weight 69,774 anticipated from the ORF was produced (Example 2). A reticular expression was found in the cytoplasm on the fusion protein of this protein and GFP (Example 4).

[0106] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda hypothetical protein 108.7 kDa (Accession No. P49958). FIG. 6 shows a comparison of the amino acid sequence between the human protein encoded by clone 9 and the nematoda hypothetical protein 108.7 kDa. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the C-terminal region 602 amino acid residues, they had a homology of 30.2%.

[0107] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 9, those having a homology of not less than 90% (e.g. Accession No. AA313350) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 9 is encoded.

[0108] 10: HP10098

[0109] As the result of determining the total base sequence of cDNA insert of clone HP10098 obtained from human lymphoma cell line U937 cDNA library, it was found that it had a structure of 35 bp 5′ untranslated region, 600 bp ORF and 266 bp 3′ untranslated region (SEQ ID No: 19). The ORF encoded the protein consisting of 199 amino acid residues (SEQ ID No: 20), and as a result of in vitro translation, a translated product of 24 kDa slightly larger than molecular weight 21,750 anticipated from the ORF was produced (Example 2). A particle expression was found in the cytoplasm on the fusion protein of this protein and GFP (Example 4).

[0110] Further, as a result of referring to GenBank on the basis of the base sequence of clone 10 cDNA, those having a homology of not less than 90% (e.g. Accession No. H40208) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 10 is encoded. Moreover, a clone (Accession No. AX014145, WO 9954447-A) showing a homology of 99.7% was found to have been registered, but this clone encodes a protein different from clone 10, because the clone causes the frame shift due to shortage of G corresponding to 139th in clone 10.

[0111] 11: HP10106

[0112] As the result of determining the total base sequence of cDNA insert of clone HP10106 obtained from human lymphoma cell line U937 cDNA library, it was found that it had a structure of 130 bp 5′ untranslated region, 981 bp ORF and 163 bp 3′ untranslated region (SEQ ID No: 21). The ORF encoded the protein consisting of 362 amino acid residues (SEQ ID No: 22), and as a result of in vitro translation, a translated product of 41 kDa slightly larger than molecular weight 36,684 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0113] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 11, those having a homology of not less than 90% (e.g. Accession No. AA384225) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 11 is encoded.

[0114] 12: HP10111

[0115] As the result of determining the total base sequence of cDNA insert of clone HP10111 obtained from human lymphoma cell line U937 cDNA, it was found that it had a structure of 32 bp 5′ untranslated region, 153 bp ORF and 815 bp 3′ untranslated region (SEQ ID No: 23). The ORF encoded the protein consisting of 50 amino acid residues (SEQ ID No: 24), and as a result of in vitro translation, a translated product of 6 kDa almost same as molecular weight 5,547 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in reticular form in the whole cell (Example 4).

[0116] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 12, those having a homology of not less than 90% (e.g. Accession No. AL110141) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 12 is encoded.

[0117] 13: HP10149

[0118] As the result of determining the total base sequence of cDNA insert of clone HP10149 obtained from human lymphoma cell line U937 cDNA library, it was found that it had a structure of 27 bp 5′ untranslated region, 531 bp ORF and 529 bp 3′ untranslated region (SEQ ID No: 25). The ORF encoded the protein consisting of 176 amino acid residues (SEQ ID No: 26), and as a result of in vitro translation, a translated product of 23 kDa slightly larger than molecular weight 20,734 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0119] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda hypothetical protein W02A11.2 (Accession No. CAB04889). FIG. 7 shows a comparison of the amino acid sequence between human protein encoded by clone 13 and nematoda hypothetical protein W02A11.2. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 42.5%.

[0120] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 13, those having a homology of not less than 90% (e.g. Accession No. T34989) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 13 is encoded. Moreover, a clone (Accession No. AR070327, U.S. Pat. No. 5,892,010) having the same partial sequence was found to have been registered, but there is no decision whether or not it is encoded by the same protein as that encoded by clone 13.

[0121] 14: HP10151

[0122] As the result of determining the total base sequence of cDNA insert of clone HP10151 obtained from human osteosarcoma cell line U-2 OS cDNA library, it was found that it had a structure of 66 bp 5′ untranslated region, 156 bp ORF and 481 bp 3′ untranslated region (SEQ ID No: 27). The ORF encoded the protein consisting of 51 amino acid residues (SEQ ID No: 28), and as a result of in vitro translation, a translated product of 6 kDa almost same as molecular weight 6,031 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized in the golgi body (Example 4).

[0123] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 14, those having a homology of not less than 90% (e.g. Accession No. AA304503) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 14 is encoded.

[0124] 15: HP10160

[0125] As the result of determining the total base sequence of cDNA insert of clone HP10160 obtained from human lymphoma cell line U937 cDNA library, it was found that it had a structure of 203 bp 5′ untranslated region, 573 bp ORF and 145 bp 3′ untranslated region (SEQ ID No: 29). The ORF encoded the protein consisting of 190 amino acid residues (SEQ ID No: 30), and as a result of in vitro translation, a translated product of 25 kDa slightly larger than molecular weight 21,481 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0126] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda hypothetical protein ZK1248.15 (Accession No. AAC71096). FIG. 8 shows a comparison of the amino acid sequence between the human protein encoded by clone 15 and the nematoda hypothetical protein ZK1248.15. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the N-terminal 159 amino acid residue, they had a homology of 36.5%.

[0127] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 15, those having a homology of not less than 90% (e.g. Accession No. AA304503) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 15 is encoded.

[0128] 16: HP10173

[0129] As the result of determining the total base sequence of cDNA insert of clone HP10173 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 40 bp 5′ untranslated region, 378 bp ORF and 166 bp 3′ untranslated region (SEQ ID No: 31). The ORF encoded the protein consisting of 125 amino acid residues (SEQ ID No: 32), and as a result of in vitro translation, a translated product of 15 kDa almost same as molecular weight 14,190 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0130] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda hypothetical protein C04H5.1 (Accession No. CAB03840). FIG. 9 shows a comparison of the amino acid sequence between the human protein encoded by clone 16 and the nematoda hypothetical protein C04H5.1. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 35.5%.

[0131] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 16, those having a homology of not less than 90% (e.g. Accession No. AA937773) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 16 is encoded. Moreover, a clone (Accession No. AX011631, WO 9955858-A) having the same partial sequence was found to have been registered, but this clone has ORF different from that of clone 16, its 5′-terminal being by 199 bp longer than that of clone 16.

[0132] 17: HP10200

[0133] As the result of determining the total base sequence of cDNA insert of clone HP10200 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 24 bp 5′ untranslated region, 531 bp ORF and 320 bp 3′ untranslated region (SEQ ID No: 33). The ORF encoded the protein consisting of 176 amino acid residues (SEQ ID No: 34), and as a result of in vitro translation, a translated product of 24 kDa slightly larger than molecular weight 18,408 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0134] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 17, those having a homology of not less than 90% (e.g. Accession No. AA187416) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 17 is encoded. Moreover, a clone (Accession No. AX015360, WO 9951727-A) having a homology of 95.6% was found to have been registered, but this clone encodes a protein different from that of clone 17, because a frame shift brings about due to shortage of C corresponding to 53rd of clone 17.

[0135] 18: HP10327

[0136] As the result of determining the total base sequence of cDNA insert of clone HP10327 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 215 bp 5′ untranslated region, 159 bp ORF and 96 bp 3′ untranslated region (SEQ ID No: 35). The ORF encoded the protein consisting of 52 amino acid residues (SEQ ID No: 36), and as a result of in vitro translation, a translated product of 6 kDa almost same as molecular weight 5,636 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the reticular form in the cytoplasm (Example 4).

[0137] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 18, those having a homology of not less than 90% (e.g. Accession No. A1097092) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 18 is encoded.

[0138] 19: HP02644

[0139] As the result of determining the total base sequence of cDNA insert of clone HP02644 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 72 bp 5′ untranslated region, 2580 bp ORF and 268 bp 3′ untranslated region (SEQ ID No: 37). The ORF encoded the protein consisting of 859 amino acid residues (SEQ ID No: 38), and as a result of in vitro translation, a translated product of 150 kDa larger than molecular weight 96,271 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the nucleolus (Example 4).

[0140] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda RNA helicase-like protein CELF55F8 (Accession No. AAB37806). FIG. 10 shows a comparison of the amino acid sequence between the human protein encoded by clone 19 and the nematoda RNA helicase-like protein. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 31.6%. The RNA helicase-like protein participates in many processes that RNA concerns, such as ribosome formation, transcription, splicing, RNA maturing, RNA transportation, RNA disassimilation, translation or the like.

[0141] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 19, those having a homology of not less than 90% (e.g. Accession No. Z48570 or A74673) were found to have been registered in EST, but any is short than cDNA of clone 19. Also those having a homology of not less than 90% (e.g. Accession No. AA788907) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 19 is encoded.

[0142] 20: HP03233

[0143] As the result of determining the total base sequence of cDNA insert of clone HP03233 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 14 bp 5′ untranslated region, 984 bp ORF and 504 bp 3′ untranslated region (SEQ ID No: 39). The ORF encoded the protein consisting of 327 amino acid residues (SEQ ID No: 40), and as a result of in vitro translation, a translated product of 37 kDa almost same as molecular weight 37,116 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the Golgi body or endoplasmic reticulum (Example 4).

[0144] As a result of searching the protein database on the basis of the amino acid sequence of this protein, there was found a similarity to fission yeast putative ubiquinone biosynthesis methyltransferase (Accession No. CAB09781). FIG. 11 shows a comparison of the amino acid sequence between the human protein encoded by clone 20 and the fission yeast putative ubiquinone biosynthesis methyltransferase. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 43.7%.

[0145] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 20, those having a homology of not less than 90% (e.g. Accession No. AA338101) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 20 is encoded.

[0146] 21: HP10384

[0147] As the result of determining the total base sequence of cDNA insert of clone HP10384 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 126 bp 5′ untranslated region, 261 bp ORF and 350 bp 3′ untranslated region (SEQ ID No: 41). The ORF encoded the protein consisting of 86 amino acid residues (SEQ ID No: 42), and as a result of in vitro translation, a translated product of 10 kDa almost same as molecular weight 10,128 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell or in the granular or coagulated mass form (Example 4).

[0148] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 21, those having a homology of not less than 90% (e.g. Accession No. AF150406) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 20 is encoded.

[0149] 22: HP10431

[0150] As the result of determining the total base sequence of cDNA insert of clone HP10431 obtained from human liver cDNA library, it was found that it had a structure of 84 bp 5′ untranslated region, 537 bp ORF and 282 bp 3′ untranslated region (SEQ ID No: 43). The ORF encoded the protein consisting of 178 amino acid residues (SEQ ID No: 44), and as a result of in vitro translation, a translated product of 23 kDa slightly larger than molecular weight 20,277 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell, and some of them was found in the granular or coagulated bulky form (Example 4).

[0151] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 22, those having a homology of not less than 90% (e.g. Accession No. AW160991) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 22 is encoded.

[0152] 23: HP10437

[0153] As the result of determining the total base sequence of cDNA insert of clone HP10437 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 186 bp 5′ untranslated region, 354 bp ORF and 630 bp 3′ untranslated region (SEQ ID No: 45). The ORF encoded the protein consisting of 117 amino acid residues (SEQ ID No: 46), and as a result of in vitro translation, a translated product of 22 kDa larger than molecular weight 13,616 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell or localized in the nucleus (Example 4).

[0154] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to human pp21 homologue (Accession No. AAF17229). FIG. 12 shows a comparison of the amino acid sequence between the human protein encoded by clone 23 and the human pp21 homologue. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 39.4%. The pp21 is an analogue of transcription elongation factor SII.

[0155] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 23, those having a homology of not less than 90% (e.g. Accession No. AA322053) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 23 is encoded.

[0156] 24: HP10525

[0157] As the result of determining the total base sequence of cDNA insert of clone HP10525 obtained from human stomach carcinoma DNA library, it was found that it had structure of 104 bp 5′ untranslated region, 261 bp ORF and 39 bp 3′ untranslated region (SEQ ID No: 47). The ORF encoded the protein consisting of 86 amino acid residues (SEQ ID No: 48), and as a result of in vitro translation, a translated product of 14 kDa slightly larger than molecular weight 10,110 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0158] As a result of searching the protein database by using the amino acid sequence of this protein, there was a found similarity to fission yeast hypothetical protein SPAC8C9.11 (Accession No. AAC71096). FIG. 13 shows a comparison of the amino acid sequence between the human protein encoded by clone 24 and the fission yeast hypothetical protein SPAC8C9.11. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 44.0%.

[0159] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 24, those having a homology of not less than 90% (e.g. Accession No. AA310786) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 24 is encoded.

[0160] 25: HP10543

[0161] As the result of determining the total base sequence of cDNA insert of clone HP10543 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 94 bp 5′ untranslated region, 540 bp ORF and 118 bp 3′ untranslated region (SEQ ID No: 49). The ORF encoded the protein consisting of 179 amino acid residues (SEQ ID No: 50), and as a result of in vitro translation, a translated product of 30 kDa larger than molecular weight 19,070 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell or nucleus (Example 4).

[0162] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to mouse leucine-rich domain interacting protein 1 (Accession No. AAD17989). FIG. 14 shows a comparison of the amino acid sequence between the human protein encoded by clone 25 and the mouse leucine-rich domain interacting protein 1. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the C-terminal 138 amino acid residues, they had a homology of 69.6%.

[0163] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 25, those having a homology of not less than 90% (e.g. Accession No. AA434567) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 25 is encoded.

[0164] 26: HP10565

[0165] As the result of determining the total base sequence of cDNA insert of clone HP10565 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 218p 5′ untranslated region, 570 bp ORF and 434 bp 3′ untranslated region (SEQ ID No: 51). The ORF encoded the protein consisting of 189 amino acid residues (SEQ ID No: 52), and as a result of in vitro translation, a translated product of 23 kDa slightly larger than molecular weight 20,663 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized in the Golgi body or endoplasmic reticulum (Example 4).

[0166] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 26, those having a homology of not less than 90% (e.g. Accession No. AA258633) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 26 is encoded.

[0167] 27: HP10570

[0168] As the result of determining the total base sequence of cDNA insert of clone HP10570 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 94 bp 5′ untranslated region, 354 bp ORF and 761 bp 3′ untranslated region (SEQ ID No: 53). The ORF encoded the protein consisting of 117 amino acid residues (SEQ ID No: 54), and as a result of in vitro translation, a translated product of 14 kDa almost same as molecular weight 12,767 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the Golgi body or endoplasmic reticulum (Example 4).

[0169] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 27, those having a homology of not less than 90% (e.g. Accession No. W07113) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 27 is encoded.

[0170] 28: HP03090

[0171] As the result of determining the total base sequence of cDNA insert of clone HP03090 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 25 bp 5′ untranslated region, 897 bp ORF and 841 bp 3′ untranslated region (SEQ ID No: 55). The ORF encoded the protein consisting of 298 amino acid residues (SEQ ID No: 56), and as a result of in vitro translation, a translated product of 34 kDa almost same as molecular weight 33,212 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0172] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda hypothetical protein 32.0 kDa (Accession No. Q09253). FIG. 15 shows a comparison of the amino acid sequence between human protein encoded by clone 28 and nematoda hypothetical protein 32.0 kDa. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 48.6%. Further, the C-terminal 292 amino acid residues starting from 7th leucine of this protein was found to coincide with the C-terminal amino acid residues starting from the 213rd leucine of human CGI-150 protein (Accession No. AAD34145).

[0173] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 28, those having a homology of not less than 90% (e.g. Accession No. H06942) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 28 is encoded.

[0174] 29: HP03115

[0175] As the result of determining the total base sequence of cDNA insert of clone HP03115 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 302 bp 5′ untranslated region, 1077 bp ORF and 534 bp 3′ untranslated region (SEQ ID No: 57). The ORF encoded the protein consisting of 358 amino acid residues (SEQ ID No: 58), and as a result of in vitro translation, a translated product of 39 kDa almost same as molecular weight 40,275 anticipated from the ORF was produced (Example 2). The fusion protein between this protein and GFP was found to be expressed in the granular form the cytoplasm (Example 4).

[0176] In the amino acid sequence of this protein, there was found the C3HC4 type zinc finger (RING finger) motif (from 42nd cysteine to 51st alanine).

[0177] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 29, those having a homology of not less than 90% (e.g. Accession No. AA428229) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 29 is encoded.

[0178] 30: HP03145

[0179] As the result of determining the total base sequence of cDNA insert of clone HP03145 obtained from human epidermal carcinoma cell line KB cDNA library, a it was found that it had structure of 31 bp 5′ untranslated region, 1116 bp ORF and 373 bp 3′ untranslated region (SEQ ID No: 59). The ORF encoded the protein consisting of 371 amino acid residues (SEQ ID No: 60), and as a result of in vitro translation, a translated product of 41 kDa almost same as molecular weight 40,463 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized in the Golgi body or endoplasmic reticulum (Example 4).

[0180] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to fission yeast mitochondrial p-hydroxybenzoate polyprenyltransferase-like protein (Accession No. Q10252). FIG. 16 shows a comparison of the amino acid sequence between the human protein encoded by clone 30 and the fission yeast mitochondria parahydroxybenzoate polyprenyltransferase-like protein. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region except for the N-terminal, they had a homology of 46.4%.

[0181] Moreover, the 120 amino acid residues from 198th methionine to 317th glutamine in this protein conincided with the N-terminal amino acid residues of human hypothetical protein (Accession No. AAC72955).

[0182] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 30, those having a homology of not less than 90% (e.g. Accession No. N94036) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 30 is encoded.

[0183] 31: HP03185

[0184] As the result of determining the total base sequence of cDNA insert of clone HP03185 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 182 bp 5′ untranslated region, 1119 bp ORF and 430 bp 3′ untranslated region (SEQ ID No: 61). The ORF encoded the protein consisting of 372 amino acid residues (SEQ ID No: 62), and as a result of in vitro translation, a translated product of 44 kDa slightly larger than molecular weight 40,033 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized in the nucleus or nucleolus (Example 4).

[0185] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to human bistone macroH2A1.2 (Accession No. AAC33433). FIG. 17 shows a comparison of the amino acid sequence between the human protein encoded by clone 31 and the human histone macroH2A1.2. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 67.5%. Further, the histone forming a complex with DNA participates in regulating the gene expression.

[0186] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 31, those having a homology of not less than 90% (e.g. Accession No. AI 878933) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 31 is encoded.

[0187] 32: HP03324

[0188] As the result of determining the total base sequence of cDNA insert of clone HP03324 obtained from human lymphoma cell line U937 cDNA library, it was found that it had a structure of 20 bp 5′ untranslated region, 678 bp ORF and 212 bp 3′ untranslated region (SEQ ID No: 63). The ORF encoded the protein consisting of 225 amino acid residues (SEQ ID No: 64), and as a result of in vitro translation, a translated product of 25 kDa almost same as molecular weight 24,415 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized in the mitochondria (Example 4).

[0189] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to bacteria ribosomal protein L2 (Accession No. AAD36563). FIG. 18 shows a comparison of the amino acid sequence between the human protein encoded by clone 32 and the bacteria ribosomal protein L2. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the intermediary 135 amino acid residues, they had a homology of 44.4%. Further, the N-terminal 211 amino acid residues of this protein were found to show a homology of 99.1% with the N-terminal amino acid residues of human CGI-22 protein (Accession No. AAD27731).

[0190] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 32, those having a homology of not less than 90% (e.g. Accession No. R72376) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 32 is encoded.

[0191] 33: HP10052

[0192] As the result of determining the total base sequence of cDNA insert of clone HP10052 obtsained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 155 bp 5′ untranslated region, 345 bp ORF and 284 bp 3′ untranslated region (SEQ ID No: 65). The ORF encoded the protein consisting of 114 amino acid residues (SEQ ID No: 66), and as a result of in vitro translation, a translated product of 17 kDa larger than molecular weight 11,770 anticipated from ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0193] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 33, those having a homology of not less than 90% (e.g. Accession No. AI 815489) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 33 is encoded.

[0194] 34: HP10626

[0195] As the result of determining the total base sequence of cDNA insert of clone HP10626 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 347 bp 5′ untranslated region, 423 bp ORF and 214 bp 3′ untranslated region (SEQ ID No: 67). The ORF encoded the protein consisting of 140 amino acid residues (SEQ ID No: 68), and as a result of in vitro translation, a translated product of 14 kDa almost same as molecular weight 14,555 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the nucleus (Example 4).

[0196] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 34, those having a homology of not less than 90% (e.g. Accession No. AA234649) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 34 is encoded.

[0197] 35: HP10633

[0198] As the result of determining the total base sequence of cDNA insert of clone HP10633 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 356 bp 5′ untranslated region, 258 bp ORF and 250 bp 3′ uintranslated region (SEQ ID No: 69). The ORF encoded the protein consisting of 85 amino acid residues (SEQ ID No: 70), and as a result of in vitro translation, a translated product of 10 kDa almost same as molecular weight 9,771 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0199] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 35, those having a homology of not less than 90% (e.g. Accession No. R73005) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 35 is encoded.

[0200] 36: HP10637

[0201] As the result of determining the total base sequence of cDNA insert of clone HP10637 obtained from human fibrosarcoma cell line HT1080 cDNA library, it was found that it had a structure of 120 bp 5′ untranslated region, 1740 bp ORF and 757 bp 3′ untranslated region (SEQ ID No: 71). The ORF encoded the protein consisting of 579 amino acid residues (SEQ ID No: 72). The fusion protein of this protein and GFP was found to be expressed in the whole cell, and some of them was found in the form of particle coagulated mass (Example 4).

[0202] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 36, those having a homology of not less than 90% (e.g. Accession No. AI 929698) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 36 is encoded.

[0203] 37: HP10648

[0204] As the result of determining the total base sequence of cDNA insert of clone HP10648 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 38 bp 5′ untranslated region, 1083 bp ORF and 689 bp 3′ untranslated region (SEQ ID No: 73). The ORF encoded the protein consisting of 360 amino acid residues (SEQ ID No: 74), and as a result of in vitro translation, a translated product of 50 kDa larger than molecular weight 40, 211 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized in the nucleus (Example 4).

[0205] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda hypothetical protein Y40B1B.7 (Accession No. CAA21606). FIG. 19 shows a comparison of the amino acid sequence between the human protein encoded by clone 37 and the nematoda hypothetical protein Y40B1B.7. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the C-terminal 111 amino acid residues, they had a homology of 43.2%.

[0206] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 37, those having a homology of not less than 90% (e.g. Accession No. W39612) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 37 is encoded.

[0207] 38: HP10211

[0208] As the result of determining the total base sequence of cDNA insert of clone HP10211 obtained from human osteosarcoma cell line Saos-2 cDNA library, it was found that it had a structure of 216p 5′ untranslated region, 381 bp ORF and 1023 bp 3′ untranslated region (SEQ ID No: 75). The ORF encoded the protein consisting of 126 amino acid residues (SEQ ID No: 76), and as a result of in vitro translation, a translated product of 14 kDa slightly larger than molecular weight 12,758 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0209] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 38, those having a homology of not less than 90% (e.g. Accession No. D81861) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 38 is encoded.

[0210] 39: HP10332

[0211] As the result of determining the total base sequence of cDNA insert of clone HP10332 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 184 bp 5′ untranslated region, 858 bp ORF and 307 bp 3′ untranslated region (SEQ ID No: 77). The ORF encoded the protein consisting of 285 amino acid residues (SEQ ID No: 78), and as a result of in vitro translation, a translated product of 35 kDa slightly larger than molecular weight 32,158 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell, but some cells were expressed in the Golgi body or endoplasmic reticulum (Example 4).

[0212] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 39, those having a homology of not less than 90% (e.g. Accession No. AA025985) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 39 is encoded.

[0213] 40: HP10641

[0214] As the result of determining the total base sequence of cDNA insert of clone HP10641 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 78 bp 5′ untranslated region, 990 bp ORF and 287 bp 3) untranslated region (SEQ ID No: 79). The ORF encoded the protein consisting of 329 amino acid residues (SEQ ID No: 80), and as a result of in vitro translation, a translated product of 42 kDa larger than molecular weight 36,537 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0215] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 40, those having a homology of not less than 90% (e.g. Accession No. T09308) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 40 is encoded. Moreover, a clone (Accession No. AF 161491) showing a homology of 99.9% was found to have been registered, but this clone encodes a protein different from that of clone 40 because it brings about a frame shift due to shortage of G corresponding to 865th of clone 40.

[0216] 41: HP10650

[0217] As the result of determining the total base sequence of cDNA insert of clone HP10650 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 28 bp 5′ untranslated region, 702 bp ORF and 813 bp 3′ untranslated region (SEQ ID No: 81). The ORF encoded the protein consisting of 233 amino acid residues (SEQ ID No: 82), and as a result of in vitro translation, a translated product of 30 kDa larger than molecular weight 25,846 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the particle form in the cytoplasm (Example 4).

[0218] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 41, those having a homology of not less than 90% (e.g. Accession No. AA494499) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 41 is encoded.

[0219] 42: HP10654

[0220] As the result of determining the total base sequence of cDNA insert of clone HP10654 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 30 bp 5′ untranslated region, 552 bp ORF and 854 bp 3′ untranslated region (SEQ ID No: 83). The ORF encoded the protein consisting of 183 amino acid residues (SEQ ID No: 84), and as a result of in vitro translation, a translated product of 24 kDa slightly larger than molecular weight 21,077 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0221] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 42, those having a homology of not less than 90% (e.g. Accession No. AA459480) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 42 is encoded.

[0222] 43: HP10657

[0223] As the result of determining the total base sequence of cDNA insert of clone HP10657 obtained from human lymphoma cell line U937 cDNA library, it was found that it had a structure of 101 bp 5′ untranslated region, 1143 bp ORF and 113 bp 3′ untranslated region (SEQ ID No: 85). The ORF encoded the protein consisting of 380 amino acid residues (SEQ ID No: 86), and as a result of in vitro translation, a translated product of 41 kDa almost same as molecular weight 40,485 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0224] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 43, those having a homology of not less than 90% (e.g. Accession No. R25280) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 43 is encoded.

[0225] 44: HP10659

[0226] As the result of determining the total base sequence of cDNA insert of clone HP10659 obtained from human lymphoma cell line U937 cDNA library, it was found that it had a structure of 73 bp 5′ untranslated region, 783 bp ORF and 543 bp 3′ untranslated region (SEQ ID No: 87). The ORF encoded the protein consisting of 260 amino acid residues (SEQ ID No: 88), and as a result of in vitro translation, a translated product of 31 kDa almost same as molecular weight 30, 815 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be localized in the bulky coagulated mass or granular form in the cytoplasm (Example 4).

[0227] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 44, those having a homology of not less than 90% (e.g. Accession No. AA356158) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 44 is encoded.

[0228] 45: HP10681

[0229] As the result of determining the total base sequence of cDNA insert of clone HP10681 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 151 bp 5′ untranslated region, 825 bp ORF and 143 bp 3′ untranslated region (SEQ ID No: 89). The ORF encoded the protein consisting of 274 amino acid residues (SEQ ID No: 90), and as a result of in vitro translation, a translated product of 32 kDa almost same as molecular weight 31,045 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell, and some of them were expressed also in the granular form (Example 4).

[0230] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 45, those having a homology of not less than 90% (e.g. Accession No. AA406451) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 45 is encoded.

[0231] 46: HP10077

[0232] As the result of determining the total base sequence of cDNA insert of clone HP10077 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 132 bp 5′ untranslated region, 306 bp ORF and 102 bp 3′ untranslated region (SEQ ID No: 91). The ORF encoded the protein consisting of 101 amino acid residues (SEQ ID No: 92), and as a result of in vitro translation, a translated product of 11 kDa almost same as molecular weight 11,521 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0233] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 46, those having a homology of not less than 90% (Accession No. AF086207) were found to have been registered in EST, but it is of the complementary sequence, it doesn't encode a protein. Moreover, those having a homology of not less than 90% (e.g. Accession No. W48698 or AF086207) were found to have been registered in the EST, but it cannot be decided whether or not the same protein as that encoded by clone 46 is encoded.

[0234] 47: HP10162

[0235] As the result of determining the total base sequence of cDNA insert of clone HP10162 obtained from human osteosarcoma cell line Saos-2 cDNA library, it was found that it had a structure of 32 bp 5′ untranslated region, 837 bp ORF and 190 bp 3′ untranslated region (SEQ ID No: 93). The ORF encoded the protein consisting of 278 amino acid residues (SEQ ID No: 94), and as a result of in vitro translation, a translated product of 32 kDa almost same as molecular weight 31,844 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found as the granular form in the whole cell (Example 4).

[0236] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to rat hypothetical protein (Accession No. AAF00052). FIG. 20 shows a comparison of the amino acid sequence between the human protein encoded by clone 47 and rat hypothetical protein. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 84.9%.

[0237] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 47, those having a homology of not less than 90% (e.g. Accession No. AA377040) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 47 is encoded.

[0238] 48: HP10334

[0239] As the result of determining the total base sequence of cDNA insert of clone HP10334 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 102 bp 5′ untranslated region, 282 bp ORF and 398 bp 3′ untranslated region (SEQ ID No: 95). The ORF encoded the protein consisting of 93 amino acid residues (SEQ ID No: 96), and as a result of in vitro translation, a translated product of 14 kDa slightly larger than molecular weight 10,431 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0240] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to human SH3 domain binding glutamic acid-rich-like protein (Accession No. NP 003013). FIG. 21 shows a comparison of the amino acid sequence between the human protein encoded by clone 48 and the human SH3 domain binding glutamic acid-rich-like protein. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, the had a homology of 37.5%.

[0241] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 48, those having a homology of not less than 90% (e.g. Accession No. AA299350) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 48 is encoded.

[0242] 49: HP10400

[0243] As the result of determining the total base sequence of cDNA insert of clone HP10400 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 21 bp 5′ untranslated region, 174 bp ORF and 222 bp 3′ untranslated region (SEQ ID No: 97). The ORF encoded the protein consisting of 57 amino acid residues (SEQ ID No: 98), and as a result of in vitro translation, a translated product of 8 kDa slightly larger than molecular weight 6,207 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0244] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 49, those having a homology of not less than 90% (e.g. Accession No. W05345) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 49 is encoded.

[0245] 50: HP10410

[0246] As the result of determining the total base sequence of cDNA insert of clone HP10410 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 64 bp 5′ untranslated region, 348 bp ORF and 285 bp 3′ untranslated region (SEQ ID No: 99). The ORF encoded the protein consisting of 115 amino acid residues (SEQ ID No: 100), and as a result of in vitro translation, a translated product of 14 kDa larger than molecular weight 12,506 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the cytoplasm and nucleus (Example 4).

[0247] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 50, those having a homology of not less than 90% (e.g. Accession No. T87538) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 50 is encoded.

[0248] 51: HP10417

[0249] As the result of determining the total base sequence of cDNA insert of clone HP10417 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 461 bp 5′ untranslated region, 333 bp ORF and 710 bp 3′ untranslated region (SEQ ID No: 101). The ORF encoded the protein consisting of 110 amino acid residues (SEQ ID No: 102), and as a result of in vitro translation, a translated product of 14 kDa slightly larger than molecular weight 11,667 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0250] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 51, those having a homology of not less than 90% (e.g. Accession No. C15811) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 51 is encoded.

[0251] 52: HP10482

[0252] As the result of determining the total base sequence of cDNA insert of clone HP10482 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 123 bp 5′ untranslated region, 402 bp ORF and 521 bp 3′ untranslated region (SEQ ID No: 103). The ORF encoded the protein consisting of 133 amino acid residues (SEQ ID No: 104), and as a result of in vitro translation, a translated product in high molecular weight was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the whole cell (Example 4).

[0253] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 52, it had a homology with complementary sequence of profilaggrin (e.g. Accession No. M60499). Further, those having a homology of not less than 90% (e.g. Accession No. M62201) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 52 is encoded.

[0254] 53: HP10499

[0255] As the result of determining the total base sequence of cDNA insert of clone HP10499 obtained from human stomach carcinoma cDNA library, considering 79th TGA as selenocysteine but not as a stop codon, it was found that it had a structure of 54 bp 5′ untranslated region, 207 bp ORF and 80 bp 3′ untranslated region (SEQ ID No: 105). The ORF encoded the protein consisting of 68 amino acid residues (SEQ ID No: 106). The fusion protein of this protein and GFP was expressed by fusing GFP cDNA just before 259th stop codon of this ORF, it was found in the whole cell (Example 4). Since the fusion protein had been expressed in spite of the initiating codon in this ORF being not found except in 55th ATG only, 79th TGA is considered to encode selenocysteine without functioning as a stop codon.

[0256] Further, as a result of referring to GenBank on the basis of the base sequence of cDNA of clone 53, those having a homology of not less than 90% (e.g. Accession No. AA523172) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 53 is encoded.

[0257] 54: HP10522

[0258] As the result of determining the total base sequence of cDNA insert of clone HP10522 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 12 bp 5′ untranslated region, 999 bp ORF and 673 bp 3′ untranslated region (SEQ ID No: 107). The ORF encoded the protein consisting of 332 amino acid residues (SEQ ID No: 108). As a result of in vitro translation, a translated product of 41 kDa slightly larger than molecular weight 37,512 expected from the ORF was produced (Example2). The fusion protein of this protein and GFP was localized in the mitochondria (Example 4).

[0259] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 54, those having a homology of not less than 90% (e.g. Accession No. C03423) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 54 is encoded.

[0260] 55: HP10532

[0261] As the result of determining the total base sequence of cDNA insert of clone HP10532 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 80 bp 5′ untranslated region, 480 bp ORF and 167 bp 3′ untranslated region (SEQ ID No: 109). The ORF encoded the protein consisting of 159 amino acid residues (SEQ ID No: 110). The fusion protein of this protein and GFP was expressed in the whole cell (Example 4).

[0262] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to human apoptosis-associated protein Bbk (Accession No. AR043361, U.S. Pat. No. 5,834,234). FIG. 22 shows a comparison of the amino acid sequence between the human protein encoded by clone 55 and the human apoptosis-associated protein Bbk. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. This protein in which arginine was inserted between 35th proline and 36th serine in the human apotosis associated protein Bbk lacked 91 amino acid residues from 143rd leucine to 233rd tryptophan of the Bbk.

[0263] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 55, those having a homology of not less than 90% (e.g. Accession No. AA251393) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 55 is encoded.

[0264] 56: HP10552

[0265] As the result of determining the total base sequence of cDNA insert of clone HP10552 obtained from human osteosarcoma cell line Saos-2 cDNA library, it was found that it had a structure of 132 bp 5′ untranslated region, 738 bp ORF and 483 bp 3′ untranslated region (SEQ ID No: 111). The ORF encoded the protein consisting of 245 amino acid residues (SEQ ID No: 112), and as a result of in vitro translation, a translated product of 37 kDa larger than molecular weight 27,609 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was found to be expressed in the coagulated mass form (Example 4).

[0266] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 56, those having a homology of not less than 90% (e.g. Accession No. AI 929089) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 56 is encoded.

[0267] 57: HP10553

[0268] As the result of determining the total base sequence of cDNA insert of clone HP10553 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 169 bp 5′ untranslated region, 333 bp ORF and 151 bp 3′ untranslated region (SEQ ID No: 113). The ORF encoded the protein consisting of 110 amino acid residues (SEQ ID No: 114). As a result of in vitro translation, a translated product of 14 kDa larger than molecular weight 12,387 anticipated from ORF was produced (Example 2). The fusion protein of this protein and GFP was expressed in the whole cell (Example 4).

[0269] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 57, those having a homology of not less than 90% (e.g. Accession No. Z43871) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 57 is encoded.

[0270] 58: HP10558

[0271] As the result of determining the total base sequence of cDNA insert of clone HP10558 obtained from human osteosarcoma cell line Saos-2 cDNA library, it was found that it had a structure of 39 bp 5′ untranslated region, 372 bp ORF and 232 bp 3′ untranslated region (SEQ ID No: 115). The ORF encoded the protein consisting of 123 amino acid residues (SEQ ID No: 116). As a result of in vitro translation, a translated product of 20 kDa larger than molecular weight 14,225 anticipated from the ORF (Example 2). The fusion protein of this protein and GFP was localized in the nucleolus (Example 4).

[0272] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 58, those having a homology of not less than 90% (e.g. Accession No. AA327056) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 58 is encoded. Further, a clone (Accession No. AX017850, WO 9946375-A) to coincide with the partial sequence of anti-sense strand was found to have been registered, but it cannot be decided whether or not the same protein as that encoded by clone 58 is encoded by this clone.

[0273] 59: HP10559

[0274] As the result of determining the total base sequence of cDNA insert of clone HP10559 obtained from human osteosarcoma cell line Saos-2 cDNA library, it was found that it had a structure of 305 bp 5′ untranslated region, 714 bp ORF and 274 bp 3′ untranslated region (SEQ ID No: 117). The ORF encoded the protein consisting of 237 amino acid residues (SEQ ID No: 118). The fusion protein of this protein and GFP was localized in the nucleus (Example 4).

[0275] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to human hypothetical protein KIAA0276 (Accession No. BAA13405). FIG. 23 shows a comparison of the amino acid sequence between the human protein encoded by clone 59 and the human hypothetical protein KIAA0276. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 69.6%.

[0276] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 59, those having a homology of not less than 90% (e.g. Accession No. A75334, WO 9401548) and other having a homology of not less than 90% (e.g. Accession No. AA099966) were found to have been registered in EST, but as they are of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 59 is encoded by this clone.

[0277] 60: HP10560

[0278] As the result of determining the total base sequence of cDNA insert of clone HP10560 obtained from human osteosarcoma cell line Saos-2 cDNA library, it was found that it had a structure of 147 bp 5′ untranslated region, 324 bp ORF and 445 bp 3′ untranslated region (SEQ ID No: 119). The ORF encoded the protein consisting of 107 amino acid residues (SEQ ID No: 120). The fusion protein of this protein and GFP was expressed in the whole cell (Example 4).

[0279] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 60, those having a homology of not less than 90% (e.g. Accession No. C17870) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 60 is encoded.

[0280] 61: HP10561

[0281] As the result of determining the total base sequence of cDNA insert of clone HP10561 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 50 bp 5′ untranslated region, 681 bp ORF and 271 bp 3′ untranslated region (SEQ ID No: 121). The ORF encoded the protein consisting of 226 amino acid residues (SEQ ID No: 122). As a result of in vitro translation, a translated product of 29 kDa larger than molecular weight 22,581 anticipated from the ORF (Example 2). The fusion protein of this protein and GFP was localized in the nucleolus (Example 4).

[0282] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 61, those having a homology of not less than 90% (e.g. Accession No. W84353) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 61 is encoded.

[0283] 62: HP10562

[0284] As the result of determining the total base sequence of cDNA insert of clone HP10562 obtained from human osteosarcoma cell line Saos-2 cDNA library, it -was found that it had a structure of 267 bp 5′ untranslated region, 1188 bp ORF and 298 bp 3′ untranslated region (SEQ ID No: 123). The ORF encoded the protein consisting of 395 amino acid residues (SEQ ID No: 124). As a result of in vitro translation, a translated product of 48 kDa larger than molecular weight 43,405 anticipated from ORF (Example 2). The fusion protein between this protein and GFP was expressed in the granular form or weakly expressed in the whole cell (Example 4).

[0285] As a result of referring to the protein database on the basis of the amino acid sequence of this protein, there was found a similarity to human basic leucine zipper protein LZIP (Accession No. BAA13405). FIG. 24 shows a comparison of the amino acid sequence between human protein encoded by clone 62 and human basic leucine zipper protein LZIP. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. In the 206 amino acid residues of the intermediary region, they had a homology of 43.7%.

[0286] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 62, those having a homology of not less than 90% (e.g. Accession No. AA203110) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 62 is encoded.

[0287] 63: HP10564

[0288] As the result of determining the total base sequence of cDNA insert of clone HP10564 obtained from human osteosarcoma cell line Saos-2 cDNA library, a structure of 53 bp 5′ untranslated region, 69 bp ORF and 546 bp 3′ untranslated region (SEQ ID No: 125). The ORF encoded the protein consisting of 22 amino acid residues (SEQ ID No: 126). The fusion protein of this protein and GFP was expressed in the whole cell (Example 4).

[0289] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 63, those having a homology of not less than 90% (e.g. Accession No. AI 879105) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 63 is encoded.

[0290] 64: HP10569

[0291] As the result of determining the total base sequence of cDNA insert of clone HP10569 obtained from human epidermal carcinoma cell line KB cDNA library, a structure of 26 bp 5′ untranslated region, 213 bp ORF and 40 bp 3′ untranslated region (SEQ ID No: 127). The ORF encoded the protein consisting of 70 amino acid residues (SEQ ID No: 128). As a result of in vitro translation, a translated product of 9 kDa almost same as molecular weight 8,691 anticipated from the ORF (Example 2). The fusion protein of this protein and GFP was expressed in the whole cell (Example 4).

[0292] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 64, those having a homology of not less than 90% (e.g. Accession No. AI 376841) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 64 is encoded.

[0293] 65: HP10601

[0294] As the result of determining the total base sequence of cDNA insert of clone HP10601 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 90 bp 5′ untranslated region, 2088 bp ORF and 1189 bp 3′ untranslated region (SEQ ID No: 129). The ORF encoded the protein consisting of 695 amino acid residues (SEQ ID No: 130). As a result of in vitro translation, a translated product of 81 kDa larger than molecular weight 76, 105 anticipated from the ORF is produced (Example 2). The fusion protein of this protein and GFP was expressed in the nucleus or in the particle form (Example 4).

[0295] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 65, those having a homology of not less than 90% (e.g. Accession No. R97122) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 65 is encoded.

[0296] 66: HP10456

[0297] As the result of determining the total base sequence of cDNA insert of clone HP10456 obtained from human osteosarcoma cell line U-2 cDNA library, it was found that it had a structure of 99 bp 5′ untranslated region, 600 bp ORF and 591 bp 3′ untranslated region (SEQ ID No: 131). The ORF encoded the protein consisting of 199 amino acid residues (SEQ ID No: 132). As a result of in vitro translation, a translated product of 31 kDa larger than molecular weight 22,095 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was expressed in the cytoplasm as a coagulated mass (Example 4).

[0298] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda BC-2-like protein LZIP (Accession No. AAD03134). FIG. 25 shows a comparison of the amino acid sequence between the human protein encoded by clone 66 and the nematoda BC-2-like protein. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 56.9%.

[0299] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 66, those having a homology of not less than 90% (e.g. Accession No. C04706) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 66 is encoded.

[0300] 67: HP10498

[0301] As the result of determining the total base sequence of cDNA insert of clone HP10498 obtained from human osteosarcoma cell line Saos-2 cDNA library, it was found that it had a structure of 23 bp 5′ untranslated region, 357 bp ORF and 184 bp 3′ untranslated region (SEQ ID No: 133). The ORF encoded the protein consisting of 118 amino acid residues (SEQ ID No: 134). As a result of in vitro translation, a translated product of 14 Da almost same as molecular weight 13,466 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was expressed in the whole cell (Example 4).

[0302] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda hypothetical protein C24D19.6 (Accession No. AAB88317). FIG. 26 shows a comparison of the amino acid sequence between the human protein encoded by clone 67 and the nematoda hypothetical protein C24D19.6. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. In the 87 amino acid residues of the intermediary region, they had a homology of 32.2%.

[0303] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 67, those having a homology of not less than 90% (e.g. Accession No. AA431880) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 67 is encoded.

[0304] 68: HP10503

[0305] As the result of determining the total base sequence of cDNA insert of clone HP10503 obtained from human osteosarcoma cell line Saos-2 cDNA library, it was found that it had a structure of 466 bp 5′ untranslated region, 345 bp ORF and 93 bp 3′ untranslated region (SEQ ID No: 135). The ORF encoded the protein consisting of 114 amino acid residues (SEQ ID No: 136). The fusion protein of this protein and GFP was expressed in the whole cell (Example 4).

[0306] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 68, those having a homology of not less than 90% (e.g. Accession No. AA 305157) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 68 is encoded.

[0307] 69: HP10505

[0308] As the result of determining the total base sequence of cDNA insert of clone HP10505 obtained from human osteosarcoma cell line Saos-2 cDNA library, it was found that it had a structure of 89 bp 5′ untranslated region, 264 bp ORF and 119 bp 3′ untranslated region (SEQ ID No: 137). The ORF encoded the protein consisting of 87 amino acid residues (SEQ ID No: 138). As a result of in vitro translation, a translated product of 14 Da larger than molecular weight 10,734 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was localized in the mitochondria (Example 4).

[0309] As a result of searching the protein database by suing the amino acid sequence of this protein, there was found a similarity to nematoda hypothetical protein F29B9.10 (Accession No. AAB09120). The nematoda hypothetical protein F29B9.10 has 30S ribosome and a weak similarity. FIG. 27 shows a comparison of the amino acid sequence between the human protein encoded by clone 69 and the nematoda hypothetical protein F29B9.10. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the 74 amino acid residues except for the N-terminal, they had a homology of 39.2%.

[0310] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 69, those having a homology of not less than 90% (e.g. Accession No. AA029070) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 69 is encoded.

[0311] 70: HP10511

[0312] As the result of determining the total base sequence of cDNA insert of clone HP10511 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 48 bp 5′ untranslated region, 120 bp ORF and 12 bp 3′ untranslated region (SEQ ID No: 139). The ORF encoded the protein consisting of 39 amino acid residues (SEQ ID No: 140). As a result of in vitro translation, a translated product of 4 kDa almost same as molecular weight 3,939 anticipated from the ORF (Example 2). The fusion protein of this protein and GFP was expressed in the whole cell (Example 4).

[0313] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 70, those having a homology of not less than 90% (e.g. Accession No. AA629178) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 70 is encoded.

[0314] 71: HP10515

[0315] As the result of determining the total base sequence of cDNA insert of clone HP10515 obtained from human liver cDNA library, it was found that it had a structure of 34 bp 5′ untranslated region, 309 bp ORF and 130 bp 3′ untranslated region (SEQ ID No: 141). The ORF encoded the protein consisting of 102 amino acid residues (SEQ ID No: 142). As a result of in vitro translation, a translated product of 15Da larger than molecular weight 12,259 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was expressed in the cytoplasm as the particle form (Example 4).

[0316] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to drosophila hypothetical protein 63B12.s (Accession No. CAA15941). FIG. 28 shows a comparison of the amino acid sequence between the human protein encoded by clone 71 and the drosophila hypothetical protein 63B12.s. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 32.4%.

[0317] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 71, those having a homology of not less than 90% (e.g. Accession No. AA349062) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 71 is encoded.

[0318] 72: HP01124

[0319] As the result of determining the total base sequence of cDNA insert of clone HP01124 obtained from human liver cDNA library, it was found that it had a structure of 105 bp 5′ untranslated region, 1026 bp ORF and 533 bp 3′ untranslated region (SEQ ID No: 143). The ORF encoded the protein consisting of 341 amino acid residues (SEQ ID No: 144). As a result of in vitro translation, a translated product of 37 kDa almost same as molecular weight 37,786 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was localized in the nucleus (Example 4).

[0320] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to human Acyl-CoA-binding protein (Accession No. P07108). FIG. 29 shows a comparison of the amino acid sequence between the human protein encoded by clone 72 and the human Acyl-CoA-binding protein. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 43.0%.

[0321] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 72, those having a homology of not less than 90% (e.g. Accession No. N41542) were found to have been registered in EST, but as it is of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 72 is encoded.

[0322] 73: HP02241

[0323] As the result of determining the total base sequence of cDNA insert of clone HP02241 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 89 bp 5′ untranslated region, 651 bp ORF and 95 bp 3′ untranslated region (SEQ ID No: 145). The ORF encoded the protein consisting of 216 amino acid residues (SEQ ID No: 146). As a result of in vitro translation, a translated product of 30 kDa larger than molecular weight 24,899 anticipated from the ORF (Example 2). The fusion protein of this protein and GFP was expressed as a partially coagulated mass in the whole cell (Example 4).

[0324] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to Xenopus ribosomal protein L24-like protein (Accession No. CAB40554). FIG. 30 shows a comparison of the amino acid sequence between the human protein encoded by clone 73 and the Xenopus ribosomal protein L24-like protein. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the 208 amino acid residues of the N-terminal, they had a homology of 69.7%.

[0325] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 73, those having a homology of not less than 90% (e.g. Accession No. AL 038493) were found to have been registered in EST, but as they are of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 73 is encoded by this clone.

[0326] 74: HP10101

[0327] As the result of determining the total base sequence of cDNA insert of clone HP10101 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 70 bp 5′ untranslated region, 119 1 bp ORF and 1204 bp 3′ untranslated region (SEQ ID No: 147). The ORF encoded the protein consisting of 396 amino acid residues (SEQ ID No: 148). As a result of in vitro translation, a translated product of 54 kDa larger than molecular weight 45,750 anticipated from the ORF (Example 2). The fusion protein of this protein and GFP was expressed in the granular form in the nucleus (Example 4).

[0328] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda hypothetical protein C32E8.5 (Accession No. AAB 42323). FIG. 31 shows a comparison of the amino acid sequence between the human protein encoded by clone 74 and the nematoda hypothetical protein C32E8.5. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the 307 amino acid residues in the C-terminal, they had a homology of 46.9%.

[0329] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 74, those having a homology of not less than 90% (e.g. Accession No. AA 460870) were found to have been registered in EST, but as they are of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 74 is encoded by this clone.

[0330] 75: HP10370

[0331] As the result of determining the total base sequence of cDNA insert of clone HP10370 obtained from human epidermal carcinoma cell line KB cDNA library, it was found that it had a structure of 148 bp 5′ untranslated region, 1356 bp ORF and 2096 bp 3′ untranslated region (SEQ ID No: 149). The ORF encoded the protein consisting of 451 amino acid residues (SEQ ID No: 150). The fusion protein of this protein and GFP was expressed in the whole cell (Example 4).

[0332] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to drosophila hypothetical protein CG11534 (Accession No. AAF49957). FIG. 32 shows a comparison of the amino acid sequence between the human protein encoded by clone 75 and the drosophila hypothetical protein CG11534. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the 382 amino acid residues in the C-terminal, they had a homology of 36.9%.

[0333] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 75, those having a homology of not less than 90% (e.g. Accession No. AA035322) were found to have been registered in EST, but as they are of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 75 is encoded by this clone.

[0334] 76: HP10427

[0335] As the result of determining the total base sequence of cDNA insert of clone HP10427 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 11 bp 5′ untranslated region, 342 bp ORF and 89 bp 3′ untranslated region (SEQ ID No: 151). The ORF encoded the protein consisting of 113 amino acid residues (SEQ ID No: 152). The fusion protein of this protein and GFP was localized in the Golgi body (Example 4).

[0336] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to nematoda hypothetical protein Y106G6H. 8 (Accession No. CAB 6338). FIG. 33 shows a comparison of the amino acid sequence between the human protein encoded by clone 76 and the nematoda hypothetical protein Y106G6H. 8. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 36.9%.

[0337] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 76, those having a homology of not less than 90% (e.g. Accession No. R76178) were found to have been registered in EST, but as they are of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 76 is encoded by this clone.

[0338] 77: HP10438

[0339] As the result of determining the total base sequence of cDNA insert of clone HP10438 obtained from human stomach carcinoma 2 cDNA library, it was found that it had a structure of 11 bp 5′ untranslated region, 669 bp ORF and 46 bp 3′ untranslated region (SEQ ID No: 153). The ORF encoded the protein consisting of 222 amino acid residues (SEQ ID No: 154). As a result of in vitro translation, a translated product of 28 kDa slightly larger than molecular weight 25,384 anticipated from the ORF was produced (Example 2). The fusion protein of this protein and GFP was expressed in the nucleus (Example 4).

[0340] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 77, those having a homology of not less than 90% (e.g. Accession No. AA088470) were found to have been registered in EST, but as they are of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 77 is encoded.

[0341] 78: HP10502

[0342] As the result of determining the total base sequence of cDNA insert of clone HP10502 obtained from human fibrosarcoma cell line HT-1080 cDNA library, it was found that it had a structure of 207 bp 5′ untranslated region, 837 bp ORF and 76 bp 3′ untranslated region (SEQ ID No:. 155). The ORF encoded the protein consisting of 278 amino acid residues (SEQ ID No: 156). The fusion protein of this protein and GFP was expressed in the nucleus (Example 4).

[0343] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 78, those having a homology of not less than 90% (e.g. Accession No. AA648423) were found to have been registered in EST, but as they are of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 78 is encoded by this clone.

[0344] 79: HP10516

[0345] As the result of determining the total base sequence of cDNA insert of clone HP10516 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 26 bp 5′ untranslated region, 666 bp ORF and 55 bp 3′ untranslated region (SEQ ID No:. 157). The ORF encoded the protein consisting of 221 amino acid residues (SEQ ID No: 158). The fusion protein of this protein and GFP was expressed in the whole cell (Example 4).

[0346] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to drosophila hypothetical protein CG14130 (Accession No. AAF50005). FIG. 34 shows a comparison of the amino acid sequence between the human protein encoded by clone 79 and the drosophila hypothetical protein CG14130. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 36.9%.

[0347] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 79, those having a homology of not less than 90% (e.g. Accession No. AW 245556) were found to have been registered in EST, but as they are of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 79 is encoded by this clone.

[0348] 80: HP10580

[0349] As the result of determining the total base sequence of cDNA insert of clone HP10580 obtained from human stomach carcinoma cDNA library, it was found that it had a structure of 94 bp 5′ untranslated region, 1326 bp ORF and 21 bp 3′ untranslated region (SEQ ID No:. 159). The ORF encoded the protein consisting of 441 amino acid residues (SEQ ID No: 160). The fusion protein of this protein and GFP was expressed as a coagulated mass in the cytoplasm (Example 4).

[0350] As a result of searching the protein database by using the amino acid sequence of this protein, there was found a similarity to drosophila hypothetical protein CG5469 (Accession No. AAF50005). FIG. 35 shows a comparison of the amino acid sequence between the human protein encoded by clone 80 and the drosophila hypothetical protein CG5469. In this figure, - means a gap, * means the same amino acid residue as the protein of this invention, and . means an amino acid residue similar to the protein of this invention, respectively. Over the whole region, they had a homology of 35.0%.

[0351] As a result of referring to GenBank on the basis of the base sequence of cDNA of clone 80, those having a homology of not less than 90% (e.g. Accession No. AI 188741) were found to have been registered in EST, but as they are of the partial sequence, it cannot be decided whether or not the same protein as that encoded by clone 80 is encoded by this clone.

Example 2 Protein Synthesis by in vitro Translation

[0352] Using plasmid vector having cDNA isolated in Example 1, in vitro transcription/translation due to T_(N)T rabbit reticulocyte lysate kit (Promega Co.) was performed. In this case, the expressed product was labelled with a radioisotope, using [³⁵S]methionine. Each reaction was carried out according to the protocol attached to the kit.

[0353] Practical procedure was as follows: 2 μg of plasmid was allowed to react in a reaction mixture (total amount: 252 μl) containing 12.5 μl of T_(N)T rabbit reticulocyte lysate, 2 μl (0.37 MBq/μl) of [³⁵S]methionine (Amersham Co.), 0.5 μl of T7RNA polymerase and 20 U of RNasin at 30° C. for 90 minutes. The reaction mixture (3 μl) was mixed with 2 μl of SDS sampling buffer (125 mM Tris-HCl buffer, pH 6.8, 120 mM 2-mercaptoethanol, 2% SDS solution, 0.025% Bromophenol Blue, 20% glycerol), heated at 95° C. for 3 minutes and subjected to electrophoresis with SDS-polyacrylamide gel. Molecular weight of the translated product was obtained by performing the autoradiography.

Example 3 Expression in COS7 cells

[0354]E. coli transformed by expression vector containing cDNA isolated in Example 1 was cultivated at 37° C. for 2 hours in 2 ml of 2xYT medium containing 100 μg/ml ampicillin, and the mixture was mixed with helper phage M13KO7 (50 μl) and cultivated at 37° C. overnight. The culture broth was centrifuged, and the separated supernatant was treated with polyethylene glycol. The precipitated single-stranded phage particle was suspended in 100 μl of 1 mM Tris-0.1 mM EDTA (pH 8 (TE)).

[0355] Culture cell COS7 derived from monkey kidney was cultivated at 37° C. in the presence of 5% CO₂ in Dulbecco's modified Eagle medium (DMEM) containing 10% fetal bovine serum. COS7 cells (1×10⁵) were inoculated onto 6-well plate (well diameter, 3 cm; Nunk Co.) and cultivated at 37° C. for 22 hours in the presence of 5% CO₂. After removing the medium, the cell surface was washed with phosphate buffer and then with DMEM containing 50 mM Tris-HCl (pH 7.5) (TDMEM). To this cell were added 1 μl of a suspension of single-stranded phage, 0.6 ml of DMEM medium and 3 μl of TRANSFECTAM™ (IBF Co.), and the resultant suspension was cultivated at 37° C. for 3 hours in the presence of 5% CO₂. The sample liquid is removed, and the cell surface was washed with TDMEM, mixed with 2 ml/well of DMEM containing 10% fetal bovine serum and cultivated at 37° C. for 2 days in the presence of 5% CO₂. The medium was replaced by a medium containing [³⁵S]cysteine or [³⁵S]methionine and cultivated for 1 hour. The broth was centrifuged to separate the medium from the cell, and the protein in the cell fraction was subjected to SDS-PAGE.

Example 4 Expression of Green Fluorescent Protein (GFP) Fusion Protein

[0356] Using 26 mer of sense primer starting from the translation initiating codon containing the recognition site EcoRI and 26 mer of anti-sense primer inclusive of up to the stop codon containing the recognition site BamHI, the translation region was amplified due to PCR by using as a template cDNA encoding the objective protein. The PCR product was digested with EcoRI and BamHI and incorporated into EcoRI-BamHI site of the vector pEGFP-N1 (manufactured by Clontech Co.) for expressing GFP fusion protein. After confirming the base sequence, the resultant fusion gene expression vector was transfected into COS7 cells according to the method described in Example 3. The region wherein the objective protein was localized was examined by observing the green fluorescent distribution by a fluorescent microscope.

Example 5 Preparation of Antibody

[0357] Using 26 mer of sense primer starting from the translation initiating codon containing the recognition site EcoRI and 26 mer of anti-sense primer inclusive of up to the stop codon containing the recognition sequence SalI, the translated region was amplified due to PCR by using as a template each cDNA. The PCR product was digested with EcoRI and SalI and incorporated into the EcoRI-SalI site of the pGEX-5X-1 (manufactured: Pharmacia Co.). After confirming the base sequence, the host E. coli JM109 was transfected. The cell was cultivated at 37° C. for 5 hours in LB medium, added with IPTG so as to 0.4 mM of the final concentration and cultivated at 37° C. for 4 hours. The cell was separated by centrifuging, dissolved in a lytic solution (50 mM Tris-HCl pH 7.5, 1 mM EDTA, 0.2 mM PMF), once frozen at −80° C., thawed, and disrupted by sonication. The resultant lysate was centrifuged at 10,000×g for 30 minutes, and the supernatant was added with glutathione sephalose 4B and incubated at 4° C. for 1 hour. The beads were sufficiently washed, and the fusion protein was eluted with an eluent (50 mM Tris-HCl pH 7.5, 50 mM glutathione). A rabbit was immunized with the resultant fusion protein as an antigen in a conventional manner to give an antiserum. The antiserum was purified by subjecting the 40% saturated ammonium sulfate-precipitated fraction to GST affinity column for removing GST antibody. The eluted fraction was further purified by using an antigen column of GST fusion protein.

INDUSTRIAL APPLICABILITY

[0358] As described in detail above, the present application is to provide a purified human protein, DNA fragment encoding the protein, expression vector for the DNA fragment, various cells transfected with the expression vector, and antibody against the protein. The protein provided by this application is useful for detecting the corresponding receptor or ligand as an intracellular targeting protein, for screening novel small molecule medicinals and so on, since each protein is considered to function within a cell. Further, the protein is useful as an antigen for manufacturing the antibody against the proteins. The DNA fragment provided by this application is useful as a probe for gene diagnosis or as a gene source for gene therapy. Further, the DNA fragment can be also used as a gene source for mass production of the protein. The cells in which the protein has been expressed by incorporating the gene can be used for preparing modified forms of the protein. The antibody provided by the present application can be used for detection, determination, purification or the like of the protein.

0 SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 160 <210> SEQ ID NO 1 <211> LENGTH: 1323 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (27)..(881) <400> SEQUENCE: 1 ctctgcccgt cttctgggaa gggaga atg gcg gcg ccc ggg ctg cgg ctg gga 53 Met Ala Ala Pro Gly Leu Arg Leu Gly 1 5 gcg gga aga ctc ttt gaa atg cct gcg gtg cta gag cga ctg agc cgc 101 Ala Gly Arg Leu Phe Glu Met Pro Ala Val Leu Glu Arg Leu Ser Arg 10 15 20 25 tat aat agc acg tcc caa gct ttt gct gag gtg ctg cgg ctg ccg aag 149 Tyr Asn Ser Thr Ser Gln Ala Phe Ala Glu Val Leu Arg Leu Pro Lys 30 35 40 cag cag ctg agg aag ctg ctg tac ccg ctg cag gaa gta gag cgg ttc 197 Gln Gln Leu Arg Lys Leu Leu Tyr Pro Leu Gln Glu Val Glu Arg Phe 45 50 55 ctc gcc ccc tac ggg agg caa gac ctt cac ctg cgt atc ttt gac cca 245 Leu Ala Pro Tyr Gly Arg Gln Asp Leu His Leu Arg Ile Phe Asp Pro 60 65 70 agc ccg gag gac ata gcc agg gcg gac aac atc ttc acg gcc act gaa 293 Ser Pro Glu Asp Ile Ala Arg Ala Asp Asn Ile Phe Thr Ala Thr Glu 75 80 85 cgg aac cgc atc gac tac gtc agc tcc gcc gtc cgt atc gac cac gcc 341 Arg Asn Arg Ile Asp Tyr Val Ser Ser Ala Val Arg Ile Asp His Ala 90 95 100 105 ccg gac ctt ccg cgg cca gag gtg tgt ttt ata ggc aga agc aat gtt 389 Pro Asp Leu Pro Arg Pro Glu Val Cys Phe Ile Gly Arg Ser Asn Val 110 115 120 gga aaa tca tct cta atc aag gct tta ttt tca ctg gcc cct gag gtt 437 Gly Lys Ser Ser Leu Ile Lys Ala Leu Phe Ser Leu Ala Pro Glu Val 125 130 135 gaa gtc aga gtc tcc aaa aaa cca gga cac aca aag aaa atg aat ttt 485 Glu Val Arg Val Ser Lys Lys Pro Gly His Thr Lys Lys Met Asn Phe 140 145 150 ttc aaa gtt gga aaa cat ttt aca gtg gtg gac atg cca ggt tat ggc 533 Phe Lys Val Gly Lys His Phe Thr Val Val Asp Met Pro Gly Tyr Gly 155 160 165 ttt aga gca cct gaa gat ttt gtt gac atg gta gag acc tat cta aaa 581 Phe Arg Ala Pro Glu Asp Phe Val Asp Met Val Glu Thr Tyr Leu Lys 170 175 180 185 gaa cga agg aac ttg aag aga aca ttt tta tta gtg gat agc gtt gtt 629 Glu Arg Arg Asn Leu Lys Arg Thr Phe Leu Leu Val Asp Ser Val Val 190 195 200 gga att caa aaa aca gac aat att gcc ata gaa atg tgt gaa gaa ttt 677 Gly Ile Gln Lys Thr Asp Asn Ile Ala Ile Glu Met Cys Glu Glu Phe 205 210 215 gca tta cct tat gtg att gta tta aca aaa att gac aaa tct tcc aag 725 Ala Leu Pro Tyr Val Ile Val Leu Thr Lys Ile Asp Lys Ser Ser Lys 220 225 230 gga cat ctt tta aaa caa gtg ctt cag atc cag aaa ttt gtt aac atg 773 Gly His Leu Leu Lys Gln Val Leu Gln Ile Gln Lys Phe Val Asn Met 235 240 245 aaa act caa gga tgt ttt cct cag ttg ttt cct gta agt gct gtg acc 821 Lys Thr Gln Gly Cys Phe Pro Gln Leu Phe Pro Val Ser Ala Val Thr 250 255 260 265 ttt tct gga atc cac ctg ttg aga tgc ttt ata gcc agt gta aca gga 869 Phe Ser Gly Ile His Leu Leu Arg Cys Phe Ile Ala Ser Val Thr Gly 270 275 280 agt ctt gac taa tggttcccgg tttagctgaa gattcaaaag ctttatgcta 921 Ser Leu Asp actggagtta aatacctaga agaatttcaa cattgtttta aatgttgtgc atctgtaact 981 tcaggaggat cacttgagct ttaaaacctg tgccttctcg aaacaagaat ttgtgcctga 1041 ggtgaaaaaa gtttgtaagt tattgaatta tggtgttcat tagaacagct actagctgat 1101 tcccctattt taacaaactg acaagagcac atccataaaa tgaaaacctg ttacaactat 1161 gtacagaagg gtttgacgtt ttattgggct tttgtctttt aaagaatatg tctactatgg 1221 gtattttttt tttaaatgtt aaaatgggct aggtaaaagg gggctgcttt tctgttaagc 1281 atcgataggt aagttgatgg ataaaagtta ctatgtaagc ct 1323 <210> SEQ ID NO 2 <211> LENGTH: 284 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 2 Met Ala Ala Pro Gly Leu Arg Leu Gly Ala Gly Arg Leu Phe Glu Met 1 5 10 15 Pro Ala Val Leu Glu Arg Leu Ser Arg Tyr Asn Ser Thr Ser Gln Ala 20 25 30 Phe Ala Glu Val Leu Arg Leu Pro Lys Gln Gln Leu Arg Lys Leu Leu 35 40 45 Tyr Pro Leu Gln Glu Val Glu Arg Phe Leu Ala Pro Tyr Gly Arg Gln 50 55 60 Asp Leu His Leu Arg Ile Phe Asp Pro Ser Pro Glu Asp Ile Ala Arg 65 70 75 80 Ala Asp Asn Ile Phe Thr Ala Thr Glu Arg Asn Arg Ile Asp Tyr Val 85 90 95 Ser Ser Ala Val Arg Ile Asp His Ala Pro Asp Leu Pro Arg Pro Glu 100 105 110 Val Cys Phe Ile Gly Arg Ser Asn Val Gly Lys Ser Ser Leu Ile Lys 115 120 125 Ala Leu Phe Ser Leu Ala Pro Glu Val Glu Val Arg Val Ser Lys Lys 130 135 140 Pro Gly His Thr Lys Lys Met Asn Phe Phe Lys Val Gly Lys His Phe 145 150 155 160 Thr Val Val Asp Met Pro Gly Tyr Gly Phe Arg Ala Pro Glu Asp Phe 165 170 175 Val Asp Met Val Glu Thr Tyr Leu Lys Glu Arg Arg Asn Leu Lys Arg 180 185 190 Thr Phe Leu Leu Val Asp Ser Val Val Gly Ile Gln Lys Thr Asp Asn 195 200 205 Ile Ala Ile Glu Met Cys Glu Glu Phe Ala Leu Pro Tyr Val Ile Val 210 215 220 Leu Thr Lys Ile Asp Lys Ser Ser Lys Gly His Leu Leu Lys Gln Val 225 230 235 240 Leu Gln Ile Gln Lys Phe Val Asn Met Lys Thr Gln Gly Cys Phe Pro 245 250 255 Gln Leu Phe Pro Val Ser Ala Val Thr Phe Ser Gly Ile His Leu Leu 260 265 270 Arg Cys Phe Ile Ala Ser Val Thr Gly Ser Leu Asp 275 280 <210> SEQ ID NO 3 <211> LENGTH: 1120 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (18)..(719) <400> SEQUENCE: 3 attctgtgcc tgtgaac atg gcg gcg ccc gtt gtc acg gcc ccg ggc aga 50 Met Ala Ala Pro Val Val Thr Ala Pro Gly Arg 1 5 10 gct ctg ctg cgg gcg ggc gct gga cgg ctg ctt cgg gga ggc gtc cag 98 Ala Leu Leu Arg Ala Gly Ala Gly Arg Leu Leu Arg Gly Gly Val Gln 15 20 25 gag cta ctg cgg ccg cga cat gaa ggg aac gcc cct gac ctg gcc tgc 146 Glu Leu Leu Arg Pro Arg His Glu Gly Asn Ala Pro Asp Leu Ala Cys 30 35 40 aac ttc agc ctt tct caa aat cgg ggc acg gtc atc gtg gag cgc tgg 194 Asn Phe Ser Leu Ser Gln Asn Arg Gly Thr Val Ile Val Glu Arg Trp 45 50 55 tgg aag gta ccg ctg gcc ggg ggg ggc cgg aag ccg cgc ctg cac cgg 242 Trp Lys Val Pro Leu Ala Gly Gly Gly Arg Lys Pro Arg Leu His Arg 60 65 70 75 cga cat cgc gtc tat aag ctg gtg gag gac acg aag cat cgg ccc aaa 290 Arg His Arg Val Tyr Lys Leu Val Glu Asp Thr Lys His Arg Pro Lys 80 85 90 gaa aac ctg gag ctc atc ctg acg cag tcg gtg gag aat gtt gga gtc 338 Glu Asn Leu Glu Leu Ile Leu Thr Gln Ser Val Glu Asn Val Gly Val 95 100 105 cgg ggt gac ctg gtc tca gtg aag aaa tct tta ggc cgg aat cga ctc 386 Arg Gly Asp Leu Val Ser Val Lys Lys Ser Leu Gly Arg Asn Arg Leu 110 115 120 ctt cct cag gga ctg gct gta tat gca tcc cct gaa aac aag aag ctg 434 Leu Pro Gln Gly Leu Ala Val Tyr Ala Ser Pro Glu Asn Lys Lys Leu 125 130 135 ttt gaa gag gag aaa ttg ctg aga caa gaa gga aaa tta gag aag atc 482 Phe Glu Glu Glu Lys Leu Leu Arg Gln Glu Gly Lys Leu Glu Lys Ile 140 145 150 155 cag acc aag gca ggt gag gcg ctt ggt gtt gtg gtt gcc cca cat aca 530 Gln Thr Lys Ala Gly Glu Ala Leu Gly Val Val Val Ala Pro His Thr 160 165 170 tta aag tta cca gca gag cct atc aca cgg tgg ggc gag tat tgg tgt 578 Leu Lys Leu Pro Ala Glu Pro Ile Thr Arg Trp Gly Glu Tyr Trp Cys 175 180 185 gag gtg acg gta aat ggg ctt gat act gtg aga gtg cct atg tct gtc 626 Glu Val Thr Val Asn Gly Leu Asp Thr Val Arg Val Pro Met Ser Val 190 195 200 gtg aac ttt gag aag ccc aag acc aaa aga tat aag tac tgg tta gcc 674 Val Asn Phe Glu Lys Pro Lys Thr Lys Arg Tyr Lys Tyr Trp Leu Ala 205 210 215 cag caa gct gcc aag gct atg gcc ccc acc agc ccc cag atc taa 719 Gln Gln Ala Ala Lys Ala Met Ala Pro Thr Ser Pro Gln Ile 220 225 230 atctactctc cctccaaggc agcaaagcag aatcgggagc agtggagcag aaatgtgcaa 779 gcaccctgat ctcactccca gctctgacca aatacagaat tttagagaac atctgaagac 839 atcagactgc actgcgtata catgttgaat tcttcatttt tgccatcttt aactgtcatc 899 actggggcag ggaagtcctg ttccagaagt accaggctgt agatttgata agctagatgc 959 agtagaccga aaccatccaa aacctgttta gcttcttcct ccattggagt ttattgggac 1019 aaacaggaga gccagccatt gtctccagta cttgcctcat tctcatcatc caaactgaac 1079 atttgtatcc caagcagaaa taaagagaat atgttctttt t 1120 <210> SEQ ID NO 4 <211> LENGTH: 233 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 4 Met Ala Ala Pro Val Val Thr Ala Pro Gly Arg Ala Leu Leu Arg Ala 1 5 10 15 Gly Ala Gly Arg Leu Leu Arg Gly Gly Val Gln Glu Leu Leu Arg Pro 20 25 30 Arg His Glu Gly Asn Ala Pro Asp Leu Ala Cys Asn Phe Ser Leu Ser 35 40 45 Gln Asn Arg Gly Thr Val Ile Val Glu Arg Trp Trp Lys Val Pro Leu 50 55 60 Ala Gly Gly Gly Arg Lys Pro Arg Leu His Arg Arg His Arg Val Tyr 65 70 75 80 Lys Leu Val Glu Asp Thr Lys His Arg Pro Lys Glu Asn Leu Glu Leu 85 90 95 Ile Leu Thr Gln Ser Val Glu Asn Val Gly Val Arg Gly Asp Leu Val 100 105 110 Ser Val Lys Lys Ser Leu Gly Arg Asn Arg Leu Leu Pro Gln Gly Leu 115 120 125 Ala Val Tyr Ala Ser Pro Glu Asn Lys Lys Leu Phe Glu Glu Glu Lys 130 135 140 Leu Leu Arg Gln Glu Gly Lys Leu Glu Lys Ile Gln Thr Lys Ala Gly 145 150 155 160 Glu Ala Leu Gly Val Val Val Ala Pro His Thr Leu Lys Leu Pro Ala 165 170 175 Glu Pro Ile Thr Arg Trp Gly Glu Tyr Trp Cys Glu Val Thr Val Asn 180 185 190 Gly Leu Asp Thr Val Arg Val Pro Met Ser Val Val Asn Phe Glu Lys 195 200 205 Pro Lys Thr Lys Arg Tyr Lys Tyr Trp Leu Ala Gln Gln Ala Ala Lys 210 215 220 Ala Met Ala Pro Thr Ser Pro Gln Ile 225 230 <210> SEQ ID NO 5 <211> LENGTH: 528 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (90)..(284) <400> SEQUENCE: 5 aaggaaattg acgaacacgt gacgcggtcg ggcggaccac tgcagactga gcggtggacc 60 gaattgggac cgctggctta taagcgatc atg ttt ctc cag tat tac ctc aac 113 Met Phe Leu Gln Tyr Tyr Leu Asn 1 5 gag cag gga gat cga gtc tat acg ctg aag aaa ttt gac ccg atg gga 161 Glu Gln Gly Asp Arg Val Tyr Thr Leu Lys Lys Phe Asp Pro Met Gly 10 15 20 caa cag acc tgc tca gcc cat cct gct cgg ttc tcc cca gat gac aaa 209 Gln Gln Thr Cys Ser Ala His Pro Ala Arg Phe Ser Pro Asp Asp Lys 25 30 35 40 tac tct cga cac cga atc acc atc aag aaa cgc ttc aag gtg ctc atg 257 Tyr Ser Arg His Arg Ile Thr Ile Lys Lys Arg Phe Lys Val Leu Met 45 50 55 acc cag caa ccg cgc cct gtc ctc tga gggtccctta aactgatgtc 304 Thr Gln Gln Pro Arg Pro Val Leu 60 ttttctgccg tctgttaccc ctcgcagact ccgtaaccaa actcttcgga ctgtgagccc 364 tgatgccttt ttgccagcca tactctttgg catccagtct ctcgtggcga ttgatcatgc 424 ttgtgtgagg caatcatggt ggcatcaccc ataaagggaa cacatttgac ttttttttct 484 catattttaa attactacaa gattattaaa gataaaatga tttg 528 <210> SEQ ID NO 6 <211> LENGTH: 64 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 6 Met Phe Leu Gln Tyr Tyr Leu Asn Glu Gln Gly Asp Arg Val Tyr Thr 1 5 10 15 Leu Lys Lys Phe Asp Pro Met Gly Gln Gln Thr Cys Ser Ala His Pro 20 25 30 Ala Arg Phe Ser Pro Asp Asp Lys Tyr Ser Arg His Arg Ile Thr Ile 35 40 45 Lys Lys Arg Phe Lys Val Leu Met Thr Gln Gln Pro Arg Pro Val Leu 50 55 60 <210> SEQ ID NO 7 <211> LENGTH: 1306 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (53)..(841) <400> SEQUENCE: 7 ccttagtaac ctgggcgata gctgtggatg tttccaagga ttgtcttcag tc atg gcc 58 Met Ala 1 ttg gga tta aag tgc ttc cgc atg gtc cac cct acc ttt cgc aat tat 106 Leu Gly Leu Lys Cys Phe Arg Met Val His Pro Thr Phe Arg Asn Tyr 5 10 15 ctt gca gcc tct atc aga ccc gtt tca gaa gtt aca ctg aag aca gtg 154 Leu Ala Ala Ser Ile Arg Pro Val Ser Glu Val Thr Leu Lys Thr Val 20 25 30 cat gaa aga caa cat ggc cat agg caa tac atg gcc tat tca gct gta 202 His Glu Arg Gln His Gly His Arg Gln Tyr Met Ala Tyr Ser Ala Val 35 40 45 50 cca gtc cgc cat ttt gct acc aag aaa gcc aaa gcc aaa ggg aaa gga 250 Pro Val Arg His Phe Ala Thr Lys Lys Ala Lys Ala Lys Gly Lys Gly 55 60 65 cag tcc caa acc aga gtg aat att aat gct gcc ttg gtt gag gat ata 298 Gln Ser Gln Thr Arg Val Asn Ile Asn Ala Ala Leu Val Glu Asp Ile 70 75 80 atc aac ttg gaa gag gtg aat gaa gaa atg aag tct gtg ata gaa gct 346 Ile Asn Leu Glu Glu Val Asn Glu Glu Met Lys Ser Val Ile Glu Ala 85 90 95 ctc aag gat aat ttc aat aag act ctc aat ata agg acc tca cca gga 394 Leu Lys Asp Asn Phe Asn Lys Thr Leu Asn Ile Arg Thr Ser Pro Gly 100 105 110 tcc ctt gac aag att gct gtg gta act gct gac ggg aag ctt gct tta 442 Ser Leu Asp Lys Ile Ala Val Val Thr Ala Asp Gly Lys Leu Ala Leu 115 120 125 130 aac cag att agc cag atc tcc atg aag tcg cca cag ctg att ttg gtg 490 Asn Gln Ile Ser Gln Ile Ser Met Lys Ser Pro Gln Leu Ile Leu Val 135 140 145 aat atg gcc agc ttc cca gag tgt aca gct gca gct atc aag gct ata 538 Asn Met Ala Ser Phe Pro Glu Cys Thr Ala Ala Ala Ile Lys Ala Ile 150 155 160 aga gaa agt gga atg aat ctg aac cca gaa gtg gaa ggg acg cta att 586 Arg Glu Ser Gly Met Asn Leu Asn Pro Glu Val Glu Gly Thr Leu Ile 165 170 175 cgg gta ccc att ccc caa gta acc aga gag cac aga gaa atg ctg gtg 634 Arg Val Pro Ile Pro Gln Val Thr Arg Glu His Arg Glu Met Leu Val 180 185 190 aaa ctg gcc aaa cag aac acc aac aag gcc aaa gac tct tta cgg aag 682 Lys Leu Ala Lys Gln Asn Thr Asn Lys Ala Lys Asp Ser Leu Arg Lys 195 200 205 210 gtt cgc acc aac tca atg aac aag ctg aag aaa tcc aag gat aca gtc 730 Val Arg Thr Asn Ser Met Asn Lys Leu Lys Lys Ser Lys Asp Thr Val 215 220 225 tca gag gac acc att agg cta ata gag aaa cag atc agc caa atg gcc 778 Ser Glu Asp Thr Ile Arg Leu Ile Glu Lys Gln Ile Ser Gln Met Ala 230 235 240 gat gac aca gtg gca gaa ctg gac agg cat ctg gca gtg aag acc aaa 826 Asp Asp Thr Val Ala Glu Leu Asp Arg His Leu Ala Val Lys Thr Lys 245 250 255 gaa ctc ctt gga tga aagtccactg gggccagcaa tactccagag cccagtttct 881 Glu Leu Leu Gly 260 gctggatccc atgggtggca cattgggact tctctccctc ccccatctac acagaagact 941 gtcaccatgc tgacagaagc ctgtccttgt aaggcccagc cttccagggg aacactcaga 1001 catgttcatt ctcttcctgc ttctgctctg ggccggtggg tggctctcag aaaatacttg 1061 ctgctggcaa aaggcctgta ctcaggcatt tgctttgact tgatgttgcc aagggactga 1121 ggccattggc aggcttagta ccacctgctc ctcatcttag gagtctcctt ttcaaataat 1181 taggctctgt tcccatttta aaactctgat attggccttc acctgtgact ggacacttta 1241 ctagaggccc attttcacta aacaataaaa tctaaataaa ttggaaggaa taacaaccac 1301 aaagg 1306 <210> SEQ ID NO 8 <211> LENGTH: 262 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 8 Met Ala Leu Gly Leu Lys Cys Phe Arg Met Val His Pro Thr Phe Arg 1 5 10 15 Asn Tyr Leu Ala Ala Ser Ile Arg Pro Val Ser Glu Val Thr Leu Lys 20 25 30 Thr Val His Glu Arg Gln His Gly His Arg Gln Tyr Met Ala Tyr Ser 35 40 45 Ala Val Pro Val Arg His Phe Ala Thr Lys Lys Ala Lys Ala Lys Gly 50 55 60 Lys Gly Gln Ser Gln Thr Arg Val Asn Ile Asn Ala Ala Leu Val Glu 65 70 75 80 Asp Ile Ile Asn Leu Glu Glu Val Asn Glu Glu Met Lys Ser Val Ile 85 90 95 Glu Ala Leu Lys Asp Asn Phe Asn Lys Thr Leu Asn Ile Arg Thr Ser 100 105 110 Pro Gly Ser Leu Asp Lys Ile Ala Val Val Thr Ala Asp Gly Lys Leu 115 120 125 Ala Leu Asn Gln Ile Ser Gln Ile Ser Met Lys Ser Pro Gln Leu Ile 130 135 140 Leu Val Asn Met Ala Ser Phe Pro Glu Cys Thr Ala Ala Ala Ile Lys 145 150 155 160 Ala Ile Arg Glu Ser Gly Met Asn Leu Asn Pro Glu Val Glu Gly Thr 165 170 175 Leu Ile Arg Val Pro Ile Pro Gln Val Thr Arg Glu His Arg Glu Met 180 185 190 Leu Val Lys Leu Ala Lys Gln Asn Thr Asn Lys Ala Lys Asp Ser Leu 195 200 205 Arg Lys Val Arg Thr Asn Ser Met Asn Lys Leu Lys Lys Ser Lys Asp 210 215 220 Thr Val Ser Glu Asp Thr Ile Arg Leu Ile Glu Lys Gln Ile Ser Gln 225 230 235 240 Met Ala Asp Asp Thr Val Ala Glu Leu Asp Arg His Leu Ala Val Lys 245 250 255 Thr Lys Glu Leu Leu Gly 260 <210> SEQ ID NO 9 <211> LENGTH: 893 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (96)..(404) <400> SEQUENCE: 9 aaaaaaattt gaagaccagg aagttgatca atcccgaggc tgctgagaga cggtggcgcg 60 attgggacag tcgccaggga tggctgagcg tgaag atg cag cgg gtg tcc ggg 113 Met Gln Arg Val Ser Gly 1 5 ctg ctc tcc tgg acg ctg agc aga gtc ctg tgg ctc tcc ggc ctc tct 161 Leu Leu Ser Trp Thr Leu Ser Arg Val Leu Trp Leu Ser Gly Leu Ser 10 15 20 gag ccg gga gct gcc cgg cag ccc cgg atc atg gaa gag aaa gcg cta 209 Glu Pro Gly Ala Ala Arg Gln Pro Arg Ile Met Glu Glu Lys Ala Leu 25 30 35 gag gtt tat gat ttg att aga act atc cgg gac cca gaa aag ccc aat 257 Glu Val Tyr Asp Leu Ile Arg Thr Ile Arg Asp Pro Glu Lys Pro Asn 40 45 50 act tta gaa gaa ctg gaa gtg gtc tcg gaa agt tgt gtg gaa gtt cag 305 Thr Leu Glu Glu Leu Glu Val Val Ser Glu Ser Cys Val Glu Val Gln 55 60 65 70 gag ata aat gaa gaa gaa tat ctg gtt att atc agg ttc acg cca aca 353 Glu Ile Asn Glu Glu Glu Tyr Leu Val Ile Ile Arg Phe Thr Pro Thr 75 80 85 gta cct cat tgc tct ttg gcg act ctt att gtt gga aat cta cat ttc 401 Val Pro His Cys Ser Leu Ala Thr Leu Ile Val Gly Asn Leu His Phe 90 95 100 tga aggaacccac tcaacagaag aagacatcaa taagcagata aatgacaaag 454 agcgagtggc agctgcaatg gaaaacccca acttacggga aattgtggaa cagtgtgtcc 514 ttgaacctga ctgatagctg ttttaagagc cactggcctg taattgtttg atatatttgt 574 ttaaactctt tgtataatgt cagagactca tgtttaatac ataggtgatt tgtacctcag 634 agcatttttt aaaggattct ttccaagcga gatttaatta taaggtagta cctaatttgt 694 tcaatgtata acattctcag gatttgtaac acttaaatga tcagacagaa taatattttc 754 tagttattat gtgtaagatg agttgctatt tttctgatgc tcattctgat acaactattt 814 ttcgtgtcaa atatctactg tgcccaaatg tactcaattt aaatcattac tctgtaaaat 874 aaataagcag atgattctt 893 <210> SEQ ID NO 10 <211> LENGTH: 102 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 10 Met Gln Arg Val Ser Gly Leu Leu Ser Trp Thr Leu Ser Arg Val Leu 1 5 10 15 Trp Leu Ser Gly Leu Ser Glu Pro Gly Ala Ala Arg Gln Pro Arg Ile 20 25 30 Met Glu Glu Lys Ala Leu Glu Val Tyr Asp Leu Ile Arg Thr Ile Arg 35 40 45 Asp Pro Glu Lys Pro Asn Thr Leu Glu Glu Leu Glu Val Val Ser Glu 50 55 60 Ser Cys Val Glu Val Gln Glu Ile Asn Glu Glu Glu Tyr Leu Val Ile 65 70 75 80 Ile Arg Phe Thr Pro Thr Val Pro His Cys Ser Leu Ala Thr Leu Ile 85 90 95 Val Gly Asn Leu His Phe 100 <210> SEQ ID NO 11 <211> LENGTH: 597 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (21)..(497) <400> SEQUENCE: 11 actttccgcg ggccgcgggg atg gcg gcg cag ggc gta ggg cct ggg ccg ggg 53 Met Ala Ala Gln Gly Val Gly Pro Gly Pro Gly 1 5 10 tcg gcg gcg ccc ccg ggg ctg gag gcg gcc cgg cag aag ctg gcg ctg 101 Ser Ala Ala Pro Pro Gly Leu Glu Ala Ala Arg Gln Lys Leu Ala Leu 15 20 25 cgg cgg aag aag gtg ctg agc acc gag gag atg gag ctg tac gag ctg 149 Arg Arg Lys Lys Val Leu Ser Thr Glu Glu Met Glu Leu Tyr Glu Leu 30 35 40 gcg cag gcg gcg ggc ggc gct atc gac ccc gac gtg ttc aag atc ctg 197 Ala Gln Ala Ala Gly Gly Ala Ile Asp Pro Asp Val Phe Lys Ile Leu 45 50 55 gtg gac ctg ctg aag ctg aac gtg gcc ccc ctc gcc gtc ttc cag atg 245 Val Asp Leu Leu Lys Leu Asn Val Ala Pro Leu Ala Val Phe Gln Met 60 65 70 75 ctc aag tcc atg tgt gcc ggg cag agg cta gcg agc gag ccc cag gac 293 Leu Lys Ser Met Cys Ala Gly Gln Arg Leu Ala Ser Glu Pro Gln Asp 80 85 90 cct gcg gcc gtg tct ctg ccc acg tcg agc gtg ccc gag acc cga ggg 341 Pro Ala Ala Val Ser Leu Pro Thr Ser Ser Val Pro Glu Thr Arg Gly 95 100 105 aga aac aaa ggc agc gct gcc ctc ggg gga gca ttg gcc ctg gcg gaa 389 Arg Asn Lys Gly Ser Ala Ala Leu Gly Gly Ala Leu Ala Leu Ala Glu 110 115 120 cgc agc agc cgc gaa gga tcc agc cag agg atg cca cgc cag ccc agc 437 Arg Ser Ser Arg Glu Gly Ser Ser Gln Arg Met Pro Arg Gln Pro Ser 125 130 135 gct acc agg ctg ccc aag ggg ggc ggg cct ggg aag agc cct aca cgg 485 Ala Thr Arg Leu Pro Lys Gly Gly Gly Pro Gly Lys Ser Pro Thr Arg 140 145 150 155 ggc agc acc tag gatggggcag agacttgttg catctttgtc cccagcaaag 537 Gly Ser Thr gctacatgtt acctccttca attgataata aacctttctg agatgcagag ggtccaggtc 597 <210> SEQ ID NO 12 <211> LENGTH: 158 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 12 Met Ala Ala Gln Gly Val Gly Pro Gly Pro Gly Ser Ala Ala Pro Pro 1 5 10 15 Gly Leu Glu Ala Ala Arg Gln Lys Leu Ala Leu Arg Arg Lys Lys Val 20 25 30 Leu Ser Thr Glu Glu Met Glu Leu Tyr Glu Leu Ala Gln Ala Ala Gly 35 40 45 Gly Ala Ile Asp Pro Asp Val Phe Lys Ile Leu Val Asp Leu Leu Lys 50 55 60 Leu Asn Val Ala Pro Leu Ala Val Phe Gln Met Leu Lys Ser Met Cys 65 70 75 80 Ala Gly Gln Arg Leu Ala Ser Glu Pro Gln Asp Pro Ala Ala Val Ser 85 90 95 Leu Pro Thr Ser Ser Val Pro Glu Thr Arg Gly Arg Asn Lys Gly Ser 100 105 110 Ala Ala Leu Gly Gly Ala Leu Ala Leu Ala Glu Arg Ser Ser Arg Glu 115 120 125 Gly Ser Ser Gln Arg Met Pro Arg Gln Pro Ser Ala Thr Arg Leu Pro 130 135 140 Lys Gly Gly Gly Pro Gly Lys Ser Pro Thr Arg Gly Ser Thr 145 150 155 <210> SEQ ID NO 13 <211> LENGTH: 760 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (97)..(696) <400> SEQUENCE: 13 ttggggacgg accggaagtg cccgagggcg gccgcagaac ggtcaatttg agccgcgtcg 60 agctcccctg ggacctgtgg ccgccgccca cagacc atg ctc ctg ggg cgc ctg 114 Met Leu Leu Gly Arg Leu 1 5 act tcc cag ctg ttg agg gcc gtt cct tgg gca ggc ggc cgc ccg cct 162 Thr Ser Gln Leu Leu Arg Ala Val Pro Trp Ala Gly Gly Arg Pro Pro 10 15 20 tgg ccc gtc tct gga gtg ctg ggc agc cgg gtc tgc ggg ccc ctt tac 210 Trp Pro Val Ser Gly Val Leu Gly Ser Arg Val Cys Gly Pro Leu Tyr 25 30 35 agc aca tcg ccg gcc ggc cca ggt agg gcg gcc tct ctc cct cgc aag 258 Ser Thr Ser Pro Ala Gly Pro Gly Arg Ala Ala Ser Leu Pro Arg Lys 40 45 50 ggg gcc cag ctg gag ctg gag gag atg ctg gtc ccc agg aag atg tcc 306 Gly Ala Gln Leu Glu Leu Glu Glu Met Leu Val Pro Arg Lys Met Ser 55 60 65 70 gtc agc ccc ctg gag agc tgg ctc acg gcc cgc tgc ttc ctg ccc aga 354 Val Ser Pro Leu Glu Ser Trp Leu Thr Ala Arg Cys Phe Leu Pro Arg 75 80 85 ctg gat acc ggg acc gca ggg act gtg gct cca ccg caa tcc tac cag 402 Leu Asp Thr Gly Thr Ala Gly Thr Val Ala Pro Pro Gln Ser Tyr Gln 90 95 100 tgt ccg ccc agc cag ata ggg gaa ggg gcc gag cag ggg gat gaa ggc 450 Cys Pro Pro Ser Gln Ile Gly Glu Gly Ala Glu Gln Gly Asp Glu Gly 105 110 115 gtc gcg gat gcg cct caa att cag tgc aaa aac gtg ctg aag atc cgc 498 Val Ala Asp Ala Pro Gln Ile Gln Cys Lys Asn Val Leu Lys Ile Arg 120 125 130 cgg cgg aag atg aac cac cac aag tac cgg aag ctg gtg aag aag acg 546 Arg Arg Lys Met Asn His His Lys Tyr Arg Lys Leu Val Lys Lys Thr 135 140 145 150 cgg ttc ctg cgg agg aag gtc cag gag gga cgc ctg aga cgc aag cag 594 Arg Phe Leu Arg Arg Lys Val Gln Glu Gly Arg Leu Arg Arg Lys Gln 155 160 165 atc aag ttc gag aaa gac ctg agg cgc atc tgg ctg aag gcg ggg cta 642 Ile Lys Phe Glu Lys Asp Leu Arg Arg Ile Trp Leu Lys Ala Gly Leu 170 175 180 aag gaa gcc ccc gaa ggc tgg cag acc ccc aag atc tac ctg cgg ggc 690 Lys Glu Ala Pro Glu Gly Trp Gln Thr Pro Lys Ile Tyr Leu Arg Gly 185 190 195 aaa tga gtctggcgcc gcccttcccg cccgttgctg ctgtgatccg tagtaataaa 746 Lys ttctcagaga actc 760 <210> SEQ ID NO 14 <211> LENGTH: 199 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 14 Met Leu Leu Gly Arg Leu Thr Ser Gln Leu Leu Arg Ala Val Pro Trp 1 5 10 15 Ala Gly Gly Arg Pro Pro Trp Pro Val Ser Gly Val Leu Gly Ser Arg 20 25 30 Val Cys Gly Pro Leu Tyr Ser Thr Ser Pro Ala Gly Pro Gly Arg Ala 35 40 45 Ala Ser Leu Pro Arg Lys Gly Ala Gln Leu Glu Leu Glu Glu Met Leu 50 55 60 Val Pro Arg Lys Met Ser Val Ser Pro Leu Glu Ser Trp Leu Thr Ala 65 70 75 80 Arg Cys Phe Leu Pro Arg Leu Asp Thr Gly Thr Ala Gly Thr Val Ala 85 90 95 Pro Pro Gln Ser Tyr Gln Cys Pro Pro Ser Gln Ile Gly Glu Gly Ala 100 105 110 Glu Gln Gly Asp Glu Gly Val Ala Asp Ala Pro Gln Ile Gln Cys Lys 115 120 125 Asn Val Leu Lys Ile Arg Arg Arg Lys Met Asn His His Lys Tyr Arg 130 135 140 Lys Leu Val Lys Lys Thr Arg Phe Leu Arg Arg Lys Val Gln Glu Gly 145 150 155 160 Arg Leu Arg Arg Lys Gln Ile Lys Phe Glu Lys Asp Leu Arg Arg Ile 165 170 175 Trp Leu Lys Ala Gly Leu Lys Glu Ala Pro Glu Gly Trp Gln Thr Pro 180 185 190 Lys Ile Tyr Leu Arg Gly Lys 195 <210> SEQ ID NO 15 <211> LENGTH: 806 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (15)..(767) <400> SEQUENCE: 15 agttatgcga aaac atg gct gcg gcc ggt ttg gcc ctt ctt tgt agg aga 50 Met Ala Ala Ala Gly Leu Ala Leu Leu Cys Arg Arg 1 5 10 gtt tca tcc gcc ctg aaa tct tcc cga tcg tta ata act cct cag gtc 98 Val Ser Ser Ala Leu Lys Ser Ser Arg Ser Leu Ile Thr Pro Gln Val 15 20 25 cct gcc tgc aca ggg ttt ttt ctt agt ttg ttg cct aag agt aca cca 146 Pro Ala Cys Thr Gly Phe Phe Leu Ser Leu Leu Pro Lys Ser Thr Pro 30 35 40 aat gtg aca tcc ttt cac caa tat aga tta ctt cat acc aca ttg tca 194 Asn Val Thr Ser Phe His Gln Tyr Arg Leu Leu His Thr Thr Leu Ser 45 50 55 60 agg aaa gga cta gaa gaa ttt ttt gat gac cca aaa aac tgg ggg caa 242 Arg Lys Gly Leu Glu Glu Phe Phe Asp Asp Pro Lys Asn Trp Gly Gln 65 70 75 gaa aaa gta aaa tct gga gca gca tgg acc tgt cag caa cta agg aac 290 Glu Lys Val Lys Ser Gly Ala Ala Trp Thr Cys Gln Gln Leu Arg Asn 80 85 90 aaa agt aat gaa gat tta cac aaa ctt tgg tat gtc tta ctg aaa gaa 338 Lys Ser Asn Glu Asp Leu His Lys Leu Trp Tyr Val Leu Leu Lys Glu 95 100 105 aga aac atg ctt cta acc cta gag cag gag gcc aag cgg cag aga ttg 386 Arg Asn Met Leu Leu Thr Leu Glu Gln Glu Ala Lys Arg Gln Arg Leu 110 115 120 cca atg cca agt cca gag cgg tta gat aag gta gta gat tcc atg gat 434 Pro Met Pro Ser Pro Glu Arg Leu Asp Lys Val Val Asp Ser Met Asp 125 130 135 140 gca tta gat aaa gtt gtc cag gaa aga gaa gat gcc cta agg ctt ctt 482 Ala Leu Asp Lys Val Val Gln Glu Arg Glu Asp Ala Leu Arg Leu Leu 145 150 155 cag act ggt caa gaa aga gct aga cct ggt gct tgg aga aga gac atc 530 Gln Thr Gly Gln Glu Arg Ala Arg Pro Gly Ala Trp Arg Arg Asp Ile 160 165 170 ttt gga aga atc atc tgg cac aag ttc aag cag tgg gtt ata cct tgg 578 Phe Gly Arg Ile Ile Trp His Lys Phe Lys Gln Trp Val Ile Pro Trp 175 180 185 cac cta aat aaa aga tac aat agg aaa cga ttc ttt gcc ttg cct tat 626 His Leu Asn Lys Arg Tyr Asn Arg Lys Arg Phe Phe Ala Leu Pro Tyr 190 195 200 gtg gac cat ttt ctc aga ctg gaa cgt gag aaa cga gcc cgc atc aaa 674 Val Asp His Phe Leu Arg Leu Glu Arg Glu Lys Arg Ala Arg Ile Lys 205 210 215 220 gca cgg aag gaa aat tta gag aga aag aaa gca aaa att ctt tta aaa 722 Ala Arg Lys Glu Asn Leu Glu Arg Lys Lys Ala Lys Ile Leu Leu Lys 225 230 235 aag ttt cca cat ctt gct gaa gcc caa aag tca agt ctt gtc taa 767 Lys Phe Pro His Leu Ala Glu Ala Gln Lys Ser Ser Leu Val 240 245 250 gatgtctgaa ctattaaatt taccattttg tttttcttg 806 <210> SEQ ID NO 16 <211> LENGTH: 250 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 16 Met Ala Ala Ala Gly Leu Ala Leu Leu Cys Arg Arg Val Ser Ser Ala 1 5 10 15 Leu Lys Ser Ser Arg Ser Leu Ile Thr Pro Gln Val Pro Ala Cys Thr 20 25 30 Gly Phe Phe Leu Ser Leu Leu Pro Lys Ser Thr Pro Asn Val Thr Ser 35 40 45 Phe His Gln Tyr Arg Leu Leu His Thr Thr Leu Ser Arg Lys Gly Leu 50 55 60 Glu Glu Phe Phe Asp Asp Pro Lys Asn Trp Gly Gln Glu Lys Val Lys 65 70 75 80 Ser Gly Ala Ala Trp Thr Cys Gln Gln Leu Arg Asn Lys Ser Asn Glu 85 90 95 Asp Leu His Lys Leu Trp Tyr Val Leu Leu Lys Glu Arg Asn Met Leu 100 105 110 Leu Thr Leu Glu Gln Glu Ala Lys Arg Gln Arg Leu Pro Met Pro Ser 115 120 125 Pro Glu Arg Leu Asp Lys Val Val Asp Ser Met Asp Ala Leu Asp Lys 130 135 140 Val Val Gln Glu Arg Glu Asp Ala Leu Arg Leu Leu Gln Thr Gly Gln 145 150 155 160 Glu Arg Ala Arg Pro Gly Ala Trp Arg Arg Asp Ile Phe Gly Arg Ile 165 170 175 Ile Trp His Lys Phe Lys Gln Trp Val Ile Pro Trp His Leu Asn Lys 180 185 190 Arg Tyr Asn Arg Lys Arg Phe Phe Ala Leu Pro Tyr Val Asp His Phe 195 200 205 Leu Arg Leu Glu Arg Glu Lys Arg Ala Arg Ile Lys Ala Arg Lys Glu 210 215 220 Asn Leu Glu Arg Lys Lys Ala Lys Ile Leu Leu Lys Lys Phe Pro His 225 230 235 240 Leu Ala Glu Ala Gln Lys Ser Ser Leu Val 245 250 <210> SEQ ID NO 17 <211> LENGTH: 3907 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (132)..(1976) <400> SEQUENCE: 17 aacatggccg cgcccagggg agatggcgtg caagtatccg ctgcggtgtt ctggtgctag 60 agtggagagg ctggcaaaga agaaggcaca cgcatggtga gaatccggcc tgagccgaag 120 cggagtttgc t atg gac agc aac cat caa agt aat tac aaa ctc agt aaa 170 Met Asp Ser Asn His Gln Ser Asn Tyr Lys Leu Ser Lys 1 5 10 act gag aag aag ttc tta agg aaa cag att aaa gcc aag cat act ttg 218 Thr Glu Lys Lys Phe Leu Arg Lys Gln Ile Lys Ala Lys His Thr Leu 15 20 25 ctg aga cat gaa ggc att gag aca gta tcc tat gcc act cag agc ctg 266 Leu Arg His Glu Gly Ile Glu Thr Val Ser Tyr Ala Thr Gln Ser Leu 30 35 40 45 gtt gtt gcc aat ggt ggt ttg ggt aat ggt gtg agt cgg aac cag ctg 314 Val Val Ala Asn Gly Gly Leu Gly Asn Gly Val Ser Arg Asn Gln Leu 50 55 60 ctc ccg gtt tta gag aaa tgt gga ctg gtg gat gct ctc tta atg cca 362 Leu Pro Val Leu Glu Lys Cys Gly Leu Val Asp Ala Leu Leu Met Pro 65 70 75 cct aac aag ccg tac tca ttt gca aga tac aga act aca gaa gaa tct 410 Pro Asn Lys Pro Tyr Ser Phe Ala Arg Tyr Arg Thr Thr Glu Glu Ser 80 85 90 aag aga gcc tat gtt acc ctc aat gga aaa gaa gta gtg gat gat tta 458 Lys Arg Ala Tyr Val Thr Leu Asn Gly Lys Glu Val Val Asp Asp Leu 95 100 105 gga caa aag atc act ctg tat ttg aat ttt gtg gaa aaa gtg cag tgg 506 Gly Gln Lys Ile Thr Leu Tyr Leu Asn Phe Val Glu Lys Val Gln Trp 110 115 120 125 aag gag ttg agg cct caa gcc tta cca cca gga ctc atg gta gta gaa 554 Lys Glu Leu Arg Pro Gln Ala Leu Pro Pro Gly Leu Met Val Val Glu 130 135 140 gaa ata att tct tct gag gag gag aaa atg ctt ttg gaa agt gtt gat 602 Glu Ile Ile Ser Ser Glu Glu Glu Lys Met Leu Leu Glu Ser Val Asp 145 150 155 tgg aca gaa gat aca gac aat caa aac tct caa aaa tcc tta aaa cac 650 Trp Thr Glu Asp Thr Asp Asn Gln Asn Ser Gln Lys Ser Leu Lys His 160 165 170 aga aga gta aag cat ttt ggt tat gag ttc cac tat gag aac aac aat 698 Arg Arg Val Lys His Phe Gly Tyr Glu Phe His Tyr Glu Asn Asn Asn 175 180 185 gta gat aaa gat aag cca tta tct ggg ggt ctt cct gac att tgt gaa 746 Val Asp Lys Asp Lys Pro Leu Ser Gly Gly Leu Pro Asp Ile Cys Glu 190 195 200 205 agc ttt ttg gag aaa tgg ttg agg aaa ggt tac att aaa cat aaa cct 794 Ser Phe Leu Glu Lys Trp Leu Arg Lys Gly Tyr Ile Lys His Lys Pro 210 215 220 gat caa atg acc ata aat cag tat gaa cct ggg caa gga att ccc gct 842 Asp Gln Met Thr Ile Asn Gln Tyr Glu Pro Gly Gln Gly Ile Pro Ala 225 230 235 cat att gac aca cat tcc gct ttt gag gat gag atc gtt tct ctc agt 890 His Ile Asp Thr His Ser Ala Phe Glu Asp Glu Ile Val Ser Leu Ser 240 245 250 ttg ggg tca gag att gtc atg gat ttt aag cac cca gat ggc att gca 938 Leu Gly Ser Glu Ile Val Met Asp Phe Lys His Pro Asp Gly Ile Ala 255 260 265 gtg cca gtt atg ttg cct cgt cgg agt ttg ctg gtg atg aca gga gaa 986 Val Pro Val Met Leu Pro Arg Arg Ser Leu Leu Val Met Thr Gly Glu 270 275 280 285 tct aga tac ctt tgg acc cat gga atc acg tgc aga aaa ttt gat act 1034 Ser Arg Tyr Leu Trp Thr His Gly Ile Thr Cys Arg Lys Phe Asp Thr 290 295 300 gtt caa gca tct gag agt ctt aaa agt gga att atc acc agt gat gtt 1082 Val Gln Ala Ser Glu Ser Leu Lys Ser Gly Ile Ile Thr Ser Asp Val 305 310 315 gga gac tta act tta agc aag agg gga cta cga aca tca ttt aca ttt 1130 Gly Asp Leu Thr Leu Ser Lys Arg Gly Leu Arg Thr Ser Phe Thr Phe 320 325 330 agg aaa gtg agg caa aca cct tgt aac tgt agt tac ccg ttg gtc tgt 1178 Arg Lys Val Arg Gln Thr Pro Cys Asn Cys Ser Tyr Pro Leu Val Cys 335 340 345 gat agc cag agg aaa gag act ccc ccc tca ttt cca gag agt gat aaa 1226 Asp Ser Gln Arg Lys Glu Thr Pro Pro Ser Phe Pro Glu Ser Asp Lys 350 355 360 365 gaa gcc tca cgg ctg gag caa gag tac gtc cat cag gtt tat gaa gag 1274 Glu Ala Ser Arg Leu Glu Gln Glu Tyr Val His Gln Val Tyr Glu Glu 370 375 380 att gct ggg cac ttc agc agc aca aga cat acc cct tgg ccg cac att 1322 Ile Ala Gly His Phe Ser Ser Thr Arg His Thr Pro Trp Pro His Ile 385 390 395 gtg gag ttt ttg aag gct ttg cca agt ggt tca ata gtg gct gat att 1370 Val Glu Phe Leu Lys Ala Leu Pro Ser Gly Ser Ile Val Ala Asp Ile 400 405 410 gga tgt ggt aat gga aag tat ctt ggc atc aat aag gag tta tat atg 1418 Gly Cys Gly Asn Gly Lys Tyr Leu Gly Ile Asn Lys Glu Leu Tyr Met 415 420 425 gag cgt aga gtg gca gct ctc caa gaa att gtt cga ctc ctg aga cca 1466 Glu Arg Arg Val Ala Ala Leu Gln Glu Ile Val Arg Leu Leu Arg Pro 430 435 440 445 ggt ggg aag gca ctc att tat gtc tgg gca atg gaa caa gaa tat aat 1514 Gly Gly Lys Ala Leu Ile Tyr Val Trp Ala Met Glu Gln Glu Tyr Asn 450 455 460 aag cag aag tcc aag tat ctt aga gga aac aga aat agc caa gga aag 1562 Lys Gln Lys Ser Lys Tyr Leu Arg Gly Asn Arg Asn Ser Gln Gly Lys 465 470 475 aaa gag gag atg aac agt gat acc tca gtg cag agg tca ctt gtg gag 1610 Lys Glu Glu Met Asn Ser Asp Thr Ser Val Gln Arg Ser Leu Val Glu 480 485 490 caa atg cgt gac atg ggc agt cga gac tcg gca tct tct gtc ccc cgc 1658 Gln Met Arg Asp Met Gly Ser Arg Asp Ser Ala Ser Ser Val Pro Arg 495 500 505 att aat gac tct cag gaa gga gga tgt aat tca agg caa gtt tct aat 1706 Ile Asn Asp Ser Gln Glu Gly Gly Cys Asn Ser Arg Gln Val Ser Asn 510 515 520 525 tcc aag ctg cct gtt cat gtt aac agg act tct ttt tat tct caa gat 1754 Ser Lys Leu Pro Val His Val Asn Arg Thr Ser Phe Tyr Ser Gln Asp 530 535 540 gta ctg gtt ccc tgg cac ctt aag gga aat cct gat aaa ggc aaa cct 1802 Val Leu Val Pro Trp His Leu Lys Gly Asn Pro Asp Lys Gly Lys Pro 545 550 555 gtt gag cca ttt ggt ccc ata gga tcc cag gac cca agt cct gtg ttt 1850 Val Glu Pro Phe Gly Pro Ile Gly Ser Gln Asp Pro Ser Pro Val Phe 560 565 570 cat cgt tac tac cat gtg ttc cgt gag gga gaa ctg gaa ggt gcc tgc 1898 His Arg Tyr Tyr His Val Phe Arg Glu Gly Glu Leu Glu Gly Ala Cys 575 580 585 agg act gtg agt gat gtc aga att ctg caa agc tac tac gat caa gga 1946 Arg Thr Val Ser Asp Val Arg Ile Leu Gln Ser Tyr Tyr Asp Gln Gly 590 595 600 605 aac tgg tgt gtg att ctt caa aag gcc tga ttatttacct gaacacatca 1996 Asn Trp Cys Val Ile Leu Gln Lys Ala 610 tatataaaga agaaatgctc acttaaaaaa aaagagagaa taaattaatt acccttttaa 2056 ttaaagagaa aacttgtggg aaagtaccaa aggaaagctg agaaaaattt ggaagtaggg 2116 attcattagg agacattcaa atgtctcctg ttggctgaca tcacagatgt ggtgttggct 2176 cctcctactt ccctaggaga ggtggtttct aaaagtgatt gaagcagttt gtgcagtgtt 2236 tgtaattctt gggtaagagc ccaggatttt gaagataata gttttttagt aaagtgctac 2296 taaatgtagt aaatcatgta ggattttagg gatgtaatta tatgttaata cagaaaatag 2356 tcctggtcaa tagaaaattg tctgaagttt tacctatgat ttttagctct gtaaaatcat 2416 agacaataac cattctattt ccatgcctga ctagcccagg gctggacgta tagcgggtgt 2476 ccaataacgt ttagtcaatc agataatacc cagaacttag taggagtttc attcaaaaac 2536 tattttttga acccaaccat gtaccagtta ctattttaag tactgataat gaagcagtga 2596 ataagaaaga gcaaagctct tgcccttatg gtgcttacat tctagacggg gagacagaca 2656 gcaggcaaat caataaatag atactatgtg ccagatagtg ataaatgcca tgaaaaacat 2716 aaaatgagag acgattcacc ttggagcaaa agattacttt taagtgactg aaataactac 2776 taatcctgac taatttatta tcaagagtta attggtattc caaattcatt gagcagggtg 2836 ctaaaaacaa cccaaatgtg ctcctttaac tcctttgttt aaatgacaaa agttagaatg 2896 tggtcactca gacctaactg tgcccttaga gccaaagctg tggtgtcatt attggttatt 2956 tctagttgat tcatagtttg tcccaatcca ggttcaatcg ggttattttt aagatctgta 3016 caatattgca taatagtaac ccagttaact taccacttag gttagatttc ctggaggaac 3076 aaaggtagaa attcaaccat aggtcaaatt atcacataga aggaaaaggc tttttttcaa 3136 agaaaaaatt ttttgaacac tttactccca gtatgcatta cttttgtagt agtaatgctt 3196 aagactgttt taaagaaaaa ttgctttctg tttaattaat gtttactgtt attaatgcta 3256 gtgatactta atcttgaagc atcaagtttt cagaaaccta tagtgatcaa taatgggtct 3316 cagatgagag gatgattatt tttttcatgg aatttcagtc caacatcctg gtgtactggt 3376 ccctctggga tgaatttata aggctcatga tataggaaaa ggaatatagg gctaaaaata 3436 gttttatttc tgatataaat tctggtactt gacaccaaag tttgaagtca agtcatgcca 3496 ataaatttta acatccaaat gaaatagatg attttctatg aagatgaaaa ataccaaaat 3556 tgactcaaga agggagagaa aatggaagat gttgaaaaat agcataggaa ttcagaactg 3616 ggctctagaa tcagatttcc tgagagttga attctagatc tgccatttat tagctgtggg 3676 attttgggca aatttcttga ctttctgtgc ttcagttttc ttagctgtaa aattggaaga 3736 gttgttatga aaattcactg aaagtatatt tgtatacatc ataggatagt gtaagaatat 3796 agtatggctt tgagaaatgt tcattattat tactcccaga ggagttttag gtattaagtg 3856 atgccaaata taatttgtta attgtataat aaaaatctat attcttactg a 3907 <210> SEQ ID NO 18 <211> LENGTH: 614 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 18 Met Asp Ser Asn His Gln Ser Asn Tyr Lys Leu Ser Lys Thr Glu Lys 1 5 10 15 Lys Phe Leu Arg Lys Gln Ile Lys Ala Lys His Thr Leu Leu Arg His 20 25 30 Glu Gly Ile Glu Thr Val Ser Tyr Ala Thr Gln Ser Leu Val Val Ala 35 40 45 Asn Gly Gly Leu Gly Asn Gly Val Ser Arg Asn Gln Leu Leu Pro Val 50 55 60 Leu Glu Lys Cys Gly Leu Val Asp Ala Leu Leu Met Pro Pro Asn Lys 65 70 75 80 Pro Tyr Ser Phe Ala Arg Tyr Arg Thr Thr Glu Glu Ser Lys Arg Ala 85 90 95 Tyr Val Thr Leu Asn Gly Lys Glu Val Val Asp Asp Leu Gly Gln Lys 100 105 110 Ile Thr Leu Tyr Leu Asn Phe Val Glu Lys Val Gln Trp Lys Glu Leu 115 120 125 Arg Pro Gln Ala Leu Pro Pro Gly Leu Met Val Val Glu Glu Ile Ile 130 135 140 Ser Ser Glu Glu Glu Lys Met Leu Leu Glu Ser Val Asp Trp Thr Glu 145 150 155 160 Asp Thr Asp Asn Gln Asn Ser Gln Lys Ser Leu Lys His Arg Arg Val 165 170 175 Lys His Phe Gly Tyr Glu Phe His Tyr Glu Asn Asn Asn Val Asp Lys 180 185 190 Asp Lys Pro Leu Ser Gly Gly Leu Pro Asp Ile Cys Glu Ser Phe Leu 195 200 205 Glu Lys Trp Leu Arg Lys Gly Tyr Ile Lys His Lys Pro Asp Gln Met 210 215 220 Thr Ile Asn Gln Tyr Glu Pro Gly Gln Gly Ile Pro Ala His Ile Asp 225 230 235 240 Thr His Ser Ala Phe Glu Asp Glu Ile Val Ser Leu Ser Leu Gly Ser 245 250 255 Glu Ile Val Met Asp Phe Lys His Pro Asp Gly Ile Ala Val Pro Val 260 265 270 Met Leu Pro Arg Arg Ser Leu Leu Val Met Thr Gly Glu Ser Arg Tyr 275 280 285 Leu Trp Thr His Gly Ile Thr Cys Arg Lys Phe Asp Thr Val Gln Ala 290 295 300 Ser Glu Ser Leu Lys Ser Gly Ile Ile Thr Ser Asp Val Gly Asp Leu 305 310 315 320 Thr Leu Ser Lys Arg Gly Leu Arg Thr Ser Phe Thr Phe Arg Lys Val 325 330 335 Arg Gln Thr Pro Cys Asn Cys Ser Tyr Pro Leu Val Cys Asp Ser Gln 340 345 350 Arg Lys Glu Thr Pro Pro Ser Phe Pro Glu Ser Asp Lys Glu Ala Ser 355 360 365 Arg Leu Glu Gln Glu Tyr Val His Gln Val Tyr Glu Glu Ile Ala Gly 370 375 380 His Phe Ser Ser Thr Arg His Thr Pro Trp Pro His Ile Val Glu Phe 385 390 395 400 Leu Lys Ala Leu Pro Ser Gly Ser Ile Val Ala Asp Ile Gly Cys Gly 405 410 415 Asn Gly Lys Tyr Leu Gly Ile Asn Lys Glu Leu Tyr Met Glu Arg Arg 420 425 430 Val Ala Ala Leu Gln Glu Ile Val Arg Leu Leu Arg Pro Gly Gly Lys 435 440 445 Ala Leu Ile Tyr Val Trp Ala Met Glu Gln Glu Tyr Asn Lys Gln Lys 450 455 460 Ser Lys Tyr Leu Arg Gly Asn Arg Asn Ser Gln Gly Lys Lys Glu Glu 465 470 475 480 Met Asn Ser Asp Thr Ser Val Gln Arg Ser Leu Val Glu Gln Met Arg 485 490 495 Asp Met Gly Ser Arg Asp Ser Ala Ser Ser Val Pro Arg Ile Asn Asp 500 505 510 Ser Gln Glu Gly Gly Cys Asn Ser Arg Gln Val Ser Asn Ser Lys Leu 515 520 525 Pro Val His Val Asn Arg Thr Ser Phe Tyr Ser Gln Asp Val Leu Val 530 535 540 Pro Trp His Leu Lys Gly Asn Pro Asp Lys Gly Lys Pro Val Glu Pro 545 550 555 560 Phe Gly Pro Ile Gly Ser Gln Asp Pro Ser Pro Val Phe His Arg Tyr 565 570 575 Tyr His Val Phe Arg Glu Gly Glu Leu Glu Gly Ala Cys Arg Thr Val 580 585 590 Ser Asp Val Arg Ile Leu Gln Ser Tyr Tyr Asp Gln Gly Asn Trp Cys 595 600 605 Val Ile Leu Gln Lys Ala 610 <210> SEQ ID NO 19 <211> LENGTH: 901 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (36)..(635) <400> SEQUENCE: 19 aaaaagaaat tcccgggctc tggcttcttg gcgcg atg agg ttc cgg ttc tgt 53 Met Arg Phe Arg Phe Cys 1 5 ggt gat ctg gac tgt ccc gac tgg gtc ctg gca gaa atc agc acg ctg 101 Gly Asp Leu Asp Cys Pro Asp Trp Val Leu Ala Glu Ile Ser Thr Leu 10 15 20 gcc aag atg tcc tct gtg aag ttg cgg ctg ctc tgc agc cag gta cta 149 Ala Lys Met Ser Ser Val Lys Leu Arg Leu Leu Cys Ser Gln Val Leu 25 30 35 aag gag ctg ctg gga cag ggg att gat tat gag aag atc ctg aag ctc 197 Lys Glu Leu Leu Gly Gln Gly Ile Asp Tyr Glu Lys Ile Leu Lys Leu 40 45 50 acg gct gac gcc aag ttt gag tca ggc gat gtg aag gcc aca gtg gca 245 Thr Ala Asp Ala Lys Phe Glu Ser Gly Asp Val Lys Ala Thr Val Ala 55 60 65 70 gtg ctg agt ttc atc ctc tcc agt gcg gcc aag cac agt gtc gat ggc 293 Val Leu Ser Phe Ile Leu Ser Ser Ala Ala Lys His Ser Val Asp Gly 75 80 85 gaa tcc ttg tcc agt gaa ctg cag cag ctg ggg ctg ccc aaa gag cac 341 Glu Ser Leu Ser Ser Glu Leu Gln Gln Leu Gly Leu Pro Lys Glu His 90 95 100 gcg gcc agc ctg tgc cgc tgt tat gag gag aag caa agc ccc ttg cag 389 Ala Ala Ser Leu Cys Arg Cys Tyr Glu Glu Lys Gln Ser Pro Leu Gln 105 110 115 aag cac ttg cgg gtc tgc agc cta cgc atg aat agg ttg gca ggt gtg 437 Lys His Leu Arg Val Cys Ser Leu Arg Met Asn Arg Leu Ala Gly Val 120 125 130 ggc tgg cgg gtg gac tac acc ctg agc tcc agc ctg ctg caa tcc gtg 485 Gly Trp Arg Val Asp Tyr Thr Leu Ser Ser Ser Leu Leu Gln Ser Val 135 140 145 150 gaa gag ccc atg gtg cac ctg cgg ctg gag gtg gca gct gcc cca ggg 533 Glu Glu Pro Met Val His Leu Arg Leu Glu Val Ala Ala Ala Pro Gly 155 160 165 acc cca gcc cag cct gtt gcc atg tcc ctc tca gca gac aag ttc cag 581 Thr Pro Ala Gln Pro Val Ala Met Ser Leu Ser Ala Asp Lys Phe Gln 170 175 180 gtc ctc ctg gca gaa ctg aag cag gcc cag acc ctg atg agc tcc ctg 629 Val Leu Leu Ala Glu Leu Lys Gln Ala Gln Thr Leu Met Ser Ser Leu 185 190 195 ggc tga ggagaagggt gttccaggcc tgtgtggagc cgccctgccc gtatggagtc 685 Gly acgccctctg aactgctctt cgggaggcag ccctggttct aggatgctga ggccctggcc 745 cggactctgg cctcccagat ccccagctgc ctcacttctc tcttgagaac ttggctcagg 805 gctcctgagg acctttccca gcattacctt cccttccctt gaaaggcaat tgttggctgt 865 tttcataagc aggaaaaata aacagaagta taaagg 901 <210> SEQ ID NO 20 <211> LENGTH: 199 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 20 Met Arg Phe Arg Phe Cys Gly Asp Leu Asp Cys Pro Asp Trp Val Leu 1 5 10 15 Ala Glu Ile Ser Thr Leu Ala Lys Met Ser Ser Val Lys Leu Arg Leu 20 25 30 Leu Cys Ser Gln Val Leu Lys Glu Leu Leu Gly Gln Gly Ile Asp Tyr 35 40 45 Glu Lys Ile Leu Lys Leu Thr Ala Asp Ala Lys Phe Glu Ser Gly Asp 50 55 60 Val Lys Ala Thr Val Ala Val Leu Ser Phe Ile Leu Ser Ser Ala Ala 65 70 75 80 Lys His Ser Val Asp Gly Glu Ser Leu Ser Ser Glu Leu Gln Gln Leu 85 90 95 Gly Leu Pro Lys Glu His Ala Ala Ser Leu Cys Arg Cys Tyr Glu Glu 100 105 110 Lys Gln Ser Pro Leu Gln Lys His Leu Arg Val Cys Ser Leu Arg Met 115 120 125 Asn Arg Leu Ala Gly Val Gly Trp Arg Val Asp Tyr Thr Leu Ser Ser 130 135 140 Ser Leu Leu Gln Ser Val Glu Glu Pro Met Val His Leu Arg Leu Glu 145 150 155 160 Val Ala Ala Ala Pro Gly Thr Pro Ala Gln Pro Val Ala Met Ser Leu 165 170 175 Ser Ala Asp Lys Phe Gln Val Leu Leu Ala Glu Leu Lys Gln Ala Gln 180 185 190 Thr Leu Met Ser Ser Leu Gly 195 <210> SEQ ID NO 21 <211> LENGTH: 1274 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (131)..(1111) <400> SEQUENCE: 21 acagcgcgtc gcggcagccc ccaaggaaga ccagcctgcc tctggtcggt tcctggcgct 60 ctgcgtttcg tgaccttgtc cagtagaagg ctatttaatt ttcacaactg cttgaatttt 120 gacatacaag atg aag caa gat gcc tca aga aat gct gcc tac act gtg 169 Met Lys Gln Asp Ala Ser Arg Asn Ala Ala Tyr Thr Val 1 5 10 gat tgt gaa gat tat gtg cat gtg gta gaa ttt aat ccc ttt gag aat 217 Asp Cys Glu Asp Tyr Val His Val Val Glu Phe Asn Pro Phe Glu Asn 15 20 25 ggg gat tca gga aac cta att gca tat ggt ggc aat aat tat gtg gtc 265 Gly Asp Ser Gly Asn Leu Ile Ala Tyr Gly Gly Asn Asn Tyr Val Val 30 35 40 45 att ggc acg tgt acg ttt cag gaa gaa gaa gca gac gtt gaa ggc att 313 Ile Gly Thr Cys Thr Phe Gln Glu Glu Glu Ala Asp Val Glu Gly Ile 50 55 60 cag tat aaa aca ctt cga aca ttt cac cat gga gtc agg gtt gat ggc 361 Gln Tyr Lys Thr Leu Arg Thr Phe His His Gly Val Arg Val Asp Gly 65 70 75 ata gct tgg agc cca gag act aga ctt gat tca ttg cct cca gta atc 409 Ile Ala Trp Ser Pro Glu Thr Arg Leu Asp Ser Leu Pro Pro Val Ile 80 85 90 aaa ttt tgt act tca gct gct gat atg aaa att aga tta ttt act tca 457 Lys Phe Cys Thr Ser Ala Ala Asp Met Lys Ile Arg Leu Phe Thr Ser 95 100 105 gat ctt cag gat aaa aat gaa tat aag gtt tta gag ggc cat acc gat 505 Asp Leu Gln Asp Lys Asn Glu Tyr Lys Val Leu Glu Gly His Thr Asp 110 115 120 125 ttc att aat ggt ttg gtg ttt gat ccc aaa gaa ggc caa gaa att gca 553 Phe Ile Asn Gly Leu Val Phe Asp Pro Lys Glu Gly Gln Glu Ile Ala 130 135 140 agt gtg agt gac gat cac acc tgc agg att tgg aac ttg gaa gga gtg 601 Ser Val Ser Asp Asp His Thr Cys Arg Ile Trp Asn Leu Glu Gly Val 145 150 155 caa aca gct cat ttt gtt ctt cat tct cct ggc atg agt gtg tgc tgg 649 Gln Thr Ala His Phe Val Leu His Ser Pro Gly Met Ser Val Cys Trp 160 165 170 cat cct gag gag act ttt aag cta atg gtt gca gag aag aat gga aca 697 His Pro Glu Glu Thr Phe Lys Leu Met Val Ala Glu Lys Asn Gly Thr 175 180 185 atc cgg ttt tat gat ctt ttg gcc caa cag gct att tta tct ctt gaa 745 Ile Arg Phe Tyr Asp Leu Leu Ala Gln Gln Ala Ile Leu Ser Leu Glu 190 195 200 205 tca gaa caa gtg cca tta atg tca gca cac tgg tgc tta aaa aac acc 793 Ser Glu Gln Val Pro Leu Met Ser Ala His Trp Cys Leu Lys Asn Thr 210 215 220 ttc aaa gtt gga gcc gtt gca gga aat gat tgg tta att tgg gat att 841 Phe Lys Val Gly Ala Val Ala Gly Asn Asp Trp Leu Ile Trp Asp Ile 225 230 235 act cgg tcc agt tat cct caa aat aag aga cct gtt cac atg gat cga 889 Thr Arg Ser Ser Tyr Pro Gln Asn Lys Arg Pro Val His Met Asp Arg 240 245 250 gcc tgc tta ttc agg tgg tcc aca att agt gaa aat ctg ttt gca acc 937 Ala Cys Leu Phe Arg Trp Ser Thr Ile Ser Glu Asn Leu Phe Ala Thr 255 260 265 act ggt tat cct ggc aaa atg gca agc cag ttt caa att cat cat tta 985 Thr Gly Tyr Pro Gly Lys Met Ala Ser Gln Phe Gln Ile His His Leu 270 275 280 285 gga cac cct cag ccc atc ctc atg ggt tct gta gcc gtt gga tct gga 1033 Gly His Pro Gln Pro Ile Leu Met Gly Ser Val Ala Val Gly Ser Gly 290 295 300 ctg tcc tgg cat cga act ctc cct ctg tgt gta att gga gga gac cac 1081 Leu Ser Trp His Arg Thr Leu Pro Leu Cys Val Ile Gly Gly Asp His 305 310 315 aag ctg ttg ttt tgg gtg act gaa gta taa agtgttttct gtaccttaga 1131 Lys Leu Leu Phe Trp Val Thr Glu Val 320 325 ttcacaaact ttgtattttt agtacatatt ttgaagaatt tctatagtac atattttgaa 1191 gaatttttat atcaaatata ccgtatactt tagaaaatgt ctcagttgct tttattaaat 1251 aaaatgttga tggtttgaaa aat 1274 <210> SEQ ID NO 22 <211> LENGTH: 326 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 22 Met Lys Gln Asp Ala Ser Arg Asn Ala Ala Tyr Thr Val Asp Cys Glu 1 5 10 15 Asp Tyr Val His Val Val Glu Phe Asn Pro Phe Glu Asn Gly Asp Ser 20 25 30 Gly Asn Leu Ile Ala Tyr Gly Gly Asn Asn Tyr Val Val Ile Gly Thr 35 40 45 Cys Thr Phe Gln Glu Glu Glu Ala Asp Val Glu Gly Ile Gln Tyr Lys 50 55 60 Thr Leu Arg Thr Phe His His Gly Val Arg Val Asp Gly Ile Ala Trp 65 70 75 80 Ser Pro Glu Thr Arg Leu Asp Ser Leu Pro Pro Val Ile Lys Phe Cys 85 90 95 Thr Ser Ala Ala Asp Met Lys Ile Arg Leu Phe Thr Ser Asp Leu Gln 100 105 110 Asp Lys Asn Glu Tyr Lys Val Leu Glu Gly His Thr Asp Phe Ile Asn 115 120 125 Gly Leu Val Phe Asp Pro Lys Glu Gly Gln Glu Ile Ala Ser Val Ser 130 135 140 Asp Asp His Thr Cys Arg Ile Trp Asn Leu Glu Gly Val Gln Thr Ala 145 150 155 160 His Phe Val Leu His Ser Pro Gly Met Ser Val Cys Trp His Pro Glu 165 170 175 Glu Thr Phe Lys Leu Met Val Ala Glu Lys Asn Gly Thr Ile Arg Phe 180 185 190 Tyr Asp Leu Leu Ala Gln Gln Ala Ile Leu Ser Leu Glu Ser Glu Gln 195 200 205 Val Pro Leu Met Ser Ala His Trp Cys Leu Lys Asn Thr Phe Lys Val 210 215 220 Gly Ala Val Ala Gly Asn Asp Trp Leu Ile Trp Asp Ile Thr Arg Ser 225 230 235 240 Ser Tyr Pro Gln Asn Lys Arg Pro Val His Met Asp Arg Ala Cys Leu 245 250 255 Phe Arg Trp Ser Thr Ile Ser Glu Asn Leu Phe Ala Thr Thr Gly Tyr 260 265 270 Pro Gly Lys Met Ala Ser Gln Phe Gln Ile His His Leu Gly His Pro 275 280 285 Gln Pro Ile Leu Met Gly Ser Val Ala Val Gly Ser Gly Leu Ser Trp 290 295 300 His Arg Thr Leu Pro Leu Cys Val Ile Gly Gly Asp His Lys Leu Leu 305 310 315 320 Phe Trp Val Thr Glu Val 325 <210> SEQ ID NO 23 <211> LENGTH: 1000 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (33)..(185) <400> SEQUENCE: 23 cttttcgagg taggagtcga ctcctgtgag gt atg gtg ctg ggt gca gat gca 53 Met Val Leu Gly Ala Asp Ala 1 5 gtg tgg ctc tgg ata gca cct tat gga cag ttg tgt ccc caa gga agg 101 Val Trp Leu Trp Ile Ala Pro Tyr Gly Gln Leu Cys Pro Gln Gly Arg 10 15 20 atg aga ata gct act gaa gtc cta aag agc aag cct aac tca agc cat 149 Met Arg Ile Ala Thr Glu Val Leu Lys Ser Lys Pro Asn Ser Ser His 25 30 35 tgg cac aca ggc att aga cag aaa gct gga agt tga aatggtggag 195 Trp His Thr Gly Ile Arg Gln Lys Ala Gly Ser 40 45 50 tccaacttgc ctggaccagc ttaatggttc tgctcctggt aacgttttta tccatggatg 255 acttgcttgg gtaaggacat gaagacagtt cctgtcatac cttttaaagg tacatgtttt 315 attgatgtta acgttaattg attgagctac tgttagtgat gattttaaaa ttaaagcaga 375 tgggaatctc tctgagaaag aaaatggaga ttaatcttaa actgaaacag tagttgggaa 435 atcttttaga aatccaccta ttactaccta ttggtaaagg agattaaatt tctacaggta 495 tggagagtcg gcttgactac actgtgtgga gcaagtttta aagaagcaaa ggactcagaa 555 ttcatgattg aagaaatgca ggcagacctg ttatcctaaa ctaggtgagt cagcttttgg 615 tacatgtgat gattttcagt gtaaccaatg atgtaatgat tctgccaaat gaaatataat 675 gatatcactg taaaaccgtt ccattttgat tctgaggtta ctctactaac aagcatcaca 735 catttgtatt ttgccctgat taatatgttg gcttcgcttt cagggttttt aatgaccaca 795 acaagcaagc atgcagctta ctgcttgaaa gggtcttgcc tcacccaagc tagagtgcag 855 tggcctttga agcttactac agcctcaaac ttctgggctc aagtgatcct cagcctccca 915 gtggtctttg tagactgcct gatggagtct catggcacaa gaagattaaa acagtgtctc 975 caattttaat aaatttttgc aatcc 1000 <210> SEQ ID NO 24 <211> LENGTH: 50 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 24 Met Val Leu Gly Ala Asp Ala Val Trp Leu Trp Ile Ala Pro Tyr Gly 1 5 10 15 Gln Leu Cys Pro Gln Gly Arg Met Arg Ile Ala Thr Glu Val Leu Lys 20 25 30 Ser Lys Pro Asn Ser Ser His Trp His Thr Gly Ile Arg Gln Lys Ala 35 40 45 Gly Ser 50 <210> SEQ ID NO 25 <211> LENGTH: 1087 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (28)..(558) <400> SEQUENCE: 25 agcttccggg tttcctgggc tactacg atg gcg atg agt ttc gag tgg ccg tgg 54 Met Ala Met Ser Phe Glu Trp Pro Trp 1 5 cag tat cgc ttc cca ccc ttc ttt acg tta caa ccg aat gtg gac act 102 Gln Tyr Arg Phe Pro Pro Phe Phe Thr Leu Gln Pro Asn Val Asp Thr 10 15 20 25 cgg cag aag cag ctg gcc gcc tgg tgc tcg ctg gtc ctg tcc ttc tgc 150 Arg Gln Lys Gln Leu Ala Ala Trp Cys Ser Leu Val Leu Ser Phe Cys 30 35 40 cgc ctg cac aaa cag tcc agc atg acg gtg atg gaa gct cag gag agc 198 Arg Leu His Lys Gln Ser Ser Met Thr Val Met Glu Ala Gln Glu Ser 45 50 55 ccg ctc ttc aac aac gtc aag cta cag cga aag ctt cct gtg gag tcg 246 Pro Leu Phe Asn Asn Val Lys Leu Gln Arg Lys Leu Pro Val Glu Ser 60 65 70 atc cag att gta tta gag gaa ctg agg aag aaa ggg aac ctc gag tgg 294 Ile Gln Ile Val Leu Glu Glu Leu Arg Lys Lys Gly Asn Leu Glu Trp 75 80 85 ttg gat aag agc aag tcc agc ttc ctg atc atg tgg cgg agg cca gaa 342 Leu Asp Lys Ser Lys Ser Ser Phe Leu Ile Met Trp Arg Arg Pro Glu 90 95 100 105 gaa tgg ggg aaa ctc atc tat cag tgg gtt tcc agg agt ggc cag aac 390 Glu Trp Gly Lys Leu Ile Tyr Gln Trp Val Ser Arg Ser Gly Gln Asn 110 115 120 aac tcc gtc ttt acc ctg tat gaa ctg act aat ggg gaa gac aca gag 438 Asn Ser Val Phe Thr Leu Tyr Glu Leu Thr Asn Gly Glu Asp Thr Glu 125 130 135 gat gag gag ttc cac ggg ctg gat gaa gcc act cta ctg cgg gct ctg 486 Asp Glu Glu Phe His Gly Leu Asp Glu Ala Thr Leu Leu Arg Ala Leu 140 145 150 cag gcc cta cag cag gag cac aag gcc gag atc atc act gtc agc gat 534 Gln Ala Leu Gln Gln Glu His Lys Ala Glu Ile Ile Thr Val Ser Asp 155 160 165 ggc cga ggc gtc aag ttc ttc tag cagggacctg tctcccttta cttcttacct 588 Gly Arg Gly Val Lys Phe Phe 170 175 cccacctttc cagggctttc aaaaggagac agacccagtg tcccccaaag actggatctg 648 tgactccacc agactcaaaa ggactccagt cctgaaggct gggacctggg gatgggtttc 708 tcacacccca tatgtctgtc ccttggatag ggtgaggctg aagcaccagg gagaaaatat 768 gtgcttcttc tcgccctacc tcctttccca tcctagactg tccttgagcc agggtctgta 828 aacctgacac tttatatgtg ttcacacatg taagtacata cacacatgcg cctgcagcac 888 atgcttctgt ctcctcctcc tcccacccct ttagctgctg ttgcctccct tctcaggctg 948 gtgctggatc cttcctaggg gatgggggaa gccctggctg caggcagcct tccaggcaat 1008 atgaagatag gaggcccacg ggcctggcag tgagaggtgt ggccccacac cgatttatga 1068 tattaaaatc tcaactccc 1087 <210> SEQ ID NO 26 <211> LENGTH: 176 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 26 Met Ala Met Ser Phe Glu Trp Pro Trp Gln Tyr Arg Phe Pro Pro Phe 1 5 10 15 Phe Thr Leu Gln Pro Asn Val Asp Thr Arg Gln Lys Gln Leu Ala Ala 20 25 30 Trp Cys Ser Leu Val Leu Ser Phe Cys Arg Leu His Lys Gln Ser Ser 35 40 45 Met Thr Val Met Glu Ala Gln Glu Ser Pro Leu Phe Asn Asn Val Lys 50 55 60 Leu Gln Arg Lys Leu Pro Val Glu Ser Ile Gln Ile Val Leu Glu Glu 65 70 75 80 Leu Arg Lys Lys Gly Asn Leu Glu Trp Leu Asp Lys Ser Lys Ser Ser 85 90 95 Phe Leu Ile Met Trp Arg Arg Pro Glu Glu Trp Gly Lys Leu Ile Tyr 100 105 110 Gln Trp Val Ser Arg Ser Gly Gln Asn Asn Ser Val Phe Thr Leu Tyr 115 120 125 Glu Leu Thr Asn Gly Glu Asp Thr Glu Asp Glu Glu Phe His Gly Leu 130 135 140 Asp Glu Ala Thr Leu Leu Arg Ala Leu Gln Ala Leu Gln Gln Glu His 145 150 155 160 Lys Ala Glu Ile Ile Thr Val Ser Asp Gly Arg Gly Val Lys Phe Phe 165 170 175 <210> SEQ ID NO 27 <211> LENGTH: 703 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (67)..(222) <400> SEQUENCE: 27 cgggcgcgag gcggccaccg tggagagcag agcgcggcgg ctggaagctg ctaagtcaga 60 gccgcg atg ttc cgg att gag ggc ctc gcg ccg aag ctg gac ccg gag 108 Met Phe Arg Ile Glu Gly Leu Ala Pro Lys Leu Asp Pro Glu 1 5 10 gag atg aaa cgg aag atg cgc gag gat gtg atc tcc tcc ata cgg aac 156 Glu Met Lys Arg Lys Met Arg Glu Asp Val Ile Ser Ser Ile Arg Asn 15 20 25 30 ttt ctc atc tac gtg gcc ctc ctg cga gtc act cca ttt atc tta aag 204 Phe Leu Ile Tyr Val Ala Leu Leu Arg Val Thr Pro Phe Ile Leu Lys 35 40 45 aaa ttg gac agc ata tga agacaggaca tcacatatga atgcacgata 252 Lys Leu Asp Ser Ile 50 tgaagagcct ggttacagtt tcgactcctc tctgcaagtg aataggccca gaaaggtgta 312 agagactctt tgaatggaca taaaattctg cttgttaaga acaagtttgg ctctggtaac 372 tgaccttcaa agctaaaata taaaactatt tgggaagtat gaaacgatgt ctcgtgatct 432 ggtgtaccct tatccctgtg acgtttggcc cctgacaata ctggtataat tgtaaataat 492 gtcaaactcc gttttctagc aagtattaag ggagctgtgt ctgaaatggc actgtcttgt 552 cagtcatttc tgtttacctt tttcttctgc ccagagtgta tttgtgaaga gtctcttata 612 ttatgttttg tggaaatcag cacacaacca caatgacatt taagcacagg atcattatta 672 gtctatgttt ttaataaaca tatcaattaa g 703 <210> SEQ ID NO 28 <211> LENGTH: 51 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 28 Met Phe Arg Ile Glu Gly Leu Ala Pro Lys Leu Asp Pro Glu Glu Met 1 5 10 15 Lys Arg Lys Met Arg Glu Asp Val Ile Ser Ser Ile Arg Asn Phe Leu 20 25 30 Ile Tyr Val Ala Leu Leu Arg Val Thr Pro Phe Ile Leu Lys Lys Leu 35 40 45 Asp Ser Ile 50 <210> SEQ ID NO 29 <211> LENGTH: 921 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (204)..(776) <400> SEQUENCE: 29 ctcccccggc gcggtccgcc aggccagtgc cctcagcatc tccaccccga ggtggtttga 60 actttgagcc ttttgtagtc ctgatgaata atttcatttt cctcaagttt atgacactcg 120 gaacgtcaag aactggaggt ttgtgcaatt tgagaccggt cggcactgtg cagagatcag 180 agtactaaga gacagagatt aaa atg gct tcc aga gga aag aca gag aca agc 233 Met Ala Ser Arg Gly Lys Thr Glu Thr Ser 1 5 10 aaa tta aag cag aat tta gaa gaa cag ttg gat aga ctc atg caa caa 281 Lys Leu Lys Gln Asn Leu Glu Glu Gln Leu Asp Arg Leu Met Gln Gln 15 20 25 tta caa gat ctg gag gaa tgc aga gag gaa ctt gat aca gat gaa tat 329 Leu Gln Asp Leu Glu Glu Cys Arg Glu Glu Leu Asp Thr Asp Glu Tyr 30 35 40 gaa gaa acc aaa aag gaa act ctg gag caa cta agt gaa ttt aat gat 377 Glu Glu Thr Lys Lys Glu Thr Leu Glu Gln Leu Ser Glu Phe Asn Asp 45 50 55 tca cta aag aaa att atg tct gga aat atg act ttg gta gat gaa cta 425 Ser Leu Lys Lys Ile Met Ser Gly Asn Met Thr Leu Val Asp Glu Leu 60 65 70 agt gga atg cag ctg gct att cag gca gct atc agc cag gcc ttt aaa 473 Ser Gly Met Gln Leu Ala Ile Gln Ala Ala Ile Ser Gln Ala Phe Lys 75 80 85 90 acc cca gag gtc atc aga ttg ttt gca aag aaa caa cca ggt cag ctt 521 Thr Pro Glu Val Ile Arg Leu Phe Ala Lys Lys Gln Pro Gly Gln Leu 95 100 105 cgg aca agg tta gca gag atg gat aga gat ctg atg gta gga aag ctg 569 Arg Thr Arg Leu Ala Glu Met Asp Arg Asp Leu Met Val Gly Lys Leu 110 115 120 gaa aga gac ctg tac act caa cag aaa gtg gag ata cta aca gct ctt 617 Glu Arg Asp Leu Tyr Thr Gln Gln Lys Val Glu Ile Leu Thr Ala Leu 125 130 135 agg aaa ctt gga gag aag ctg act gca gat gat gag gcc ttc ttg tca 665 Arg Lys Leu Gly Glu Lys Leu Thr Ala Asp Asp Glu Ala Phe Leu Ser 140 145 150 gca aat gca ggt gct ata ctc agc cag ttt gag aaa gtc tct aca gac 713 Ala Asn Ala Gly Ala Ile Leu Ser Gln Phe Glu Lys Val Ser Thr Asp 155 160 165 170 ctt ggc tct gga gac aaa att ctt gct ctg gca agt ttt gag gtt gaa 761 Leu Gly Ser Gly Asp Lys Ile Leu Ala Leu Ala Ser Phe Glu Val Glu 175 180 185 aaa aca aaa aaa tga catggtgcag aagcttgtaa cattgatcac attcttaatg 816 Lys Thr Lys Lys 190 taaatggtgt ctttcttctg gggttttcag ttattgcaaa gaaatgaaga gattctggaa 876 atgcatcaat aacctaagaa aaagcgacat aaaaatatac ttatg 921 <210> SEQ ID NO 30 <211> LENGTH: 190 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 30 Met Ala Ser Arg Gly Lys Thr Glu Thr Ser Lys Leu Lys Gln Asn Leu 1 5 10 15 Glu Glu Gln Leu Asp Arg Leu Met Gln Gln Leu Gln Asp Leu Glu Glu 20 25 30 Cys Arg Glu Glu Leu Asp Thr Asp Glu Tyr Glu Glu Thr Lys Lys Glu 35 40 45 Thr Leu Glu Gln Leu Ser Glu Phe Asn Asp Ser Leu Lys Lys Ile Met 50 55 60 Ser Gly Asn Met Thr Leu Val Asp Glu Leu Ser Gly Met Gln Leu Ala 65 70 75 80 Ile Gln Ala Ala Ile Ser Gln Ala Phe Lys Thr Pro Glu Val Ile Arg 85 90 95 Leu Phe Ala Lys Lys Gln Pro Gly Gln Leu Arg Thr Arg Leu Ala Glu 100 105 110 Met Asp Arg Asp Leu Met Val Gly Lys Leu Glu Arg Asp Leu Tyr Thr 115 120 125 Gln Gln Lys Val Glu Ile Leu Thr Ala Leu Arg Lys Leu Gly Glu Lys 130 135 140 Leu Thr Ala Asp Asp Glu Ala Phe Leu Ser Ala Asn Ala Gly Ala Ile 145 150 155 160 Leu Ser Gln Phe Glu Lys Val Ser Thr Asp Leu Gly Ser Gly Asp Lys 165 170 175 Ile Leu Ala Leu Ala Ser Phe Glu Val Glu Lys Thr Lys Lys 180 185 190 <210> SEQ ID NO 31 <211> LENGTH: 584 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (41)..(418) <400> SEQUENCE: 31 ttttttccgg ttccggcctg gcgagagttt gtgcggcgac atg aaa ctg ctt acc 55 Met Lys Leu Leu Thr 1 5 Tcac aat ctg ctg agc tcg cat gtg cgg ggg gtg ggg tcc cgt ggc ttc 103 His Asn Leu Leu Ser Ser His Val Arg Gly Val Gly Ser Arg Gly Phe 10 15 20 ccc ctg cgc ctc cag gcc acc gag gtc cgt atc tgc cct gtg gaa ttc 151 Pro Leu Arg Leu Gln Ala Thr Glu Val Arg Ile Cys Pro Val Glu Phe 25 30 35 aac ccc aac ttc gtg gcg cgt atg ata cct aaa gtg gag tgg tcg gcg 199 Asn Pro Asn Phe Val Ala Arg Met Ile Pro Lys Val Glu Trp Ser Ala 40 45 50 ttc ctg gag gcg gcc gat aac ttg cgt ctg atc cag gtg ccg aaa ggg 247 Phe Leu Glu Ala Ala Asp Asn Leu Arg Leu Ile Gln Val Pro Lys Gly 55 60 65 ccg gtt gag gga tat gag gag aat gag gag ttt ctg agg acc atg cac 295 Pro Val Glu Gly Tyr Glu Glu Asn Glu Glu Phe Leu Arg Thr Met His 70 75 80 85 cac ctg ctg ctg gag gtg gaa gtg ata gag ggc acc ctg cag tgc ccg 343 His Leu Leu Leu Glu Val Glu Val Ile Glu Gly Thr Leu Gln Cys Pro 90 95 100 gaa tct gga cgt atg ttc ccc atc agc cgc ggg atc ccc aac atg ctg 391 Glu Ser Gly Arg Met Phe Pro Ile Ser Arg Gly Ile Pro Asn Met Leu 105 110 115 ctg agt gaa gag gaa act gag agt tga ttgtgccagg cgccagtttt 438 Leu Ser Glu Glu Glu Thr Glu Ser 120 125 tcttgttatg actgtgtatt tttgttgatc tataccctgt ttccgaattc tgccgtgtgt 498 atccccaacc cttgacccaa tgacaccaaa cacagtgttt ttgagctcgg tattatatat 558 ttttttctca ttaaaggttt aaaacc 584 <210> SEQ ID NO 32 <211> LENGTH: 125 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 32 Met Lys Leu Leu Thr His Asn Leu Leu Ser Ser His Val Arg Gly Val 1 5 10 15 Gly Ser Arg Gly Phe Pro Leu Arg Leu Gln Ala Thr Glu Val Arg Ile 20 25 30 Cys Pro Val Glu Phe Asn Pro Asn Phe Val Ala Arg Met Ile Pro Lys 35 40 45 Val Glu Trp Ser Ala Phe Leu Glu Ala Ala Asp Asn Leu Arg Leu Ile 50 55 60 Gln Val Pro Lys Gly Pro Val Glu Gly Tyr Glu Glu Asn Glu Glu Phe 65 70 75 80 Leu Arg Thr Met His His Leu Leu Leu Glu Val Glu Val Ile Glu Gly 85 90 95 Thr Leu Gln Cys Pro Glu Ser Gly Arg Met Phe Pro Ile Ser Arg Gly 100 105 110 Ile Pro Asn Met Leu Leu Ser Glu Glu Glu Thr Glu Ser 115 120 125 <210> SEQ ID NO 33 <211> LENGTH: 875 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (25)..(555) <400> SEQUENCE: 33 ctttgcgcgg cacctggcga caaa atg gct gcc cga ggg aga cgg gcg gag 51 Met Ala Ala Arg Gly Arg Arg Ala Glu 1 5 cct cag ggc cgg gag gct ccg ggc ccc gcg ggc ggt ggc ggt ggc ggg 99 Pro Gln Gly Arg Glu Ala Pro Gly Pro Ala Gly Gly Gly Gly Gly Gly 10 15 20 25 agc cgt tgg gct gag tcg gga tcg ggg acg tcg ccc gag agc ggg gac 147 Ser Arg Trp Ala Glu Ser Gly Ser Gly Thr Ser Pro Glu Ser Gly Asp 30 35 40 gag gag gtg tcg ggc gcg ggt tcg agc ccg gtg tcg ggc ggc gtg aac 195 Glu Glu Val Ser Gly Ala Gly Ser Ser Pro Val Ser Gly Gly Val Asn 45 50 55 ttg ttc gcc aac gac ggc agc ttc ctg gag ctg ttc aag cgg aag atg 243 Leu Phe Ala Asn Asp Gly Ser Phe Leu Glu Leu Phe Lys Arg Lys Met 60 65 70 gag gag gag cag cgg cag cgg cag gag gag ccg ccc ccg ggt ccg cag 291 Glu Glu Glu Gln Arg Gln Arg Gln Glu Glu Pro Pro Pro Gly Pro Gln 75 80 85 cga ccc gac cag tcg gcc gcc gcc gct ggc ccc ggg gat ccg aag agg 339 Arg Pro Asp Gln Ser Ala Ala Ala Ala Gly Pro Gly Asp Pro Lys Arg 90 95 100 105 aag ggc ggt ccg ggc tcc aca ctt agc ttc gtg ggc aaa cgc aga ggc 387 Lys Gly Gly Pro Gly Ser Thr Leu Ser Phe Val Gly Lys Arg Arg Gly 110 115 120 ggg aac aaa cta gcc ctc aag acg gga ata gta gcc aag aag cag aag 435 Gly Asn Lys Leu Ala Leu Lys Thr Gly Ile Val Ala Lys Lys Gln Lys 125 130 135 acg gag gat gag gta tta aca agt aaa ggt gac gcg tgg gcc aag tac 483 Thr Glu Asp Glu Val Leu Thr Ser Lys Gly Asp Ala Trp Ala Lys Tyr 140 145 150 atg gca gaa gtg aaa aag tac aaa gct cac cag tgc ggt gac gat gat 531 Met Ala Glu Val Lys Lys Tyr Lys Ala His Gln Cys Gly Asp Asp Asp 155 160 165 aaa act cgg ccc ctg gtg aaa tga cgcccctccc ccacctgccc atggcctggg 585 Lys Thr Arg Pro Leu Val Lys 170 175 actctctgcg atgtacataa ctatttaatg cagcggcagc ggcgacagcc ttccctgaga 645 ggacttaaaa gcagaaggaa accgagatgc ttcccgcagc cgtggacgat tctccaggac 705 tcttttttta ccttgagcac ttgcctcgtg agacttcata gaacagtggt ttactgtccc 765 ccccttctca cctcctcatt ctctctggct ctttctgtct tcctcttctc accctcctcc 825 ctccccttag ccatcacttc tgggaagtaa agaacttgac ttagtgccgg 875 <210> SEQ ID NO 34 <211> LENGTH: 176 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 34 Met Ala Ala Arg Gly Arg Arg Ala Glu Pro Gln Gly Arg Glu Ala Pro 1 5 10 15 Gly Pro Ala Gly Gly Gly Gly Gly Gly Ser Arg Trp Ala Glu Ser Gly 20 25 30 Ser Gly Thr Ser Pro Glu Ser Gly Asp Glu Glu Val Ser Gly Ala Gly 35 40 45 Ser Ser Pro Val Ser Gly Gly Val Asn Leu Phe Ala Asn Asp Gly Ser 50 55 60 Phe Leu Glu Leu Phe Lys Arg Lys Met Glu Glu Glu Gln Arg Gln Arg 65 70 75 80 Gln Glu Glu Pro Pro Pro Gly Pro Gln Arg Pro Asp Gln Ser Ala Ala 85 90 95 Ala Ala Gly Pro Gly Asp Pro Lys Arg Lys Gly Gly Pro Gly Ser Thr 100 105 110 Leu Ser Phe Val Gly Lys Arg Arg Gly Gly Asn Lys Leu Ala Leu Lys 115 120 125 Thr Gly Ile Val Ala Lys Lys Gln Lys Thr Glu Asp Glu Val Leu Thr 130 135 140 Ser Lys Gly Asp Ala Trp Ala Lys Tyr Met Ala Glu Val Lys Lys Tyr 145 150 155 160 Lys Ala His Gln Cys Gly Asp Asp Asp Lys Thr Arg Pro Leu Val Lys 165 170 175 <210> SEQ ID NO 35 <211> LENGTH: 470 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (216)..(374) <400> SEQUENCE: 35 cttagtcgtg tgtacatcat tgggaatgga gggaaataaa tgactggatg gtcgctgctt 60 tttaagtttc aaattgacat tccagacaag cggtgcctga gcccgtgcct gtcttcagat 120 cttcacagca cagttcctgg gaaggtggag ccaccagcct ctccttgaat aactgggaga 180 tgaaacagga agctctatga cacacttgat cgaat atg aca gac acc gaa aat 233 Met Thr Asp Thr Glu Asn 1 5 cac gac tca gcc ccc tcc agc acc tct acc tgt tgc ccg ccg atc aca 281 His Asp Ser Ala Pro Ser Ser Thr Ser Thr Cys Cys Pro Pro Ile Thr 10 15 20 gcc gga atg cag ctg aaa gat tcc ctg ggg cct ggt tcc aac cgc cca 329 Ala Gly Met Gln Leu Lys Asp Ser Leu Gly Pro Gly Ser Asn Arg Pro 25 30 35 ctg tgg act ctg agg cct ctg cat ttg tgg gtg gtc tgc ctg tga 374 Leu Trp Thr Leu Arg Pro Leu His Leu Trp Val Val Cys Leu 40 45 50 tattttggtc atgggctggt ctggtcggtt tcccatttgt ctggccagtc tctatgtgtc 434 ttaatccctt gtccttcatt aaaagcaaaa ctaaag 470 <210> SEQ ID NO 36 <211> LENGTH: 52 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 36 Met Thr Asp Thr Glu Asn His Asp Ser Ala Pro Ser Ser Thr Ser Thr 1 5 10 15 Cys Cys Pro Pro Ile Thr Ala Gly Met Gln Leu Lys Asp Ser Leu Gly 20 25 30 Pro Gly Ser Asn Arg Pro Leu Trp Thr Leu Arg Pro Leu His Leu Trp 35 40 45 Val Val Cys Leu 50 <210> SEQ ID NO 37 <211> LENGTH: 2920 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (73)..(2652) <400> SEQUENCE: 37 aggtacagcg gcggtttctg aggttcttca ctcgcgactg acggagctgc ggtggcgtct 60 ccacacgcaa cc atg aag ttg aag gac aca aaa tca agg cca aag cag tca 111 Met Lys Leu Lys Asp Thr Lys Ser Arg Pro Lys Gln Ser 1 5 10 agc tgt ggc aaa ttt cag aca aag gga atc aaa gtt gtg gga aaa tgg 159 Ser Cys Gly Lys Phe Gln Thr Lys Gly Ile Lys Val Val Gly Lys Trp 15 20 25 aag gaa gtg aag att gac cca aat atg ttt gca gat gga cag atg gat 207 Lys Glu Val Lys Ile Asp Pro Asn Met Phe Ala Asp Gly Gln Met Asp 30 35 40 45 gac ttg gtg tgc ttt gag gaa ttg aca gat tac cag ttg gtc tcc cct 255 Asp Leu Val Cys Phe Glu Glu Leu Thr Asp Tyr Gln Leu Val Ser Pro 50 55 60 gcc aag aat ccc tcc agt ctc ttc tca aag gaa gca ccc aag aga aag 303 Ala Lys Asn Pro Ser Ser Leu Phe Ser Lys Glu Ala Pro Lys Arg Lys 65 70 75 gca caa gct gtt tca gaa gaa gag gag gag gag gag gga aag tct agc 351 Ala Gln Ala Val Ser Glu Glu Glu Glu Glu Glu Glu Gly Lys Ser Ser 80 85 90 tca cca aag aaa aag atc aag ttg aag aaa agt aaa aat gta gca act 399 Ser Pro Lys Lys Lys Ile Lys Leu Lys Lys Ser Lys Asn Val Ala Thr 95 100 105 gaa gga acc agt acc cag aaa gaa ttt gaa gtg aaa gat cct gag ctg 447 Glu Gly Thr Ser Thr Gln Lys Glu Phe Glu Val Lys Asp Pro Glu Leu 110 115 120 125 gag gcc cag gga gat gac atg gtt tgt gat gat ccg gag gct ggg gag 495 Glu Ala Gln Gly Asp Asp Met Val Cys Asp Asp Pro Glu Ala Gly Glu 130 135 140 atg aca tca gaa aac ctg gtc caa act gct cca aaa aag aag aaa aat 543 Met Thr Ser Glu Asn Leu Val Gln Thr Ala Pro Lys Lys Lys Lys Asn 145 150 155 aaa ggg aaa aaa ggg ttg gag cct tct cag agc act gct gcc aag gtg 591 Lys Gly Lys Lys Gly Leu Glu Pro Ser Gln Ser Thr Ala Ala Lys Val 160 165 170 ccc aaa aaa gcg aag aca tgg att cct gaa gtt cat gat cag aaa gca 639 Pro Lys Lys Ala Lys Thr Trp Ile Pro Glu Val His Asp Gln Lys Ala 175 180 185 gat gtg tca gct tgg aag gac ctg ttt gtt ccc agg ccg gtt ctc cga 687 Asp Val Ser Ala Trp Lys Asp Leu Phe Val Pro Arg Pro Val Leu Arg 190 195 200 205 gca ctc agc ttt cta ggc ttc tct gca ccc aca cca atc caa gcc ctg 735 Ala Leu Ser Phe Leu Gly Phe Ser Ala Pro Thr Pro Ile Gln Ala Leu 210 215 220 acc ttg gca cct gcc atc cgt gac aaa ctg gac atc ctt ggg gct gct 783 Thr Leu Ala Pro Ala Ile Arg Asp Lys Leu Asp Ile Leu Gly Ala Ala 225 230 235 gag aca gga agt ggg aaa act ctt gcc ttt gcc atc cca atg att cat 831 Glu Thr Gly Ser Gly Lys Thr Leu Ala Phe Ala Ile Pro Met Ile His 240 245 250 gcg gtg ttg cag tgg cag aag agg aat gct gcc cct cct cca agt aac 879 Ala Val Leu Gln Trp Gln Lys Arg Asn Ala Ala Pro Pro Pro Ser Asn 255 260 265 acc gaa gca cca cct gga gag acc aga act gag gcc gga gct gag act 927 Thr Glu Ala Pro Pro Gly Glu Thr Arg Thr Glu Ala Gly Ala Glu Thr 270 275 280 285 aga tca cca ggc aag gct gaa gct gag tct gat gca ttg cct gac gat 975 Arg Ser Pro Gly Lys Ala Glu Ala Glu Ser Asp Ala Leu Pro Asp Asp 290 295 300 act gta att gag agt gaa gca ctg ccc agt gat att gca gcc gag gcc 1023 Thr Val Ile Glu Ser Glu Ala Leu Pro Ser Asp Ile Ala Ala Glu Ala 305 310 315 aga gcc aag act gga ggc act gtc tca gac cag gcg ttg ctc ttt ggt 1071 Arg Ala Lys Thr Gly Gly Thr Val Ser Asp Gln Ala Leu Leu Phe Gly 320 325 330 gac gat gat gct ggt gaa ggg cct tct tcc ctg atc agg gag aaa cct 1119 Asp Asp Asp Ala Gly Glu Gly Pro Ser Ser Leu Ile Arg Glu Lys Pro 335 340 345 gtt ccc aaa cag aat gag aat gag gag gaa aat ctt gat aaa gag cag 1167 Val Pro Lys Gln Asn Glu Asn Glu Glu Glu Asn Leu Asp Lys Glu Gln 350 355 360 365 act gga aat cta aaa cag gag ttg gat gac aaa agc gcc acc tgt aag 1215 Thr Gly Asn Leu Lys Gln Glu Leu Asp Asp Lys Ser Ala Thr Cys Lys 370 375 380 gca tat cca aag cgt cct ctg ctt gga ctg gtt ctg act ccc act cga 1263 Ala Tyr Pro Lys Arg Pro Leu Leu Gly Leu Val Leu Thr Pro Thr Arg 385 390 395 gag ctg gcc gtc cag gtc aaa cag cac att gat gct gtg gcc agg ttt 1311 Glu Leu Ala Val Gln Val Lys Gln His Ile Asp Ala Val Ala Arg Phe 400 405 410 aca gga att aaa act gct att ttg gtt ggt gga atg tcc acg cag aaa 1359 Thr Gly Ile Lys Thr Ala Ile Leu Val Gly Gly Met Ser Thr Gln Lys 415 420 425 cag cag agg atg ctg aac cgt cgt cct gag att gtg gtt gct act cca 1407 Gln Gln Arg Met Leu Asn Arg Arg Pro Glu Ile Val Val Ala Thr Pro 430 435 440 445 ggc cgg ctg tgg gaa tta att aaa gaa aag cat tat cat ttg agg aac 1455 Gly Arg Leu Trp Glu Leu Ile Lys Glu Lys His Tyr His Leu Arg Asn 450 455 460 ctt cgg cag ctc agg tgc ctg gta gtg gat gag gct gac cgg atg gtt 1503 Leu Arg Gln Leu Arg Cys Leu Val Val Asp Glu Ala Asp Arg Met Val 465 470 475 gag aaa ggc cat ttt gct gag ctc tca cag ctg cta gag atg ctc aat 1551 Glu Lys Gly His Phe Ala Glu Leu Ser Gln Leu Leu Glu Met Leu Asn 480 485 490 gac tcc caa tac aac cca aag aga caa acg ctt gtt ttt tct gcc aca 1599 Asp Ser Gln Tyr Asn Pro Lys Arg Gln Thr Leu Val Phe Ser Ala Thr 495 500 505 ctc acc ctg gtg cat cag gct cct gct cga atc ctt cat aag aag cac 1647 Leu Thr Leu Val His Gln Ala Pro Ala Arg Ile Leu His Lys Lys His 510 515 520 525 acc aag aaa atg gat aaa aca gcc aaa ctt gac ctc ctt atg cag aaa 1695 Thr Lys Lys Met Asp Lys Thr Ala Lys Leu Asp Leu Leu Met Gln Lys 530 535 540 att ggc atg agg ggc aag ccc aag gtc att gac ctc aca agg aat gag 1743 Ile Gly Met Arg Gly Lys Pro Lys Val Ile Asp Leu Thr Arg Asn Glu 545 550 555 gcc acg gtg gag acg cta aca gag acc aag atc cat tgt gag act gat 1791 Ala Thr Val Glu Thr Leu Thr Glu Thr Lys Ile His Cys Glu Thr Asp 560 565 570 gag aaa gac ttc tac ttg tac tac ttc ctg atg cag tat cca ggc cgc 1839 Glu Lys Asp Phe Tyr Leu Tyr Tyr Phe Leu Met Gln Tyr Pro Gly Arg 575 580 585 agc tta gtg ttt gcc aac agt atc tcc tgc atc aaa cgc ctc tct ggg 1887 Ser Leu Val Phe Ala Asn Ser Ile Ser Cys Ile Lys Arg Leu Ser Gly 590 595 600 605 ctc ctc aaa gtc ctt gat atc atg ccc ttg acc ctg cat gcc tgt atg 1935 Leu Leu Lys Val Leu Asp Ile Met Pro Leu Thr Leu His Ala Cys Met 610 615 620 cac cag aag cag agg ctc aga aac ctg gag cag ttt gcc cgt ctg gaa 1983 His Gln Lys Gln Arg Leu Arg Asn Leu Glu Gln Phe Ala Arg Leu Glu 625 630 635 gac tgt gtt ctc ttg gca aca gat gtg gca gct cgg ggt ctg gat att 2031 Asp Cys Val Leu Leu Ala Thr Asp Val Ala Ala Arg Gly Leu Asp Ile 640 645 650 cct aaa gtc cag cat gtc atc cat tac cag gtc cca cgt acc tcg gag 2079 Pro Lys Val Gln His Val Ile His Tyr Gln Val Pro Arg Thr Ser Glu 655 660 665 att tat gtc cac cga agt ggt cga act gct cga gct acc aat gaa ggc 2127 Ile Tyr Val His Arg Ser Gly Arg Thr Ala Arg Ala Thr Asn Glu Gly 670 675 680 685 ctc agt ctg atg ctc att ggg cct gag gat gtg atc aac ttt aag aag 2175 Leu Ser Leu Met Leu Ile Gly Pro Glu Asp Val Ile Asn Phe Lys Lys 690 695 700 att tac aaa acg ctc aag aaa gat gag gat atc cca ctg ttc ccc gtg 2223 Ile Tyr Lys Thr Leu Lys Lys Asp Glu Asp Ile Pro Leu Phe Pro Val 705 710 715 cag aca aaa tac atg gat gtg gtc aag gag cga atc cgt tta gct cga 2271 Gln Thr Lys Tyr Met Asp Val Val Lys Glu Arg Ile Arg Leu Ala Arg 720 725 730 cag att gag aaa tct gag tat cgg aac ttc cag gct tgc ctg cac aac 2319 Gln Ile Glu Lys Ser Glu Tyr Arg Asn Phe Gln Ala Cys Leu His Asn 735 740 745 tct tgg att gag cag gca gca gct gcc ctg gag att gag ctg gaa gaa 2367 Ser Trp Ile Glu Gln Ala Ala Ala Ala Leu Glu Ile Glu Leu Glu Glu 750 755 760 765 gac atg tat aag gga gga aaa gct gac cag caa gaa gaa cgt cgg aga 2415 Asp Met Tyr Lys Gly Gly Lys Ala Asp Gln Gln Glu Glu Arg Arg Arg 770 775 780 caa aag cag atg aag gtt ctg aag aag gag ctg cgc cac ctg ctg tcc 2463 Gln Lys Gln Met Lys Val Leu Lys Lys Glu Leu Arg His Leu Leu Ser 785 790 795 cag cca ctg ttt acg gag agc cag aaa acc aag tat ccc act cag tct 2511 Gln Pro Leu Phe Thr Glu Ser Gln Lys Thr Lys Tyr Pro Thr Gln Ser 800 805 810 ggc aag ccg ccc ctg ctt gtg tct gcc cca agt aag agc gag tct gct 2559 Gly Lys Pro Pro Leu Leu Val Ser Ala Pro Ser Lys Ser Glu Ser Ala 815 820 825 ttg agc tgt ctc tcc aag cag aag aag aag aag aca aag aag ccg aag 2607 Leu Ser Cys Leu Ser Lys Gln Lys Lys Lys Lys Thr Lys Lys Pro Lys 830 835 840 845 gag cca cag ccg gaa cag cca cag cca agt aca agt gca aat taa 2652 Glu Pro Gln Pro Glu Gln Pro Gln Pro Ser Thr Ser Ala Asn 850 855 ctggtcaagt gtgtcagtga ctgcacattg gtttctgttc tctggctatt tgcaaaacct 2712 ctcccaccct tgtgtttcac tccaccacca accccaggta aaaaagtctc cctctcttcc 2772 actcacaccc atagcgggag agacctcatg cagatttgca ttgttttgga gtaagaattc 2832 aatgcagcag cttaattttt ctgtattgca gtgtttatag gcttcttgtg tgttaaactt 2892 gatttcataa attaaaaaca atggtcag 2920 <210> SEQ ID NO 38 <211> LENGTH: 859 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 38 Met Lys Leu Lys Asp Thr Lys Ser Arg Pro Lys Gln Ser Ser Cys Gly 1 5 10 15 Lys Phe Gln Thr Lys Gly Ile Lys Val Val Gly Lys Trp Lys Glu Val 20 25 30 Lys Ile Asp Pro Asn Met Phe Ala Asp Gly Gln Met Asp Asp Leu Val 35 40 45 Cys Phe Glu Glu Leu Thr Asp Tyr Gln Leu Val Ser Pro Ala Lys Asn 50 55 60 Pro Ser Ser Leu Phe Ser Lys Glu Ala Pro Lys Arg Lys Ala Gln Ala 65 70 75 80 Val Ser Glu Glu Glu Glu Glu Glu Glu Gly Lys Ser Ser Ser Pro Lys 85 90 95 Lys Lys Ile Lys Leu Lys Lys Ser Lys Asn Val Ala Thr Glu Gly Thr 100 105 110 Ser Thr Gln Lys Glu Phe Glu Val Lys Asp Pro Glu Leu Glu Ala Gln 115 120 125 Gly Asp Asp Met Val Cys Asp Asp Pro Glu Ala Gly Glu Met Thr Ser 130 135 140 Glu Asn Leu Val Gln Thr Ala Pro Lys Lys Lys Lys Asn Lys Gly Lys 145 150 155 160 Lys Gly Leu Glu Pro Ser Gln Ser Thr Ala Ala Lys Val Pro Lys Lys 165 170 175 Ala Lys Thr Trp Ile Pro Glu Val His Asp Gln Lys Ala Asp Val Ser 180 185 190 Ala Trp Lys Asp Leu Phe Val Pro Arg Pro Val Leu Arg Ala Leu Ser 195 200 205 Phe Leu Gly Phe Ser Ala Pro Thr Pro Ile Gln Ala Leu Thr Leu Ala 210 215 220 Pro Ala Ile Arg Asp Lys Leu Asp Ile Leu Gly Ala Ala Glu Thr Gly 225 230 235 240 Ser Gly Lys Thr Leu Ala Phe Ala Ile Pro Met Ile His Ala Val Leu 245 250 255 Gln Trp Gln Lys Arg Asn Ala Ala Pro Pro Pro Ser Asn Thr Glu Ala 260 265 270 Pro Pro Gly Glu Thr Arg Thr Glu Ala Gly Ala Glu Thr Arg Ser Pro 275 280 285 Gly Lys Ala Glu Ala Glu Ser Asp Ala Leu Pro Asp Asp Thr Val Ile 290 295 300 Glu Ser Glu Ala Leu Pro Ser Asp Ile Ala Ala Glu Ala Arg Ala Lys 305 310 315 320 Thr Gly Gly Thr Val Ser Asp Gln Ala Leu Leu Phe Gly Asp Asp Asp 325 330 335 Ala Gly Glu Gly Pro Ser Ser Leu Ile Arg Glu Lys Pro Val Pro Lys 340 345 350 Gln Asn Glu Asn Glu Glu Glu Asn Leu Asp Lys Glu Gln Thr Gly Asn 355 360 365 Leu Lys Gln Glu Leu Asp Asp Lys Ser Ala Thr Cys Lys Ala Tyr Pro 370 375 380 Lys Arg Pro Leu Leu Gly Leu Val Leu Thr Pro Thr Arg Glu Leu Ala 385 390 395 400 Val Gln Val Lys Gln His Ile Asp Ala Val Ala Arg Phe Thr Gly Ile 405 410 415 Lys Thr Ala Ile Leu Val Gly Gly Met Ser Thr Gln Lys Gln Gln Arg 420 425 430 Met Leu Asn Arg Arg Pro Glu Ile Val Val Ala Thr Pro Gly Arg Leu 435 440 445 Trp Glu Leu Ile Lys Glu Lys His Tyr His Leu Arg Asn Leu Arg Gln 450 455 460 Leu Arg Cys Leu Val Val Asp Glu Ala Asp Arg Met Val Glu Lys Gly 465 470 475 480 His Phe Ala Glu Leu Ser Gln Leu Leu Glu Met Leu Asn Asp Ser Gln 485 490 495 Tyr Asn Pro Lys Arg Gln Thr Leu Val Phe Ser Ala Thr Leu Thr Leu 500 505 510 Val His Gln Ala Pro Ala Arg Ile Leu His Lys Lys His Thr Lys Lys 515 520 525 Met Asp Lys Thr Ala Lys Leu Asp Leu Leu Met Gln Lys Ile Gly Met 530 535 540 Arg Gly Lys Pro Lys Val Ile Asp Leu Thr Arg Asn Glu Ala Thr Val 545 550 555 560 Glu Thr Leu Thr Glu Thr Lys Ile His Cys Glu Thr Asp Glu Lys Asp 565 570 575 Phe Tyr Leu Tyr Tyr Phe Leu Met Gln Tyr Pro Gly Arg Ser Leu Val 580 585 590 Phe Ala Asn Ser Ile Ser Cys Ile Lys Arg Leu Ser Gly Leu Leu Lys 595 600 605 Val Leu Asp Ile Met Pro Leu Thr Leu His Ala Cys Met His Gln Lys 610 615 620 Gln Arg Leu Arg Asn Leu Glu Gln Phe Ala Arg Leu Glu Asp Cys Val 625 630 635 640 Leu Leu Ala Thr Asp Val Ala Ala Arg Gly Leu Asp Ile Pro Lys Val 645 650 655 Gln His Val Ile His Tyr Gln Val Pro Arg Thr Ser Glu Ile Tyr Val 660 665 670 His Arg Ser Gly Arg Thr Ala Arg Ala Thr Asn Glu Gly Leu Ser Leu 675 680 685 Met Leu Ile Gly Pro Glu Asp Val Ile Asn Phe Lys Lys Ile Tyr Lys 690 695 700 Thr Leu Lys Lys Asp Glu Asp Ile Pro Leu Phe Pro Val Gln Thr Lys 705 710 715 720 Tyr Met Asp Val Val Lys Glu Arg Ile Arg Leu Ala Arg Gln Ile Glu 725 730 735 Lys Ser Glu Tyr Arg Asn Phe Gln Ala Cys Leu His Asn Ser Trp Ile 740 745 750 Glu Gln Ala Ala Ala Ala Leu Glu Ile Glu Leu Glu Glu Asp Met Tyr 755 760 765 Lys Gly Gly Lys Ala Asp Gln Gln Glu Glu Arg Arg Arg Gln Lys Gln 770 775 780 Met Lys Val Leu Lys Lys Glu Leu Arg His Leu Leu Ser Gln Pro Leu 785 790 795 800 Phe Thr Glu Ser Gln Lys Thr Lys Tyr Pro Thr Gln Ser Gly Lys Pro 805 810 815 Pro Leu Leu Val Ser Ala Pro Ser Lys Ser Glu Ser Ala Leu Ser Cys 820 825 830 Leu Ser Lys Gln Lys Lys Lys Lys Thr Lys Lys Pro Lys Glu Pro Gln 835 840 845 Pro Glu Gln Pro Gln Pro Ser Thr Ser Ala Asn 850 855 <210> SEQ ID NO 39 <211> LENGTH: 1502 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (15)..(998) <400> SEQUENCE: 39 actcgactac caag atg gcg gcc ccc ggg agc tgt gct cta tgg agc tat 50 Met Ala Ala Pro Gly Ser Cys Ala Leu Trp Ser Tyr 1 5 10 tgc ggc cgt ggg tgg tcg cgg gcg atg cgg ggc tgc cag ctc ctc ggg 98 Cys Gly Arg Gly Trp Ser Arg Ala Met Arg Gly Cys Gln Leu Leu Gly 15 20 25 ctt cgt agc tct tgg ccc ggg gac cta cta agt gct cgg ctc ttg tcc 146 Leu Arg Ser Ser Trp Pro Gly Asp Leu Leu Ser Ala Arg Leu Leu Ser 30 35 40 caa gag aag cgg gca gcg gaa acg cac ttt ggg ttt gag act gtg tcg 194 Gln Glu Lys Arg Ala Ala Glu Thr His Phe Gly Phe Glu Thr Val Ser 45 50 55 60 gaa gag gag aag ggg ggc aaa gtc tat cag gtg ttt gaa agt gtg gct 242 Glu Glu Glu Lys Gly Gly Lys Val Tyr Gln Val Phe Glu Ser Val Ala 65 70 75 aag aag tat gat gtg atg aat gat atg atg agt ctt ggt atc cat cgt 290 Lys Lys Tyr Asp Val Met Asn Asp Met Met Ser Leu Gly Ile His Arg 80 85 90 gtt tgg aag gat ttg ctg ctc tgg aag atg cac ccg ctt cct ggg acc 338 Val Trp Lys Asp Leu Leu Leu Trp Lys Met His Pro Leu Pro Gly Thr 95 100 105 cag ctg ctt gat gtt gct gga ggc aca ggt gac att gca ttc cgg ttc 386 Gln Leu Leu Asp Val Ala Gly Gly Thr Gly Asp Ile Ala Phe Arg Phe 110 115 120 ctt aat tat gtt cag tcc cag cat cag aga aaa cag aag agg cag tta 434 Leu Asn Tyr Val Gln Ser Gln His Gln Arg Lys Gln Lys Arg Gln Leu 125 130 135 140 agg gcc caa caa aat tta tcc tgg gaa gaa att gcc aaa gag tac cag 482 Arg Ala Gln Gln Asn Leu Ser Trp Glu Glu Ile Ala Lys Glu Tyr Gln 145 150 155 aat gaa gaa gat tcc ttg ggc ggg tct cgt gtc gtg gtg tgt gac atc 530 Asn Glu Glu Asp Ser Leu Gly Gly Ser Arg Val Val Val Cys Asp Ile 160 165 170 aac aag gag atg cta aag gtt gga aag cag aaa gcc ttg gct caa gga 578 Asn Lys Glu Met Leu Lys Val Gly Lys Gln Lys Ala Leu Ala Gln Gly 175 180 185 tac aga gct gga ctt gca tgg gta tta gga gat gct gaa gaa ctg ccc 626 Tyr Arg Ala Gly Leu Ala Trp Val Leu Gly Asp Ala Glu Glu Leu Pro 190 195 200 ttt gat gat gac aag ttt gat att tac acc att gcc ttt ggg atc cgg 674 Phe Asp Asp Asp Lys Phe Asp Ile Tyr Thr Ile Ala Phe Gly Ile Arg 205 210 215 220 aat gtc aca cac att gat cag gca ctc cag gaa gct cat cgg gtg ctg 722 Asn Val Thr His Ile Asp Gln Ala Leu Gln Glu Ala His Arg Val Leu 225 230 235 aaa cca gga gga cgg ttt ctc tgt ctg gaa ttt agc caa gtg aac aat 770 Lys Pro Gly Gly Arg Phe Leu Cys Leu Glu Phe Ser Gln Val Asn Asn 240 245 250 ccc ctc ata tcc agg ctt tat gat cta tat agc ttc cag gtc atc cct 818 Pro Leu Ile Ser Arg Leu Tyr Asp Leu Tyr Ser Phe Gln Val Ile Pro 255 260 265 gtc ctg gga gag gtc atc gct gga gac tgg aag tcc tat cag tac ctt 866 Val Leu Gly Glu Val Ile Ala Gly Asp Trp Lys Ser Tyr Gln Tyr Leu 270 275 280 gta gag agt atc cga agg ttt ccg tct cag gaa gag ttc aag gac atg 914 Val Glu Ser Ile Arg Arg Phe Pro Ser Gln Glu Glu Phe Lys Asp Met 285 290 295 300 ata gaa gat gca ggc ttt cac aag gtg act tac gaa agt cta aca tca 962 Ile Glu Asp Ala Gly Phe His Lys Val Thr Tyr Glu Ser Leu Thr Ser 305 310 315 ggc att gtg gcc att cat tct ggc ttc aaa ctt taa ttcctttcct 1008 Gly Ile Val Ala Ile His Ser Gly Phe Lys Leu 320 325 atcatggagc atgaaccagt catatcctgt tgaaagcctg gaactgaagg ataatctggc 1068 aaatgagaca gcagcagagc atctcctctt aaggatacgt gccttggact catgtttgaa 1128 tcgaacagtc tcaaagtgga agaacaaatt cttgtcactt ttttacagct ttctttggag 1188 ctgcttcagt ccatctccca gaggcatttg gtctgtatct ttgctcaact gctaatttct 1248 cttggctgta gggtgtgtgg ttaaggtaca accaccccta aagctcagtt ttgaagtgag 1308 tgtatttata gcttctctgc tggtgctgcc ttctagaggg atgatagatc atttgaaccc 1368 aatgacaatt tttaaccaga aaatttaatt gtacctgaat caacctttca gcctaggacg 1428 aagtctaggc ccaagtcaga gtattaatga tcatgagaat tgtgtgctga accagtaaac 1488 gagtttacct tttg 1502 <210> SEQ ID NO 40 <211> LENGTH: 327 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 40 Met Ala Ala Pro Gly Ser Cys Ala Leu Trp Ser Tyr Cys Gly Arg Gly 1 5 10 15 Trp Ser Arg Ala Met Arg Gly Cys Gln Leu Leu Gly Leu Arg Ser Ser 20 25 30 Trp Pro Gly Asp Leu Leu Ser Ala Arg Leu Leu Ser Gln Glu Lys Arg 35 40 45 Ala Ala Glu Thr His Phe Gly Phe Glu Thr Val Ser Glu Glu Glu Lys 50 55 60 Gly Gly Lys Val Tyr Gln Val Phe Glu Ser Val Ala Lys Lys Tyr Asp 65 70 75 80 Val Met Asn Asp Met Met Ser Leu Gly Ile His Arg Val Trp Lys Asp 85 90 95 Leu Leu Leu Trp Lys Met His Pro Leu Pro Gly Thr Gln Leu Leu Asp 100 105 110 Val Ala Gly Gly Thr Gly Asp Ile Ala Phe Arg Phe Leu Asn Tyr Val 115 120 125 Gln Ser Gln His Gln Arg Lys Gln Lys Arg Gln Leu Arg Ala Gln Gln 130 135 140 Asn Leu Ser Trp Glu Glu Ile Ala Lys Glu Tyr Gln Asn Glu Glu Asp 145 150 155 160 Ser Leu Gly Gly Ser Arg Val Val Val Cys Asp Ile Asn Lys Glu Met 165 170 175 Leu Lys Val Gly Lys Gln Lys Ala Leu Ala Gln Gly Tyr Arg Ala Gly 180 185 190 Leu Ala Trp Val Leu Gly Asp Ala Glu Glu Leu Pro Phe Asp Asp Asp 195 200 205 Lys Phe Asp Ile Tyr Thr Ile Ala Phe Gly Ile Arg Asn Val Thr His 210 215 220 Ile Asp Gln Ala Leu Gln Glu Ala His Arg Val Leu Lys Pro Gly Gly 225 230 235 240 Arg Phe Leu Cys Leu Glu Phe Ser Gln Val Asn Asn Pro Leu Ile Ser 245 250 255 Arg Leu Tyr Asp Leu Tyr Ser Phe Gln Val Ile Pro Val Leu Gly Glu 260 265 270 Val Ile Ala Gly Asp Trp Lys Ser Tyr Gln Tyr Leu Val Glu Ser Ile 275 280 285 Arg Arg Phe Pro Ser Gln Glu Glu Phe Lys Asp Met Ile Glu Asp Ala 290 295 300 Gly Phe His Lys Val Thr Tyr Glu Ser Leu Thr Ser Gly Ile Val Ala 305 310 315 320 Ile His Ser Gly Phe Lys Leu 325 <210> SEQ ID NO 41 <211> LENGTH: 737 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (127)..(387) <400> SEQUENCE: 41 aaaaattctt cttcgacggc gcggacctgg agcttccgcg cggtggcttc actctcctgt 60 aaaacgctag agcggcgagt tgttacctgc gtcctctgac ctgagagcga aggggaaagc 120 ggcgag atg act gac cgc tac acc atc cat agc cag ctg gag cac ctg 168 Met Thr Asp Arg Tyr Thr Ile His Ser Gln Leu Glu His Leu 1 5 10 cag tcc aag tac atc ggc acg ggc cac gcc gac acc acc aag tgg gag 216 Gln Ser Lys Tyr Ile Gly Thr Gly His Ala Asp Thr Thr Lys Trp Glu 15 20 25 30 tgg ctg gtg aac caa cac cgc gac tcg tac tgc tcc tac atg ggc cac 264 Trp Leu Val Asn Gln His Arg Asp Ser Tyr Cys Ser Tyr Met Gly His 35 40 45 ttc gac ctt ctc aac tac ttc gcc att gcg gag aat gag agc aaa gcg 312 Phe Asp Leu Leu Asn Tyr Phe Ala Ile Ala Glu Asn Glu Ser Lys Ala 50 55 60 cga gtc cgc ttc aac ttg atg gaa aag atg ctt cag cct tgt gga ccg 360 Arg Val Arg Phe Asn Leu Met Glu Lys Met Leu Gln Pro Cys Gly Pro 65 70 75 cca gcc gac aag ccc gag gag aac tga gactctgcct taccacctca 407 Pro Ala Asp Lys Pro Glu Glu Asn 80 85 gtgcggggca cctctcccag cgtttctccg gtttgccaat cctcttaagt attcctgtct 467 ccaaaggacc ggctctccat ggctcctgcg cctcgtgctt tccgcgtaca gaagtgcttg 527 cccggggagt cccgcctgac ctgccttcat gtggaccctt agaacagcac tgggagacca 587 gcaggactcc tgagaactgt gctggtggag aggtcctaga gccggcgagc gtttgagaag 647 agggcatggc gctggagtga gatgggattt ggcgtctcgt ttttggctaa ttgattgtca 707 ttggcttttt ccataaagtt tagaaatcgt 737 <210> SEQ ID NO 42 <211> LENGTH: 86 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 42 Met Thr Asp Arg Tyr Thr Ile His Ser Gln Leu Glu His Leu Gln Ser 1 5 10 15 Lys Tyr Ile Gly Thr Gly His Ala Asp Thr Thr Lys Trp Glu Trp Leu 20 25 30 Val Asn Gln His Arg Asp Ser Tyr Cys Ser Tyr Met Gly His Phe Asp 35 40 45 Leu Leu Asn Tyr Phe Ala Ile Ala Glu Asn Glu Ser Lys Ala Arg Val 50 55 60 Arg Phe Asn Leu Met Glu Lys Met Leu Gln Pro Cys Gly Pro Pro Ala 65 70 75 80 Asp Lys Pro Glu Glu Asn 85 <210> SEQ ID NO 43 <211> LENGTH: 903 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (85)..(621) <400> SEQUENCE: 43 ctgaggcccc acagcctccc aattccgggc agacccctga cacctgctgt ctggcccctt 60 ccggcctgaa gctgcagccg cgcc atg tcc acc cct ccg ttg gcc gcg tcg 111 Met Ser Thr Pro Pro Leu Ala Ala Ser 1 5 ggg atg gcg ccc ggg ccc ttc gcc ggg ccc cag gct cag cag gcc gcc 159 Gly Met Ala Pro Gly Pro Phe Ala Gly Pro Gln Ala Gln Gln Ala Ala 10 15 20 25 cgg gaa gtc aac acg gcg tcg ctg tgc cgc atc ggg cag gag aca gtg 207 Arg Glu Val Asn Thr Ala Ser Leu Cys Arg Ile Gly Gln Glu Thr Val 30 35 40 cag gac atc gtg tac cgc acc atg gag atc ttc cag ctc ctg agg aac 255 Gln Asp Ile Val Tyr Arg Thr Met Glu Ile Phe Gln Leu Leu Arg Asn 45 50 55 atg cag ctg cca aat ggt gtc act tac cac act gga aca tat caa gac 303 Met Gln Leu Pro Asn Gly Val Thr Tyr His Thr Gly Thr Tyr Gln Asp 60 65 70 cgg tta aca aag cta cag gat aat ctt cgc caa ctt tca gtt ctc ttc 351 Arg Leu Thr Lys Leu Gln Asp Asn Leu Arg Gln Leu Ser Val Leu Phe 75 80 85 agg aag ctg aga ttg gta tat gac aaa tgc aat gaa aac tgt ggt ggg 399 Arg Lys Leu Arg Leu Val Tyr Asp Lys Cys Asn Glu Asn Cys Gly Gly 90 95 100 105 atg gat ccc att cca gtc gag caa ctt att cca tat gtg gaa gaa gat 447 Met Asp Pro Ile Pro Val Glu Gln Leu Ile Pro Tyr Val Glu Glu Asp 110 115 120 ggc tca aag aat gat gat cgg gct ggc cca cct cgt ttt gct agt gaa 495 Gly Ser Lys Asn Asp Asp Arg Ala Gly Pro Pro Arg Phe Ala Ser Glu 125 130 135 gag agg cga gaa att gct gaa gta aat aaa aaa ctc aaa cag aag aat 543 Glu Arg Arg Glu Ile Ala Glu Val Asn Lys Lys Leu Lys Gln Lys Asn 140 145 150 caa cag ctg aaa caa att atg gat caa tta cga aat ctc atc tgg gat 591 Gln Gln Leu Lys Gln Ile Met Asp Gln Leu Arg Asn Leu Ile Trp Asp 155 160 165 ata aat gcc atg ttg gca atg agg aac taa gctgatattt aaatttcctg 641 Ile Asn Ala Met Leu Ala Met Arg Asn 170 175 ctttacacat gttataccat tgttttttcc ctcaagtatt ttttccctgt gaagaagatt 701 atttatctgc ttttatttta gtcactaaaa ctaaagtttt tatttttaca ttgtgatttt 761 tacattaaaa tattaacttt ttttaatgct attttatgaa agattattgt aataaacttt 821 gatggggttt gtattttggt taatcttcat gaattgaata attgtttttt taaagcaaaa 881 taaagttttt taaataaatg tt 903 <210> SEQ ID NO 44 <211> LENGTH: 178 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 44 Met Ser Thr Pro Pro Leu Ala Ala Ser Gly Met Ala Pro Gly Pro Phe 1 5 10 15 Ala Gly Pro Gln Ala Gln Gln Ala Ala Arg Glu Val Asn Thr Ala Ser 20 25 30 Leu Cys Arg Ile Gly Gln Glu Thr Val Gln Asp Ile Val Tyr Arg Thr 35 40 45 Met Glu Ile Phe Gln Leu Leu Arg Asn Met Gln Leu Pro Asn Gly Val 50 55 60 Thr Tyr His Thr Gly Thr Tyr Gln Asp Arg Leu Thr Lys Leu Gln Asp 65 70 75 80 Asn Leu Arg Gln Leu Ser Val Leu Phe Arg Lys Leu Arg Leu Val Tyr 85 90 95 Asp Lys Cys Asn Glu Asn Cys Gly Gly Met Asp Pro Ile Pro Val Glu 100 105 110 Gln Leu Ile Pro Tyr Val Glu Glu Asp Gly Ser Lys Asn Asp Asp Arg 115 120 125 Ala Gly Pro Pro Arg Phe Ala Ser Glu Glu Arg Arg Glu Ile Ala Glu 130 135 140 Val Asn Lys Lys Leu Lys Gln Lys Asn Gln Gln Leu Lys Gln Ile Met 145 150 155 160 Asp Gln Leu Arg Asn Leu Ile Trp Asp Ile Asn Ala Met Leu Ala Met 165 170 175 Arg Asn <210> SEQ ID NO 45 <211> LENGTH: 1170 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (187)..(540) <400> SEQUENCE: 45 tatagtccag ggcctgtttc cctgtagcag ctccttattg ctggagaagg agaaaagtgc 60 ccaagatcct ttcaggatat ttggtttttt gggcgcgaca caaatcgagg tgagggaaga 120 gagaggaaaa tcccctgaat ccctgcagga ttaatttatt caaaaaggaa ataaaaaata 180 ctcaat atg caa aag tct tgt gaa gaa aat gag gga aaa cca cag aac 228 Met Gln Lys Ser Cys Glu Glu Asn Glu Gly Lys Pro Gln Asn 1 5 10 atg cca aag gcc gag gaa gat cgc cct ttg gag gat gta cca cag gag 276 Met Pro Lys Ala Glu Glu Asp Arg Pro Leu Glu Asp Val Pro Gln Glu 15 20 25 30 gca gaa gga aat cct caa cct tcc gaa gaa ggc gta agc cag gaa gca 324 Ala Glu Gly Asn Pro Gln Pro Ser Glu Glu Gly Val Ser Gln Glu Ala 35 40 45 gaa gga aac ccc aga gga ggg ccg aat cag cct ggc cag gga ttt aaa 372 Glu Gly Asn Pro Arg Gly Gly Pro Asn Gln Pro Gly Gln Gly Phe Lys 50 55 60 gag gac aca ccc gtt agg cat ttg gac cct gaa gaa atg ata aga gga 420 Glu Asp Thr Pro Val Arg His Leu Asp Pro Glu Glu Met Ile Arg Gly 65 70 75 gta gat gag ctt gaa agg ctt agg gaa gag ata aga aga gta aga aac 468 Val Asp Glu Leu Glu Arg Leu Arg Glu Glu Ile Arg Arg Val Arg Asn 80 85 90 aag ttt gtg atg atg cat tgg aag caa aga cat tca cgc agc cgt cct 516 Lys Phe Val Met Met His Trp Lys Gln Arg His Ser Arg Ser Arg Pro 95 100 105 110 tat cct gtg tgc ttt agg cct tga attcattttt gcctaatatt aaaatctggc 570 Tyr Pro Val Cys Phe Arg Pro 115 cccagctttc tttctgttag cattttctga tgtatctttg acctccattt tacttttaat 630 catctgatga aattttgttt taggtaattt ccttggtacc agcatctcat tggattttgg 690 attttgaccc attttccagg tctatttttc aattggaaac tttcacacat ttgcatggga 750 atatgttcat tccatgttgt aaagtaaaac ataacaggtt atggcaaagc agcatattta 810 atatcagctc acatatgtag gataaaattc caaactttgt gtgtgtgcgt gtgtgtatac 870 atacatccat ataacatata tcacaaactt aaccaagctt atttctgtgt ggtgtgaaat 930 tttatttgtt ttcttctttt tgttcttttt gcttatatgt actttttaat gaacacgtgt 990 ctcacacaca aaaagaatta aggatttttt ttacaagtaa gagtcaaata atttgcaacc 1050 agcttatgag ggcaatgggg gcacctaaac tcttgatgaa agaactttaa aaagaaatgt 1110 aaacctcaaa ttacctctgg atctcttagc cagaggaata aactggcaat tattacagat 1170 <210> SEQ ID NO 46 <211> LENGTH: 117 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 46 Met Gln Lys Ser Cys Glu Glu Asn Glu Gly Lys Pro Gln Asn Met Pro 1 5 10 15 Lys Ala Glu Glu Asp Arg Pro Leu Glu Asp Val Pro Gln Glu Ala Glu 20 25 30 Gly Asn Pro Gln Pro Ser Glu Glu Gly Val Ser Gln Glu Ala Glu Gly 35 40 45 Asn Pro Arg Gly Gly Pro Asn Gln Pro Gly Gln Gly Phe Lys Glu Asp 50 55 60 Thr Pro Val Arg His Leu Asp Pro Glu Glu Met Ile Arg Gly Val Asp 65 70 75 80 Glu Leu Glu Arg Leu Arg Glu Glu Ile Arg Arg Val Arg Asn Lys Phe 85 90 95 Val Met Met His Trp Lys Gln Arg His Ser Arg Ser Arg Pro Tyr Pro 100 105 110 Val Cys Phe Arg Pro 115 <210> SEQ ID NO 47 <211> LENGTH: 404 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (105)..(365) <400> SEQUENCE: 47 tttttccagc ggaagtggct cctgtaaggc agcaaggtag cgtggccggc gcccgagctg 60 gggttgtgtc cctgctgggc tgccgttcca gctggactgc cgcc atg gaa ctc agc 116 Met Glu Leu Ser 1 gcc gaa tac ctc cgc gag aag ctg cag cgg gac ctg gag gcg gag cat 164 Ala Glu Tyr Leu Arg Glu Lys Leu Gln Arg Asp Leu Glu Ala Glu His 5 10 15 20 gtg gag gtg gag gac acg acc ctc aac cgt tgc tcc tgt agc ttc cga 212 Val Glu Val Glu Asp Thr Thr Leu Asn Arg Cys Ser Cys Ser Phe Arg 25 30 35 gtc ctg gtg gtg tcg gcc aag ttc gag ggg aaa ccg ctg ctt cag aga 260 Val Leu Val Val Ser Ala Lys Phe Glu Gly Lys Pro Leu Leu Gln Arg 40 45 50 cac agg ctg gtg aac gcg tgc cta gca gaa gag ctc ccg cac atc cat 308 His Arg Leu Val Asn Ala Cys Leu Ala Glu Glu Leu Pro His Ile His 55 60 65 gcc ttt gaa cag aaa acc ctg acc cca gac cag tgg gca cgt gag cga 356 Ala Phe Glu Gln Lys Thr Leu Thr Pro Asp Gln Trp Ala Arg Glu Arg 70 75 80 cag aaa tga gggactggga tctgcacagc cattaaatta taaatctgg 404 Gln Lys 85 <210> SEQ ID NO 48 <211> LENGTH: 86 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 48 Met Glu Leu Ser Ala Glu Tyr Leu Arg Glu Lys Leu Gln Arg Asp Leu 1 5 10 15 Glu Ala Glu His Val Glu Val Glu Asp Thr Thr Leu Asn Arg Cys Ser 20 25 30 Cys Ser Phe Arg Val Leu Val Val Ser Ala Lys Phe Glu Gly Lys Pro 35 40 45 Leu Leu Gln Arg His Arg Leu Val Asn Ala Cys Leu Ala Glu Glu Leu 50 55 60 Pro His Ile His Ala Phe Glu Gln Lys Thr Leu Thr Pro Asp Gln Trp 65 70 75 80 Ala Arg Glu Arg Gln Lys 85 <210> SEQ ID NO 49 <211> LENGTH: 752 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (95)..(634) <400> SEQUENCE: 49 ttttcgcttc cggctgccgc aggcgcttcg ctggtgcaga cgcagtgctg agcacacagc 60 taccggacaa agagtgacgc ccggagctgg agtt atg gcg gct acg gag ccg atc 115 Met Ala Ala Thr Glu Pro Ile 1 5 ttg gcg gcc act ggg agt ccc gcg gcg gtg cca ccg gag aaa ctg gaa 163 Leu Ala Ala Thr Gly Ser Pro Ala Ala Val Pro Pro Glu Lys Leu Glu 10 15 20 gga gcc ggt tcg agc tca gcc cct gag cgt aac tgt gtg ggc tcc tcg 211 Gly Ala Gly Ser Ser Ser Ala Pro Glu Arg Asn Cys Val Gly Ser Ser 25 30 35 ctg cca gag gcc tca ccg cct gcc cct gag cct tcc agt ccc aac gcc 259 Leu Pro Glu Ala Ser Pro Pro Ala Pro Glu Pro Ser Ser Pro Asn Ala 40 45 50 55 gcg gtc cct gaa gcc atc cct acg ccc cga gct gcg gcc tcc gcg gcc 307 Ala Val Pro Glu Ala Ile Pro Thr Pro Arg Ala Ala Ala Ser Ala Ala 60 65 70 ctg gag ctg cct ctc ggg ccc gca ccc gtg agc gta gcg cct cag gcc 355 Leu Glu Leu Pro Leu Gly Pro Ala Pro Val Ser Val Ala Pro Gln Ala 75 80 85 gaa gct gaa gcg cgc tcc aca cca ggc ccc gcc ggc tct aga ctc ggt 403 Glu Ala Glu Ala Arg Ser Thr Pro Gly Pro Ala Gly Ser Arg Leu Gly 90 95 100 ccc gag acg ttc cgc cag cgt ttc cgg cag ttc cgc tac cag gat gcg 451 Pro Glu Thr Phe Arg Gln Arg Phe Arg Gln Phe Arg Tyr Gln Asp Ala 105 110 115 gcg ggt ccc cgg gag gct ttc cgg cag ctg cgg gag ctg tcc cgc cag 499 Ala Gly Pro Arg Glu Ala Phe Arg Gln Leu Arg Glu Leu Ser Arg Gln 120 125 130 135 tgg ctg cgg cct gac atc cgc acc aag gag cag atc gtg gag atg ctg 547 Trp Leu Arg Pro Asp Ile Arg Thr Lys Glu Gln Ile Val Glu Met Leu 140 145 150 gtg caa gag cag ctg ctc gcc atc ctg ccc gag gcg gct cgg gcc cgg 595 Val Gln Glu Gln Leu Leu Ala Ile Leu Pro Glu Ala Ala Arg Ala Arg 155 160 165 cgg atc cgc cgc cgc acg gat gtg cgc atc act ggc tga gcggtggagc 644 Arg Ile Arg Arg Arg Thr Asp Val Arg Ile Thr Gly 170 175 tgcgggcggc cagggccggg cgctctgtgc ggactggggc catgatcggg cccgggggcc 704 tgagcctggg accccacccc gtgttaatga aaaatgagtt ttggcagc 752 <210> SEQ ID NO 50 <211> LENGTH: 179 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 50 Met Ala Ala Thr Glu Pro Ile Leu Ala Ala Thr Gly Ser Pro Ala Ala 1 5 10 15 Val Pro Pro Glu Lys Leu Glu Gly Ala Gly Ser Ser Ser Ala Pro Glu 20 25 30 Arg Asn Cys Val Gly Ser Ser Leu Pro Glu Ala Ser Pro Pro Ala Pro 35 40 45 Glu Pro Ser Ser Pro Asn Ala Ala Val Pro Glu Ala Ile Pro Thr Pro 50 55 60 Arg Ala Ala Ala Ser Ala Ala Leu Glu Leu Pro Leu Gly Pro Ala Pro 65 70 75 80 Val Ser Val Ala Pro Gln Ala Glu Ala Glu Ala Arg Ser Thr Pro Gly 85 90 95 Pro Ala Gly Ser Arg Leu Gly Pro Glu Thr Phe Arg Gln Arg Phe Arg 100 105 110 Gln Phe Arg Tyr Gln Asp Ala Ala Gly Pro Arg Glu Ala Phe Arg Gln 115 120 125 Leu Arg Glu Leu Ser Arg Gln Trp Leu Arg Pro Asp Ile Arg Thr Lys 130 135 140 Glu Gln Ile Val Glu Met Leu Val Gln Glu Gln Leu Leu Ala Ile Leu 145 150 155 160 Pro Glu Ala Ala Arg Ala Arg Arg Ile Arg Arg Arg Thr Asp Val Arg 165 170 175 Ile Thr Gly <210> SEQ ID NO 51 <211> LENGTH: 1222 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (219)..(788) <400> SEQUENCE: 51 ctcctgcctc agcctcccga gtagctggga ctacaggcgg ccgccaccat gcccggctaa 60 ttttttgtat ttttagtaga gacggggttt caccatgtta gccaggatgg cctcgatctc 120 ctgaccgcgt gatccgcccg cctcggcctc cgaaactgct gaaattacag gcgtgagcca 180 ccgcgcccgg ccctccctct tccgctgccg ccgtggga atg gaa aca tct gcc cca 236 Met Glu Thr Ser Ala Pro 1 5 cgt gcc gga agc caa gtg gtg gcg aca act gcg cgc cac tcc gcg gcc 284 Arg Ala Gly Ser Gln Val Val Ala Thr Thr Ala Arg His Ser Ala Ala 10 15 20 tac cgc gca gat cct cta cgt gtg tcc tcg cga gac aag ctc acc gaa 332 Tyr Arg Ala Asp Pro Leu Arg Val Ser Ser Arg Asp Lys Leu Thr Glu 25 30 35 atg gcc gcg tcc agt caa gga aac ttt gag gga aat ttt gag tca ctg 380 Met Ala Ala Ser Ser Gln Gly Asn Phe Glu Gly Asn Phe Glu Ser Leu 40 45 50 gac ctt gcg gaa ttt gct aag aag cag cca tgg tgg cgt aag ctg ttc 428 Asp Leu Ala Glu Phe Ala Lys Lys Gln Pro Trp Trp Arg Lys Leu Phe 55 60 65 70 ggg cag gaa tct gga cct tca gca gaa aag tat agc gtg gca acc cag 476 Gly Gln Glu Ser Gly Pro Ser Ala Glu Lys Tyr Ser Val Ala Thr Gln 75 80 85 ctg ttc att gga ggt gtc act gga tgg tgc aca ggt ttc ata ttc cag 524 Leu Phe Ile Gly Gly Val Thr Gly Trp Cys Thr Gly Phe Ile Phe Gln 90 95 100 aag gtt gga aag ttg gct gca aca gct gtg gga ggt gga ttt ttt ctc 572 Lys Val Gly Lys Leu Ala Ala Thr Ala Val Gly Gly Gly Phe Phe Leu 105 110 115 ctt cag ctt gca aac cat act ggg tac atc aaa gtt gac tgg caa cga 620 Leu Gln Leu Ala Asn His Thr Gly Tyr Ile Lys Val Asp Trp Gln Arg 120 125 130 gtg gag aag gac atg aag aaa gcc aaa gag cag ctg aag atc cgt aag 668 Val Glu Lys Asp Met Lys Lys Ala Lys Glu Gln Leu Lys Ile Arg Lys 135 140 145 150 agc aat cag ata cct act gag gtc agg agc aaa gct gag gag gtg gtg 716 Ser Asn Gln Ile Pro Thr Glu Val Arg Ser Lys Ala Glu Glu Val Val 155 160 165 tca ttt gtg aag aag aat gtt cta gta act ggg gga ttt ttc gga ggc 764 Ser Phe Val Lys Lys Asn Val Leu Val Thr Gly Gly Phe Phe Gly Gly 170 175 180 ttt ctg ctt ggc atg gca tcc taa ggaagatgac ctcatgttca ttgttcctgg 818 Phe Leu Leu Gly Met Ala Ser 185 ttttttccag ccagcagcct ctacactcca tcataggaca tcgagtccct cctcctcttc 878 tcccatgcct tcttccctgc catggcaaat ctgagtggct tctctaagca tctgctggta 938 caagtcaatg tggcaccatg agcttcatgg tggcagaaga gacaatagtc cttagctctc 998 ctcccagtac accccctact tggccagtct gtaggccaac aagaaggttc ctttaccccc 1058 atgcaagaca cttatgagaa cacattacaa gatggctgac cgtggaggat gagtggatcc 1118 tgaaaggttg tcccaaactg ttgatttgga aaagaaataa gcacatagat aaccttattg 1178 tgtgctgcat ggaaaggaac tgaatacatt tgcctttaag catg 1222 <210> SEQ ID NO 52 <211> LENGTH: 189 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 52 Met Glu Thr Ser Ala Pro Arg Ala Gly Ser Gln Val Val Ala Thr Thr 1 5 10 15 Ala Arg His Ser Ala Ala Tyr Arg Ala Asp Pro Leu Arg Val Ser Ser 20 25 30 Arg Asp Lys Leu Thr Glu Met Ala Ala Ser Ser Gln Gly Asn Phe Glu 35 40 45 Gly Asn Phe Glu Ser Leu Asp Leu Ala Glu Phe Ala Lys Lys Gln Pro 50 55 60 Trp Trp Arg Lys Leu Phe Gly Gln Glu Ser Gly Pro Ser Ala Glu Lys 65 70 75 80 Tyr Ser Val Ala Thr Gln Leu Phe Ile Gly Gly Val Thr Gly Trp Cys 85 90 95 Thr Gly Phe Ile Phe Gln Lys Val Gly Lys Leu Ala Ala Thr Ala Val 100 105 110 Gly Gly Gly Phe Phe Leu Leu Gln Leu Ala Asn His Thr Gly Tyr Ile 115 120 125 Lys Val Asp Trp Gln Arg Val Glu Lys Asp Met Lys Lys Ala Lys Glu 130 135 140 Gln Leu Lys Ile Arg Lys Ser Asn Gln Ile Pro Thr Glu Val Arg Ser 145 150 155 160 Lys Ala Glu Glu Val Val Ser Phe Val Lys Lys Asn Val Leu Val Thr 165 170 175 Gly Gly Phe Phe Gly Gly Phe Leu Leu Gly Met Ala Ser 180 185 <210> SEQ ID NO 53 <211> LENGTH: 1209 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (95)..(448) <400> SEQUENCE: 53 tcgcgcttgc ctgtgtcccg ggcttgtctg tgaagtgggc gtgaagatcg ttgccacctt 60 ccaacctacc tcacaggggt gttgtgggga cacc atg atc tct gga ttg ttc atg 115 Met Ile Ser Gly Leu Phe Met 1 5 tcg ttg tgc tgc gcc ggg agc cac cgc cct ccg gag aca ggg cag ctc 163 Ser Leu Cys Cys Ala Gly Ser His Arg Pro Pro Glu Thr Gly Gln Leu 10 15 20 ccc tac gac cct agc gcc tcc gcc ctc cgc ggc ccc tct cct ctc ttc 211 Pro Tyr Asp Pro Ser Ala Ser Ala Leu Arg Gly Pro Ser Pro Leu Phe 25 30 35 ctg ctc tgt ccc tcc ttc tcc atc agg gag cag cgt gac ttc agc gag 259 Leu Leu Cys Pro Ser Phe Ser Ile Arg Glu Gln Arg Asp Phe Ser Glu 40 45 50 55 tcc cgc gag cac ctg gct aga cag tta aca agc acg tcc ttc cag cct 307 Ser Arg Glu His Leu Ala Arg Gln Leu Thr Ser Thr Ser Phe Gln Pro 60 65 70 gag cca gcg cag gtt tgg gag ggg gct tcc tgg ccc ccc cca cgg tgt 355 Glu Pro Ala Gln Val Trp Glu Gly Ala Ser Trp Pro Pro Pro Arg Cys 75 80 85 tcc agc ccc tcc tct ctt ccg ccc cct agt ctc cca ccc ttc cct ccc 403 Ser Ser Pro Ser Ser Leu Pro Pro Pro Ser Leu Pro Pro Phe Pro Pro 90 95 100 cgt agt gac caa ttc cta tct ctt ccc tct ccg cag gct caa tga 448 Arg Ser Asp Gln Phe Leu Ser Leu Pro Ser Pro Gln Ala Gln 105 110 115 atcgaatgaa tgtgaacttc ttcatctgtg aaaaatcttt tttttttcca ttttgttctg 508 tttgggggct tctgttttgt ttggcgagag agcgatggct gccgtgggga gtactgggga 568 gccctcgcgg caagcagggt gggggggact tgggggcatg ccgggccctc actctctcgc 628 ctgttctgtg tctcacatgc tttttctttc aaaattggga tccttccatg ttgagccagc 688 cagagaagat agcgagatct aaatctctgc caaaaaaaaa aaaaacttaa aaattaaaaa 748 cacaaagagc aaagcagaac ttataaaatt atatatatat atattaaaaa gtctctattc 808 ttcacccccc agccttcctg aacctgcctc tctgaggata aagcaattca ttttctccca 868 ccctcggccc tcttgttttt aaaataaact tttaaaaagg aaaaaaaaaa gtcactcttg 928 ctatttcttt tttttagtta gaggtggaac attccttgga ccaggtgttg tattgcagga 988 ccccttcccc cagcagccaa gccccctctt ctctccctcc cgccctggct cagctcccgc 1048 ggccccgccc gtcccccctc ccaggactgg tctgttgtct tttcatctgt tcaagaggag 1108 attgaaactg aaaacaaaat gagaacaaca aaaaaaattg tatggcagtt tttacttttt 1168 atcgctcgtt tttaacttca caaataaatg ataacaaaac c 1209 <210> SEQ ID NO 54 <211> LENGTH: 117 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 54 Met Ile Ser Gly Leu Phe Met Ser Leu Cys Cys Ala Gly Ser His Arg 1 5 10 15 Pro Pro Glu Thr Gly Gln Leu Pro Tyr Asp Pro Ser Ala Ser Ala Leu 20 25 30 Arg Gly Pro Ser Pro Leu Phe Leu Leu Cys Pro Ser Phe Ser Ile Arg 35 40 45 Glu Gln Arg Asp Phe Ser Glu Ser Arg Glu His Leu Ala Arg Gln Leu 50 55 60 Thr Ser Thr Ser Phe Gln Pro Glu Pro Ala Gln Val Trp Glu Gly Ala 65 70 75 80 Ser Trp Pro Pro Pro Arg Cys Ser Ser Pro Ser Ser Leu Pro Pro Pro 85 90 95 Ser Leu Pro Pro Phe Pro Pro Arg Ser Asp Gln Phe Leu Ser Leu Pro 100 105 110 Ser Pro Gln Ala Gln 115 <210> SEQ ID NO 55 <211> LENGTH: 1763 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (26)..(922) <400> SEQUENCE: 55 gtgacggctg cgtgcggcgg gaatc atg gct gct cgc aga gct ctg cac ttc 52 Met Ala Ala Arg Arg Ala Leu His Phe 1 5 gta ttc aaa gtg gga aac cgc ttc cag acg gcg cgt ttc tat cgg gac 100 Val Phe Lys Val Gly Asn Arg Phe Gln Thr Ala Arg Phe Tyr Arg Asp 10 15 20 25 gtc ctg ggg atg aag gtt ctg cgg cat gag gaa ttt gaa gaa ggc tgc 148 Val Leu Gly Met Lys Val Leu Arg His Glu Glu Phe Glu Glu Gly Cys 30 35 40 aaa gct gcc tgt aat ggg cct tat gat ggg aaa tgg agt aaa aca atg 196 Lys Ala Ala Cys Asn Gly Pro Tyr Asp Gly Lys Trp Ser Lys Thr Met 45 50 55 gtg gga ttt ggg cct gag gat gat cat ttt gtc gca gaa ctg act tac 244 Val Gly Phe Gly Pro Glu Asp Asp His Phe Val Ala Glu Leu Thr Tyr 60 65 70 aat tat ggc gtc gga gac tac aag ctt ggc aat gac ttt atg gga atc 292 Asn Tyr Gly Val Gly Asp Tyr Lys Leu Gly Asn Asp Phe Met Gly Ile 75 80 85 acg ctc gct tct agc cag gct gtc agc aac gcc agg aag ctg gag tgg 340 Thr Leu Ala Ser Ser Gln Ala Val Ser Asn Ala Arg Lys Leu Glu Trp 90 95 100 105 cca ctg acg gaa gtt gca gaa ggt gtt ttt gaa acc gag gcc ccg gga 388 Pro Leu Thr Glu Val Ala Glu Gly Val Phe Glu Thr Glu Ala Pro Gly 110 115 120 gga tat aag ttc tat ttg cag aat cgc agt ctg cct cag tca gat cct 436 Gly Tyr Lys Phe Tyr Leu Gln Asn Arg Ser Leu Pro Gln Ser Asp Pro 125 130 135 gta tta aaa gta act cta gca gtg tct gat ctt caa aag tcc ttg aac 484 Val Leu Lys Val Thr Leu Ala Val Ser Asp Leu Gln Lys Ser Leu Asn 140 145 150 tac tgg tgt aat cta ctg gga atg aaa att tat gaa aaa gat gaa gaa 532 Tyr Trp Cys Asn Leu Leu Gly Met Lys Ile Tyr Glu Lys Asp Glu Glu 155 160 165 aag caa agg gct ttg ctg ggc tat gct gat aac cag tgt aag ctg gag 580 Lys Gln Arg Ala Leu Leu Gly Tyr Ala Asp Asn Gln Cys Lys Leu Glu 170 175 180 185 cta cag ggc gtc aag ggt ggg gtg gac cat gca gca gct ttt gga aga 628 Leu Gln Gly Val Lys Gly Gly Val Asp His Ala Ala Ala Phe Gly Arg 190 195 200 att gcc ttc tct tgc ccc cag aaa gag ttg cca gac tta gaa gac ttg 676 Ile Ala Phe Ser Cys Pro Gln Lys Glu Leu Pro Asp Leu Glu Asp Leu 205 210 215 atg aaa agg gag aac cag aag att ctg act ccc ctg gtg agc ctg gac 724 Met Lys Arg Glu Asn Gln Lys Ile Leu Thr Pro Leu Val Ser Leu Asp 220 225 230 acc cca ggg aaa gca aca gta cag gtg gtc att ctg gcc gac cct gac 772 Thr Pro Gly Lys Ala Thr Val Gln Val Val Ile Leu Ala Asp Pro Asp 235 240 245 gga cat gaa att tgc ttt gtc ggg gat gaa gca ttt cga gaa ctt tct 820 Gly His Glu Ile Cys Phe Val Gly Asp Glu Ala Phe Arg Glu Leu Ser 250 255 260 265 aag atg gat cca gag gga agc aaa ttg ttg gat gat gca atg gca gca 868 Lys Met Asp Pro Glu Gly Ser Lys Leu Leu Asp Asp Ala Met Ala Ala 270 275 280 gat aaa agt gac gag tgg ttt gcc aaa cac aat aaa ccc aaa gct tca 916 Asp Lys Ser Asp Glu Trp Phe Ala Lys His Asn Lys Pro Lys Ala Ser 285 290 295 ggt taa cggaagacat gatgcagagc aagcctctgt gattcctgcc cagcacctgt 972 Gly gaggcctgac gtgtcagttc ccaataaatg ctcttctgat ttgtttcccg tacaggcaag 1032 gaggcttggg tagtgcagat ttgtgtattt caatctttga aagctctgat gtaatttaga 1092 aatgaaatcc aatcatgagt ccaggtagag aacgcctgct gtaatctaca ctgttgctgg 1152 gactgcgcat tctgtatata actgtgttgg atgagtgaca gatgattgtc cagactagga 1212 cagcggcatg aacatgactt tggttgggat tgcggatagt tagggttacc tctgaatcgt 1272 gtagctttta tgagagcagc tgtgcaagtg aatccacatt aatgccttgt cgtggtgcca 1332 ttcccagcgc ctgacgatac gctcttctat tgtcttattc tggcaggttt tgacgtttta 1392 aattttttaa agaaatttta ttccttggac caaaaggttt ggttaaccac ccccctctta 1452 cttgctttca cattttgagt gtccagagga aacagaaagg aatgagtgtg tgacgttgct 1512 gcacgcctga ctctgtgcga gcttctttct gtgtatatat tttgttttat ttttttccgt 1572 gtatattttt aatcccgaca gaacatcatg tgagatttct ttaaaatgga ttaaacgatt 1632 tcttcagcct gaaaaaaaag gttttgaaaa tgttttcttg tagttttgtt tggttctaaa 1692 caacaaatag gttttaatca ctcgaaatgg aattatattg tgtattcatt gaataaattt 1752 tttttgaaag t 1763 <210> SEQ ID NO 56 <211> LENGTH: 298 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 56 Met Ala Ala Arg Arg Ala Leu His Phe Val Phe Lys Val Gly Asn Arg 1 5 10 15 Phe Gln Thr Ala Arg Phe Tyr Arg Asp Val Leu Gly Met Lys Val Leu 20 25 30 Arg His Glu Glu Phe Glu Glu Gly Cys Lys Ala Ala Cys Asn Gly Pro 35 40 45 Tyr Asp Gly Lys Trp Ser Lys Thr Met Val Gly Phe Gly Pro Glu Asp 50 55 60 Asp His Phe Val Ala Glu Leu Thr Tyr Asn Tyr Gly Val Gly Asp Tyr 65 70 75 80 Lys Leu Gly Asn Asp Phe Met Gly Ile Thr Leu Ala Ser Ser Gln Ala 85 90 95 Val Ser Asn Ala Arg Lys Leu Glu Trp Pro Leu Thr Glu Val Ala Glu 100 105 110 Gly Val Phe Glu Thr Glu Ala Pro Gly Gly Tyr Lys Phe Tyr Leu Gln 115 120 125 Asn Arg Ser Leu Pro Gln Ser Asp Pro Val Leu Lys Val Thr Leu Ala 130 135 140 Val Ser Asp Leu Gln Lys Ser Leu Asn Tyr Trp Cys Asn Leu Leu Gly 145 150 155 160 Met Lys Ile Tyr Glu Lys Asp Glu Glu Lys Gln Arg Ala Leu Leu Gly 165 170 175 Tyr Ala Asp Asn Gln Cys Lys Leu Glu Leu Gln Gly Val Lys Gly Gly 180 185 190 Val Asp His Ala Ala Ala Phe Gly Arg Ile Ala Phe Ser Cys Pro Gln 195 200 205 Lys Glu Leu Pro Asp Leu Glu Asp Leu Met Lys Arg Glu Asn Gln Lys 210 215 220 Ile Leu Thr Pro Leu Val Ser Leu Asp Thr Pro Gly Lys Ala Thr Val 225 230 235 240 Gln Val Val Ile Leu Ala Asp Pro Asp Gly His Glu Ile Cys Phe Val 245 250 255 Gly Asp Glu Ala Phe Arg Glu Leu Ser Lys Met Asp Pro Glu Gly Ser 260 265 270 Lys Leu Leu Asp Asp Ala Met Ala Ala Asp Lys Ser Asp Glu Trp Phe 275 280 285 Ala Lys His Asn Lys Pro Lys Ala Ser Gly 290 295 <210> SEQ ID NO 57 <211> LENGTH: 1913 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (303)..(1379) <400> SEQUENCE: 57 aacagtgcta cccacagagt gaacaagaga gagtcatttg ggaaacaaaa ggagaatttt 60 acagagagag agggatagct aaaactacgt gagcctggcg agggtgcaga gcagaaagta 120 gagactgtcc gaagactgct atctgggacg agacaagttg ttaaagggac aggagagaaa 180 gcagagctat ttcaagagtg agccacagaa gggaatccag aggccatcta agcgaggaag 240 ggtctacagg cagtgagtga aggccaggag cagggcccag gccaggcacg accaccgagg 300 gg atg aac ttc aca gtg ggt ttc aag ccg ctg cta ggg gat gca cac 347 Met Asn Phe Thr Val Gly Phe Lys Pro Leu Leu Gly Asp Ala His 1 5 10 15 agc atg gac aac ctg gag aag cag ctc atc tgc ccc atc tgc ctg gag 395 Ser Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu 20 25 30 atg ttc tcc aaa cca gtg gtg atc ctg ccc tgc caa cac aac ctg tgc 443 Met Phe Ser Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys 35 40 45 cgc aaa tgt gcc aac gac gtc ttc cag gcc tcg aat cct cta tgg cag 491 Arg Lys Cys Ala Asn Asp Val Phe Gln Ala Ser Asn Pro Leu Trp Gln 50 55 60 tcc cgg ggc tcc acc act gtg tct tca gga ggc cgt ttc cgc tgc cca 539 Ser Arg Gly Ser Thr Thr Val Ser Ser Gly Gly Arg Phe Arg Cys Pro 65 70 75 tcg tgc agg cat gag gtt gtc ctg gac aga cac ggt gtc tac ggc ctg 587 Ser Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu 80 85 90 95 cag cga aac ctg cta gtg gag aac att atc gac att tac aag cag gag 635 Gln Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu 100 105 110 tca tcc agg ccg ctg cac tcc aag gct gag cag cac ctc atg tgc gag 683 Ser Ser Arg Pro Leu His Ser Lys Ala Glu Gln His Leu Met Cys Glu 115 120 125 gag cat gaa gaa gag aag atc aat att tac tgc ctg agc tgt gag gtg 731 Glu His Glu Glu Glu Lys Ile Asn Ile Tyr Cys Leu Ser Cys Glu Val 130 135 140 ccc acc tgc tct ctc tgc aag gtc ttc ggt gcc cac aag gac tgt gag 779 Pro Thr Cys Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Glu 145 150 155 gtg gcc cca ctg ccc acc att tac aaa cgc cag aag agt gag ctc agc 827 Val Ala Pro Leu Pro Thr Ile Tyr Lys Arg Gln Lys Ser Glu Leu Ser 160 165 170 175 gat ggc atc gcg atg ctg gtg gca ggc aat gac cgc gtg caa gca gtg 875 Asp Gly Ile Ala Met Leu Val Ala Gly Asn Asp Arg Val Gln Ala Val 180 185 190 atc aca cag atg gag gag gtg tgc cag act atc gag gac aat agc cgg 923 Ile Thr Gln Met Glu Glu Val Cys Gln Thr Ile Glu Asp Asn Ser Arg 195 200 205 agg cag aag cag ttg tta aac cag agg ttt gag agc ctg tgc gca gtg 971 Arg Gln Lys Gln Leu Leu Asn Gln Arg Phe Glu Ser Leu Cys Ala Val 210 215 220 ctg gag gag cgc aag ggt gag ctg ctg cag gcg ctg gcc cgg gag caa 1019 Leu Glu Glu Arg Lys Gly Glu Leu Leu Gln Ala Leu Ala Arg Glu Gln 225 230 235 gag gag aag ctg cag cgc gtc cgc ggc ctc atc cgt cag tat ggc gac 1067 Glu Glu Lys Leu Gln Arg Val Arg Gly Leu Ile Arg Gln Tyr Gly Asp 240 245 250 255 cac ctg gag gcc tcc tct aag ctg gtg gag tct gcc atc cag tcc atg 1115 His Leu Glu Ala Ser Ser Lys Leu Val Glu Ser Ala Ile Gln Ser Met 260 265 270 gaa gag cca caa atg gcg ctg tat ctc cag cag gcc aag gag ctg atc 1163 Glu Glu Pro Gln Met Ala Leu Tyr Leu Gln Gln Ala Lys Glu Leu Ile 275 280 285 aat aag gtc ggg gcc atg tcg aag gtg gag ctg gca ggg cgg ccg gag 1211 Asn Lys Val Gly Ala Met Ser Lys Val Glu Leu Ala Gly Arg Pro Glu 290 295 300 cca ggc tat gag agc atg gag caa ttc acc gta agg gtg gag cac gtg 1259 Pro Gly Tyr Glu Ser Met Glu Gln Phe Thr Val Arg Val Glu His Val 305 310 315 gcc gaa atg ctg cgg acc atc gac ttc cag cca ggc gct tcc ggg gag 1307 Ala Glu Met Leu Arg Thr Ile Asp Phe Gln Pro Gly Ala Ser Gly Glu 320 325 330 335 gaa gag gag gtg gcc cca gac gga gag gag ggc agc gcg ggg ccg gag 1355 Glu Glu Glu Val Ala Pro Asp Gly Glu Glu Gly Ser Ala Gly Pro Glu 340 345 350 gaa gag cgg ccg gat ggg cct taa ggcctgcgcc gacccgaccc tgctcgagag 1409 Glu Glu Arg Pro Asp Gly Pro 355 cccgcgctag agtcggggag gatctgcgca gagaccgcag catcacccaa atcggcgccg 1469 gccccgggag gatctcaata aagaactcga gcgtcccaga cccgtatctc ctttcgctgc 1529 ccaaccccgc agcctgggct tcgaaggcga cccgcccacc atcctgccct tcccagaacc 1589 tgagaccgtc tggggggcgg aagccaaatg aacccctatt gggcacctct gtgatgccag 1649 gagcgaactg gtgagcccag cgccctggga agagggccga gggcggggcg gtggtgccgg 1709 gacctctgag gtcctgggga tttggggacc cttggggtcc acatgcacct ggctgacctg 1769 gctgaaagcc gctgtctcgg agccccccac agcattttgt tcccctcccg ctggcccggg 1829 ggccccacct tcccacgggt tcccacgctg ctgtgactgc cctgcctcta cgacaaaagc 1889 caacgggtct tcagtacttt tatt 1913 <210> SEQ ID NO 58 <211> LENGTH: 358 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 58 Met Asn Phe Thr Val Gly Phe Lys Pro Leu Leu Gly Asp Ala His Ser 1 5 10 15 Met Asp Asn Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met 20 25 30 Phe Ser Lys Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg 35 40 45 Lys Cys Ala Asn Asp Val Phe Gln Ala Ser Asn Pro Leu Trp Gln Ser 50 55 60 Arg Gly Ser Thr Thr Val Ser Ser Gly Gly Arg Phe Arg Cys Pro Ser 65 70 75 80 Cys Arg His Glu Val Val Leu Asp Arg His Gly Val Tyr Gly Leu Gln 85 90 95 Arg Asn Leu Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Ser 100 105 110 Ser Arg Pro Leu His Ser Lys Ala Glu Gln His Leu Met Cys Glu Glu 115 120 125 His Glu Glu Glu Lys Ile Asn Ile Tyr Cys Leu Ser Cys Glu Val Pro 130 135 140 Thr Cys Ser Leu Cys Lys Val Phe Gly Ala His Lys Asp Cys Glu Val 145 150 155 160 Ala Pro Leu Pro Thr Ile Tyr Lys Arg Gln Lys Ser Glu Leu Ser Asp 165 170 175 Gly Ile Ala Met Leu Val Ala Gly Asn Asp Arg Val Gln Ala Val Ile 180 185 190 Thr Gln Met Glu Glu Val Cys Gln Thr Ile Glu Asp Asn Ser Arg Arg 195 200 205 Gln Lys Gln Leu Leu Asn Gln Arg Phe Glu Ser Leu Cys Ala Val Leu 210 215 220 Glu Glu Arg Lys Gly Glu Leu Leu Gln Ala Leu Ala Arg Glu Gln Glu 225 230 235 240 Glu Lys Leu Gln Arg Val Arg Gly Leu Ile Arg Gln Tyr Gly Asp His 245 250 255 Leu Glu Ala Ser Ser Lys Leu Val Glu Ser Ala Ile Gln Ser Met Glu 260 265 270 Glu Pro Gln Met Ala Leu Tyr Leu Gln Gln Ala Lys Glu Leu Ile Asn 275 280 285 Lys Val Gly Ala Met Ser Lys Val Glu Leu Ala Gly Arg Pro Glu Pro 290 295 300 Gly Tyr Glu Ser Met Glu Gln Phe Thr Val Arg Val Glu His Val Ala 305 310 315 320 Glu Met Leu Arg Thr Ile Asp Phe Gln Pro Gly Ala Ser Gly Glu Glu 325 330 335 Glu Glu Val Ala Pro Asp Gly Glu Glu Gly Ser Ala Gly Pro Glu Glu 340 345 350 Glu Arg Pro Asp Gly Pro 355 <210> SEQ ID NO 59 <211> LENGTH: 1520 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (32)..(1147) <400> SEQUENCE: 59 aatccgagct cgtcccggcc tcaccagcgc c atg ctg ggc tcg cga gcc gcg 52 Met Leu Gly Ser Arg Ala Ala 1 5 ggg ttc gcg cgg ggc ctg cgg gct ttg gca ctg gcg tgg ctg ccg ggc 100 Gly Phe Ala Arg Gly Leu Arg Ala Leu Ala Leu Ala Trp Leu Pro Gly 10 15 20 tgg cgg ggc cgc tcc ttc gcc ctg gcg cgt gcg gca ggc gcg ccc cac 148 Trp Arg Gly Arg Ser Phe Ala Leu Ala Arg Ala Ala Gly Ala Pro His 25 30 35 ggt ggt gac ttg cag ccc ccc gcc tgt ccc gag ccg cgc ggg cgc cag 196 Gly Gly Asp Leu Gln Pro Pro Ala Cys Pro Glu Pro Arg Gly Arg Gln 40 45 50 55 ctc agt ttg tcc gcg gcg gcg gtg gtg gac tct gcg ccc cgc ccc ctg 244 Leu Ser Leu Ser Ala Ala Ala Val Val Asp Ser Ala Pro Arg Pro Leu 60 65 70 cag ccg tac ttg cgc ctc atg cgg ttg gac aag ccc att gga acc tgg 292 Gln Pro Tyr Leu Arg Leu Met Arg Leu Asp Lys Pro Ile Gly Thr Trp 75 80 85 ctt ctg tat tta cca tgt acc tgg agc att ggt ttg gca gct gaa cca 340 Leu Leu Tyr Leu Pro Cys Thr Trp Ser Ile Gly Leu Ala Ala Glu Pro 90 95 100 ggt tgt ttt cca gat tgg tac atg ctc tcc ctc ttt ggc act gga gct 388 Gly Cys Phe Pro Asp Trp Tyr Met Leu Ser Leu Phe Gly Thr Gly Ala 105 110 115 att ctg atg cgt gga gca ggc tgt act att aat gac atg tgg gac cag 436 Ile Leu Met Arg Gly Ala Gly Cys Thr Ile Asn Asp Met Trp Asp Gln 120 125 130 135 gac tat gat aaa aag gtt aca aga aca gcc aat cgt cca ata gcc gct 484 Asp Tyr Asp Lys Lys Val Thr Arg Thr Ala Asn Arg Pro Ile Ala Ala 140 145 150 gga gac att tca act ttt cag tcc ttt gtt ttt ctt ggg gga cag cta 532 Gly Asp Ile Ser Thr Phe Gln Ser Phe Val Phe Leu Gly Gly Gln Leu 155 160 165 acc ctg gca ctg ggt gtt ctt ctg tgt cta aat tac tac agt ata gct 580 Thr Leu Ala Leu Gly Val Leu Leu Cys Leu Asn Tyr Tyr Ser Ile Ala 170 175 180 ctg gga gca gga tcc tta ctt ctt gtc atc acc tac cca cta atg aaa 628 Leu Gly Ala Gly Ser Leu Leu Leu Val Ile Thr Tyr Pro Leu Met Lys 185 190 195 aga att tca tac tgg cct caa cta gcc ttg ggc ttg aca ttt aat tgg 676 Arg Ile Ser Tyr Trp Pro Gln Leu Ala Leu Gly Leu Thr Phe Asn Trp 200 205 210 215 gga gcg tta ctt gga tgg tct gct atc aag ggt tcc tgt gat cca tct 724 Gly Ala Leu Leu Gly Trp Ser Ala Ile Lys Gly Ser Cys Asp Pro Ser 220 225 230 gtt tgc ctg cct ctt tat ttt tct gga gtt atg tgg aca cta ata tat 772 Val Cys Leu Pro Leu Tyr Phe Ser Gly Val Met Trp Thr Leu Ile Tyr 235 240 245 gac act att tat gcc cat cag gac aaa aga gat gat gtt ttg att ggt 820 Asp Thr Ile Tyr Ala His Gln Asp Lys Arg Asp Asp Val Leu Ile Gly 250 255 260 ctt aag tca acg gct ctg cgg ttc gga gaa aat acc aag ccg tgg ctc 868 Leu Lys Ser Thr Ala Leu Arg Phe Gly Glu Asn Thr Lys Pro Trp Leu 265 270 275 agc ggc ttc agt gtt gca atg ctg ggg gca ctg agc cta gtg ggt gtg 916 Ser Gly Phe Ser Val Ala Met Leu Gly Ala Leu Ser Leu Val Gly Val 280 285 290 295 aac agt gga cag act gct ccc tac tac gct gcc ctg ggt gct gta gga 964 Asn Ser Gly Gln Thr Ala Pro Tyr Tyr Ala Ala Leu Gly Ala Val Gly 300 305 310 gcc cat ctg act cac cag att tac act cta gac atc cac aga cct gag 1012 Ala His Leu Thr His Gln Ile Tyr Thr Leu Asp Ile His Arg Pro Glu 315 320 325 gat tgt tgg aat aaa ttt atc tcc aac cga aca ctg gga cta ata gtt 1060 Asp Cys Trp Asn Lys Phe Ile Ser Asn Arg Thr Leu Gly Leu Ile Val 330 335 340 ttt tta ggg att gtc ctt ggg aat ttg tgg aaa gaa aag aag aca gac 1108 Phe Leu Gly Ile Val Leu Gly Asn Leu Trp Lys Glu Lys Lys Thr Asp 345 350 355 aaa aca aag aag ggt ata gag aat aaa ata gaa aat taa tgaatgaaat 1157 Lys Thr Lys Lys Gly Ile Glu Asn Lys Ile Glu Asn 360 365 370 ttatctagga atttttaaaa cattttttac aaaatataat tagatttgaa tacaaaatct 1217 gatacaatat gttaaagaat taagaacctg aagatgaaga tttagagcat atttacctgg 1277 attttactta tttgctagca aaattccccc ttgtcacaga aaccagggac tcttcaggat 1337 ttgagatggc cttgagtatt ttagttgata cattcttctg cccattataa ttctcacctg 1397 aagttatggg gattgcacag gttttggcac tttagaaaaa gcctgatgtg ggtcttacat 1457 aaatgaatgt ctgtataaga aaatggactc ttttttttag ggaaaaataa aagcaactat 1517 ggg 1520 <210> SEQ ID NO 60 <211> LENGTH: 371 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 60 Met Leu Gly Ser Arg Ala Ala Gly Phe Ala Arg Gly Leu Arg Ala Leu 1 5 10 15 Ala Leu Ala Trp Leu Pro Gly Trp Arg Gly Arg Ser Phe Ala Leu Ala 20 25 30 Arg Ala Ala Gly Ala Pro His Gly Gly Asp Leu Gln Pro Pro Ala Cys 35 40 45 Pro Glu Pro Arg Gly Arg Gln Leu Ser Leu Ser Ala Ala Ala Val Val 50 55 60 Asp Ser Ala Pro Arg Pro Leu Gln Pro Tyr Leu Arg Leu Met Arg Leu 65 70 75 80 Asp Lys Pro Ile Gly Thr Trp Leu Leu Tyr Leu Pro Cys Thr Trp Ser 85 90 95 Ile Gly Leu Ala Ala Glu Pro Gly Cys Phe Pro Asp Trp Tyr Met Leu 100 105 110 Ser Leu Phe Gly Thr Gly Ala Ile Leu Met Arg Gly Ala Gly Cys Thr 115 120 125 Ile Asn Asp Met Trp Asp Gln Asp Tyr Asp Lys Lys Val Thr Arg Thr 130 135 140 Ala Asn Arg Pro Ile Ala Ala Gly Asp Ile Ser Thr Phe Gln Ser Phe 145 150 155 160 Val Phe Leu Gly Gly Gln Leu Thr Leu Ala Leu Gly Val Leu Leu Cys 165 170 175 Leu Asn Tyr Tyr Ser Ile Ala Leu Gly Ala Gly Ser Leu Leu Leu Val 180 185 190 Ile Thr Tyr Pro Leu Met Lys Arg Ile Ser Tyr Trp Pro Gln Leu Ala 195 200 205 Leu Gly Leu Thr Phe Asn Trp Gly Ala Leu Leu Gly Trp Ser Ala Ile 210 215 220 Lys Gly Ser Cys Asp Pro Ser Val Cys Leu Pro Leu Tyr Phe Ser Gly 225 230 235 240 Val Met Trp Thr Leu Ile Tyr Asp Thr Ile Tyr Ala His Gln Asp Lys 245 250 255 Arg Asp Asp Val Leu Ile Gly Leu Lys Ser Thr Ala Leu Arg Phe Gly 260 265 270 Glu Asn Thr Lys Pro Trp Leu Ser Gly Phe Ser Val Ala Met Leu Gly 275 280 285 Ala Leu Ser Leu Val Gly Val Asn Ser Gly Gln Thr Ala Pro Tyr Tyr 290 295 300 Ala Ala Leu Gly Ala Val Gly Ala His Leu Thr His Gln Ile Tyr Thr 305 310 315 320 Leu Asp Ile His Arg Pro Glu Asp Cys Trp Asn Lys Phe Ile Ser Asn 325 330 335 Arg Thr Leu Gly Leu Ile Val Phe Leu Gly Ile Val Leu Gly Asn Leu 340 345 350 Trp Lys Glu Lys Lys Thr Asp Lys Thr Lys Lys Gly Ile Glu Asn Lys 355 360 365 Ile Glu Asn 370 <210> SEQ ID NO 61 <211> LENGTH: 1731 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (183)..(1301) <400> SEQUENCE: 61 aagatagaac ccaaagaaag gcaaagagtc ctgcccggca ccggcgccgc gtgggccaaa 60 cctgcgcccg tggaggggcg cgcagagggc accgggcgcc gggagcaggc ggcgcagcac 120 cagcattgtg ttagtgccgg gaggccactg tgtcagcaag ctgagaggga aactgaagca 180 ag atg tcg ggc cgg agt ggg aag aag aaa atg tcc aag ctg tcc cgt 227 Met Ser Gly Arg Ser Gly Lys Lys Lys Met Ser Lys Leu Ser Arg 1 5 10 15 tca gct agg gca ggt gtc atc ttt cca gtg ggg agg ctg atg cgt tat 275 Ser Ala Arg Ala Gly Val Ile Phe Pro Val Gly Arg Leu Met Arg Tyr 20 25 30 ctg aag aaa ggg acg ttc aag tac cgg atc agc gtg ggc gcc cct gtc 323 Leu Lys Lys Gly Thr Phe Lys Tyr Arg Ile Ser Val Gly Ala Pro Val 35 40 45 tac atg gcg gca gtc att gag tac ctg gca gcg gaa att cta gaa ttg 371 Tyr Met Ala Ala Val Ile Glu Tyr Leu Ala Ala Glu Ile Leu Glu Leu 50 55 60 gcc ggc aat gcc gcg agg gac aac aag aag gcc cgg ata gcc ccg aga 419 Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Ala Arg Ile Ala Pro Arg 65 70 75 cac atc ttg ctg gca gtt gcc aat gac gag gag ctc aac cag ctg cta 467 His Ile Leu Leu Ala Val Ala Asn Asp Glu Glu Leu Asn Gln Leu Leu 80 85 90 95 aaa gga gtg acc atc gcc agt gga ggc gtc ctg ccc aga att cac ccc 515 Lys Gly Val Thr Ile Ala Ser Gly Gly Val Leu Pro Arg Ile His Pro 100 105 110 gaa ctg ctg gcc aaa aag cga ggg acc aaa ggc aag tcg gaa acg atc 563 Glu Leu Leu Ala Lys Lys Arg Gly Thr Lys Gly Lys Ser Glu Thr Ile 115 120 125 ctc tcc cca ccc cca gag aaa aga ggc agg aag gcc acg tca ggc aag 611 Leu Ser Pro Pro Pro Glu Lys Arg Gly Arg Lys Ala Thr Ser Gly Lys 130 135 140 aag ggg ggg aag aaa tcc aag gct gcc aaa cca cgg acg tcc aaa aag 659 Lys Gly Gly Lys Lys Ser Lys Ala Ala Lys Pro Arg Thr Ser Lys Lys 145 150 155 tcc aaa cca aag gac agc gat aaa gaa gga act tca aat tcc acc tct 707 Ser Lys Pro Lys Asp Ser Asp Lys Glu Gly Thr Ser Asn Ser Thr Ser 160 165 170 175 gaa gat ggg cca ggg gat gga ttc acc att ctg tct tct aag agc ctt 755 Glu Asp Gly Pro Gly Asp Gly Phe Thr Ile Leu Ser Ser Lys Ser Leu 180 185 190 gtt ctg gga cag aag ctg tcc tta acc cag agt gac atc agc cat att 803 Val Leu Gly Gln Lys Leu Ser Leu Thr Gln Ser Asp Ile Ser His Ile 195 200 205 ggc tcc atg aga gtg gag ggc att gtc cac cca acc aca gcc gaa att 851 Gly Ser Met Arg Val Glu Gly Ile Val His Pro Thr Thr Ala Glu Ile 210 215 220 gac ctc aaa gaa gat ata ggt aaa gcc ttg gaa aag gct ggg gga aaa 899 Asp Leu Lys Glu Asp Ile Gly Lys Ala Leu Glu Lys Ala Gly Gly Lys 225 230 235 gag ttc ttg gaa acg gta aag gag ctt cgc aaa tcc caa ggc cct ttg 947 Glu Phe Leu Glu Thr Val Lys Glu Leu Arg Lys Ser Gln Gly Pro Leu 240 245 250 255 gaa gtc gcc gaa gcc gcc gtc agc caa tcc agt gga ctc gca gcc aaa 995 Glu Val Ala Glu Ala Ala Val Ser Gln Ser Ser Gly Leu Ala Ala Lys 260 265 270 ttt gtc atc cac tgt cac atc cct cag tgg ggc tcc gac aaa tgt gaa 1043 Phe Val Ile His Cys His Ile Pro Gln Trp Gly Ser Asp Lys Cys Glu 275 280 285 gaa cag ctt gaa gag acc atc aaa aac tgc ctg tca gcg gcg gag gac 1091 Glu Gln Leu Glu Glu Thr Ile Lys Asn Cys Leu Ser Ala Ala Glu Asp 290 295 300 aag aag cta aag tcc gtc gcg ttc ccg cct ttc ccc agc ggc aga aac 1139 Lys Lys Leu Lys Ser Val Ala Phe Pro Pro Phe Pro Ser Gly Arg Asn 305 310 315 tgc ttt ccc aaa cag act gcg gcc cag gtg acc ctc aaa gcc atc tca 1187 Cys Phe Pro Lys Gln Thr Ala Ala Gln Val Thr Leu Lys Ala Ile Ser 320 325 330 335 gcc cac ttt gat gac tcg agc gcg tcc tcg ctg aag aac gtg tac ttc 1235 Ala His Phe Asp Asp Ser Ser Ala Ser Ser Leu Lys Asn Val Tyr Phe 340 345 350 ctg ctc ttc gac agc gag agc atc ggc atc tac gtg cag gag atg gcc 1283 Leu Leu Phe Asp Ser Glu Ser Ile Gly Ile Tyr Val Gln Glu Met Ala 355 360 365 aag ctc gac gcc aag tag ccgccgcact ttccagcagg gatcggagga 1331 Lys Leu Asp Ala Lys 370 cgacccgagt cccaagagtg gggttttgct ttttaaaagg agagaggagg ggtgatggca 1391 ggggagtgga gggtggccgg gcaggtcctg ccggcgcagg gagccctctg cccttcacac 1451 tctcctccaa aagagcctcc atctgtaagg aagcaggtct ccgcgagggg tttctttcca 1511 tgtgttttcc tcctgttgtt ttagaacttt tttaaaaaaa cagacctcgt tttagattta 1571 tagcattgac ttttacacac attcacacaa gaaaaaaatc ctttcaaaat tcttaaatct 1631 tctgttcctc ctttttccaa gggaagaggg caaaaagtgg cctgggctct gttggtgtgc 1691 gtgttccgtg gcggagagaa gaaaatggga aagacatctc 1731 <210> SEQ ID NO 62 <211> LENGTH: 372 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 62 Met Ser Gly Arg Ser Gly Lys Lys Lys Met Ser Lys Leu Ser Arg Ser 1 5 10 15 Ala Arg Ala Gly Val Ile Phe Pro Val Gly Arg Leu Met Arg Tyr Leu 20 25 30 Lys Lys Gly Thr Phe Lys Tyr Arg Ile Ser Val Gly Ala Pro Val Tyr 35 40 45 Met Ala Ala Val Ile Glu Tyr Leu Ala Ala Glu Ile Leu Glu Leu Ala 50 55 60 Gly Asn Ala Ala Arg Asp Asn Lys Lys Ala Arg Ile Ala Pro Arg His 65 70 75 80 Ile Leu Leu Ala Val Ala Asn Asp Glu Glu Leu Asn Gln Leu Leu Lys 85 90 95 Gly Val Thr Ile Ala Ser Gly Gly Val Leu Pro Arg Ile His Pro Glu 100 105 110 Leu Leu Ala Lys Lys Arg Gly Thr Lys Gly Lys Ser Glu Thr Ile Leu 115 120 125 Ser Pro Pro Pro Glu Lys Arg Gly Arg Lys Ala Thr Ser Gly Lys Lys 130 135 140 Gly Gly Lys Lys Ser Lys Ala Ala Lys Pro Arg Thr Ser Lys Lys Ser 145 150 155 160 Lys Pro Lys Asp Ser Asp Lys Glu Gly Thr Ser Asn Ser Thr Ser Glu 165 170 175 Asp Gly Pro Gly Asp Gly Phe Thr Ile Leu Ser Ser Lys Ser Leu Val 180 185 190 Leu Gly Gln Lys Leu Ser Leu Thr Gln Ser Asp Ile Ser His Ile Gly 195 200 205 Ser Met Arg Val Glu Gly Ile Val His Pro Thr Thr Ala Glu Ile Asp 210 215 220 Leu Lys Glu Asp Ile Gly Lys Ala Leu Glu Lys Ala Gly Gly Lys Glu 225 230 235 240 Phe Leu Glu Thr Val Lys Glu Leu Arg Lys Ser Gln Gly Pro Leu Glu 245 250 255 Val Ala Glu Ala Ala Val Ser Gln Ser Ser Gly Leu Ala Ala Lys Phe 260 265 270 Val Ile His Cys His Ile Pro Gln Trp Gly Ser Asp Lys Cys Glu Glu 275 280 285 Gln Leu Glu Glu Thr Ile Lys Asn Cys Leu Ser Ala Ala Glu Asp Lys 290 295 300 Lys Leu Lys Ser Val Ala Phe Pro Pro Phe Pro Ser Gly Arg Asn Cys 305 310 315 320 Phe Pro Lys Gln Thr Ala Ala Gln Val Thr Leu Lys Ala Ile Ser Ala 325 330 335 His Phe Asp Asp Ser Ser Ala Ser Ser Leu Lys Asn Val Tyr Phe Leu 340 345 350 Leu Phe Asp Ser Glu Ser Ile Gly Ile Tyr Val Gln Glu Met Ala Lys 355 360 365 Leu Asp Ala Lys 370 <210> SEQ ID NO 63 <211> LENGTH: 910 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (21)..(698) <400> SEQUENCE: 63 aaagtaaggg tgtcgtgctg atg gcc ctg tgc gca ctg acc cgc gct ctg cgc 53 Met Ala Leu Cys Ala Leu Thr Arg Ala Leu Arg 1 5 10 tct ctg aac ctg gcg ccc ccg acc gtc gcc gcc cct gcc ccg agt ctg 101 Ser Leu Asn Leu Ala Pro Pro Thr Val Ala Ala Pro Ala Pro Ser Leu 15 20 25 ttc ccc gcc gcc cag atg atg aac aat ggc ctc ctc caa cag ccc tct 149 Phe Pro Ala Ala Gln Met Met Asn Asn Gly Leu Leu Gln Gln Pro Ser 30 35 40 gcc ttg atg ttg ctc ccc tgc cgc cca gtt ctt act tct gtg gcc ctt 197 Ala Leu Met Leu Leu Pro Cys Arg Pro Val Leu Thr Ser Val Ala Leu 45 50 55 aat gcc aac ttt gtg tcc tgg aag agt cgt acc aag tac acc att aca 245 Asn Ala Asn Phe Val Ser Trp Lys Ser Arg Thr Lys Tyr Thr Ile Thr 60 65 70 75 cca gtg aag atg agg aag tct ggg ggc cga gac cac aca ggc cga atc 293 Pro Val Lys Met Arg Lys Ser Gly Gly Arg Asp His Thr Gly Arg Ile 80 85 90 cgg gtg cat ggt att ggc ggg ggc cac aag caa cgt tat cga atg att 341 Arg Val His Gly Ile Gly Gly Gly His Lys Gln Arg Tyr Arg Met Ile 95 100 105 gac ttt ctg cgt ttc cgg cct gag gag acc aag tca gga ccc ttt gag 389 Asp Phe Leu Arg Phe Arg Pro Glu Glu Thr Lys Ser Gly Pro Phe Glu 110 115 120 gag aag gtt atc caa gtc cgc tat gat ccc tgt agg tca gca gac ata 437 Glu Lys Val Ile Gln Val Arg Tyr Asp Pro Cys Arg Ser Ala Asp Ile 125 130 135 gct ctg gtt gct ggg ggc agc cgg aaa cgc tgg atc atc gcc aca gaa 485 Ala Leu Val Ala Gly Gly Ser Arg Lys Arg Trp Ile Ile Ala Thr Glu 140 145 150 155 aac atg cag gct gga gat aca atc ttg aac tct aac cac ata ggc cga 533 Asn Met Gln Ala Gly Asp Thr Ile Leu Asn Ser Asn His Ile Gly Arg 160 165 170 atg gca gtt gct gct cgg gaa ggg gat gcg cat cct ctt ggg gct ctg 581 Met Ala Val Ala Ala Arg Glu Gly Asp Ala His Pro Leu Gly Ala Leu 175 180 185 cct gtg ggg acc ctc atc aac aac gtg gaa agt gag cca ggc cgg ggt 629 Pro Val Gly Thr Leu Ile Asn Asn Val Glu Ser Glu Pro Gly Arg Gly 190 195 200 gcc caa tat atc cga gct gca ggt gct gga aac gtg cgt agc aac agt 677 Ala Gln Tyr Ile Arg Ala Ala Gly Ala Gly Asn Val Arg Ser Asn Ser 205 210 215 agg ccg agt atc caa cgt tga tcataacaaa cgggtcattg gcaaggcagg 728 Arg Pro Ser Ile Gln Arg 220 225 tcgcaaccgc tggctgggca agaggcctaa cagtgggcgg tggcaccgca aggggggctg 788 ggctggccga aagattcggc cactaccccc catgaagagt tacgtgaagc tgccttctgc 848 ttctgcccaa agctgatatc cctgtactct aataaaatgc cccccccccc cgttttaatc 908 tg 910 <210> SEQ ID NO 64 <211> LENGTH: 225 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 64 Met Ala Leu Cys Ala Leu Thr Arg Ala Leu Arg Ser Leu Asn Leu Ala 1 5 10 15 Pro Pro Thr Val Ala Ala Pro Ala Pro Ser Leu Phe Pro Ala Ala Gln 20 25 30 Met Met Asn Asn Gly Leu Leu Gln Gln Pro Ser Ala Leu Met Leu Leu 35 40 45 Pro Cys Arg Pro Val Leu Thr Ser Val Ala Leu Asn Ala Asn Phe Val 50 55 60 Ser Trp Lys Ser Arg Thr Lys Tyr Thr Ile Thr Pro Val Lys Met Arg 65 70 75 80 Lys Ser Gly Gly Arg Asp His Thr Gly Arg Ile Arg Val His Gly Ile 85 90 95 Gly Gly Gly His Lys Gln Arg Tyr Arg Met Ile Asp Phe Leu Arg Phe 100 105 110 Arg Pro Glu Glu Thr Lys Ser Gly Pro Phe Glu Glu Lys Val Ile Gln 115 120 125 Val Arg Tyr Asp Pro Cys Arg Ser Ala Asp Ile Ala Leu Val Ala Gly 130 135 140 Gly Ser Arg Lys Arg Trp Ile Ile Ala Thr Glu Asn Met Gln Ala Gly 145 150 155 160 Asp Thr Ile Leu Asn Ser Asn His Ile Gly Arg Met Ala Val Ala Ala 165 170 175 Arg Glu Gly Asp Ala His Pro Leu Gly Ala Leu Pro Val Gly Thr Leu 180 185 190 Ile Asn Asn Val Glu Ser Glu Pro Gly Arg Gly Ala Gln Tyr Ile Arg 195 200 205 Ala Ala Gly Ala Gly Asn Val Arg Ser Asn Ser Arg Pro Ser Ile Gln 210 215 220 Arg 225 <210> SEQ ID NO 65 <211> LENGTH: 784 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (156)..(500) <400> SEQUENCE: 65 accccgcgcg cgcctctctg tcgtggcgcg gcttcccgcg gtcttctctg caaatgggct 60 ccgtggccta gcgcccccgt ccccgccacc cgtgatcgtg cgccgaggcc cgcgaggggt 120 cgccgcccag atcccaccag ccagcaagct aaagc atg gcg gcc atc ccc tcc 173 Met Ala Ala Ile Pro Ser 1 5 agc ggc tcg ctc gtg gcc acc cac gac tac tac cgg cgc cgc ctg ggt 221 Ser Gly Ser Leu Val Ala Thr His Asp Tyr Tyr Arg Arg Arg Leu Gly 10 15 20 tcc act tcc agc aac agc tcc tgc agc agt acc gag tgc ccc ggg gaa 269 Ser Thr Ser Ser Asn Ser Ser Cys Ser Ser Thr Glu Cys Pro Gly Glu 25 30 35 gcc att ccc cac ccc cca ggt ctc ccc aag gct gac ccg ggt cat tgg 317 Ala Ile Pro His Pro Pro Gly Leu Pro Lys Ala Asp Pro Gly His Trp 40 45 50 tgg gcc agc ttc ttt ttc ggg aag tcc acc ctc ccg ttc atg gcc acg 365 Trp Ala Ser Phe Phe Phe Gly Lys Ser Thr Leu Pro Phe Met Ala Thr 55 60 65 70 gtg ttg gag tcc gca gag cac tcg gaa cct ccc cag gcc tcc agc agc 413 Val Leu Glu Ser Ala Glu His Ser Glu Pro Pro Gln Ala Ser Ser Ser 75 80 85 atg acc gcc tgt ggc ctg gct cgg gac gcc ccg agg aag cag ccc ggc 461 Met Thr Ala Cys Gly Leu Ala Arg Asp Ala Pro Arg Lys Gln Pro Gly 90 95 100 ggt cag tcc agc aca gcc agc gct ggg ccc ccg tcc tga cctgagcggt 510 Gly Gln Ser Ser Thr Ala Ser Ala Gly Pro Pro Ser 105 110 taccaccagc cccaggcctg cggaggcgct agtccaccag agcccctccc cgcccctctc 570 cccactccgc atccctcgcc cccctcccca cctcccaccc cccaccctgt aaactaggcg 630 gctgcagcaa gcagaccttc gcatcaacac agcagacacc aaaaaccagt gagagccccg 690 ctctctaccg cccggcccca gcactcgcta gctttcctga cacctggaac tgtgcacctg 750 gcaccaagcg gaaaataaac tccaagcagc cagt 784 <210> SEQ ID NO 66 <211> LENGTH: 114 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 66 Met Ala Ala Ile Pro Ser Ser Gly Ser Leu Val Ala Thr His Asp Tyr 1 5 10 15 Tyr Arg Arg Arg Leu Gly Ser Thr Ser Ser Asn Ser Ser Cys Ser Ser 20 25 30 Thr Glu Cys Pro Gly Glu Ala Ile Pro His Pro Pro Gly Leu Pro Lys 35 40 45 Ala Asp Pro Gly His Trp Trp Ala Ser Phe Phe Phe Gly Lys Ser Thr 50 55 60 Leu Pro Phe Met Ala Thr Val Leu Glu Ser Ala Glu His Ser Glu Pro 65 70 75 80 Pro Gln Ala Ser Ser Ser Met Thr Ala Cys Gly Leu Ala Arg Asp Ala 85 90 95 Pro Arg Lys Gln Pro Gly Gly Gln Ser Ser Thr Ala Ser Ala Gly Pro 100 105 110 Pro Ser <210> SEQ ID NO 67 <211> LENGTH: 984 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (348)..(770) <400> SEQUENCE: 67 agaagacagg gcacccgcgg ccttgctgcg catgctcgcg ctgtgacccc ggcttgaggt 60 aacagcgcga gctgaggctg gggcccttgg cgcggaggct gagggacccg ccgcggcgct 120 gtcgccggag agggagggca ccgctgtcgc cagaagccaa ggagtcctca gtgaccgtgg 180 gatccacaac atctccacat cgctgtcccc acccagccag ggcagcgcca gcactagctc 240 agacgcaagg acggaaccgc tggactccag gttccttgcc tgggagtagg agaaatccac 300 ctgctggggg ctgagtgtgg cctgagggac aggccctggg tcccggg atg ccc ctg 356 Met Pro Leu 1 ccc gag ccc agc gag cag gag ggt gag agt gtg aag gcc agc cag gag 404 Pro Glu Pro Ser Glu Gln Glu Gly Glu Ser Val Lys Ala Ser Gln Glu 5 10 15 cca tcc ccc aag cca ggc aca gaa gtc atc ccg gca gcc ccc agg aag 452 Pro Ser Pro Lys Pro Gly Thr Glu Val Ile Pro Ala Ala Pro Arg Lys 20 25 30 35 ccc aga aag ttc tcc aaa ctg gtc ctg ctc aca gcc tcc aaa gac agc 500 Pro Arg Lys Phe Ser Lys Leu Val Leu Leu Thr Ala Ser Lys Asp Ser 40 45 50 acc aag gtg gcg ggg gcc aag cgc aag ggt gtg cac tgt gtc atg tcc 548 Thr Lys Val Ala Gly Ala Lys Arg Lys Gly Val His Cys Val Met Ser 55 60 65 ctg ggg gtg ccc ggc ccc gcc acc ctt gcc aag gcc ctc ctc cag acc 596 Leu Gly Val Pro Gly Pro Ala Thr Leu Ala Lys Ala Leu Leu Gln Thr 70 75 80 cac ccc gag gcc cag cgg gcc att gag gca gcc cct cag gag cct gag 644 His Pro Glu Ala Gln Arg Ala Ile Glu Ala Ala Pro Gln Glu Pro Glu 85 90 95 cag aaa cgg agc agg cag gac cca ggc aca gac aga aca gaa gac agt 692 Gln Lys Arg Ser Arg Gln Asp Pro Gly Thr Asp Arg Thr Glu Asp Ser 100 105 110 115 gga tta gca gcg ggg cct cct gag gct gct ggg gag aac ttt gcc ccc 740 Gly Leu Ala Ala Gly Pro Pro Glu Ala Ala Gly Glu Asn Phe Ala Pro 120 125 130 tgc tct gtg gcg ccc ggc aag tcc ctg taa ccttgacaac aggcgcatcc 790 Cys Ser Val Ala Pro Gly Lys Ser Leu 135 140 tcccgggcca ccaacccagc cataggctct tctctgtccg cagggcttct ggggccaaat 850 gggtgaatct ttgctttcaa cattgtgtga tttcttttct tttttttttt ttttttttag 910 atcaagtata agttactttt gtaagcagaa aaatactttc aaacaagaat aaaagaagct 970 gttcgctaga cccc 984 <210> SEQ ID NO 68 <211> LENGTH: 140 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 68 Met Pro Leu Pro Glu Pro Ser Glu Gln Glu Gly Glu Ser Val Lys Ala 1 5 10 15 Ser Gln Glu Pro Ser Pro Lys Pro Gly Thr Glu Val Ile Pro Ala Ala 20 25 30 Pro Arg Lys Pro Arg Lys Phe Ser Lys Leu Val Leu Leu Thr Ala Ser 35 40 45 Lys Asp Ser Thr Lys Val Ala Gly Ala Lys Arg Lys Gly Val His Cys 50 55 60 Val Met Ser Leu Gly Val Pro Gly Pro Ala Thr Leu Ala Lys Ala Leu 65 70 75 80 Leu Gln Thr His Pro Glu Ala Gln Arg Ala Ile Glu Ala Ala Pro Gln 85 90 95 Glu Pro Glu Gln Lys Arg Ser Arg Gln Asp Pro Gly Thr Asp Arg Thr 100 105 110 Glu Asp Ser Gly Leu Ala Ala Gly Pro Pro Glu Ala Ala Gly Glu Asn 115 120 125 Phe Ala Pro Cys Ser Val Ala Pro Gly Lys Ser Leu 130 135 140 <210> SEQ ID NO 69 <211> LENGTH: 864 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (357)..(614) <400> SEQUENCE: 69 gtatgatgga agtcgtagta ggaaatggcg tcgtggcatt gaggggcatc cctcctagaa 60 cctccaggaa aagctcgcgg aagacgaggt tctgcggaga gagaggctcc aagcagtctg 120 ggaagtgtag tccagttggc ttagcagtag tttcgttggg ggggagccga ggttccggga 180 aggggctagg ccggcttgaa aagagattat gactgtacct tttaactttg tagctggaac 240 acaagaagtg tttgtttaat gaatgacgta cacatttaag atctgtttgg acgcggagga 300 taatcctgtg aattgctaat agttcactgg gtttggccct tagtgttgac ttcagt atg 359 Met 1 ctg aga cgg aaa cca aca cgc cta gag cta aag ctt gat gac att gaa 407 Leu Arg Arg Lys Pro Thr Arg Leu Glu Leu Lys Leu Asp Asp Ile Glu 5 10 15 gag ttt gag aac att cga aag gac ctg gag acc cgt aag aaa cag aag 455 Glu Phe Glu Asn Ile Arg Lys Asp Leu Glu Thr Arg Lys Lys Gln Lys 20 25 30 gaa gat gtg gaa gtt gta gga ggc agt gat gga gaa gga gcc att ggg 503 Glu Asp Val Glu Val Val Gly Gly Ser Asp Gly Glu Gly Ala Ile Gly 35 40 45 ctt agc agt gat ccc aag agc cgg gaa caa atg atc aat gat cgg att 551 Leu Ser Ser Asp Pro Lys Ser Arg Glu Gln Met Ile Asn Asp Arg Ile 50 55 60 65 ggt tat aaa ccc caa ccc aag ccc aat aat cgt tca tct caa ttt gga 599 Gly Tyr Lys Pro Gln Pro Lys Pro Asn Asn Arg Ser Ser Gln Phe Gly 70 75 80 agt ctt gaa ttt tag agatggatta tcttgcatgc cagagcgctg gaatggaata 654 Ser Leu Glu Phe 85 aaatgatggc agaagtacaa accagattta gagaattgag tgcttgcagt caagcagaat 714 gtacctcctg cagagacaaa tcttctgcat gagattactg atgcttcact tgcactctaa 774 gctggaatcc aaactctggt ttgtctcttg aaaatttgac tctataaaac tgatctgatt 834 ttctgttttt aaaaataaat atatttttgg 864 <210> SEQ ID NO 70 <211> LENGTH: 85 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 70 Met Leu Arg Arg Lys Pro Thr Arg Leu Glu Leu Lys Leu Asp Asp Ile 1 5 10 15 Glu Glu Phe Glu Asn Ile Arg Lys Asp Leu Glu Thr Arg Lys Lys Gln 20 25 30 Lys Glu Asp Val Glu Val Val Gly Gly Ser Asp Gly Glu Gly Ala Ile 35 40 45 Gly Leu Ser Ser Asp Pro Lys Ser Arg Glu Gln Met Ile Asn Asp Arg 50 55 60 Ile Gly Tyr Lys Pro Gln Pro Lys Pro Asn Asn Arg Ser Ser Gln Phe 65 70 75 80 Gly Ser Leu Glu Phe 85 <210> SEQ ID NO 71 <211> LENGTH: 2617 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (121)..(1860) <400> SEQUENCE: 71 aggcctgcgg aggggcgtta tctggagggc cgcgggtgca ggccgcagtg acagggccgc 60 tcgccccgct agtcctgcct gtctcccggt gcagctgtgt tcgcggcctg caggcccaac 120 atg gcg cag gag gtg tcg gag tac ctg agc cag aac ccg cgg gtg gca 168 Met Ala Gln Glu Val Ser Glu Tyr Leu Ser Gln Asn Pro Arg Val Ala 1 5 10 15 gcc tgg gtg gag gcg ctg cgc tgc gac ggc gag act gac aaa cac tgg 216 Ala Trp Val Glu Ala Leu Arg Cys Asp Gly Glu Thr Asp Lys His Trp 20 25 30 cgc cac cgc cgg gat ttt ttg ctt cgc aac gcc ggg gac ctg gcc ccc 264 Arg His Arg Arg Asp Phe Leu Leu Arg Asn Ala Gly Asp Leu Ala Pro 35 40 45 gct ggc ggc gct gcc tcc gct agc acg gat gaa gct gcc gac gcc gag 312 Ala Gly Gly Ala Ala Ser Ala Ser Thr Asp Glu Ala Ala Asp Ala Glu 50 55 60 agc ggg acc cga aac cgg cag ctg cag cag ctc atc tcc ttt tcc atg 360 Ser Gly Thr Arg Asn Arg Gln Leu Gln Gln Leu Ile Ser Phe Ser Met 65 70 75 80 gcc tgg gcg aac cac gtc ttc ctc ggg tgc cga tac cct caa aaa gtt 408 Ala Trp Ala Asn His Val Phe Leu Gly Cys Arg Tyr Pro Gln Lys Val 85 90 95 atg gat aaa ata ctt agt atg gct gaa ggc atc aaa gtg aca gat gct 456 Met Asp Lys Ile Leu Ser Met Ala Glu Gly Ile Lys Val Thr Asp Ala 100 105 110 cca acc tat aca aca aga gat gaa ctg gtt gcc aag gtg aag aaa aga 504 Pro Thr Tyr Thr Thr Arg Asp Glu Leu Val Ala Lys Val Lys Lys Arg 115 120 125 ggg ata tcg agt agc aat gaa ggg gta gaa gag cca tcc aaa aaa cga 552 Gly Ile Ser Ser Ser Asn Glu Gly Val Glu Glu Pro Ser Lys Lys Arg 130 135 140 gtt ata gaa gga aaa aac agt tct gca gtt gag caa gat cac gca aaa 600 Val Ile Glu Gly Lys Asn Ser Ser Ala Val Glu Gln Asp His Ala Lys 145 150 155 160 acc tct gcc aag aca gaa cgt gca tca gct cag cag gaa aac agt tca 648 Thr Ser Ala Lys Thr Glu Arg Ala Ser Ala Gln Gln Glu Asn Ser Ser 165 170 175 acg tgt ata ggg tcg gcc atc aaa tca gag agt ggg aac tca gct cgg 696 Thr Cys Ile Gly Ser Ala Ile Lys Ser Glu Ser Gly Asn Ser Ala Arg 180 185 190 agc tct ggc atc tcc agt cag aat agc tct aca agt gat gga gat cga 744 Ser Ser Gly Ile Ser Ser Gln Asn Ser Ser Thr Ser Asp Gly Asp Arg 195 200 205 tct gtt tcc agc caa agc agc agc agc gtt tcc tct cag gta aca acg 792 Ser Val Ser Ser Gln Ser Ser Ser Ser Val Ser Ser Gln Val Thr Thr 210 215 220 gca gga tct ggg aaa gct tct gaa gca gaa gct cca gat aaa cac ggt 840 Ala Gly Ser Gly Lys Ala Ser Glu Ala Glu Ala Pro Asp Lys His Gly 225 230 235 240 tca tca ttt gtt tcc ttg ctg aaa tcc agt gtg aat agt cac atg acc 888 Ser Ser Phe Val Ser Leu Leu Lys Ser Ser Val Asn Ser His Met Thr 245 250 255 caa tcc act gat tct aga caa caa agt gga tca cct aaa aag agt gct 936 Gln Ser Thr Asp Ser Arg Gln Gln Ser Gly Ser Pro Lys Lys Ser Ala 260 265 270 ttg gaa ggc tct tca gcc tca gct tct cga agc agc tca gag atc gag 984 Leu Glu Gly Ser Ser Ala Ser Ala Ser Arg Ser Ser Ser Glu Ile Glu 275 280 285 gtg ccc ttg ttg ggc tcc tca gga agc tca gag gta gaa ttg cca cta 1032 Val Pro Leu Leu Gly Ser Ser Gly Ser Ser Glu Val Glu Leu Pro Leu 290 295 300 ttg tct tcc aaa cct agt tca gag aca gct tca agt ggg tta act tcc 1080 Leu Ser Ser Lys Pro Ser Ser Glu Thr Ala Ser Ser Gly Leu Thr Ser 305 310 315 320 aaa act agt tca gag gca agt gtt tca tca tca gtt gct aaa aac agt 1128 Lys Thr Ser Ser Glu Ala Ser Val Ser Ser Ser Val Ala Lys Asn Ser 325 330 335 tcc tca tca ggc aca tcc tta ctg act ccc aag agc agc tct tca aca 1176 Ser Ser Ser Gly Thr Ser Leu Leu Thr Pro Lys Ser Ser Ser Ser Thr 340 345 350 aat aca tcg ctg cta act tcc aag agc act tcc cag gta gct gca tca 1224 Asn Thr Ser Leu Leu Thr Ser Lys Ser Thr Ser Gln Val Ala Ala Ser 355 360 365 cta cta gct tcc aag agc agc tcc cag acc agt gga tct ctg gtt tcc 1272 Leu Leu Ala Ser Lys Ser Ser Ser Gln Thr Ser Gly Ser Leu Val Ser 370 375 380 aaa agc act tcc tta gca agt gtg tcc cag ttg gct tct aag agt agt 1320 Lys Ser Thr Ser Leu Ala Ser Val Ser Gln Leu Ala Ser Lys Ser Ser 385 390 395 400 tct cag act agc acc tca cag ttg cct tct aaa agt act tca cag tca 1368 Ser Gln Thr Ser Thr Ser Gln Leu Pro Ser Lys Ser Thr Ser Gln Ser 405 410 415 agt gag agt tct gtc aaa ttc tct tgc aag tta acc aat gaa gat gtg 1416 Ser Glu Ser Ser Val Lys Phe Ser Cys Lys Leu Thr Asn Glu Asp Val 420 425 430 aaa cag aag caa cct ttt ttc aat aga cta tat aaa acg gtg gca tgg 1464 Lys Gln Lys Gln Pro Phe Phe Asn Arg Leu Tyr Lys Thr Val Ala Trp 435 440 445 aag ttg gta gct gtt ggt ggc ttt agt ccc aat gtg aat cat gga gag 1512 Lys Leu Val Ala Val Gly Gly Phe Ser Pro Asn Val Asn His Gly Glu 450 455 460 ctc cta aat gca gct att gag gct ctg aaa gca aca ctg gat gta ttt 1560 Leu Leu Asn Ala Ala Ile Glu Ala Leu Lys Ala Thr Leu Asp Val Phe 465 470 475 480 ttt gtc cca cta aaa gaa ttg gca gat ctg cct caa aat aag agc tct 1608 Phe Val Pro Leu Lys Glu Leu Ala Asp Leu Pro Gln Asn Lys Ser Ser 485 490 495 caa gaa agt att gtt tgt gaa ttg agg tgc aag tct gtg tat ttg ggc 1656 Gln Glu Ser Ile Val Cys Glu Leu Arg Cys Lys Ser Val Tyr Leu Gly 500 505 510 act ggc tgt gga aaa agc aaa gaa aat gca aaa gca gtt gca tca aga 1704 Thr Gly Cys Gly Lys Ser Lys Glu Asn Ala Lys Ala Val Ala Ser Arg 515 520 525 gaa gca ttg aag tta ttt ctc aag aaa aag gtg gtg gta aaa ata tgt 1752 Glu Ala Leu Lys Leu Phe Leu Lys Lys Lys Val Val Val Lys Ile Cys 530 535 540 aaa agg aaa tac aga ggc agt gaa ata gaa gat cta gta ctc ctt gat 1800 Lys Arg Lys Tyr Arg Gly Ser Glu Ile Glu Asp Leu Val Leu Leu Asp 545 550 555 560 gaa gaa tcg agg cct gta aac tta cct cca gca cta aaa cat cct caa 1848 Glu Glu Ser Arg Pro Val Asn Leu Pro Pro Ala Leu Lys His Pro Gln 565 570 575 gaa tta cta taa tgtgtccaaa atatcactgc atacaatatc tggtatttga 1900 Glu Leu Leu agagaaaaac tgacttttgt atagtataaa acacaggctt tcacaaattt tgtattgctt 1960 tttttccagt tttgcagaaa atttacattc tagttctctt cacacagtag cagttgtaaa 2020 taatttatga atgacagtac acattaaaag gtatgcatta gcagcatatt agtatgctgt 2080 tttatttgct gaagaaaata ctgtcttcta tttttaatga tacattaggt acgatgtgta 2140 gttcggtaga gtcctaaaat ttttgtacta ctttcaattt ggtgaaaatg tattaagttg 2200 tctaccatgt tttcttttct agctgaataa accacatcaa aggaaaggga ccacagtatt 2260 tgaatgtttg aaagtctgta aagcttaagg ttttaaaaat gttgcccgta atgttgaacg 2320 tgtctgttaa aaaataaaag aaaaaatagt tgcttcaaac tatttttatg agaagttgta 2380 agcatttttt agatataaag cagtataaag tacttgttat tttactctga agttgtttaa 2440 aattcaccat gactttgacc gctgaagatt ctttaagcgg gttaatttat gttttgaggt 2500 ggaatacaat ttacactttt ttcttaaaaa catgaatgtg ggtttctata ttaagcatat 2560 tttgtgacta ctattaacag attgatttgt ttagatatta aatgctttaa gctattt 2617 <210> SEQ ID NO 72 <211> LENGTH: 579 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 72 Met Ala Gln Glu Val Ser Glu Tyr Leu Ser Gln Asn Pro Arg Val Ala 1 5 10 15 Ala Trp Val Glu Ala Leu Arg Cys Asp Gly Glu Thr Asp Lys His Trp 20 25 30 Arg His Arg Arg Asp Phe Leu Leu Arg Asn Ala Gly Asp Leu Ala Pro 35 40 45 Ala Gly Gly Ala Ala Ser Ala Ser Thr Asp Glu Ala Ala Asp Ala Glu 50 55 60 Ser Gly Thr Arg Asn Arg Gln Leu Gln Gln Leu Ile Ser Phe Ser Met 65 70 75 80 Ala Trp Ala Asn His Val Phe Leu Gly Cys Arg Tyr Pro Gln Lys Val 85 90 95 Met Asp Lys Ile Leu Ser Met Ala Glu Gly Ile Lys Val Thr Asp Ala 100 105 110 Pro Thr Tyr Thr Thr Arg Asp Glu Leu Val Ala Lys Val Lys Lys Arg 115 120 125 Gly Ile Ser Ser Ser Asn Glu Gly Val Glu Glu Pro Ser Lys Lys Arg 130 135 140 Val Ile Glu Gly Lys Asn Ser Ser Ala Val Glu Gln Asp His Ala Lys 145 150 155 160 Thr Ser Ala Lys Thr Glu Arg Ala Ser Ala Gln Gln Glu Asn Ser Ser 165 170 175 Thr Cys Ile Gly Ser Ala Ile Lys Ser Glu Ser Gly Asn Ser Ala Arg 180 185 190 Ser Ser Gly Ile Ser Ser Gln Asn Ser Ser Thr Ser Asp Gly Asp Arg 195 200 205 Ser Val Ser Ser Gln Ser Ser Ser Ser Val Ser Ser Gln Val Thr Thr 210 215 220 Ala Gly Ser Gly Lys Ala Ser Glu Ala Glu Ala Pro Asp Lys His Gly 225 230 235 240 Ser Ser Phe Val Ser Leu Leu Lys Ser Ser Val Asn Ser His Met Thr 245 250 255 Gln Ser Thr Asp Ser Arg Gln Gln Ser Gly Ser Pro Lys Lys Ser Ala 260 265 270 Leu Glu Gly Ser Ser Ala Ser Ala Ser Arg Ser Ser Ser Glu Ile Glu 275 280 285 Val Pro Leu Leu Gly Ser Ser Gly Ser Ser Glu Val Glu Leu Pro Leu 290 295 300 Leu Ser Ser Lys Pro Ser Ser Glu Thr Ala Ser Ser Gly Leu Thr Ser 305 310 315 320 Lys Thr Ser Ser Glu Ala Ser Val Ser Ser Ser Val Ala Lys Asn Ser 325 330 335 Ser Ser Ser Gly Thr Ser Leu Leu Thr Pro Lys Ser Ser Ser Ser Thr 340 345 350 Asn Thr Ser Leu Leu Thr Ser Lys Ser Thr Ser Gln Val Ala Ala Ser 355 360 365 Leu Leu Ala Ser Lys Ser Ser Ser Gln Thr Ser Gly Ser Leu Val Ser 370 375 380 Lys Ser Thr Ser Leu Ala Ser Val Ser Gln Leu Ala Ser Lys Ser Ser 385 390 395 400 Ser Gln Thr Ser Thr Ser Gln Leu Pro Ser Lys Ser Thr Ser Gln Ser 405 410 415 Ser Glu Ser Ser Val Lys Phe Ser Cys Lys Leu Thr Asn Glu Asp Val 420 425 430 Lys Gln Lys Gln Pro Phe Phe Asn Arg Leu Tyr Lys Thr Val Ala Trp 435 440 445 Lys Leu Val Ala Val Gly Gly Phe Ser Pro Asn Val Asn His Gly Glu 450 455 460 Leu Leu Asn Ala Ala Ile Glu Ala Leu Lys Ala Thr Leu Asp Val Phe 465 470 475 480 Phe Val Pro Leu Lys Glu Leu Ala Asp Leu Pro Gln Asn Lys Ser Ser 485 490 495 Gln Glu Ser Ile Val Cys Glu Leu Arg Cys Lys Ser Val Tyr Leu Gly 500 505 510 Thr Gly Cys Gly Lys Ser Lys Glu Asn Ala Lys Ala Val Ala Ser Arg 515 520 525 Glu Ala Leu Lys Leu Phe Leu Lys Lys Lys Val Val Val Lys Ile Cys 530 535 540 Lys Arg Lys Tyr Arg Gly Ser Glu Ile Glu Asp Leu Val Leu Leu Asp 545 550 555 560 Glu Glu Ser Arg Pro Val Asn Leu Pro Pro Ala Leu Lys His Pro Gln 565 570 575 Glu Leu Leu <210> SEQ ID NO 73 <211> LENGTH: 1810 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (39)..(1121) <400> SEQUENCE: 73 gcacgtgcgc aggggtgtgg aaacttaccg gctgagcc atg gat aca ccg tta agg 56 Met Asp Thr Pro Leu Arg 1 5 cgc agc cga cgg ctg gga ggc cta agg ccc gaa tcc ccc gag agc ctc 104 Arg Ser Arg Arg Leu Gly Gly Leu Arg Pro Glu Ser Pro Glu Ser Leu 10 15 20 acc tca gtt tcg cgg acg aga cgg gcc ctt gtg gag ttc gag tcg aac 152 Thr Ser Val Ser Arg Thr Arg Arg Ala Leu Val Glu Phe Glu Ser Asn 25 30 35 cca gaa gaa acg agg gag ccc ggg tct cct ccg agt gtg cag cgg gct 200 Pro Glu Glu Thr Arg Glu Pro Gly Ser Pro Pro Ser Val Gln Arg Ala 40 45 50 ggc ctg ggg tcc ccc gaa agg ccg ccg aag aca agc cca gga tca ccc 248 Gly Leu Gly Ser Pro Glu Arg Pro Pro Lys Thr Ser Pro Gly Ser Pro 55 60 65 70 cgt ctg cag cag ggt gca ggc ttg gag tca ccc caa ggg cag cca gag 296 Arg Leu Gln Gln Gly Ala Gly Leu Glu Ser Pro Gln Gly Gln Pro Glu 75 80 85 cca ggc gca gcg tcc ccc cag cgt cag caa gac cta cac ctg gag tcg 344 Pro Gly Ala Ala Ser Pro Gln Arg Gln Gln Asp Leu His Leu Glu Ser 90 95 100 cct caa aga cag cca gag tac agt cct gaa tcc cca cga tgt cag ccg 392 Pro Gln Arg Gln Pro Glu Tyr Ser Pro Glu Ser Pro Arg Cys Gln Pro 105 110 115 aag cca agt gag gag gca cca aag tgt tct cag gac cag gga gta ctg 440 Lys Pro Ser Glu Glu Ala Pro Lys Cys Ser Gln Asp Gln Gly Val Leu 120 125 130 gcc tcg gag ttg gcc cag aat aag gag gag ctg acc ccg ggg gcc ccc 488 Ala Ser Glu Leu Ala Gln Asn Lys Glu Glu Leu Thr Pro Gly Ala Pro 135 140 145 150 cag cat cag cta ccg ccg gtc cca gga tca cca gag cct tac ccc ggt 536 Gln His Gln Leu Pro Pro Val Pro Gly Ser Pro Glu Pro Tyr Pro Gly 155 160 165 cag caa gct ccc ggt ccg gag ccc tct cag cca cta ctg gag ctg aca 584 Gln Gln Ala Pro Gly Pro Glu Pro Ser Gln Pro Leu Leu Glu Leu Thr 170 175 180 ccc agg gca cct ggc tcc ccc cgg ggt cag cat gag ccg agc aag cca 632 Pro Arg Ala Pro Gly Ser Pro Arg Gly Gln His Glu Pro Ser Lys Pro 185 190 195 cct cca gct ggg gag acg gtg aca ggc ggc ttc ggg gca aag aag cga 680 Pro Pro Ala Gly Glu Thr Val Thr Gly Gly Phe Gly Ala Lys Lys Arg 200 205 210 aaa ggt tct tca tcc cag gcc cca gcg tcc aag aag ttg aat aaa gag 728 Lys Gly Ser Ser Ser Gln Ala Pro Ala Ser Lys Lys Leu Asn Lys Glu 215 220 225 230 gag ctt cct gta atc ccg aag ggg aag ccc aaa tcg ggg cga gtg tgg 776 Glu Leu Pro Val Ile Pro Lys Gly Lys Pro Lys Ser Gly Arg Val Trp 235 240 245 aag gac cgc tcc aag aaa aga ttc tcc cag atg ctt cag gac aag ccc 824 Lys Asp Arg Ser Lys Lys Arg Phe Ser Gln Met Leu Gln Asp Lys Pro 250 255 260 ctg cgc aca tcg tgg cag cgg aag atg aag gaa cga cag gag agg aag 872 Leu Arg Thr Ser Trp Gln Arg Lys Met Lys Glu Arg Gln Glu Arg Lys 265 270 275 ctg gcc aag gac ttt gcc cgt cac ctg gag gag gag aag gag agg cgc 920 Leu Ala Lys Asp Phe Ala Arg His Leu Glu Glu Glu Lys Glu Arg Arg 280 285 290 cgc cag gag aag aaa cag cgc cgg gct gag aac ctg aaa cgc cgc ctg 968 Arg Gln Glu Lys Lys Gln Arg Arg Ala Glu Asn Leu Lys Arg Arg Leu 295 300 305 310 gag aat gag cgg aag gca gag gtc gtc caa gtg atc cga aac ccc gcc 1016 Glu Asn Glu Arg Lys Ala Glu Val Val Gln Val Ile Arg Asn Pro Ala 315 320 325 aag ctc aag cgg gca aag aag aag cag ctg cgc tcc att gag aag cgg 1064 Lys Leu Lys Arg Ala Lys Lys Lys Gln Leu Arg Ser Ile Glu Lys Arg 330 335 340 gac acc ctg gcc ctg ctg cag aag cag ccg ccc cag cag ccg gca gcc 1112 Asp Thr Leu Ala Leu Leu Gln Lys Gln Pro Pro Gln Gln Pro Ala Ala 345 350 355 aag atc tga gctcaggacg gcccgaggcc ttccatggcc aacaaccatg 1161 Lys Ile 360 tcagacacag cacctcaggc cgctgctcag atgcctctgc tggagctggc actccaaacc 1221 catggctcca gaacagggac ccccaccccg accggggctc ctcagccttt gaaggcttcc 1281 aggcaggtct gtgtgggaca gaagccaaaa gggtcctggg acctggcaga gatgggggcg 1341 ggaagagatt cagctcccat ccctccttcc tctccttctc caagtgcctt caaaccaaga 1401 actgtacatt cttctggttc ctcagtgagc tggtgactgg caggtgactc cctcagcagt 1461 gtatgccctt tctcagcatc ctaggtccat cccaggcctg gaggctgaca gttgggaatc 1521 cagcttcccc cacaccttcc caaaggctgc tctgagcacc tccacacccc actgcctctg 1581 tccccagcaa actgaatccg gttcctctcc acttttcaat actgaaagat taaaatgggg 1641 aggttgcagg gagcagagct tttccctagc acccactttc ccaaaccagt ctctgcagaa 1701 gccccagaga atctaactca tgcctgtcca gtctacagca aaaatattta ttgagtgcct 1761 gttgcataca ggcacaatcc taggcactgg caaatacaga caatagacc 1810 <210> SEQ ID NO 74 <211> LENGTH: 360 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 74 Met Asp Thr Pro Leu Arg Arg Ser Arg Arg Leu Gly Gly Leu Arg Pro 1 5 10 15 Glu Ser Pro Glu Ser Leu Thr Ser Val Ser Arg Thr Arg Arg Ala Leu 20 25 30 Val Glu Phe Glu Ser Asn Pro Glu Glu Thr Arg Glu Pro Gly Ser Pro 35 40 45 Pro Ser Val Gln Arg Ala Gly Leu Gly Ser Pro Glu Arg Pro Pro Lys 50 55 60 Thr Ser Pro Gly Ser Pro Arg Leu Gln Gln Gly Ala Gly Leu Glu Ser 65 70 75 80 Pro Gln Gly Gln Pro Glu Pro Gly Ala Ala Ser Pro Gln Arg Gln Gln 85 90 95 Asp Leu His Leu Glu Ser Pro Gln Arg Gln Pro Glu Tyr Ser Pro Glu 100 105 110 Ser Pro Arg Cys Gln Pro Lys Pro Ser Glu Glu Ala Pro Lys Cys Ser 115 120 125 Gln Asp Gln Gly Val Leu Ala Ser Glu Leu Ala Gln Asn Lys Glu Glu 130 135 140 Leu Thr Pro Gly Ala Pro Gln His Gln Leu Pro Pro Val Pro Gly Ser 145 150 155 160 Pro Glu Pro Tyr Pro Gly Gln Gln Ala Pro Gly Pro Glu Pro Ser Gln 165 170 175 Pro Leu Leu Glu Leu Thr Pro Arg Ala Pro Gly Ser Pro Arg Gly Gln 180 185 190 His Glu Pro Ser Lys Pro Pro Pro Ala Gly Glu Thr Val Thr Gly Gly 195 200 205 Phe Gly Ala Lys Lys Arg Lys Gly Ser Ser Ser Gln Ala Pro Ala Ser 210 215 220 Lys Lys Leu Asn Lys Glu Glu Leu Pro Val Ile Pro Lys Gly Lys Pro 225 230 235 240 Lys Ser Gly Arg Val Trp Lys Asp Arg Ser Lys Lys Arg Phe Ser Gln 245 250 255 Met Leu Gln Asp Lys Pro Leu Arg Thr Ser Trp Gln Arg Lys Met Lys 260 265 270 Glu Arg Gln Glu Arg Lys Leu Ala Lys Asp Phe Ala Arg His Leu Glu 275 280 285 Glu Glu Lys Glu Arg Arg Arg Gln Glu Lys Lys Gln Arg Arg Ala Glu 290 295 300 Asn Leu Lys Arg Arg Leu Glu Asn Glu Arg Lys Ala Glu Val Val Gln 305 310 315 320 Val Ile Arg Asn Pro Ala Lys Leu Lys Arg Ala Lys Lys Lys Gln Leu 325 330 335 Arg Ser Ile Glu Lys Arg Asp Thr Leu Ala Leu Leu Gln Lys Gln Pro 340 345 350 Pro Gln Gln Pro Ala Ala Lys Ile 355 360 <210> SEQ ID NO 75 <211> LENGTH: 1620 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (217)..(597) <400> SEQUENCE: 75 gtttttctgc cgcgtccacc acaacctctg ctgtatcaga gggggccttc gccgccgccg 60 cccccaccac cgcccctgcc gccatcgcca cctccgccgc tgccgccttg gggccctcct 120 ccttcaccgc ccccttcacc acctctacac gttctaggcc ttctgtcctg gagaagaagc 180 tatagtcgtt ctcccttgtg ggcccggggc gcagcc atg gcg gac ggc ggc ggc 234 Met Ala Asp Gly Gly Gly 1 5 ggc ggg gga act ggc gcg gtg ggc ggc ggc gga act agc cag gcc tct 282 Gly Gly Gly Thr Gly Ala Val Gly Gly Gly Gly Thr Ser Gln Ala Ser 10 15 20 gcc ggg gca gcg act ggc gct act ggg gcc agc ggg ggc ggt ggc ccc 330 Ala Gly Ala Ala Thr Gly Ala Thr Gly Ala Ser Gly Gly Gly Gly Pro 25 30 35 atc aac ccg gcc tcg ctg cct ccc ggc gac ccg cag ctc atc gct ctc 378 Ile Asn Pro Ala Ser Leu Pro Pro Gly Asp Pro Gln Leu Ile Ala Leu 40 45 50 atc gtg gag cag ctc aag agc cgg ggc ctt ttt gac agc ttc cgc cgg 426 Ile Val Glu Gln Leu Lys Ser Arg Gly Leu Phe Asp Ser Phe Arg Arg 55 60 65 70 gac tgc ctg gcc gac gtg gac acc aag cca gct tac caa aac ctg agg 474 Asp Cys Leu Ala Asp Val Asp Thr Lys Pro Ala Tyr Gln Asn Leu Arg 75 80 85 cag aaa gtg gat aat ttt gtg tca aca cat ctg gac aag cag gaa tgg 522 Gln Lys Val Asp Asn Phe Val Ser Thr His Leu Asp Lys Gln Glu Trp 90 95 100 aat cct acg atg aac aaa aac cag ttg cga aat ggt ctg agg cag agt 570 Asn Pro Thr Met Asn Lys Asn Gln Leu Arg Asn Gly Leu Arg Gln Ser 105 110 115 gtg gtt cag ttg ggt gat tgt ggg tga gattgtgcag taggaataac 617 Val Val Gln Leu Gly Asp Cys Gly 120 125 agctgctggt tgagaattac ccctcaaaag tgaaaatagc gtgagctgta tatggtcagg 677 gatgttggaa gctggagtag acaggattat ttctcaggtg gtggatccaa aacttaacca 737 catcttcagg ccacaaatag aacgagcaat tcatgagttc ctggcggccc agaaaaaagc 797 agctgtgcca gcaccccctc cagagcccga aggccaggac cctccagctc catctcagga 857 cacttcctaa gaatacgcca gacacctttt gaaagctaat ttttggtgaa gaaatggatt 917 cggttacata agagtgcaac ttcagactga agataggcca aggtcgtcac tgatctcaag 977 atttcaacct tgaccatggg cagtgaccag attgaaaggg gagcaagttc ggcagtggga 1037 gagttgaccg tgtcaccccc tgcattgtgc tgccatttgg ccagcctgtc caagggcatg 1097 acaccaagta gacactacag agagagaaac actacagcaa cccagggttg tcctgaaaca 1157 gacttttata cttgaacatg gagactgcac atggacttta gggtttgtgc tgtgggataa 1217 acggaagcta cagtgagaac atagccagtc ccaaagacaa tttcaaagaa aaatgacagt 1277 aaagattagc tgggagtagt ctttgacagt gcttatttga tactgtctct cagagtttgc 1337 aaaccagatt gtacaagtca ttagcgtcag atagctttaa agttgtgacc ttcttgtaca 1397 tgaatcttct agccagtttc ctttcctttg taacgaaaca tgaaatccta gaatgtatga 1457 gaagttcaga cattaggcat aaggaaactc gtttgcaggc tctctgtcca gggctgcttc 1517 ctgtcctgga ggggccagtg agtcttaggt atgtttattt tattctcaca tttgtgtttt 1577 tttagaaaag tgaatggtca ataaatggct tatctttcat aat 1620 <210> SEQ ID NO 76 <211> LENGTH: 126 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 76 Met Ala Asp Gly Gly Gly Gly Gly Gly Thr Gly Ala Val Gly Gly Gly 1 5 10 15 Gly Thr Ser Gln Ala Ser Ala Gly Ala Ala Thr Gly Ala Thr Gly Ala 20 25 30 Ser Gly Gly Gly Gly Pro Ile Asn Pro Ala Ser Leu Pro Pro Gly Asp 35 40 45 Pro Gln Leu Ile Ala Leu Ile Val Glu Gln Leu Lys Ser Arg Gly Leu 50 55 60 Phe Asp Ser Phe Arg Arg Asp Cys Leu Ala Asp Val Asp Thr Lys Pro 65 70 75 80 Ala Tyr Gln Asn Leu Arg Gln Lys Val Asp Asn Phe Val Ser Thr His 85 90 95 Leu Asp Lys Gln Glu Trp Asn Pro Thr Met Asn Lys Asn Gln Leu Arg 100 105 110 Asn Gly Leu Arg Gln Ser Val Val Gln Leu Gly Asp Cys Gly 115 120 125 <210> SEQ ID NO 77 <211> LENGTH: 1349 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (185)..(1042) <400> SEQUENCE: 77 gtatttccaa ggactccaaa gcgaggccgg ggactgaagg tgtgggtgtc gagccctctg 60 gcagagggtt aacctgggtc aaatgcacgg attctcacct cgtacagtta cgctctcccg 120 cggcacgtcc gcgaggactt gaagtcctga gcgctcaagt ttgtccgtag gtcgagagaa 180 ggcc atg gag gtg ccg cca ccg gca ccg cgg agc ttt ctc tgt aga gca 229 Met Glu Val Pro Pro Pro Ala Pro Arg Ser Phe Leu Cys Arg Ala 1 5 10 15 ttg tgc cta ttt ccc cga gtc ttt gct gcc gaa gct gtg act gcc gat 277 Leu Cys Leu Phe Pro Arg Val Phe Ala Ala Glu Ala Val Thr Ala Asp 20 25 30 tcg gaa gtc ctt gag gag cgt cag aag cgg ctt ccc tac gtc cca gag 325 Ser Glu Val Leu Glu Glu Arg Gln Lys Arg Leu Pro Tyr Val Pro Glu 35 40 45 ccc tat tac ccg gaa tct gga tgg gac cgc ctc cgg gag ctg ttt ggc 373 Pro Tyr Tyr Pro Glu Ser Gly Trp Asp Arg Leu Arg Glu Leu Phe Gly 50 55 60 aaa gat gaa cag cag aga att tca aag gac ctt gct aat atc tgt aag 421 Lys Asp Glu Gln Gln Arg Ile Ser Lys Asp Leu Ala Asn Ile Cys Lys 65 70 75 acg gca gct aca gca ggc atc att ggc tgg gtg tat ggg gga ata cca 469 Thr Ala Ala Thr Ala Gly Ile Ile Gly Trp Val Tyr Gly Gly Ile Pro 80 85 90 95 gct ttt att cat gct aaa caa caa tac att gag cag agc cag gca gaa 517 Ala Phe Ile His Ala Lys Gln Gln Tyr Ile Glu Gln Ser Gln Ala Glu 100 105 110 att tat cat aac cgg ttt gat gct gtg caa tct gca cat cgt gct gcc 565 Ile Tyr His Asn Arg Phe Asp Ala Val Gln Ser Ala His Arg Ala Ala 115 120 125 aca cga ggc ttc att cgt tat ggc tgg cgc tgg ggt tgg aga act gca 613 Thr Arg Gly Phe Ile Arg Tyr Gly Trp Arg Trp Gly Trp Arg Thr Ala 130 135 140 gtg ttt gtg act ata ttc aac aca gtg aac act agt ctg aat gta tac 661 Val Phe Val Thr Ile Phe Asn Thr Val Asn Thr Ser Leu Asn Val Tyr 145 150 155 cga aat aaa gat gcc tta agc cat ttt gta att gca gga gct gtc acg 709 Arg Asn Lys Asp Ala Leu Ser His Phe Val Ile Ala Gly Ala Val Thr 160 165 170 175 gga agt ctt ttt agg ata aac gta ggc ctg cgt ggc ctg gtg gct ggt 757 Gly Ser Leu Phe Arg Ile Asn Val Gly Leu Arg Gly Leu Val Ala Gly 180 185 190 ggc ata att gga gcc ttg ctg ggc act cct gta gga ggc ctg ctg atg 805 Gly Ile Ile Gly Ala Leu Leu Gly Thr Pro Val Gly Gly Leu Leu Met 195 200 205 gca ttt cag aag tac tct ggt gag act gtt cag gaa aga aaa cag aag 853 Ala Phe Gln Lys Tyr Ser Gly Glu Thr Val Gln Glu Arg Lys Gln Lys 210 215 220 gat cga aag gca ctc cat gag cta aaa ctg gaa gag tgg aaa ggc aga 901 Asp Arg Lys Ala Leu His Glu Leu Lys Leu Glu Glu Trp Lys Gly Arg 225 230 235 cta caa gtt act gag cac ctc cct gag aaa att gaa agt agt tta cag 949 Leu Gln Val Thr Glu His Leu Pro Glu Lys Ile Glu Ser Ser Leu Gln 240 245 250 255 gaa gat gaa cct gag aat gat gct aag aaa att gaa gca ctg cta aac 997 Glu Asp Glu Pro Glu Asn Asp Ala Lys Lys Ile Glu Ala Leu Leu Asn 260 265 270 ctt cct aga aac cct tca gta ata gat aaa caa gac aag gac tga 1042 Leu Pro Arg Asn Pro Ser Val Ile Asp Lys Gln Asp Lys Asp 275 280 285 aagtgctctg aacttgaaac tcactggaga gctgaaggga gctgccatgt ccgatgaatg 1102 ccaacagaca ggccactctt tggtcagcct gctgacaaat ttaagtgctg gtacctgtgg 1162 tggcagtggc ttgctcttgt ctttttcttt tctttttaac taagaatggg gctgttgtac 1222 tctcacttta cttatccttc aatttaaata catacttatg tttgtattaa tctatcaata 1282 tatgcataca tgaatatatc cacccaccta gattttaagc agtaaataaa acatttcgca 1342 aaagatt 1349 <210> SEQ ID NO 78 <211> LENGTH: 285 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 78 Met Glu Val Pro Pro Pro Ala Pro Arg Ser Phe Leu Cys Arg Ala Leu 1 5 10 15 Cys Leu Phe Pro Arg Val Phe Ala Ala Glu Ala Val Thr Ala Asp Ser 20 25 30 Glu Val Leu Glu Glu Arg Gln Lys Arg Leu Pro Tyr Val Pro Glu Pro 35 40 45 Tyr Tyr Pro Glu Ser Gly Trp Asp Arg Leu Arg Glu Leu Phe Gly Lys 50 55 60 Asp Glu Gln Gln Arg Ile Ser Lys Asp Leu Ala Asn Ile Cys Lys Thr 65 70 75 80 Ala Ala Thr Ala Gly Ile Ile Gly Trp Val Tyr Gly Gly Ile Pro Ala 85 90 95 Phe Ile His Ala Lys Gln Gln Tyr Ile Glu Gln Ser Gln Ala Glu Ile 100 105 110 Tyr His Asn Arg Phe Asp Ala Val Gln Ser Ala His Arg Ala Ala Thr 115 120 125 Arg Gly Phe Ile Arg Tyr Gly Trp Arg Trp Gly Trp Arg Thr Ala Val 130 135 140 Phe Val Thr Ile Phe Asn Thr Val Asn Thr Ser Leu Asn Val Tyr Arg 145 150 155 160 Asn Lys Asp Ala Leu Ser His Phe Val Ile Ala Gly Ala Val Thr Gly 165 170 175 Ser Leu Phe Arg Ile Asn Val Gly Leu Arg Gly Leu Val Ala Gly Gly 180 185 190 Ile Ile Gly Ala Leu Leu Gly Thr Pro Val Gly Gly Leu Leu Met Ala 195 200 205 Phe Gln Lys Tyr Ser Gly Glu Thr Val Gln Glu Arg Lys Gln Lys Asp 210 215 220 Arg Lys Ala Leu His Glu Leu Lys Leu Glu Glu Trp Lys Gly Arg Leu 225 230 235 240 Gln Val Thr Glu His Leu Pro Glu Lys Ile Glu Ser Ser Leu Gln Glu 245 250 255 Asp Glu Pro Glu Asn Asp Ala Lys Lys Ile Glu Ala Leu Leu Asn Leu 260 265 270 Pro Arg Asn Pro Ser Val Ile Asp Lys Gln Asp Lys Asp 275 280 285 <210> SEQ ID NO 79 <211> LENGTH: 1355 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (79)..(1068) <400> SEQUENCE: 79 gatggcggct tcctagtgag tcggcggctg atttagaagg aggttcaggc tacggtgagc 60 cgaagccaca caggagcc atg gaa gtg gca gag ccc agc agc ccc act gaa 111 Met Glu Val Ala Glu Pro Ser Ser Pro Thr Glu 1 5 10 gag gag gag gag gaa gag gag cac tcg gca gag cct cgg ccc cgc act 159 Glu Glu Glu Glu Glu Glu Glu His Ser Ala Glu Pro Arg Pro Arg Thr 15 20 25 cgc tcc aat cct gaa ggg gct gag gac cgg gca gta ggg gca cag gcc 207 Arg Ser Asn Pro Glu Gly Ala Glu Asp Arg Ala Val Gly Ala Gln Ala 30 35 40 agc gtg ggc agc cgc agc gag ggt gag ggt gag gcc gcc agt gct gat 255 Ser Val Gly Ser Arg Ser Glu Gly Glu Gly Glu Ala Ala Ser Ala Asp 45 50 55 gat ggg agc ctc aac act tca gga gcc ggc cct aag tcc tgg cag gtg 303 Asp Gly Ser Leu Asn Thr Ser Gly Ala Gly Pro Lys Ser Trp Gln Val 60 65 70 75 ccc ccg cca gcc cct gag gtc caa att cgg aca cca agg gtc aac tgt 351 Pro Pro Pro Ala Pro Glu Val Gln Ile Arg Thr Pro Arg Val Asn Cys 80 85 90 cca gag aaa gtg att atc tgc ctg gac ctg tca gag gaa atg tca ctg 399 Pro Glu Lys Val Ile Ile Cys Leu Asp Leu Ser Glu Glu Met Ser Leu 95 100 105 cca aag ctg gag tcg ttc aac ggc tcc aaa acc aac gcc ctc aat gtc 447 Pro Lys Leu Glu Ser Phe Asn Gly Ser Lys Thr Asn Ala Leu Asn Val 110 115 120 tcc cag aag atg att gag atg ttc gtg cgg aca aaa cac aag atc gac 495 Ser Gln Lys Met Ile Glu Met Phe Val Arg Thr Lys His Lys Ile Asp 125 130 135 aaa agc cac gag ttt gca ctg gtg gtg gtg aac gat gac acg gcc tgg 543 Lys Ser His Glu Phe Ala Leu Val Val Val Asn Asp Asp Thr Ala Trp 140 145 150 155 ctg tct ggc ctg acc tcc gac ccc cgc gag ctc tgt agc tgc ctc tat 591 Leu Ser Gly Leu Thr Ser Asp Pro Arg Glu Leu Cys Ser Cys Leu Tyr 160 165 170 gat ctg gag acg gcc tcc tgt tcc acc ttc aat ctg gaa gga ctt ttc 639 Asp Leu Glu Thr Ala Ser Cys Ser Thr Phe Asn Leu Glu Gly Leu Phe 175 180 185 agc ctc atc cag cag aaa act gag ctt ccg gtc aca gag aac gtg cag 687 Ser Leu Ile Gln Gln Lys Thr Glu Leu Pro Val Thr Glu Asn Val Gln 190 195 200 acg att ccc ccg cca tat gtg gtc cgc acc atc ctt gtc tac agc cgt 735 Thr Ile Pro Pro Pro Tyr Val Val Arg Thr Ile Leu Val Tyr Ser Arg 205 210 215 cca cct tgc cag ccc cag ttc tcc ttg acg gag ccc atg aag aaa atg 783 Pro Pro Cys Gln Pro Gln Phe Ser Leu Thr Glu Pro Met Lys Lys Met 220 225 230 235 ttc cag tgc cca tat ttc ttc ttt gac gtt gtt tac atc cac aat ggc 831 Phe Gln Cys Pro Tyr Phe Phe Phe Asp Val Val Tyr Ile His Asn Gly 240 245 250 act gag gag aag gag gag gag atg agt tgg aag gat atg ttt gcc ttc 879 Thr Glu Glu Lys Glu Glu Glu Met Ser Trp Lys Asp Met Phe Ala Phe 255 260 265 atg ggc agc ctg gat acc aag ggt acc agc tac aaa tat gag gtg gca 927 Met Gly Ser Leu Asp Thr Lys Gly Thr Ser Tyr Lys Tyr Glu Val Ala 270 275 280 ctg gct ggg cca gcc ctg gag ttg cac aac tgc atg gcg aaa ctg ttg 975 Leu Ala Gly Pro Ala Leu Glu Leu His Asn Cys Met Ala Lys Leu Leu 285 290 295 gcc cac ccc ctg cag cgg cct tgc cag agc cat gct tcc tac agc ctg 1023 Ala His Pro Leu Gln Arg Pro Cys Gln Ser His Ala Ser Tyr Ser Leu 300 305 310 315 ctg gag gag gag gat gaa gcc att gag gtt gag gcc act gtc tga 1068 Leu Glu Glu Glu Asp Glu Ala Ile Glu Val Glu Ala Thr Val 320 325 accatccctg tacatctgca ccttcttgtg caaggaagtc cttggcctaa agccttggtt 1128 ctcaaactgg gttccttggg acctccgggg tgggggggtt ccaggaggca cgtagggtac 1188 cttgcagggt cctaggaggg aaacccagga ttccaggagg gatcccagga actgtgggca 1248 cccattttct gtgtctccca gcccatttcc actcctagtt tgtcatggat aatttttgtt 1308 cttccctgtg tgatttttgc catcaaaata aaaatttgag actcgtt 1355 <210> SEQ ID NO 80 <211> LENGTH: 329 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 80 Met Glu Val Ala Glu Pro Ser Ser Pro Thr Glu Glu Glu Glu Glu Glu 1 5 10 15 Glu Glu His Ser Ala Glu Pro Arg Pro Arg Thr Arg Ser Asn Pro Glu 20 25 30 Gly Ala Glu Asp Arg Ala Val Gly Ala Gln Ala Ser Val Gly Ser Arg 35 40 45 Ser Glu Gly Glu Gly Glu Ala Ala Ser Ala Asp Asp Gly Ser Leu Asn 50 55 60 Thr Ser Gly Ala Gly Pro Lys Ser Trp Gln Val Pro Pro Pro Ala Pro 65 70 75 80 Glu Val Gln Ile Arg Thr Pro Arg Val Asn Cys Pro Glu Lys Val Ile 85 90 95 Ile Cys Leu Asp Leu Ser Glu Glu Met Ser Leu Pro Lys Leu Glu Ser 100 105 110 Phe Asn Gly Ser Lys Thr Asn Ala Leu Asn Val Ser Gln Lys Met Ile 115 120 125 Glu Met Phe Val Arg Thr Lys His Lys Ile Asp Lys Ser His Glu Phe 130 135 140 Ala Leu Val Val Val Asn Asp Asp Thr Ala Trp Leu Ser Gly Leu Thr 145 150 155 160 Ser Asp Pro Arg Glu Leu Cys Ser Cys Leu Tyr Asp Leu Glu Thr Ala 165 170 175 Ser Cys Ser Thr Phe Asn Leu Glu Gly Leu Phe Ser Leu Ile Gln Gln 180 185 190 Lys Thr Glu Leu Pro Val Thr Glu Asn Val Gln Thr Ile Pro Pro Pro 195 200 205 Tyr Val Val Arg Thr Ile Leu Val Tyr Ser Arg Pro Pro Cys Gln Pro 210 215 220 Gln Phe Ser Leu Thr Glu Pro Met Lys Lys Met Phe Gln Cys Pro Tyr 225 230 235 240 Phe Phe Phe Asp Val Val Tyr Ile His Asn Gly Thr Glu Glu Lys Glu 245 250 255 Glu Glu Met Ser Trp Lys Asp Met Phe Ala Phe Met Gly Ser Leu Asp 260 265 270 Thr Lys Gly Thr Ser Tyr Lys Tyr Glu Val Ala Leu Ala Gly Pro Ala 275 280 285 Leu Glu Leu His Asn Cys Met Ala Lys Leu Leu Ala His Pro Leu Gln 290 295 300 Arg Pro Cys Gln Ser His Ala Ser Tyr Ser Leu Leu Glu Glu Glu Asp 305 310 315 320 Glu Ala Ile Glu Val Glu Ala Thr Val 325 <210> SEQ ID NO 81 <211> LENGTH: 1543 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (29)..(730) <400> SEQUENCE: 81 gctctggggc gcgggcgatt tgtaggta atg gca ggc gtt cgg tca ctg agg 52 Met Ala Gly Val Arg Ser Leu Arg 1 5 tgt agc aga gga tgc gct ggc ggc tgt gag tgc ggc gac aag ggc aaa 100 Cys Ser Arg Gly Cys Ala Gly Gly Cys Glu Cys Gly Asp Lys Gly Lys 10 15 20 tgc agc gac tcc tcg ctg ttg ggc aag aga ctc tcc gaa gac tcg agc 148 Cys Ser Asp Ser Ser Leu Leu Gly Lys Arg Leu Ser Glu Asp Ser Ser 25 30 35 40 cgc cac cag ctg ttg cag aag tgg gcg agc atg tgg agc tcc atg agc 196 Arg His Gln Leu Leu Gln Lys Trp Ala Ser Met Trp Ser Ser Met Ser 45 50 55 gaa gac gcg tcg gtg gcc gac atg gag agg gcg cag ctg gag gag gag 244 Glu Asp Ala Ser Val Ala Asp Met Glu Arg Ala Gln Leu Glu Glu Glu 60 65 70 gcg gcg gct gcg gag gag agg ccg ctg gtg ttc ctg tgc tcc ggc tgc 292 Ala Ala Ala Ala Glu Glu Arg Pro Leu Val Phe Leu Cys Ser Gly Cys 75 80 85 cgg cgg ccg ctg ggc gac tcg ctg agc tgg gtg gcc agc cag gag gac 340 Arg Arg Pro Leu Gly Asp Ser Leu Ser Trp Val Ala Ser Gln Glu Asp 90 95 100 acc aac tgc atc ctg ctt cgc tgt gtt tcc tgt aat gtt tct gtg gat 388 Thr Asn Cys Ile Leu Leu Arg Cys Val Ser Cys Asn Val Ser Val Asp 105 110 115 120 aag gaa cag aag cta tcc aaa cgt gaa aag gaa aat ggt tgc gtc ctt 436 Lys Glu Gln Lys Leu Ser Lys Arg Glu Lys Glu Asn Gly Cys Val Leu 125 130 135 gag act ttg tgc tgc gcg ggg tgc tca ctc aat ctt ggc tac gtg tac 484 Glu Thr Leu Cys Cys Ala Gly Cys Ser Leu Asn Leu Gly Tyr Val Tyr 140 145 150 aga tgc acg ccc aag aat ctt gat tac aag aga gac ttg ttt tgc ctc 532 Arg Cys Thr Pro Lys Asn Leu Asp Tyr Lys Arg Asp Leu Phe Cys Leu 155 160 165 agt gtt gaa gcc att gaa agt tat gtt tta ggg tcc tct gaa aag caa 580 Ser Val Glu Ala Ile Glu Ser Tyr Val Leu Gly Ser Ser Glu Lys Gln 170 175 180 att gtg tca gaa gat aaa gag ctt ttt aat ctt gaa agc aga gtt gaa 628 Ile Val Ser Glu Asp Lys Glu Leu Phe Asn Leu Glu Ser Arg Val Glu 185 190 195 200 ata gaa aag tct cta aca cag atg gaa gat gtc ttg aaa gca tta caa 676 Ile Glu Lys Ser Leu Thr Gln Met Glu Asp Val Leu Lys Ala Leu Gln 205 210 215 atg aag ctg tgg gag gcc gaa tcc aaa ttg tcc ttt gcc act tgt aaa 724 Met Lys Leu Trp Glu Ala Glu Ser Lys Leu Ser Phe Ala Thr Cys Lys 220 225 230 agc tga actctagtct gtgtcctcca ttctgccccc gcccttcctc cccttatttg 780 Ser ttaaatgaag caacatagtg agacgtcgtc tctacaaaaa aaaaaagaaa aaaaaaaatt 840 agccaggcat gcgaaacgct gaggtgggag gatcagatga gcttgggagg ttgaggctgc 900 agtgagcctt ggtcatgcca ctactgcgtt ctagtctggg caacagagtg agaccttctc 960 tcaaaaaaaa aacccaaaat tgtagaatta cttctatagc tatattttat gataaagaag 1020 tgattgtttc tcaaaatcgc attttaaaga cgttttatgg tacttgttgg aattgggact 1080 taggagtttt gattttgata agaaactggg atgattttct gaactttttt tcctctgtat 1140 cacatttatt tactattttt aaaaactttg acatttaaca cttgggacaa catttattat 1200 aaatgataag aaaaatctta gaggtttgtc tacccacagt gtcatggaat cttctctgaa 1260 aactaatcca taaagttccc tggagaaatt ggtcagaatg atctgtcaga accatttgaa 1320 aacttgctca agagcagttg cttatatata gtaggatttt actttttcct gcttatgtac 1380 tactatatgc ttaaaaaacc tggaggaata cttaccaaag aggagtaacc atctctgagg 1440 gtgggattct gggggaattt ttgttttttt ctgttttcta taatgtgaaa cttttgtagt 1500 atgtattttt ctaattgaag agaataaaga ttaaaacaaa gtg 1543 <210> SEQ ID NO 82 <211> LENGTH: 233 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 82 Met Ala Gly Val Arg Ser Leu Arg Cys Ser Arg Gly Cys Ala Gly Gly 1 5 10 15 Cys Glu Cys Gly Asp Lys Gly Lys Cys Ser Asp Ser Ser Leu Leu Gly 20 25 30 Lys Arg Leu Ser Glu Asp Ser Ser Arg His Gln Leu Leu Gln Lys Trp 35 40 45 Ala Ser Met Trp Ser Ser Met Ser Glu Asp Ala Ser Val Ala Asp Met 50 55 60 Glu Arg Ala Gln Leu Glu Glu Glu Ala Ala Ala Ala Glu Glu Arg Pro 65 70 75 80 Leu Val Phe Leu Cys Ser Gly Cys Arg Arg Pro Leu Gly Asp Ser Leu 85 90 95 Ser Trp Val Ala Ser Gln Glu Asp Thr Asn Cys Ile Leu Leu Arg Cys 100 105 110 Val Ser Cys Asn Val Ser Val Asp Lys Glu Gln Lys Leu Ser Lys Arg 115 120 125 Glu Lys Glu Asn Gly Cys Val Leu Glu Thr Leu Cys Cys Ala Gly Cys 130 135 140 Ser Leu Asn Leu Gly Tyr Val Tyr Arg Cys Thr Pro Lys Asn Leu Asp 145 150 155 160 Tyr Lys Arg Asp Leu Phe Cys Leu Ser Val Glu Ala Ile Glu Ser Tyr 165 170 175 Val Leu Gly Ser Ser Glu Lys Gln Ile Val Ser Glu Asp Lys Glu Leu 180 185 190 Phe Asn Leu Glu Ser Arg Val Glu Ile Glu Lys Ser Leu Thr Gln Met 195 200 205 Glu Asp Val Leu Lys Ala Leu Gln Met Lys Leu Trp Glu Ala Glu Ser 210 215 220 Lys Leu Ser Phe Ala Thr Cys Lys Ser 225 230 <210> SEQ ID NO 83 <211> LENGTH: 1436 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (31)..(582) <400> SEQUENCE: 83 acgtgaccca agccccagct tcgcgcaggg atg gag ccg gaa gag ggg acg ccc 54 Met Glu Pro Glu Glu Gly Thr Pro 1 5 ttg tgg cgg ctg cag aag ctg ccg gcc gag ctg ggc ccg cag ctt ctt 102 Leu Trp Arg Leu Gln Lys Leu Pro Ala Glu Leu Gly Pro Gln Leu Leu 10 15 20 cac aaa ata att gat ggc att tgt ggt cga gct tat cct gtg tac caa 150 His Lys Ile Ile Asp Gly Ile Cys Gly Arg Ala Tyr Pro Val Tyr Gln 25 30 35 40 gat tat cac act gtt tgg gaa tca gaa gaa tgg atg cac gtt tta gaa 198 Asp Tyr His Thr Val Trp Glu Ser Glu Glu Trp Met His Val Leu Glu 45 50 55 gat att gcc aaa ttt ttc aaa gcc ata gtt ggt aaa aac tta cct gat 246 Asp Ile Ala Lys Phe Phe Lys Ala Ile Val Gly Lys Asn Leu Pro Asp 60 65 70 gaa gag ata ttt cag cag ttg aat cag ttg aat tca ctt cat caa gaa 294 Glu Glu Ile Phe Gln Gln Leu Asn Gln Leu Asn Ser Leu His Gln Glu 75 80 85 act atc atg aaa tgc gtg aaa agt agg aaa gat gaa atc aaa cag gct 342 Thr Ile Met Lys Cys Val Lys Ser Arg Lys Asp Glu Ile Lys Gln Ala 90 95 100 ctg tca aga gaa ata gtt gct att tcc tct gca cag cta cag gat ttt 390 Leu Ser Arg Glu Ile Val Ala Ile Ser Ser Ala Gln Leu Gln Asp Phe 105 110 115 120 gat tgg cag gta aag ctt gca ctt tcc agt gac aag att gct gca tta 438 Asp Trp Gln Val Lys Leu Ala Leu Ser Ser Asp Lys Ile Ala Ala Leu 125 130 135 cga atg cca ctt tta agc ctg cat cta gat gta aaa gaa aat ggt gaa 486 Arg Met Pro Leu Leu Ser Leu His Leu Asp Val Lys Glu Asn Gly Glu 140 145 150 gta aaa cct tat tct att gaa atg agt aga gag gag ctg cag aat cta 534 Val Lys Pro Tyr Ser Ile Glu Met Ser Arg Glu Glu Leu Gln Asn Leu 155 160 165 ata cag tcc ttg gaa gca gcg aat aag gtg gtc ctg cag ttg aaa taa 582 Ile Gln Ser Leu Glu Ala Ala Asn Lys Val Val Leu Gln Leu Lys 170 175 180 ctggaaatga tgaataccag tcctatcaga ttttattgct ccaacttata tggcagagtg 642 aatactgcgt gttcagaaac cttgtgatgt cttgactgtt gcaccaggct gagaaagcag 702 caatattgat attataaaga taaaaattta tcaacattcc ttaacaggaa attacatggt 762 tgagaggaaa tgcataaaat gaaagatgaa aaatctatag tagcagttta tattttcatg 822 attgttttgc ctcatttatt aaatatttga gaaatctttg gagatacata gttttattga 882 aagctaaaaa taggttctaa agtaatgtaa aaatataaag cacaaatata cttgaatatt 942 gcttaaagaa ttgtgtgaat agcaacatat attatggata tatactttgt gatattttta 1002 aaaaataatt ttttcaaaga atgtataagc tgcatatata actcaggaga ttccatgtct 1062 ttctcatatt tcagaggaaa gattataaaa tataaaattt cttagagaac acctctttgt 1122 cagagataaa caagaacaaa tactctaaac ttatgtgaac agttttgagt ttatgaattc 1182 tagaaactaa aatcaagaat acagaaaaat gaaaataaca ttttacttct gcgcttctat 1242 gtttgggaaa cattgctctg ataaaaaata gctgtcatta tgcagtgtgt atattcaaat 1302 atgagataag actatgtaca catccacttt tgttaataaa ctcaatattg aatacttttg 1362 gatgttaaat tcattggaaa aacaaaccat ttgtaacctc agttaacttt aacaacaagc 1422 attctgagca aatg 1436 <210> SEQ ID NO 84 <211> LENGTH: 183 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 84 Met Glu Pro Glu Glu Gly Thr Pro Leu Trp Arg Leu Gln Lys Leu Pro 1 5 10 15 Ala Glu Leu Gly Pro Gln Leu Leu His Lys Ile Ile Asp Gly Ile Cys 20 25 30 Gly Arg Ala Tyr Pro Val Tyr Gln Asp Tyr His Thr Val Trp Glu Ser 35 40 45 Glu Glu Trp Met His Val Leu Glu Asp Ile Ala Lys Phe Phe Lys Ala 50 55 60 Ile Val Gly Lys Asn Leu Pro Asp Glu Glu Ile Phe Gln Gln Leu Asn 65 70 75 80 Gln Leu Asn Ser Leu His Gln Glu Thr Ile Met Lys Cys Val Lys Ser 85 90 95 Arg Lys Asp Glu Ile Lys Gln Ala Leu Ser Arg Glu Ile Val Ala Ile 100 105 110 Ser Ser Ala Gln Leu Gln Asp Phe Asp Trp Gln Val Lys Leu Ala Leu 115 120 125 Ser Ser Asp Lys Ile Ala Ala Leu Arg Met Pro Leu Leu Ser Leu His 130 135 140 Leu Asp Val Lys Glu Asn Gly Glu Val Lys Pro Tyr Ser Ile Glu Met 145 150 155 160 Ser Arg Glu Glu Leu Gln Asn Leu Ile Gln Ser Leu Glu Ala Ala Asn 165 170 175 Lys Val Val Leu Gln Leu Lys 180 <210> SEQ ID NO 85 <211> LENGTH: 1357 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (102)..(1244) <400> SEQUENCE: 85 ggtttccggc gagagggcca gagtgagtgt ttacaccggc ggcagtgcgg ccgggttcct 60 tccgcgggac ggggagaaag agagagcgcg aaagagagag g atg tct ctc tca gac 116 Met Ser Leu Ser Asp 1 5 tgg cac ctg gcg gtg aag ctg gct gac cag cca ctt act cca aag tct 164 Trp His Leu Ala Val Lys Leu Ala Asp Gln Pro Leu Thr Pro Lys Ser 10 15 20 att ctt cgg ttg cca gag aca gaa ctg gga gaa tac tcg cta ggg ggc 212 Ile Leu Arg Leu Pro Glu Thr Glu Leu Gly Glu Tyr Ser Leu Gly Gly 25 30 35 tat agt att tca ttt ctg aag cag ctt att gct ggc aaa ctc cag gag 260 Tyr Ser Ile Ser Phe Leu Lys Gln Leu Ile Ala Gly Lys Leu Gln Glu 40 45 50 tct gtt cca gac cct gag ctg att gat ctg atc tac tgt ggt cgg aag 308 Ser Val Pro Asp Pro Glu Leu Ile Asp Leu Ile Tyr Cys Gly Arg Lys 55 60 65 cta aaa gat gac cag aca ctt gac ttc tat ggc att caa cct ggg tcc 356 Leu Lys Asp Asp Gln Thr Leu Asp Phe Tyr Gly Ile Gln Pro Gly Ser 70 75 80 85 act gtc cat gtt ctg cga aag tcc tgg cct gaa cct gat cag aaa ccg 404 Thr Val His Val Leu Arg Lys Ser Trp Pro Glu Pro Asp Gln Lys Pro 90 95 100 gaa cct gtg gac aaa gtg gct gcc atg aga gag ttc cgg gtg ttg cac 452 Glu Pro Val Asp Lys Val Ala Ala Met Arg Glu Phe Arg Val Leu His 105 110 115 act gcc ctg cac agc agc tcc tct tac agg gag gcg gtc ttt aag atg 500 Thr Ala Leu His Ser Ser Ser Ser Tyr Arg Glu Ala Val Phe Lys Met 120 125 130 ctc agc aat aag gag tct ctg gat cag atc att gtg gcc acc cca ggc 548 Leu Ser Asn Lys Glu Ser Leu Asp Gln Ile Ile Val Ala Thr Pro Gly 135 140 145 ctc agc agt gac cct att gct ctt ggg gtt ctc cag gac aag gac ctc 596 Leu Ser Ser Asp Pro Ile Ala Leu Gly Val Leu Gln Asp Lys Asp Leu 150 155 160 165 ttc tct gtc ttc gct gat ccc aat atg ctt gat acg ttg gtg cct gct 644 Phe Ser Val Phe Ala Asp Pro Asn Met Leu Asp Thr Leu Val Pro Ala 170 175 180 cac cca gcc ctc gtc aat gcc att gtc ctg gtt ctg cac tcc gta gca 692 His Pro Ala Leu Val Asn Ala Ile Val Leu Val Leu His Ser Val Ala 185 190 195 ggc agt gcc cca atg cct ggg act gac tcc tct tcc cgg agc atg ccc 740 Gly Ser Ala Pro Met Pro Gly Thr Asp Ser Ser Ser Arg Ser Met Pro 200 205 210 tcc agc tca tac cgg gat atg cca ggt ggc ttc ctg ttt gaa ggg ctc 788 Ser Ser Ser Tyr Arg Asp Met Pro Gly Gly Phe Leu Phe Glu Gly Leu 215 220 225 tca gat gat gag gat gac ttt cac cca aac acc agg tcc aca ccc tct 836 Ser Asp Asp Glu Asp Asp Phe His Pro Asn Thr Arg Ser Thr Pro Ser 230 235 240 245 agc agt act ccc agc tcc cgc cca gcc tcc ctg ggg tac agt gga gct 884 Ser Ser Thr Pro Ser Ser Arg Pro Ala Ser Leu Gly Tyr Ser Gly Ala 250 255 260 gct ggg ccc cgg ccc atc acc cag agt gag ctg gcc acc gcc ttg gcc 932 Ala Gly Pro Arg Pro Ile Thr Gln Ser Glu Leu Ala Thr Ala Leu Ala 265 270 275 ctg gcc agc act ccg gag agc agc tct cac aca ccg act cct ggc acc 980 Leu Ala Ser Thr Pro Glu Ser Ser Ser His Thr Pro Thr Pro Gly Thr 280 285 290 cag ggt cat tcc tca ggg acc tca cca atg tcc tct ggt gtc cag tca 1028 Gln Gly His Ser Ser Gly Thr Ser Pro Met Ser Ser Gly Val Gln Ser 295 300 305 ggg acg ccc atc acc aat gat ctc ttc agc caa gcc cta cag cat gcc 1076 Gly Thr Pro Ile Thr Asn Asp Leu Phe Ser Gln Ala Leu Gln His Ala 310 315 320 325 ctt cag gcc tct ggg cag ccc agc ctt cag agc cag tgg cag ccc cag 1124 Leu Gln Ala Ser Gly Gln Pro Ser Leu Gln Ser Gln Trp Gln Pro Gln 330 335 340 ctg cag cag cta cgt gac atg ggc atc cag gac gat gag ctg agc ctg 1172 Leu Gln Gln Leu Arg Asp Met Gly Ile Gln Asp Asp Glu Leu Ser Leu 345 350 355 cgg gcc ctg cag gcc acc ggt ggg gac atc caa gca gcc ctg gag ctc 1220 Arg Ala Leu Gln Ala Thr Gly Gly Asp Ile Gln Ala Ala Leu Glu Leu 360 365 370 atc ttt gct gga gga gcc cca tga actccctgct tcccctgaac ccccagcaag 1274 Ile Phe Ala Gly Gly Ala Pro 375 380 ttgcagaggc tactgccctt gggaggcact catgaaggtg cctccatctc tcccttcccc 1334 aatatacctg atggtcaact ctc 1357 <210> SEQ ID NO 86 <211> LENGTH: 380 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 86 Met Ser Leu Ser Asp Trp His Leu Ala Val Lys Leu Ala Asp Gln Pro 1 5 10 15 Leu Thr Pro Lys Ser Ile Leu Arg Leu Pro Glu Thr Glu Leu Gly Glu 20 25 30 Tyr Ser Leu Gly Gly Tyr Ser Ile Ser Phe Leu Lys Gln Leu Ile Ala 35 40 45 Gly Lys Leu Gln Glu Ser Val Pro Asp Pro Glu Leu Ile Asp Leu Ile 50 55 60 Tyr Cys Gly Arg Lys Leu Lys Asp Asp Gln Thr Leu Asp Phe Tyr Gly 65 70 75 80 Ile Gln Pro Gly Ser Thr Val His Val Leu Arg Lys Ser Trp Pro Glu 85 90 95 Pro Asp Gln Lys Pro Glu Pro Val Asp Lys Val Ala Ala Met Arg Glu 100 105 110 Phe Arg Val Leu His Thr Ala Leu His Ser Ser Ser Ser Tyr Arg Glu 115 120 125 Ala Val Phe Lys Met Leu Ser Asn Lys Glu Ser Leu Asp Gln Ile Ile 130 135 140 Val Ala Thr Pro Gly Leu Ser Ser Asp Pro Ile Ala Leu Gly Val Leu 145 150 155 160 Gln Asp Lys Asp Leu Phe Ser Val Phe Ala Asp Pro Asn Met Leu Asp 165 170 175 Thr Leu Val Pro Ala His Pro Ala Leu Val Asn Ala Ile Val Leu Val 180 185 190 Leu His Ser Val Ala Gly Ser Ala Pro Met Pro Gly Thr Asp Ser Ser 195 200 205 Ser Arg Ser Met Pro Ser Ser Ser Tyr Arg Asp Met Pro Gly Gly Phe 210 215 220 Leu Phe Glu Gly Leu Ser Asp Asp Glu Asp Asp Phe His Pro Asn Thr 225 230 235 240 Arg Ser Thr Pro Ser Ser Ser Thr Pro Ser Ser Arg Pro Ala Ser Leu 245 250 255 Gly Tyr Ser Gly Ala Ala Gly Pro Arg Pro Ile Thr Gln Ser Glu Leu 260 265 270 Ala Thr Ala Leu Ala Leu Ala Ser Thr Pro Glu Ser Ser Ser His Thr 275 280 285 Pro Thr Pro Gly Thr Gln Gly His Ser Ser Gly Thr Ser Pro Met Ser 290 295 300 Ser Gly Val Gln Ser Gly Thr Pro Ile Thr Asn Asp Leu Phe Ser Gln 305 310 315 320 Ala Leu Gln His Ala Leu Gln Ala Ser Gly Gln Pro Ser Leu Gln Ser 325 330 335 Gln Trp Gln Pro Gln Leu Gln Gln Leu Arg Asp Met Gly Ile Gln Asp 340 345 350 Asp Glu Leu Ser Leu Arg Ala Leu Gln Ala Thr Gly Gly Asp Ile Gln 355 360 365 Ala Ala Leu Glu Leu Ile Phe Ala Gly Gly Ala Pro 370 375 380 <210> SEQ ID NO 87 <211> LENGTH: 1399 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (74)..(856) <400> SEQUENCE: 87 aaaaagcgga cccgcggacg gtggcgttaa gggaacgctg aggtcccgcg ctccccgacc 60 gaggtatatc tcc atg aat aac cta aat gat ccc cca aat tgg aat atc 109 Met Asn Asn Leu Asn Asp Pro Pro Asn Trp Asn Ile 1 5 10 cgg cct aat tcc agg gcg gat ggt ggt gat gga agc agg tgg aat tat 157 Arg Pro Asn Ser Arg Ala Asp Gly Gly Asp Gly Ser Arg Trp Asn Tyr 15 20 25 gcc ctg ttg gtt cca atg ctg gga ttg gct gct ttt cgt tgg att tgg 205 Ala Leu Leu Val Pro Met Leu Gly Leu Ala Ala Phe Arg Trp Ile Trp 30 35 40 tct agg gag tcc cag aaa gaa gta gaa aaa gag aga gaa gcc tac cgt 253 Ser Arg Glu Ser Gln Lys Glu Val Glu Lys Glu Arg Glu Ala Tyr Arg 45 50 55 60 cgg aga act gct gct ttt caa cag gat ctg gaa gcc aag tac cac gcc 301 Arg Arg Thr Ala Ala Phe Gln Gln Asp Leu Glu Ala Lys Tyr His Ala 65 70 75 atg atc tca gaa aat cgg cgt gct gtc gct cag ttg tcc ttg gaa ctc 349 Met Ile Ser Glu Asn Arg Arg Ala Val Ala Gln Leu Ser Leu Glu Leu 80 85 90 gaa aag gaa caa aac aga act gct agt tac cga gaa gcc ctt atc tct 397 Glu Lys Glu Gln Asn Arg Thr Ala Ser Tyr Arg Glu Ala Leu Ile Ser 95 100 105 cag gga cgc aag ttg gta gaa gaa aag aag ctt ctg gaa cag gaa cgg 445 Gln Gly Arg Lys Leu Val Glu Glu Lys Lys Leu Leu Glu Gln Glu Arg 110 115 120 gcc cag gtg atg caa gaa aaa aga cag gtg cag cct ttg aga agt gcg 493 Ala Gln Val Met Gln Glu Lys Arg Gln Val Gln Pro Leu Arg Ser Ala 125 130 135 140 tat ttg agc tgc ctg caa agg gaa gaa aac tgg caa agg aga gcc agg 541 Tyr Leu Ser Cys Leu Gln Arg Glu Glu Asn Trp Gln Arg Arg Ala Arg 145 150 155 ctt ttg ctg aaa gaa ttt gaa gct gtt ctc aca gaa aga cag aat atc 589 Leu Leu Leu Lys Glu Phe Glu Ala Val Leu Thr Glu Arg Gln Asn Ile 160 165 170 tac tgc agt ctg ttt ctt cct cgc agc aag cgg ctg gag ata gag aag 637 Tyr Cys Ser Leu Phe Leu Pro Arg Ser Lys Arg Leu Glu Ile Glu Lys 175 180 185 agc tta ctg gtg cga gcg tcc gtc gac ccc gtc gcc gct gac cta gag 685 Ser Leu Leu Val Arg Ala Ser Val Asp Pro Val Ala Ala Asp Leu Glu 190 195 200 atg gca gcc ggt ctc acc gac ata ttt cag cat gat aca tac tgt ggt 733 Met Ala Ala Gly Leu Thr Asp Ile Phe Gln His Asp Thr Tyr Cys Gly 205 210 215 220 gat gtc tgg aac acc aac aaa cgc cag aat ggc aga ctc atg tgg ctc 781 Asp Val Trp Asn Thr Asn Lys Arg Gln Asn Gly Arg Leu Met Trp Leu 225 230 235 tat ctc aaa tac tgg gaa ctc gtt gtc gaa ctg aag aag ttt aag aga 829 Tyr Leu Lys Tyr Trp Glu Leu Val Val Glu Leu Lys Lys Phe Lys Arg 240 245 250 gta gag gaa gcc ata cta gaa aag taa gacaagagtg aaatcaaact 876 Val Glu Glu Ala Ile Leu Glu Lys 255 260 gcttttagtg actcgaggcc aggcagtcat gcgccttctg ggtctccggc gtcttccgtt 936 cccgtgctgc ccgtgtcatg gccacaccgt cacccttcag cagcgacctc cactcccgcc 996 accgtctgag cagaagtgca ccgaagcctc agagacagag ggtctcctcc cgatgctctg 1056 ccgctgttgg ggatatggtt tcttgaagca tttttaggct gccagtattg tattaagcag 1116 aacagtataa cctcgtattt tagctccagg gtaaaaatgg ttttttaaaa agtcaaatac 1176 aatactggtc cttagcacaa gtaattttct gtctgtttca tcactcccta aatactttct 1236 cctcaaatta tttttctctg tcaccagatt acattaagaa tttgtcagat aatgtgtaga 1296 actgcataac aggtaataga aagtagtaat attatattat caagggttta tattttaaag 1356 atctctctca ctccataaag gggaaatacc aagtgtttct tgt 1399 <210> SEQ ID NO 88 <211> LENGTH: 260 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 88 Met Asn Asn Leu Asn Asp Pro Pro Asn Trp Asn Ile Arg Pro Asn Ser 1 5 10 15 Arg Ala Asp Gly Gly Asp Gly Ser Arg Trp Asn Tyr Ala Leu Leu Val 20 25 30 Pro Met Leu Gly Leu Ala Ala Phe Arg Trp Ile Trp Ser Arg Glu Ser 35 40 45 Gln Lys Glu Val Glu Lys Glu Arg Glu Ala Tyr Arg Arg Arg Thr Ala 50 55 60 Ala Phe Gln Gln Asp Leu Glu Ala Lys Tyr His Ala Met Ile Ser Glu 65 70 75 80 Asn Arg Arg Ala Val Ala Gln Leu Ser Leu Glu Leu Glu Lys Glu Gln 85 90 95 Asn Arg Thr Ala Ser Tyr Arg Glu Ala Leu Ile Ser Gln Gly Arg Lys 100 105 110 Leu Val Glu Glu Lys Lys Leu Leu Glu Gln Glu Arg Ala Gln Val Met 115 120 125 Gln Glu Lys Arg Gln Val Gln Pro Leu Arg Ser Ala Tyr Leu Ser Cys 130 135 140 Leu Gln Arg Glu Glu Asn Trp Gln Arg Arg Ala Arg Leu Leu Leu Lys 145 150 155 160 Glu Phe Glu Ala Val Leu Thr Glu Arg Gln Asn Ile Tyr Cys Ser Leu 165 170 175 Phe Leu Pro Arg Ser Lys Arg Leu Glu Ile Glu Lys Ser Leu Leu Val 180 185 190 Arg Ala Ser Val Asp Pro Val Ala Ala Asp Leu Glu Met Ala Ala Gly 195 200 205 Leu Thr Asp Ile Phe Gln His Asp Thr Tyr Cys Gly Asp Val Trp Asn 210 215 220 Thr Asn Lys Arg Gln Asn Gly Arg Leu Met Trp Leu Tyr Leu Lys Tyr 225 230 235 240 Trp Glu Leu Val Val Glu Leu Lys Lys Phe Lys Arg Val Glu Glu Ala 245 250 255 Ile Leu Glu Lys 260 <210> SEQ ID NO 89 <211> LENGTH: 1119 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (152)..(976) <400> SEQUENCE: 89 ttagctgctc aagctggaga actgtcttcc ttcccagctt cctccgtgtc tggggtgggg 60 gatggggggg tctcaggcag ggatactcta gccccttgac tgctgtttag accctgctgt 120 agctgctgct gctccctgcc cagccccagc c atg aaa ctg ccc aag ggg acc 172 Met Lys Leu Pro Lys Gly Thr 1 5 agg agc tct gtg tac ttt gca cag cac cca gaa aag gag cca ttg ccc 220 Arg Ser Ser Val Tyr Phe Ala Gln His Pro Glu Lys Glu Pro Leu Pro 10 15 20 tca agg cag gag gtc aag cag acc cct gtc atc atg gcc aag atc aaa 268 Ser Arg Gln Glu Val Lys Gln Thr Pro Val Ile Met Ala Lys Ile Lys 25 30 35 ggt ccg ggg ccc gcc aag tac ctc cgg cca tcc tgc acg ggc tac ata 316 Gly Pro Gly Pro Ala Lys Tyr Leu Arg Pro Ser Cys Thr Gly Tyr Ile 40 45 50 55 gat cat gac atc tcc atg ttc aag gca cca gct tat acc ctg cat agc 364 Asp His Asp Ile Ser Met Phe Lys Ala Pro Ala Tyr Thr Leu His Ser 60 65 70 cgg cac tca gag aag cgg atg gtg tgc cac agc agc cct ggg cct tgc 412 Arg His Ser Glu Lys Arg Met Val Cys His Ser Ser Pro Gly Pro Cys 75 80 85 tat ctc ttg gat ccc aaa ata act cgg ttt gga atg tcc agc tgc ccg 460 Tyr Leu Leu Asp Pro Lys Ile Thr Arg Phe Gly Met Ser Ser Cys Pro 90 95 100 cag gtc ccc atg gag gag cgc atc tcc aac ctg cgc ctg aac ccc acc 508 Gln Val Pro Met Glu Glu Arg Ile Ser Asn Leu Arg Leu Asn Pro Thr 105 110 115 ctc gca tcc tgc cag tac tac ttt gag aag atc cac cca ccg ggg gaa 556 Leu Ala Ser Cys Gln Tyr Tyr Phe Glu Lys Ile His Pro Pro Gly Glu 120 125 130 135 cgc agg gct ccc cag tac acg ttt ggc tac cgg cgc cca tac aga gtg 604 Arg Arg Ala Pro Gln Tyr Thr Phe Gly Tyr Arg Arg Pro Tyr Arg Val 140 145 150 atg gac ctc aac ccg gct ccc aac cag tac cag atg cca ctc ttg ctg 652 Met Asp Leu Asn Pro Ala Pro Asn Gln Tyr Gln Met Pro Leu Leu Leu 155 160 165 ggg ccc aac acc cct gtc agc cga gct gct ccc tgc tac agt ctg gcc 700 Gly Pro Asn Thr Pro Val Ser Arg Ala Ala Pro Cys Tyr Ser Leu Ala 170 175 180 tcc agg gac aag aac tgg ttc tac aag gag gat gtg gca gga ggc cct 748 Ser Arg Asp Lys Asn Trp Phe Tyr Lys Glu Asp Val Ala Gly Gly Pro 185 190 195 gga cct acc acg tac gcc cga cct gag cca tcc atc tat cag aac cgc 796 Gly Pro Thr Thr Tyr Ala Arg Pro Glu Pro Ser Ile Tyr Gln Asn Arg 200 205 210 215 agc cct act tac agc atg gcc aag cgc ttc gcc tac cct ctg gac ctc 844 Ser Pro Thr Tyr Ser Met Ala Lys Arg Phe Ala Tyr Pro Leu Asp Leu 220 225 230 acg cca cgg cct ggc ccc ggc tcc cac gag gtc cag cag gtc act gtg 892 Thr Pro Arg Pro Gly Pro Gly Ser His Glu Val Gln Gln Val Thr Val 235 240 245 cac aag ccc cac atc cct gct ttc acc atg ggc atc aag cac tca ctc 940 His Lys Pro His Ile Pro Ala Phe Thr Met Gly Ile Lys His Ser Leu 250 255 260 cac ctg tgc cca ctg gtc atc gac att cgt gac tga ggcccctctt 986 His Leu Cys Pro Leu Val Ile Asp Ile Arg Asp 265 270 ggggcactca ctgcccctca tccccagaaa ttatttttct acaccaaatt gagcaatttg 1046 accaagattt ctagtagcag agccggtacc tgctgagtgt ccggcacaca gaagacatta 1106 gagatacatt ttc 1119 <210> SEQ ID NO 90 <211> LENGTH: 274 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 90 Met Lys Leu Pro Lys Gly Thr Arg Ser Ser Val Tyr Phe Ala Gln His 1 5 10 15 Pro Glu Lys Glu Pro Leu Pro Ser Arg Gln Glu Val Lys Gln Thr Pro 20 25 30 Val Ile Met Ala Lys Ile Lys Gly Pro Gly Pro Ala Lys Tyr Leu Arg 35 40 45 Pro Ser Cys Thr Gly Tyr Ile Asp His Asp Ile Ser Met Phe Lys Ala 50 55 60 Pro Ala Tyr Thr Leu His Ser Arg His Ser Glu Lys Arg Met Val Cys 65 70 75 80 His Ser Ser Pro Gly Pro Cys Tyr Leu Leu Asp Pro Lys Ile Thr Arg 85 90 95 Phe Gly Met Ser Ser Cys Pro Gln Val Pro Met Glu Glu Arg Ile Ser 100 105 110 Asn Leu Arg Leu Asn Pro Thr Leu Ala Ser Cys Gln Tyr Tyr Phe Glu 115 120 125 Lys Ile His Pro Pro Gly Glu Arg Arg Ala Pro Gln Tyr Thr Phe Gly 130 135 140 Tyr Arg Arg Pro Tyr Arg Val Met Asp Leu Asn Pro Ala Pro Asn Gln 145 150 155 160 Tyr Gln Met Pro Leu Leu Leu Gly Pro Asn Thr Pro Val Ser Arg Ala 165 170 175 Ala Pro Cys Tyr Ser Leu Ala Ser Arg Asp Lys Asn Trp Phe Tyr Lys 180 185 190 Glu Asp Val Ala Gly Gly Pro Gly Pro Thr Thr Tyr Ala Arg Pro Glu 195 200 205 Pro Ser Ile Tyr Gln Asn Arg Ser Pro Thr Tyr Ser Met Ala Lys Arg 210 215 220 Phe Ala Tyr Pro Leu Asp Leu Thr Pro Arg Pro Gly Pro Gly Ser His 225 230 235 240 Glu Val Gln Gln Val Thr Val His Lys Pro His Ile Pro Ala Phe Thr 245 250 255 Met Gly Ile Lys His Ser Leu His Leu Cys Pro Leu Val Ile Asp Ile 260 265 270 Arg Asp <210> SEQ ID NO 91 <211> LENGTH: 540 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (133)..(438) <400> SEQUENCE: 91 ctagctttct gtgtgcttag gtgcccgagc tactgagggt ctaagtccgg gcagccgaag 60 agtgtggtag gtaacggtcc tcagcgcaag ggtcatttcg tcgctgggaa gggacggccc 120 tcgcccgcgg tg atg gtg gtt agc aag atg aac aaa gat gcg cag atg aga 171 Met Val Val Ser Lys Met Asn Lys Asp Ala Gln Met Arg 1 5 10 gca gcg att aac caa aag ttg ata gaa act gga gaa aga gaa cgc ctc 219 Ala Ala Ile Asn Gln Lys Leu Ile Glu Thr Gly Glu Arg Glu Arg Leu 15 20 25 aaa gag ttg ctg aga gct aaa tta att gaa tgt ggc tgg aag gat cag 267 Lys Glu Leu Leu Arg Ala Lys Leu Ile Glu Cys Gly Trp Lys Asp Gln 30 35 40 45 ttg aag gca cac tgt aaa gag gta att aaa gaa aaa gga cta gaa cac 315 Leu Lys Ala His Cys Lys Glu Val Ile Lys Glu Lys Gly Leu Glu His 50 55 60 gtt act gtt gat gac ttg gtg gct gaa atc act cca aaa ggc aga gcc 363 Val Thr Val Asp Asp Leu Val Ala Glu Ile Thr Pro Lys Gly Arg Ala 65 70 75 ctg gta cct gac agt gta aag aag gag ctc cta caa aga ata aga aca 411 Leu Val Pro Asp Ser Val Lys Lys Glu Leu Leu Gln Arg Ile Arg Thr 80 85 90 ttc ctt gct cag cat gcc agc ctt taa gattgaatta gattgtgttg 458 Phe Leu Ala Gln His Ala Ser Leu 95 100 ttgtggtttt atttctgaaa gtaaaacttg ccataaatta gaaaacaatt tcccaaaata 518 aaatcctttt ttgtatgatg gt 540 <210> SEQ ID NO 92 <211> LENGTH: 101 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 92 Met Val Val Ser Lys Met Asn Lys Asp Ala Gln Met Arg Ala Ala Ile 1 5 10 15 Asn Gln Lys Leu Ile Glu Thr Gly Glu Arg Glu Arg Leu Lys Glu Leu 20 25 30 Leu Arg Ala Lys Leu Ile Glu Cys Gly Trp Lys Asp Gln Leu Lys Ala 35 40 45 His Cys Lys Glu Val Ile Lys Glu Lys Gly Leu Glu His Val Thr Val 50 55 60 Asp Asp Leu Val Ala Glu Ile Thr Pro Lys Gly Arg Ala Leu Val Pro 65 70 75 80 Asp Ser Val Lys Lys Glu Leu Leu Gln Arg Ile Arg Thr Phe Leu Ala 85 90 95 Gln His Ala Ser Leu 100 <210> SEQ ID NO 93 <211> LENGTH: 1059 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (33)..(869) <400> SEQUENCE: 93 gagttcctag taaagtggcg ggagccgcag ct atg gag ccg cag gag gag aga 53 Met Glu Pro Gln Glu Glu Arg 1 5 gaa acg cag gtt gct gcg tgg tta aaa aaa ata ttt gga gat cat cct 101 Glu Thr Gln Val Ala Ala Trp Leu Lys Lys Ile Phe Gly Asp His Pro 10 15 20 att cca cag tat gag gtg aac cca cgg acc aca gag att tta cat cac 149 Ile Pro Gln Tyr Glu Val Asn Pro Arg Thr Thr Glu Ile Leu His His 25 30 35 ctt tca gaa cgc aac agg gtc cgg gac agg gat gtc tac ctg gta ata 197 Leu Ser Glu Arg Asn Arg Val Arg Asp Arg Asp Val Tyr Leu Val Ile 40 45 50 55 gag gac ttg aag cag aaa gca agt gaa tac gag tca gaa gcc aag tat 245 Glu Asp Leu Lys Gln Lys Ala Ser Glu Tyr Glu Ser Glu Ala Lys Tyr 60 65 70 ctt caa gac ctt ctc atg gag agt gtg aat ttt tcc ccc gcc aat ctc 293 Leu Gln Asp Leu Leu Met Glu Ser Val Asn Phe Ser Pro Ala Asn Leu 75 80 85 tct agc act ggt tcc agg tat ctg aat gct ttg gtt gac agt gcg gtg 341 Ser Ser Thr Gly Ser Arg Tyr Leu Asn Ala Leu Val Asp Ser Ala Val 90 95 100 gcc ctt gaa aca aag gat acc tcg cta gct agt ttt atc cct gca gtg 389 Ala Leu Glu Thr Lys Asp Thr Ser Leu Ala Ser Phe Ile Pro Ala Val 105 110 115 aat gat ttg acc tct gat ctc ttt cgt acc aaa tcc aaa agt gaa gaa 437 Asn Asp Leu Thr Ser Asp Leu Phe Arg Thr Lys Ser Lys Ser Glu Glu 120 125 130 135 atc aag att gaa ctg gaa aaa ctt gaa aaa aat tta act gca act tta 485 Ile Lys Ile Glu Leu Glu Lys Leu Glu Lys Asn Leu Thr Ala Thr Leu 140 145 150 gta tta gaa aaa tgt cta caa gag gat gtc aag aaa gca gag ttg cat 533 Val Leu Glu Lys Cys Leu Gln Glu Asp Val Lys Lys Ala Glu Leu His 155 160 165 ctg tct aca gaa agg gcc aaa gtt gat aat cgt cgt cag aac atg gac 581 Leu Ser Thr Glu Arg Ala Lys Val Asp Asn Arg Arg Gln Asn Met Asp 170 175 180 ttt cta aaa gca aag tca gag gaa ttc aga ttt gga atc aag gct gca 629 Phe Leu Lys Ala Lys Ser Glu Glu Phe Arg Phe Gly Ile Lys Ala Ala 185 190 195 gag gag caa ctt tca gcc aga ggc atg gat gct tct ctg tct cat cag 677 Glu Glu Gln Leu Ser Ala Arg Gly Met Asp Ala Ser Leu Ser His Gln 200 205 210 215 tcc tta gta gca cta tca gag aaa ctg gca aga tta aag caa cag act 725 Ser Leu Val Ala Leu Ser Glu Lys Leu Ala Arg Leu Lys Gln Gln Thr 220 225 230 ata cct ttg aag aaa aaa ttg gag tcc tat tta gac tta atg ccg aat 773 Ile Pro Leu Lys Lys Lys Leu Glu Ser Tyr Leu Asp Leu Met Pro Asn 235 240 245 ccg tct ctt gct caa gtg aaa att gaa gaa gca aag cga gaa cta gat 821 Pro Ser Leu Ala Gln Val Lys Ile Glu Glu Ala Lys Arg Glu Leu Asp 250 255 260 agc att gaa gct gaa ctt aca aga aga gta gac atg atg gaa ctg tga 869 Ser Ile Glu Ala Glu Leu Thr Arg Arg Val Asp Met Met Glu Leu 265 270 275 caaaagccaa ataaacatcc ttttccctaa caaagtaaat tgaataggac tttacagagt 929 tctttttcct cttggcattt cctaataaca aaactttctg tgttcttaga ttacagaata 989 tcataattga tagaatatgg tttcttactg tgtgttgcat ttttgtgccc aaatacatag 1049 ttttcatatt 1059 <210> SEQ ID NO 94 <211> LENGTH: 278 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 94 Met Glu Pro Gln Glu Glu Arg Glu Thr Gln Val Ala Ala Trp Leu Lys 1 5 10 15 Lys Ile Phe Gly Asp His Pro Ile Pro Gln Tyr Glu Val Asn Pro Arg 20 25 30 Thr Thr Glu Ile Leu His His Leu Ser Glu Arg Asn Arg Val Arg Asp 35 40 45 Arg Asp Val Tyr Leu Val Ile Glu Asp Leu Lys Gln Lys Ala Ser Glu 50 55 60 Tyr Glu Ser Glu Ala Lys Tyr Leu Gln Asp Leu Leu Met Glu Ser Val 65 70 75 80 Asn Phe Ser Pro Ala Asn Leu Ser Ser Thr Gly Ser Arg Tyr Leu Asn 85 90 95 Ala Leu Val Asp Ser Ala Val Ala Leu Glu Thr Lys Asp Thr Ser Leu 100 105 110 Ala Ser Phe Ile Pro Ala Val Asn Asp Leu Thr Ser Asp Leu Phe Arg 115 120 125 Thr Lys Ser Lys Ser Glu Glu Ile Lys Ile Glu Leu Glu Lys Leu Glu 130 135 140 Lys Asn Leu Thr Ala Thr Leu Val Leu Glu Lys Cys Leu Gln Glu Asp 145 150 155 160 Val Lys Lys Ala Glu Leu His Leu Ser Thr Glu Arg Ala Lys Val Asp 165 170 175 Asn Arg Arg Gln Asn Met Asp Phe Leu Lys Ala Lys Ser Glu Glu Phe 180 185 190 Arg Phe Gly Ile Lys Ala Ala Glu Glu Gln Leu Ser Ala Arg Gly Met 195 200 205 Asp Ala Ser Leu Ser His Gln Ser Leu Val Ala Leu Ser Glu Lys Leu 210 215 220 Ala Arg Leu Lys Gln Gln Thr Ile Pro Leu Lys Lys Lys Leu Glu Ser 225 230 235 240 Tyr Leu Asp Leu Met Pro Asn Pro Ser Leu Ala Gln Val Lys Ile Glu 245 250 255 Glu Ala Lys Arg Glu Leu Asp Ser Ile Glu Ala Glu Leu Thr Arg Arg 260 265 270 Val Asp Met Met Glu Leu 275 <210> SEQ ID NO 95 <211> LENGTH: 782 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (103)..(384) <400> SEQUENCE: 95 ggaaggaaac cgctcccgag cacggcggcg gcgtcgtctc ccggcagtgc agctgccgct 60 accgccgccc tctgcccgcc ggcccgtctg tctaccccca gc atg agc ggc ctg 114 Met Ser Gly Leu 1 cgc gtc tac agc acg tcg gtc acc ggc tcc cgc gaa atc aag tcc cag 162 Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu Ile Lys Ser Gln 5 10 15 20 cag agc gag gtg acc cga atc ctg gat ggg aag cgc atc caa tac cag 210 Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg Ile Gln Tyr Gln 25 30 35 cta gtg gac atc tcc cag gac aac gcc ctg agg gat gag atg cga gcc 258 Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp Glu Met Arg Ala 40 45 50 ttg gca ggc aac ccc aag gcc acc cca ccc cag att gtc aac ggg gac 306 Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile Val Asn Gly Asp 55 60 65 cag tac tgt ggg gac tat gag ctc ttc gtg gag gct gtg gaa caa aac 354 Gln Tyr Cys Gly Asp Tyr Glu Leu Phe Val Glu Ala Val Glu Gln Asn 70 75 80 acg ctg cag gag ttc ctg aag ctg gct tga gtcaagcctg tccagagttc 404 Thr Leu Gln Glu Phe Leu Lys Leu Ala 85 90 ccctgctgga ctccatcacc acactccccc cagccttcac ctggccatga aggacctttt 464 gaccaactcc ctgtcattcc taacctaacc ttagagtccc tcccccaatg caggccactt 524 ctcctccctc ctctctaaat gtagtcccct ctcctccatc taaaggcaac attccttacc 584 cattagtctc agaaattgtc ttaagcaaca gccccaaatg ctggctgccc ccagccaagc 644 attggggccg ccatcctgcc tggcactggc tgatgggcac ctctgttggt tccatcagcc 704 agagctctgc caaaggcccc gcagtccctc tcccaggagg accctagagg caattaaatg 764 atgtcctgtt ccattggc 782 <210> SEQ ID NO 96 <211> LENGTH: 93 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 96 Met Ser Gly Leu Arg Val Tyr Ser Thr Ser Val Thr Gly Ser Arg Glu 1 5 10 15 Ile Lys Ser Gln Gln Ser Glu Val Thr Arg Ile Leu Asp Gly Lys Arg 20 25 30 Ile Gln Tyr Gln Leu Val Asp Ile Ser Gln Asp Asn Ala Leu Arg Asp 35 40 45 Glu Met Arg Ala Leu Ala Gly Asn Pro Lys Ala Thr Pro Pro Gln Ile 50 55 60 Val Asn Gly Asp Gln Tyr Cys Gly Asp Tyr Glu Leu Phe Val Glu Ala 65 70 75 80 Val Glu Gln Asn Thr Leu Gln Glu Phe Leu Lys Leu Ala 85 90 <210> SEQ ID NO 97 <211> LENGTH: 417 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (22)..(195) <400> SEQUENCE: 97 ctagagcgcc gcggccccga g atg aag ccg gcg gtg gac gag atg ttc ccc 51 Met Lys Pro Ala Val Asp Glu Met Phe Pro 1 5 10 gag ggc gcc ggg ccc tac gtg gac ctg gac gag gcg gga ggc agc acc 99 Glu Gly Ala Gly Pro Tyr Val Asp Leu Asp Glu Ala Gly Gly Ser Thr 15 20 25 ggg ctc ttg atg gac ttg gca gcc aat gaa aag gcc gtt cat gca gac 147 Gly Leu Leu Met Asp Leu Ala Ala Asn Glu Lys Ala Val His Ala Asp 30 35 40 ttt ttt aac gat ttt gaa gat ctt ttt gat gat gat gac atc cag tga 195 Phe Phe Asn Asp Phe Glu Asp Leu Phe Asp Asp Asp Asp Ile Gln 45 50 55 gatgccctct ggctgcaggc ggggccaagc ccttggtaca gagccgcagt gtgagcctgc 255 gcaggacagt ttcaggtggt tttaaagaac acgtggaaat cccttgaatt taggacctgg 315 ttaaccagaa agataagact gttcttaacg acctagatga ttctgttcat ctctgaacgg 375 gatcaggttt tgtcctcact ccaattaaaa gaaagcaatg tc 417 <210> SEQ ID NO 98 <211> LENGTH: 57 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 98 Met Lys Pro Ala Val Asp Glu Met Phe Pro Glu Gly Ala Gly Pro Tyr 1 5 10 15 Val Asp Leu Asp Glu Ala Gly Gly Ser Thr Gly Leu Leu Met Asp Leu 20 25 30 Ala Ala Asn Glu Lys Ala Val His Ala Asp Phe Phe Asn Asp Phe Glu 35 40 45 Asp Leu Phe Asp Asp Asp Asp Ile Gln 50 55 <210> SEQ ID NO 99 <211> LENGTH: 697 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (65)..(412) <400> SEQUENCE: 99 aagacatttc ctgctcggaa ccttgtttac taatttccac tgcttttaag gccctgcact 60 gaaa atg caa gct cag gcg ccg gtg gtc gtt gtg acc caa cct gga gtc 109 Met Gln Ala Gln Ala Pro Val Val Val Val Thr Gln Pro Gly Val 1 5 10 15 ggt ccc ggt ccg gcc ccc cag aac tcc aac tgg cag aca ggc atg tgt 157 Gly Pro Gly Pro Ala Pro Gln Asn Ser Asn Trp Gln Thr Gly Met Cys 20 25 30 gac tgt ttc agc gac tgc gga gtc tgt ctc tgt ggc aca ttt tgt ttc 205 Asp Cys Phe Ser Asp Cys Gly Val Cys Leu Cys Gly Thr Phe Cys Phe 35 40 45 ccg tgc ctt ggg tgt caa gtt gca gct gat atg aat gaa tgc tgt ctg 253 Pro Cys Leu Gly Cys Gln Val Ala Ala Asp Met Asn Glu Cys Cys Leu 50 55 60 tgt gga aca agc gtc gca atg agg act ctc tac agg acc cga tat ggc 301 Cys Gly Thr Ser Val Ala Met Arg Thr Leu Tyr Arg Thr Arg Tyr Gly 65 70 75 atc cct gga tct att tgt gat gac tat atg gca act ctt tgc tgt cct 349 Ile Pro Gly Ser Ile Cys Asp Asp Tyr Met Ala Thr Leu Cys Cys Pro 80 85 90 95 cat tgt act ctt tgc caa atc aag aga gat atc aac aga agg aga gcc 397 His Cys Thr Leu Cys Gln Ile Lys Arg Asp Ile Asn Arg Arg Arg Ala 100 105 110 atg cgt act ttc taa aaactgatgg tgaaaagctc ttaccgaagc aacaaaattc 452 Met Arg Thr Phe 115 agcagacacc tcttcagctt gagttcttca ccatcttttg caactgaaat atgatggata 512 tgcttaagta caactgatgg catgaaaaaa atcaaatttt tgatttatta taaatgaatg 572 ttgtccctga acttagctaa atggtgcaac ttagtttctc cttgctttca tattatcgaa 632 tttcctggct tataaacttt ttaaattaca tttgaaatat aaaccaaatg aaatatttta 692 ctgat 697 <210> SEQ ID NO 100 <211> LENGTH: 115 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 100 Met Gln Ala Gln Ala Pro Val Val Val Val Thr Gln Pro Gly Val Gly 1 5 10 15 Pro Gly Pro Ala Pro Gln Asn Ser Asn Trp Gln Thr Gly Met Cys Asp 20 25 30 Cys Phe Ser Asp Cys Gly Val Cys Leu Cys Gly Thr Phe Cys Phe Pro 35 40 45 Cys Leu Gly Cys Gln Val Ala Ala Asp Met Asn Glu Cys Cys Leu Cys 50 55 60 Gly Thr Ser Val Ala Met Arg Thr Leu Tyr Arg Thr Arg Tyr Gly Ile 65 70 75 80 Pro Gly Ser Ile Cys Asp Asp Tyr Met Ala Thr Leu Cys Cys Pro His 85 90 95 Cys Thr Leu Cys Gln Ile Lys Arg Asp Ile Asn Arg Arg Arg Ala Met 100 105 110 Arg Thr Phe 115 <210> SEQ ID NO 101 <211> LENGTH: 1504 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (462)..(794) <400> SEQUENCE: 101 tccgtctgtt ggggggcgaa cacgccgcgg tcctcgtcgt ggtgagcgca gccactcagg 60 ctggtcctgg gggtggggct gtaggggaaa gtgctaaagc cgctgaggtg cagtggctca 120 cgcctgtaat cccagcactt tgggaggcca aggcaggtgg atcacctgag gtcgggagtt 180 caagaccagc ctgaccaaca tggagaaacc ccatctctac tagaaataca aaattagcca 240 ggcatggtgg tgcatgcctg taatcccagc tactcgggag gctgaagcag gagaatcgct 300 taaatccggg aggcggaggt tgctgtgagc cgagatcgcg ccatttccag cctgggcaac 360 aagagggaaa ctccgtctca aaaaaaaaaa aaaaaaaaga agagaaaaga aaacataagt 420 ttcagccagg catgtgaagt aagaactctg ctagagagga a atg gct gct tca tca 476 Met Ala Ala Ser Ser 1 5 tca tcc tcc tca gct ggt ggg gtc agt gga agt tct gtc act gga tct 524 Ser Ser Ser Ser Ala Gly Gly Val Ser Gly Ser Ser Val Thr Gly Ser 10 15 20 ggt ttc agt gtc tca gac ctt gcc cca cca cgg aaa gcc ctt ttc acc 572 Gly Phe Ser Val Ser Asp Leu Ala Pro Pro Arg Lys Ala Leu Phe Thr 25 30 35 tac ccc aaa gga gct gga gag atg tta gaa gat ggc tct gag aga ttc 620 Tyr Pro Lys Gly Ala Gly Glu Met Leu Glu Asp Gly Ser Glu Arg Phe 40 45 50 ctc tgc gaa tct gtt ttt agc tat caa gtg gca tcc acg ctt aaa cag 668 Leu Cys Glu Ser Val Phe Ser Tyr Gln Val Ala Ser Thr Leu Lys Gln 55 60 65 gtg aaa cat gat cag caa gtt gct cgg atg gaa aaa cta gct ggt ttg 716 Val Lys His Asp Gln Gln Val Ala Arg Met Glu Lys Leu Ala Gly Leu 70 75 80 85 gta gaa gag ctg gag gct gac gag tgg cgg ttt aag ccc atc gag cag 764 Val Glu Glu Leu Glu Ala Asp Glu Trp Arg Phe Lys Pro Ile Glu Gln 90 95 100 ctg ctg gga ttc acc ccc tct tca ggt tga tactgcctgg atggtcacct 814 Leu Leu Gly Phe Thr Pro Ser Ser Gly 105 110 ctggtgcgca gcaagtgcaa agccagtggg ggactttctc acagcttaca tagccatcca 874 gagatccaca gctacgtcac tgaattgtta atgcacattt gtacttggtt tctctgtatc 934 tattcacagg caacaaatac ttatatgtgt gatctttcag ggaatgtttt gtttatttgt 994 ttttaaaagt attgggaatc agattaagac aatcagtttc agagaaccag gaggtttggg 1054 gttaagagat actcaaaaat tttcacaagc caagtagggc atatatcaga tttggccaac 1114 tgaatggcgt ctgtcctgtc atccatatgg tgcctggaaa tatttaccag tcaaggtcaa 1174 ggtcagcatc tgtggttaaa aatatagcat tctgacctaa aaaagttatt ttgcagatga 1234 atgtgttttc aactcaggac ctatccaaat gaggaatttt taaatattct tttttttttc 1294 ctatttttag acatcaattc tatagattct gactttttct aacctcttat agacatgcca 1354 aatgctggca aaaagaagtg ctttttggat atggcagcac ttgtaaaaat aaagcagtaa 1414 gcaaaatcct tttaaacaca gaaatcctga gttcttctca ttggtggact caagcaattc 1474 tgtagcaaat aaatcctttg aaagagctcc 1504 <210> SEQ ID NO 102 <211> LENGTH: 110 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 102 Met Ala Ala Ser Ser Ser Ser Ser Ser Ala Gly Gly Val Ser Gly Ser 1 5 10 15 Ser Val Thr Gly Ser Gly Phe Ser Val Ser Asp Leu Ala Pro Pro Arg 20 25 30 Lys Ala Leu Phe Thr Tyr Pro Lys Gly Ala Gly Glu Met Leu Glu Asp 35 40 45 Gly Ser Glu Arg Phe Leu Cys Glu Ser Val Phe Ser Tyr Gln Val Ala 50 55 60 Ser Thr Leu Lys Gln Val Lys His Asp Gln Gln Val Ala Arg Met Glu 65 70 75 80 Lys Leu Ala Gly Leu Val Glu Glu Leu Glu Ala Asp Glu Trp Arg Phe 85 90 95 Lys Pro Ile Glu Gln Leu Leu Gly Phe Thr Pro Ser Ser Gly 100 105 110 <210> SEQ ID NO 103 <211> LENGTH: 1046 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (124)..(525) <400> SEQUENCE: 103 tcgaggacat gatgacgtga ccctgagtgc ctggagccgt ctcctgattg ttcctcattt 60 ctgtttgtct gcttgcactt ctggatcctg actgcccatg ggaggcatca gaccttccct 120 ggg atg tgg tgt ggc tgt gat ggg aac ctg agt gtc cag acc tat tta 168 Met Trp Cys Gly Cys Asp Gly Asn Leu Ser Val Gln Thr Tyr Leu 1 5 10 15 ccg att gct cgt ggt ggg atc cct gcc ttc ctc ctc tgc ttg acc ccg 216 Pro Ile Ala Arg Gly Gly Ile Pro Ala Phe Leu Leu Cys Leu Thr Pro 20 25 30 ggt gtc cac gaa tgg tgt cct gac cct ctt ggg acg ctg aat gcc tgg 264 Gly Val His Glu Trp Cys Pro Asp Pro Leu Gly Thr Leu Asn Ala Trp 35 40 45 agc tgt ctc gtg cct gct cgt ggt gcg atc ctt gtc ttc ctc cag tgc 312 Ser Cys Leu Val Pro Ala Arg Gly Ala Ile Leu Val Phe Leu Gln Cys 50 55 60 tgg tcc cgg tcc gtc cat ggg cag agt cag gct gtt cat gag tgc tca 360 Trp Ser Arg Ser Val His Gly Gln Ser Gln Ala Val His Glu Cys Ser 65 70 75 cct ggt aga ggg aag acc ctg aac gtc cag acc gtt ccc ctg acc ggc 408 Pro Gly Arg Gly Lys Thr Leu Asn Val Gln Thr Val Pro Leu Thr Gly 80 85 90 95 cac gtg tgg act ctt ggt ggc tct gct gtc tca gcc cag cct ttc cgt 456 His Val Trp Thr Leu Gly Gly Ser Ala Val Ser Ala Gln Pro Phe Arg 100 105 110 ggc ctg aca ctg att gtg tgt ctg agt ttt ctg aat gtc cct cac tgt 504 Gly Leu Thr Leu Ile Val Cys Leu Ser Phe Leu Asn Val Pro His Cys 115 120 125 cac tgg cct gac tac cgc tag acccccggtg tccacgatcg ctgactgcag 555 His Trp Pro Asp Tyr Arg 130 atgaagcttg cccgcgccca gtggctgagt gtctggagct gtctgctgac tgctggtggc 615 cggatccatg tctttctcct ggacttgatc ttgcctgttc atgggatgat gcagtctgtc 675 cacgagagga agtctctgcg tgacgagtgc ctgattgtct ggagctgtct gcagagtgcc 735 catgactggc tctgtcttca tcatgggacc tggggtgtct ggagccatct cttgactgct 795 cccacgcaga tccatgatgg tttctggaag ccgacccaga gtgcctctca gagtcttctg 855 agtgtccctc actgtccctg tcctggctaa ctctggatcc cctacgcttt cttgtcctgg 915 actcctgcaa tggtacctgg cttgtatttt catgtcttga cctgttcact tgagatgatg 975 atttgccatc agatgacctt gatctttcat atattttgtt ttcttctaat agactatcag 1035 tggtgtcata g 1046 <210> SEQ ID NO 104 <211> LENGTH: 133 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 104 Met Trp Cys Gly Cys Asp Gly Asn Leu Ser Val Gln Thr Tyr Leu Pro 1 5 10 15 Ile Ala Arg Gly Gly Ile Pro Ala Phe Leu Leu Cys Leu Thr Pro Gly 20 25 30 Val His Glu Trp Cys Pro Asp Pro Leu Gly Thr Leu Asn Ala Trp Ser 35 40 45 Cys Leu Val Pro Ala Arg Gly Ala Ile Leu Val Phe Leu Gln Cys Trp 50 55 60 Ser Arg Ser Val His Gly Gln Ser Gln Ala Val His Glu Cys Ser Pro 65 70 75 80 Gly Arg Gly Lys Thr Leu Asn Val Gln Thr Val Pro Leu Thr Gly His 85 90 95 Val Trp Thr Leu Gly Gly Ser Ala Val Ser Ala Gln Pro Phe Arg Gly 100 105 110 Leu Thr Leu Ile Val Cys Leu Ser Phe Leu Asn Val Pro His Cys His 115 120 125 Trp Pro Asp Tyr Arg 130 <210> SEQ ID NO 105 <211> LENGTH: 341 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (55)..(261) <221> NAME/KEY: residue <222> LOCATION: (9) <223> OTHER INFORMATION: Xaa = selenocysteine <400> SEQUENCE: 105 cttttttttt cggggtcgag tccgaggggg aagaggtttg ttaatacgtt cgcc atg 57 Met 1 tgc tac gat ctt ggg acg aac tga gcc acg agc gtg gct ttg agg gcc 105 Cys Tyr Asp Leu Gly Thr Asn Xaa Ala Thr Ser Val Ala Leu Arg Ala 5 10 15 gtc cga acg ctg cag gcc ggc cag gtc cct ggg cgt cca ggc ctg gcc 153 Val Arg Thr Leu Gln Ala Gly Gln Val Pro Gly Arg Pro Gly Leu Ala 20 25 30 tac gca cca ctt tgt ccc tta gcg ttt aaa ggt ttc ttc ccg aat ctc 201 Tyr Ala Pro Leu Cys Pro Leu Ala Phe Lys Gly Phe Phe Pro Asn Leu 35 40 45 agg ccc tca gct acc tgc agg ttt cgt cgc gag ccg gct gca agt ttt 249 Arg Pro Ser Ala Thr Cys Arg Phe Arg Arg Glu Pro Ala Ala Ser Phe 50 55 60 65 gaa cct aag taa acctcaatcc ggagggccta gcggtaaggt gggcgctgtg 301 Glu Pro Lys tctattgagg tgcttagcaa taaagaaagg tagtgagttg 341 <210> SEQ ID NO 106 <211> LENGTH: 68 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: residue <222> LOCATION: (9) <223> OTHER INFORMATION: Xaa = selenocysteine <400> SEQUENCE: 106 Met Cys Tyr Asp Leu Gly Thr Asn Xaa Ala Thr Ser Val Ala Leu Arg 1 5 10 15 Ala Val Arg Thr Leu Gln Ala Gly Gln Val Pro Gly Arg Pro Gly Leu 20 25 30 Ala Tyr Ala Pro Leu Cys Pro Leu Ala Phe Lys Gly Phe Phe Pro Asn 35 40 45 Leu Arg Pro Ser Ala Thr Cys Arg Phe Arg Arg Glu Pro Ala Ala Ser 50 55 60 Phe Glu Pro Lys 65 <210> SEQ ID NO 107 <211> LENGTH: 1684 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (13)..(1011) <400> SEQUENCE: 107 ttctctcgtg ca atg gcg tcc ggg ctg gta aga ttg ctg cag cag gga cat 51 Met Ala Ser Gly Leu Val Arg Leu Leu Gln Gln Gly His 1 5 10 cgc tgc ctc ctg gct cca gtc gcc ccc aag ctg gtc cct ccg gtt cgg 99 Arg Cys Leu Leu Ala Pro Val Ala Pro Lys Leu Val Pro Pro Val Arg 15 20 25 gga gtg aag aag gga ttc cgc gcc gcc ttc cgc ttc cag aag gag tta 147 Gly Val Lys Lys Gly Phe Arg Ala Ala Phe Arg Phe Gln Lys Glu Leu 30 35 40 45 gag cgg cag cgc ctt ctg cgg tgc ccg ccg ccg ccc gtg cgc cgt tca 195 Glu Arg Gln Arg Leu Leu Arg Cys Pro Pro Pro Pro Val Arg Arg Ser 50 55 60 gag aag ccg aac tgg gat tac cat gca gaa ata caa gct ttt gga cat 243 Glu Lys Pro Asn Trp Asp Tyr His Ala Glu Ile Gln Ala Phe Gly His 65 70 75 cgg tta cag gaa aac ttt tcc tta gat ctt ctc aaa act gca ttt gtt 291 Arg Leu Gln Glu Asn Phe Ser Leu Asp Leu Leu Lys Thr Ala Phe Val 80 85 90 aat agc tgc tat att aaa agt gag gag gcc aaa cgc caa caa ctt ggg 339 Asn Ser Cys Tyr Ile Lys Ser Glu Glu Ala Lys Arg Gln Gln Leu Gly 95 100 105 ata gag aaa gaa gct gtt ctt ctg aat ctt aaa agt aat caa gaa cta 387 Ile Glu Lys Glu Ala Val Leu Leu Asn Leu Lys Ser Asn Gln Glu Leu 110 115 120 125 tcc gaa caa ggg aca tct ttt tca cag act tgc ctt aca cag ttt ctt 435 Ser Glu Gln Gly Thr Ser Phe Ser Gln Thr Cys Leu Thr Gln Phe Leu 130 135 140 gaa gac gag tac cca gac atg ccc act gaa ggc ata aaa aat ctt gtt 483 Glu Asp Glu Tyr Pro Asp Met Pro Thr Glu Gly Ile Lys Asn Leu Val 145 150 155 gac ttt ctc act ggt gag gaa gtc gtg tgt cac gtg gct aga aac ttg 531 Asp Phe Leu Thr Gly Glu Glu Val Val Cys His Val Ala Arg Asn Leu 160 165 170 gct gtg gag cag tta aca ctg agt gaa gaa ttc cca gtg ccc cca gct 579 Ala Val Glu Gln Leu Thr Leu Ser Glu Glu Phe Pro Val Pro Pro Ala 175 180 185 gtg tta cag cag act ttc ttt gca gtt att gga gcc ctg tta cag agc 627 Val Leu Gln Gln Thr Phe Phe Ala Val Ile Gly Ala Leu Leu Gln Ser 190 195 200 205 agt gga cct gag agg act gca ctt ttc atc agg gac ttc tta att act 675 Ser Gly Pro Glu Arg Thr Ala Leu Phe Ile Arg Asp Phe Leu Ile Thr 210 215 220 caa atg act gga aaa gag ctc ttt gag atg tgg aag ata ata aat ccc 723 Gln Met Thr Gly Lys Glu Leu Phe Glu Met Trp Lys Ile Ile Asn Pro 225 230 235 atg ggg cta ttg gta gaa gaa ctg aag aaa agg aat gtt tca gct cct 771 Met Gly Leu Leu Val Glu Glu Leu Lys Lys Arg Asn Val Ser Ala Pro 240 245 250 gaa tca aga ctt act agg cag tct ggt ggc acc aca gct ttg cct ttg 819 Glu Ser Arg Leu Thr Arg Gln Ser Gly Gly Thr Thr Ala Leu Pro Leu 255 260 265 tat ttt gtt ggc tta tac tgt gat aaa aag ttg att gca gaa gga cct 867 Tyr Phe Val Gly Leu Tyr Cys Asp Lys Lys Leu Ile Ala Glu Gly Pro 270 275 280 285 ggg gaa aca gta ttg gtt gca gaa gaa gag gct gct cga gtg gcc ctt 915 Gly Glu Thr Val Leu Val Ala Glu Glu Glu Ala Ala Arg Val Ala Leu 290 295 300 aga aaa ctt tat gga ttc aca gaa aat aga cgg ccg tgg aac tat tcc 963 Arg Lys Leu Tyr Gly Phe Thr Glu Asn Arg Arg Pro Trp Asn Tyr Ser 305 310 315 aag ccc aaa gaa acc ttg aga gca gaa aag agc atc act gcc agc tag 1011 Lys Pro Lys Glu Thr Leu Arg Ala Glu Lys Ser Ile Thr Ala Ser 320 325 330 ccgccatgga tgcagcagcc tgaaacttga gagcgaaagt gagataaatg tcaaaggtgt 1071 ttcaagccag acattttcac aattgtgaag aaatagatgt tttgtttctg ttttttactg 1131 tgttcccaaa attaaataaa tgttaaccaa gtcacagtgt ttttggtttt gtttttctga 1191 aatcttggtt tgatcaaatc tttttttttt tctcttgaga tggagtctta ctctgtcgcc 1251 caggctggac tgcagtggtg cgatctcggc tcactgcaac ctccacctca caggttcaag 1311 cgattctcgt ggctcagcct ccctagtagc tgggattaca ggcacacacc accatacctg 1371 gctaattttt gtatttttgg tagacatggg gtttcaccaa gttggctagg ctagtcttga 1431 actcctgacc tcaggtgatc cacccgcctt ggcctcccaa agtgctggga ttacaggtgt 1491 gagccactat acccgaccag atcaaatctt tttttgacat ttttgcaaaa aaattttcct 1551 aatgttcttg atttaattgt atagaatttg tataattagg tgtattttat ttgcgtctag 1611 ctttgaggta tcataattta tgtatcttat gtgaattttt tgctgtaata ccaataaagt 1671 tttttttctc cac 1684 <210> SEQ ID NO 108 <211> LENGTH: 332 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 108 Met Ala Ser Gly Leu Val Arg Leu Leu Gln Gln Gly His Arg Cys Leu 1 5 10 15 Leu Ala Pro Val Ala Pro Lys Leu Val Pro Pro Val Arg Gly Val Lys 20 25 30 Lys Gly Phe Arg Ala Ala Phe Arg Phe Gln Lys Glu Leu Glu Arg Gln 35 40 45 Arg Leu Leu Arg Cys Pro Pro Pro Pro Val Arg Arg Ser Glu Lys Pro 50 55 60 Asn Trp Asp Tyr His Ala Glu Ile Gln Ala Phe Gly His Arg Leu Gln 65 70 75 80 Glu Asn Phe Ser Leu Asp Leu Leu Lys Thr Ala Phe Val Asn Ser Cys 85 90 95 Tyr Ile Lys Ser Glu Glu Ala Lys Arg Gln Gln Leu Gly Ile Glu Lys 100 105 110 Glu Ala Val Leu Leu Asn Leu Lys Ser Asn Gln Glu Leu Ser Glu Gln 115 120 125 Gly Thr Ser Phe Ser Gln Thr Cys Leu Thr Gln Phe Leu Glu Asp Glu 130 135 140 Tyr Pro Asp Met Pro Thr Glu Gly Ile Lys Asn Leu Val Asp Phe Leu 145 150 155 160 Thr Gly Glu Glu Val Val Cys His Val Ala Arg Asn Leu Ala Val Glu 165 170 175 Gln Leu Thr Leu Ser Glu Glu Phe Pro Val Pro Pro Ala Val Leu Gln 180 185 190 Gln Thr Phe Phe Ala Val Ile Gly Ala Leu Leu Gln Ser Ser Gly Pro 195 200 205 Glu Arg Thr Ala Leu Phe Ile Arg Asp Phe Leu Ile Thr Gln Met Thr 210 215 220 Gly Lys Glu Leu Phe Glu Met Trp Lys Ile Ile Asn Pro Met Gly Leu 225 230 235 240 Leu Val Glu Glu Leu Lys Lys Arg Asn Val Ser Ala Pro Glu Ser Arg 245 250 255 Leu Thr Arg Gln Ser Gly Gly Thr Thr Ala Leu Pro Leu Tyr Phe Val 260 265 270 Gly Leu Tyr Cys Asp Lys Lys Leu Ile Ala Glu Gly Pro Gly Glu Thr 275 280 285 Val Leu Val Ala Glu Glu Glu Ala Ala Arg Val Ala Leu Arg Lys Leu 290 295 300 Tyr Gly Phe Thr Glu Asn Arg Arg Pro Trp Asn Tyr Ser Lys Pro Lys 305 310 315 320 Glu Thr Leu Arg Ala Glu Lys Ser Ile Thr Ala Ser 325 330 <210> SEQ ID NO 109 <211> LENGTH: 727 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (81)..(560) <400> SEQUENCE: 109 aaaagtttgt acgagttcag tggaggagac cgcaagttga gtggaggagg cggcggtggg 60 gccccggacc aggtgcctcc atg gca ggc tct gaa gag ctg ggg ctc cgg gaa 113 Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu 1 5 10 gac acg ctg agg gtc cta gct gcc ttc ctt agg cgt ggt gag gct gcc 161 Asp Thr Leu Arg Val Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala 15 20 25 ggg tct cct gtt cca act cca cct aga agc cct gcc caa gaa gag cca 209 Gly Ser Pro Val Pro Thr Pro Pro Arg Ser Pro Ala Gln Glu Glu Pro 30 35 40 aca gac ttc ctg agc cgc ctt cga aga tgt ctt ccc tgc tcc ctg ggg 257 Thr Asp Phe Leu Ser Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly 45 50 55 cga gga gca gcc ccc tct gag tcc cct cgg cct tgc tct ctg ccc atc 305 Arg Gly Ala Ala Pro Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile 60 65 70 75 cgc ccc tgc tat ggt tta gag cct ggc cca gct act cca gac ttc tat 353 Arg Pro Cys Tyr Gly Leu Glu Pro Gly Pro Ala Thr Pro Asp Phe Tyr 80 85 90 gct ttg gtg gcc cag cgg ctg gaa cag ctg gtc caa gag cag ctg aaa 401 Ala Leu Val Ala Gln Arg Leu Glu Gln Leu Val Gln Glu Gln Leu Lys 95 100 105 tct ccg ccc agc cca gaa tta cag ggt ccc cca tcg aca gag aag gaa 449 Ser Pro Pro Ser Pro Glu Leu Gln Gly Pro Pro Ser Thr Glu Lys Glu 110 115 120 gcc ata ctg cgg agg ctg gtg gcc ctg ctg gag gag gag gca gaa gtc 497 Ala Ile Leu Arg Arg Leu Val Ala Leu Leu Glu Glu Glu Ala Glu Val 125 130 135 att aac cag aag gag ggc atc ctg gct gtt tca ccc gtg gac ttg aac 545 Ile Asn Gln Lys Glu Gly Ile Leu Ala Val Ser Pro Val Asp Leu Asn 140 145 150 155 ttg cca ttg gac tga gctctttctc agaagctgct acaagatgac acctcatgtc 600 Leu Pro Leu Asp cctgccctct tcgtgtgctt ttccaagtct tcctattcca ctcagggctg tggggtggtg 660 gttgccctac ctgtttttgc caaaaataaa ttgtttaaaa cttttcttat taaaaacgtt 720 acaaagt 727 <210> SEQ ID NO 110 <211> LENGTH: 159 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 110 Met Ala Gly Ser Glu Glu Leu Gly Leu Arg Glu Asp Thr Leu Arg Val 1 5 10 15 Leu Ala Ala Phe Leu Arg Arg Gly Glu Ala Ala Gly Ser Pro Val Pro 20 25 30 Thr Pro Pro Arg Ser Pro Ala Gln Glu Glu Pro Thr Asp Phe Leu Ser 35 40 45 Arg Leu Arg Arg Cys Leu Pro Cys Ser Leu Gly Arg Gly Ala Ala Pro 50 55 60 Ser Glu Ser Pro Arg Pro Cys Ser Leu Pro Ile Arg Pro Cys Tyr Gly 65 70 75 80 Leu Glu Pro Gly Pro Ala Thr Pro Asp Phe Tyr Ala Leu Val Ala Gln 85 90 95 Arg Leu Glu Gln Leu Val Gln Glu Gln Leu Lys Ser Pro Pro Ser Pro 100 105 110 Glu Leu Gln Gly Pro Pro Ser Thr Glu Lys Glu Ala Ile Leu Arg Arg 115 120 125 Leu Val Ala Leu Leu Glu Glu Glu Ala Glu Val Ile Asn Gln Lys Glu 130 135 140 Gly Ile Leu Ala Val Ser Pro Val Asp Leu Asn Leu Pro Leu Asp 145 150 155 <210> SEQ ID NO 111 <211> LENGTH: 1354 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (133)..(870) <400> SEQUENCE: 111 acccctcccc ctccccgcgg taccttgcac ttttctccct ccctgccccc tctcgagtcc 60 accctccggg ccttctgccc ctgatcgctt ggttttcctt gcagtcgcct gctgctgtcg 120 tcgggaggaa ag atg aat ggg agg gct gat ttt cga gag ccg aat gca gag 171 Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu 1 5 10 gtt cca aga cca att ccc cac ata ggg cct gat tac att cca aca gag 219 Val Pro Arg Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu 15 20 25 gaa gaa agg aga gtc ttc gca gaa tgc aat gat gaa agc ttc tgg ttc 267 Glu Glu Arg Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe 30 35 40 45 aga tct gtg cct ttg gct gca aca agt atg ttg att act caa gga tta 315 Arg Ser Val Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu 50 55 60 att agt aaa gga ata ctt tca agt cat ccc aaa tat ggt tcc atc cct 363 Ile Ser Lys Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro 65 70 75 aaa ctt ata ctt gct tgt atc atg gga tac ttt gct gga aaa ctt tct 411 Lys Leu Ile Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser 80 85 90 tat gtg aaa act tgc caa gag aaa ttc aag aaa ctt gaa aat tcc ccc 459 Tyr Val Lys Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro 95 100 105 ctt gga gaa gct tta cga tca gga caa gca cga cga tct tca cca cct 507 Leu Gly Glu Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro 110 115 120 125 ggg cac tat tat caa aag tca aaa tat gac tca agt gtg agt ggt caa 555 Gly His Tyr Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln 130 135 140 tca tct ttt gtg aca tcc cca gca gca gac aac ata gaa atg ctt cct 603 Ser Ser Phe Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro 145 150 155 cat tat gag cca att cca ttc agt tct tct atg aat gaa tct gct ccc 651 His Tyr Glu Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro 160 165 170 act ggt att act gat cat att gtc caa gga cct gat ccc aac ctt gaa 699 Thr Gly Ile Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu 175 180 185 gaa agt cct aaa aga aaa aat att aca tat gag gaa tta agg aat aag 747 Glu Ser Pro Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys 190 195 200 205 aac aga gag tca tat gaa gta tct tta aca caa aag act gac ccc tca 795 Asn Arg Glu Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser 210 215 220 gtc agg cct atg cat gaa aga gtg cca aaa aaa gaa gtc aaa gta aac 843 Val Arg Pro Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn 225 230 235 aag tat gga gat act tgg gat gag tga aaaattacat cattggacat 890 Lys Tyr Gly Asp Thr Trp Asp Glu 240 245 gaaggagttt caacatccag cttcatctag gtggtcatga ttacctgcat gctttgagct 950 cagcagcagt cttcataaac acatttaaaa caagatcctg ggtttttgtg gtttgacttc 1010 tatggtgttt taaaaaaaca cagattttta gtgttaatat tgtgtaaatg tactcacctt 1070 agggattcat ttgaatgatg gtattatacc atgattgtat acagtttgtg aaattgttgc 1130 aagggcaaag ataactctta aaaaaccgtc gagattacaa tgctctagaa tcagcatata 1190 agaaaataaa tgatatctgc atgttgaatt ggggtggatg gggggagcaa gcataatttt 1250 taagtgtgaa gctttgcatc aagaaattat taaaaagctt tttttctcca gtattttctg 1310 tattatctta atgtttatgg caaataaaat gtaaaggaac atgc 1354 <210> SEQ ID NO 112 <211> LENGTH: 245 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 112 Met Asn Gly Arg Ala Asp Phe Arg Glu Pro Asn Ala Glu Val Pro Arg 1 5 10 15 Pro Ile Pro His Ile Gly Pro Asp Tyr Ile Pro Thr Glu Glu Glu Arg 20 25 30 Arg Val Phe Ala Glu Cys Asn Asp Glu Ser Phe Trp Phe Arg Ser Val 35 40 45 Pro Leu Ala Ala Thr Ser Met Leu Ile Thr Gln Gly Leu Ile Ser Lys 50 55 60 Gly Ile Leu Ser Ser His Pro Lys Tyr Gly Ser Ile Pro Lys Leu Ile 65 70 75 80 Leu Ala Cys Ile Met Gly Tyr Phe Ala Gly Lys Leu Ser Tyr Val Lys 85 90 95 Thr Cys Gln Glu Lys Phe Lys Lys Leu Glu Asn Ser Pro Leu Gly Glu 100 105 110 Ala Leu Arg Ser Gly Gln Ala Arg Arg Ser Ser Pro Pro Gly His Tyr 115 120 125 Tyr Gln Lys Ser Lys Tyr Asp Ser Ser Val Ser Gly Gln Ser Ser Phe 130 135 140 Val Thr Ser Pro Ala Ala Asp Asn Ile Glu Met Leu Pro His Tyr Glu 145 150 155 160 Pro Ile Pro Phe Ser Ser Ser Met Asn Glu Ser Ala Pro Thr Gly Ile 165 170 175 Thr Asp His Ile Val Gln Gly Pro Asp Pro Asn Leu Glu Glu Ser Pro 180 185 190 Lys Arg Lys Asn Ile Thr Tyr Glu Glu Leu Arg Asn Lys Asn Arg Glu 195 200 205 Ser Tyr Glu Val Ser Leu Thr Gln Lys Thr Asp Pro Ser Val Arg Pro 210 215 220 Met His Glu Arg Val Pro Lys Lys Glu Val Lys Val Asn Lys Tyr Gly 225 230 235 240 Asp Thr Trp Asp Glu 245 <210> SEQ ID NO 113 <211> LENGTH: 653 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (170)..(502) <400> SEQUENCE: 113 cagaagaggt agggcgccgc cgtgacagat tagtcctaaa gggaacgggg ttgttagttc 60 aattggctac cggaaaaaac caggctgggc tgggcgccgc catgacaacc gataccggaa 120 aaggcgggtc gttccccccg gacagcccta cgccggcaaa ggtctcgag atg cag gcg 178 Met Gln Ala 1 gcc cta gag gtc acc gct cgc tac tgt ggc cgg gag ctg gag cag tat 226 Ala Leu Glu Val Thr Ala Arg Tyr Cys Gly Arg Glu Leu Glu Gln Tyr 5 10 15 ggc cag tgt gtg gcg gcc aag ccg gaa tcc tgg cag cgg gac tgt cac 274 Gly Gln Cys Val Ala Ala Lys Pro Glu Ser Trp Gln Arg Asp Cys His 20 25 30 35 tac ctt aag atg agc att gcc cag tgc aca tcc tcc cac cca atc atc 322 Tyr Leu Lys Met Ser Ile Ala Gln Cys Thr Ser Ser His Pro Ile Ile 40 45 50 cgc cag atc cgc cag gcc tgt gct cag cct ttt gag gcc ttc gag gag 370 Arg Gln Ile Arg Gln Ala Cys Ala Gln Pro Phe Glu Ala Phe Glu Glu 55 60 65 tgt ctt cga cag aac gag gca gct gtg ggc aac tgt gca gag cat atg 418 Cys Leu Arg Gln Asn Glu Ala Ala Val Gly Asn Cys Ala Glu His Met 70 75 80 cgc cgc ttc ctg cag tgc gct gag cag gtg cag ccg cca cgc tca cct 466 Arg Arg Phe Leu Gln Cys Ala Glu Gln Val Gln Pro Pro Arg Ser Pro 85 90 95 gca act gtg gag gca cag cca ctt cct gcc tcc tga ggactcctct 512 Ala Thr Val Glu Ala Gln Pro Leu Pro Ala Ser 100 105 110 gacggcagga aaactggaca tgaatgactg cccccccgcc cctcccctgc agagtggcca 572 gatggagtcc tgagccctgg acatgggccc ggctttcctg gatatcagga cttccaataa 632 ataaagactc tgtatactgg g 653 <210> SEQ ID NO 114 <211> LENGTH: 110 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 114 Met Gln Ala Ala Leu Glu Val Thr Ala Arg Tyr Cys Gly Arg Glu Leu 1 5 10 15 Glu Gln Tyr Gly Gln Cys Val Ala Ala Lys Pro Glu Ser Trp Gln Arg 20 25 30 Asp Cys His Tyr Leu Lys Met Ser Ile Ala Gln Cys Thr Ser Ser His 35 40 45 Pro Ile Ile Arg Gln Ile Arg Gln Ala Cys Ala Gln Pro Phe Glu Ala 50 55 60 Phe Glu Glu Cys Leu Arg Gln Asn Glu Ala Ala Val Gly Asn Cys Ala 65 70 75 80 Glu His Met Arg Arg Phe Leu Gln Cys Ala Glu Gln Val Gln Pro Pro 85 90 95 Arg Ser Pro Ala Thr Val Glu Ala Gln Pro Leu Pro Ala Ser 100 105 110 <210> SEQ ID NO 115 <211> LENGTH: 643 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (40)..(411) <400> SEQUENCE: 115 gcggaagtac ggaccgtgaa ctggagtgga atcgcgact atg gga gct ccg ggg 54 Met Gly Ala Pro Gly 1 5 gga aag atc aac cgg ccc cga acg gag ctg aag aag aag ctg ttc aaa 102 Gly Lys Ile Asn Arg Pro Arg Thr Glu Leu Lys Lys Lys Leu Phe Lys 10 15 20 cgc cgg cgg gtg ttg aat cgg gag cgg cgt ctg agg cac cgg gtg gtc 150 Arg Arg Arg Val Leu Asn Arg Glu Arg Arg Leu Arg His Arg Val Val 25 30 35 ggg gct gtg ata gac caa ggg ctg atc acg cgg cac cac ctc aag aag 198 Gly Ala Val Ile Asp Gln Gly Leu Ile Thr Arg His His Leu Lys Lys 40 45 50 cgg gcg tcc agt gca cgt gcc aac att aca ctg tca ggg aag aag cgc 246 Arg Ala Ser Ser Ala Arg Ala Asn Ile Thr Leu Ser Gly Lys Lys Arg 55 60 65 aga aaa ctc ctc cag cag atc cgg ctt gcc cag aaa gag aag aca gcc 294 Arg Lys Leu Leu Gln Gln Ile Arg Leu Ala Gln Lys Glu Lys Thr Ala 70 75 80 85 atg gaa gtg gaa gcc cct tca aag cca gcc agg act agt gaa cca cag 342 Met Glu Val Glu Ala Pro Ser Lys Pro Ala Arg Thr Ser Glu Pro Gln 90 95 100 ctc aaa agg caa aag aag aca aaa gcc ccc cag gat gta gaa atg aag 390 Leu Lys Arg Gln Lys Lys Thr Lys Ala Pro Gln Asp Val Glu Met Lys 105 110 115 gac ctt gaa gat gag agc taa acctcttcca ctagaagatt ctcaactgga 441 Asp Leu Glu Asp Glu Ser 120 gccagccttc agactcagtg gttgtttcag aggactttga caaaagcaag gccccttttc 501 actctccaga tttcctccta cctaatggcc tactgacctc ccctagaggg atgtctttgg 561 gagggaagaa ggtacagaag aaagattgga gaagggtctc tctagcagtc aactccattt 621 gtaataaagc cctagcactc tg 643 <210> SEQ ID NO 116 <211> LENGTH: 123 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 116 Met Gly Ala Pro Gly Gly Lys Ile Asn Arg Pro Arg Thr Glu Leu Lys 1 5 10 15 Lys Lys Leu Phe Lys Arg Arg Arg Val Leu Asn Arg Glu Arg Arg Leu 20 25 30 Arg His Arg Val Val Gly Ala Val Ile Asp Gln Gly Leu Ile Thr Arg 35 40 45 His His Leu Lys Lys Arg Ala Ser Ser Ala Arg Ala Asn Ile Thr Leu 50 55 60 Ser Gly Lys Lys Arg Arg Lys Leu Leu Gln Gln Ile Arg Leu Ala Gln 65 70 75 80 Lys Glu Lys Thr Ala Met Glu Val Glu Ala Pro Ser Lys Pro Ala Arg 85 90 95 Thr Ser Glu Pro Gln Leu Lys Arg Gln Lys Lys Thr Lys Ala Pro Gln 100 105 110 Asp Val Glu Met Lys Asp Leu Glu Asp Glu Ser 115 120 <210> SEQ ID NO 117 <211> LENGTH: 1293 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (306)..(1019) <400> SEQUENCE: 117 gttaggctga gcctcttgct tgctgtgact ggtggagctg ccgcgctgtc cgcgttatct 60 cctcccggtg agaacgaacc gcagtgtcca ccggcgagga gccagccctg tcccggtcag 120 agaaagacga cgaggatacc tgggagcggg cggcggccgg gctgggccgc gccggtgcgg 180 gctggcgact ctgctcctcc gcttgctgct gtctctggga actgggtgcc agcgctgagg 240 ggcttccagc ggacagggac ccccttcccc ggctcccctg cccaccctgc cggggagggc 300 ggaag atg ccg gtg aag aag aag aga aaa tcc cct ggg gtg gca gca gca 350 Met Pro Val Lys Lys Lys Arg Lys Ser Pro Gly Val Ala Ala Ala 1 5 10 15 gta gcg gaa gac gga ggc ctc aaa aag tgt aaa atc tcc agc tat tgc 398 Val Ala Glu Asp Gly Gly Leu Lys Lys Cys Lys Ile Ser Ser Tyr Cys 20 25 30 aga tcc caa ccc cct gct aga cta ata agt gga gag gaa cat ttt tca 446 Arg Ser Gln Pro Pro Ala Arg Leu Ile Ser Gly Glu Glu His Phe Ser 35 40 45 agc aag aag tgc ctg gct tgg ttt tat gaa tat gca ggt cct gat gaa 494 Ser Lys Lys Cys Leu Ala Trp Phe Tyr Glu Tyr Ala Gly Pro Asp Glu 50 55 60 gtt gta ggg cca gaa gga atg gaa aaa ttt tgt gaa gac att ggt gtt 542 Val Val Gly Pro Glu Gly Met Glu Lys Phe Cys Glu Asp Ile Gly Val 65 70 75 gaa cct gaa aat att att atg tta gtt tta gcg tgg aaa ttg gag gct 590 Glu Pro Glu Asn Ile Ile Met Leu Val Leu Ala Trp Lys Leu Glu Ala 80 85 90 95 gaa agc atg gga ttt ttt acc aag gaa gaa tgg tta aag gga atg act 638 Glu Ser Met Gly Phe Phe Thr Lys Glu Glu Trp Leu Lys Gly Met Thr 100 105 110 tca tta cag tgt gac tgc aca gaa aag tta caa aac aaa ttt gac ttt 686 Ser Leu Gln Cys Asp Cys Thr Glu Lys Leu Gln Asn Lys Phe Asp Phe 115 120 125 ttg cgc tca cag ttg aat gat att tcg tca ttt aag aat atc tac aga 734 Leu Arg Ser Gln Leu Asn Asp Ile Ser Ser Phe Lys Asn Ile Tyr Arg 130 135 140 tat gcc ttt gat ttt gca agg gat aaa gat cag aga agc ctt gat att 782 Tyr Ala Phe Asp Phe Ala Arg Asp Lys Asp Gln Arg Ser Leu Asp Ile 145 150 155 gat act gct aaa tct atg tta gct ctt ctg ctt ggg agg aca tgg cca 830 Asp Thr Ala Lys Ser Met Leu Ala Leu Leu Leu Gly Arg Thr Trp Pro 160 165 170 175 ctg ttt tca gta ttt tac cag tac ctg gag caa tca aag tat cgt gtt 878 Leu Phe Ser Val Phe Tyr Gln Tyr Leu Glu Gln Ser Lys Tyr Arg Val 180 185 190 atg aac aaa gat caa tgg tac aat gta tta gaa ttc agc aga aca gtc 926 Met Asn Lys Asp Gln Trp Tyr Asn Val Leu Glu Phe Ser Arg Thr Val 195 200 205 cat gct gat ctt agt aac tat gat gaa gat ggt gct tgg cct gtt ctt 974 His Ala Asp Leu Ser Asn Tyr Asp Glu Asp Gly Ala Trp Pro Val Leu 210 215 220 ctt gat gaa ttt gtt gag tgg caa aaa gtc cgt cag aca tca tag 1019 Leu Asp Glu Phe Val Glu Trp Gln Lys Val Arg Gln Thr Ser 225 230 235 caagaactat gtgaagaaaa tgcaaacctt tcaattccca cgtgtataca agctaatgtg 1079 atgaggggga aaaaaatcca acgggtgcat tttcattcat atgaaagact tctcatagta 1139 cttttttttc ctttttttaa aggaggtttt tcttgttaca tgtgatgggc attgagccac 1199 acctcttctt agactgaata ttgaagtttt tgttttgagt tatgtttata acatttattt 1259 cagaacaata aagattcaga tttgtgacaa aggc 1293 <210> SEQ ID NO 118 <211> LENGTH: 237 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 118 Met Pro Val Lys Lys Lys Arg Lys Ser Pro Gly Val Ala Ala Ala Val 1 5 10 15 Ala Glu Asp Gly Gly Leu Lys Lys Cys Lys Ile Ser Ser Tyr Cys Arg 20 25 30 Ser Gln Pro Pro Ala Arg Leu Ile Ser Gly Glu Glu His Phe Ser Ser 35 40 45 Lys Lys Cys Leu Ala Trp Phe Tyr Glu Tyr Ala Gly Pro Asp Glu Val 50 55 60 Val Gly Pro Glu Gly Met Glu Lys Phe Cys Glu Asp Ile Gly Val Glu 65 70 75 80 Pro Glu Asn Ile Ile Met Leu Val Leu Ala Trp Lys Leu Glu Ala Glu 85 90 95 Ser Met Gly Phe Phe Thr Lys Glu Glu Trp Leu Lys Gly Met Thr Ser 100 105 110 Leu Gln Cys Asp Cys Thr Glu Lys Leu Gln Asn Lys Phe Asp Phe Leu 115 120 125 Arg Ser Gln Leu Asn Asp Ile Ser Ser Phe Lys Asn Ile Tyr Arg Tyr 130 135 140 Ala Phe Asp Phe Ala Arg Asp Lys Asp Gln Arg Ser Leu Asp Ile Asp 145 150 155 160 Thr Ala Lys Ser Met Leu Ala Leu Leu Leu Gly Arg Thr Trp Pro Leu 165 170 175 Phe Ser Val Phe Tyr Gln Tyr Leu Glu Gln Ser Lys Tyr Arg Val Met 180 185 190 Asn Lys Asp Gln Trp Tyr Asn Val Leu Glu Phe Ser Arg Thr Val His 195 200 205 Ala Asp Leu Ser Asn Tyr Asp Glu Asp Gly Ala Trp Pro Val Leu Leu 210 215 220 Asp Glu Phe Val Glu Trp Gln Lys Val Arg Gln Thr Ser 225 230 235 <210> SEQ ID NO 119 <211> LENGTH: 916 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (148)..(471) <400> SEQUENCE: 119 ctctctcggt ttgtctgggt catcttgtct gcccgccgct ggcctggccc cgtctgtctc 60 tctcagcagc tgtctttctc gcgcccactg gccggtctct cctcttcccc gcagttgcct 120 ccttctctgc ctgcctgggt ggccgcc atg ggc cgg aag cgg ctc atc act gat 174 Met Gly Arg Lys Arg Leu Ile Thr Asp 1 5 tcc tac ccg gtt gtg aag agg agg gag ggg ccc gct ggg cac agc aag 222 Ser Tyr Pro Val Val Lys Arg Arg Glu Gly Pro Ala Gly His Ser Lys 10 15 20 25 ggg gag ctg gca ccc gag cta ggg gag gag ccc cag ccc cgc gac gag 270 Gly Glu Leu Ala Pro Glu Leu Gly Glu Glu Pro Gln Pro Arg Asp Glu 30 35 40 gag gaa gcg gag ctg gag ctg ctg agg cag ttt gac ctg gcc tgg cag 318 Glu Glu Ala Glu Leu Glu Leu Leu Arg Gln Phe Asp Leu Ala Trp Gln 45 50 55 tac ggg ccc tgc acc ggg atc aca cgg ctg cag cgc tgg tgt cgg gcc 366 Tyr Gly Pro Cys Thr Gly Ile Thr Arg Leu Gln Arg Trp Cys Arg Ala 60 65 70 aag cag atg ggc ttg gag cct ccc cca gag gtg tgg cag gtg ctg aag 414 Lys Gln Met Gly Leu Glu Pro Pro Pro Glu Val Trp Gln Val Leu Lys 75 80 85 acc cac ccc gga gac ccc cgc ttc cag tgc agt ctc tgg cat ctc tat 462 Thr His Pro Gly Asp Pro Arg Phe Gln Cys Ser Leu Trp His Leu Tyr 90 95 100 105 ccc cta tga ggcaccacgt aagacctcct gcccttagct ctcttgctca 511 Pro Leu ccacccaaga acctcaggac agaagcgaga gcccattgct cctgctcagc tcagcccggc 571 tgcggaggaa cccttggcag gcagaacctg gaggtgtcag aggctcaact cctccatcta 631 accagcaggc tcccagagtc cccggaagag cctgcgcagc tgaagcagag tgcttctaga 691 tggagagtgg tcactgggga aaaggacctg gccatcacct tccaatacct gctgcctgtc 751 tccctgaccc atgatctggc aagttaggca cagtcagaca tggacagttg atccatgagg 811 aaaagatgct ctcccaccta aggccaggaa tctgagagca ggactggctg agctcccagg 871 gcaaggggtt cactaatgct tatcaataaa gaatattgag cctgg 916 <210> SEQ ID NO 120 <211> LENGTH: 107 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 120 Met Gly Arg Lys Arg Leu Ile Thr Asp Ser Tyr Pro Val Val Lys Arg 1 5 10 15 Arg Glu Gly Pro Ala Gly His Ser Lys Gly Glu Leu Ala Pro Glu Leu 20 25 30 Gly Glu Glu Pro Gln Pro Arg Asp Glu Glu Glu Ala Glu Leu Glu Leu 35 40 45 Leu Arg Gln Phe Asp Leu Ala Trp Gln Tyr Gly Pro Cys Thr Gly Ile 50 55 60 Thr Arg Leu Gln Arg Trp Cys Arg Ala Lys Gln Met Gly Leu Glu Pro 65 70 75 80 Pro Pro Glu Val Trp Gln Val Leu Lys Thr His Pro Gly Asp Pro Arg 85 90 95 Phe Gln Cys Ser Leu Trp His Leu Tyr Pro Leu 100 105 <210> SEQ ID NO 121 <211> LENGTH: 1002 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (51)..(731) <400> SEQUENCE: 121 ctattttctc acctggttcc cgcggcgagc cagcggcagc ggcggcggcg atg aga 56 Met Arg 1 cag aag cac tac ctt gag gct gca gcg cgg gga ctg cac gac agc tgc 104 Gln Lys His Tyr Leu Glu Ala Ala Ala Arg Gly Leu His Asp Ser Cys 5 10 15 ccg ggc caa gcc cgc tac ctc ctt ctc ttt ctc ttt tac agc tgg gcc 152 Pro Gly Gln Ala Arg Tyr Leu Leu Leu Phe Leu Phe Tyr Ser Trp Ala 20 25 30 tac act tcg tcg cac gat gat aag agc act ttt gaa gaa acg tgt cca 200 Tyr Thr Ser Ser His Asp Asp Lys Ser Thr Phe Glu Glu Thr Cys Pro 35 40 45 50 tac tgt ttc cag ctg ttg gtt ctg gat aac tct cga gtg cgt ctc aaa 248 Tyr Cys Phe Gln Leu Leu Val Leu Asp Asn Ser Arg Val Arg Leu Lys 55 60 65 ccc aaa gcc agg ttg aca ccc aaa ata cag aaa ctt ctt aat cga gaa 296 Pro Lys Ala Arg Leu Thr Pro Lys Ile Gln Lys Leu Leu Asn Arg Glu 70 75 80 gcg aga aac tat aca ctc agt ttt aaa gaa gca aaa atg gtg aaa aag 344 Ala Arg Asn Tyr Thr Leu Ser Phe Lys Glu Ala Lys Met Val Lys Lys 85 90 95 ttc aaa gac tcc aaa agt gta ttg ttg atc act tgt aaa aca tgc aac 392 Phe Lys Asp Ser Lys Ser Val Leu Leu Ile Thr Cys Lys Thr Cys Asn 100 105 110 aga aca gtg aaa cat cat ggt aaa agt aga agc ttt gtg tca aca ttg 440 Arg Thr Val Lys His His Gly Lys Ser Arg Ser Phe Val Ser Thr Leu 115 120 125 130 aag agc aat cct gcc act cct aca agt aaa ctc agc ctg aag aca cca 488 Lys Ser Asn Pro Ala Thr Pro Thr Ser Lys Leu Ser Leu Lys Thr Pro 135 140 145 gag aga agg act gca aac cca aat cat gac atg tct ggc tcg aaa ggc 536 Glu Arg Arg Thr Ala Asn Pro Asn His Asp Met Ser Gly Ser Lys Gly 150 155 160 aag agc cca gca tcg gtt ttc aga aca cct aca tct gga cag tca gta 584 Lys Ser Pro Ala Ser Val Phe Arg Thr Pro Thr Ser Gly Gln Ser Val 165 170 175 tct act tgc tcc tca aag aac acc agc aaa aca aag aaa cac ttc tct 632 Ser Thr Cys Ser Ser Lys Asn Thr Ser Lys Thr Lys Lys His Phe Ser 180 185 190 caa cta aaa atg tta ctt agt cag aat gaa tcc caa aag att cca aag 680 Gln Leu Lys Met Leu Leu Ser Gln Asn Glu Ser Gln Lys Ile Pro Lys 195 200 205 210 gtg gac ttc aga aat ttc tta tct tct ctg aag ggt gga ctt tta aaa 728 Val Asp Phe Arg Asn Phe Leu Ser Ser Leu Lys Gly Gly Leu Leu Lys 215 220 225 taa gaaatgcctg atgtcaattc tgaaactaaa gttggtaaaa caacttttta 781 aactcttatt cattttttga atacatggaa actagatctg aatgcaaact tttcttggca 841 tccttcagtg tttatgggga aaatacctca ttagtgtgaa tacctgaaac ctgcctacct 901 cataggacag ctgtgaggat caaaaaatat atgaaagttc cttgtagata catatctata 961 gatatatatg tgtatgtata taaagataga tatatacatt g 1002 <210> SEQ ID NO 122 <211> LENGTH: 226 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 122 Met Arg Gln Lys His Tyr Leu Glu Ala Ala Ala Arg Gly Leu His Asp 1 5 10 15 Ser Cys Pro Gly Gln Ala Arg Tyr Leu Leu Leu Phe Leu Phe Tyr Ser 20 25 30 Trp Ala Tyr Thr Ser Ser His Asp Asp Lys Ser Thr Phe Glu Glu Thr 35 40 45 Cys Pro Tyr Cys Phe Gln Leu Leu Val Leu Asp Asn Ser Arg Val Arg 50 55 60 Leu Lys Pro Lys Ala Arg Leu Thr Pro Lys Ile Gln Lys Leu Leu Asn 65 70 75 80 Arg Glu Ala Arg Asn Tyr Thr Leu Ser Phe Lys Glu Ala Lys Met Val 85 90 95 Lys Lys Phe Lys Asp Ser Lys Ser Val Leu Leu Ile Thr Cys Lys Thr 100 105 110 Cys Asn Arg Thr Val Lys His His Gly Lys Ser Arg Ser Phe Val Ser 115 120 125 Thr Leu Lys Ser Asn Pro Ala Thr Pro Thr Ser Lys Leu Ser Leu Lys 130 135 140 Thr Pro Glu Arg Arg Thr Ala Asn Pro Asn His Asp Met Ser Gly Ser 145 150 155 160 Lys Gly Lys Ser Pro Ala Ser Val Phe Arg Thr Pro Thr Ser Gly Gln 165 170 175 Ser Val Ser Thr Cys Ser Ser Lys Asn Thr Ser Lys Thr Lys Lys His 180 185 190 Phe Ser Gln Leu Lys Met Leu Leu Ser Gln Asn Glu Ser Gln Lys Ile 195 200 205 Pro Lys Val Asp Phe Arg Asn Phe Leu Ser Ser Leu Lys Gly Gly Leu 210 215 220 Leu Lys 225 <210> SEQ ID NO 123 <211> LENGTH: 1753 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (268)..(1455) <400> SEQUENCE: 123 gcctttgttt acaaccctgc catgatctcc ctcttgcaaa agcgagggct acagaacagg 60 cattcaggag tcctgtgctc cagtcacagc cttttctgtt cttcagctag gagacaccaa 120 accctcagga agatttacta tagctaagag aaaactgcag cagaaagggc gcggctacct 180 acttcttaaa ttccgtttgt ggaccctcag actcttagtc ccctactccc agatacagcg 240 gccctaccgt ggctcctggc aagaagc atg gat ctc gga atc cct gac ctg ctg 294 Met Asp Leu Gly Ile Pro Asp Leu Leu 1 5 gac gcg tgg ctg gag ccc cca gag gat atc ttc tcg aca gga tcc gtc 342 Asp Ala Trp Leu Glu Pro Pro Glu Asp Ile Phe Ser Thr Gly Ser Val 10 15 20 25 ctg gag ctg gga ctc cac tgc ccc cct cca gag gtt ccg gta act agg 390 Leu Glu Leu Gly Leu His Cys Pro Pro Pro Glu Val Pro Val Thr Arg 30 35 40 cta cag gaa cag gga ctg caa ggc tgg aag tcc ggt ggg gac cgt ggc 438 Leu Gln Glu Gln Gly Leu Gln Gly Trp Lys Ser Gly Gly Asp Arg Gly 45 50 55 tgt ggc ctt caa gag agt gag cct gaa gat ttc ttg aag ctt ttc att 486 Cys Gly Leu Gln Glu Ser Glu Pro Glu Asp Phe Leu Lys Leu Phe Ile 60 65 70 gat ccc aat gag gtg tac tgc tca gaa gca tct cct ggc agt gac agt 534 Asp Pro Asn Glu Val Tyr Cys Ser Glu Ala Ser Pro Gly Ser Asp Ser 75 80 85 ggc atc tct gag gac ccc tgc cat cca gac agt ccc cct gcc ccc agg 582 Gly Ile Ser Glu Asp Pro Cys His Pro Asp Ser Pro Pro Ala Pro Arg 90 95 100 105 gca acc agt tct cct atg ctc tat gag gtt gtc tat gag gca ggg gcc 630 Ala Thr Ser Ser Pro Met Leu Tyr Glu Val Val Tyr Glu Ala Gly Ala 110 115 120 ctg gag agg atg cag ggg gaa act ggg cca aat gta ggc ctt atc tcc 678 Leu Glu Arg Met Gln Gly Glu Thr Gly Pro Asn Val Gly Leu Ile Ser 125 130 135 atc cag cta gat cag tgg agc cca gca ttt atg gtg cct gat tcc tgc 726 Ile Gln Leu Asp Gln Trp Ser Pro Ala Phe Met Val Pro Asp Ser Cys 140 145 150 atg gtc agt gag ctg ccc ttt gat gct cat gcc cac atc ctg ccc aga 774 Met Val Ser Glu Leu Pro Phe Asp Ala His Ala His Ile Leu Pro Arg 155 160 165 gca ggc acc gta gcc cca gtg ccc tgt aca acc ctg ctg ccc tgt caa 822 Ala Gly Thr Val Ala Pro Val Pro Cys Thr Thr Leu Leu Pro Cys Gln 170 175 180 185 acc ctg ttc ctg acc gat gag gag aag cgt ctg ctg ggg cag gaa ggg 870 Thr Leu Phe Leu Thr Asp Glu Glu Lys Arg Leu Leu Gly Gln Glu Gly 190 195 200 gtt tcc ctg ccc tct cac ctg ccc ctc acc aag gca gag gag agg gtc 918 Val Ser Leu Pro Ser His Leu Pro Leu Thr Lys Ala Glu Glu Arg Val 205 210 215 ctc aag aag gtc agg agg aaa atc cgt aac aag cag tca gct cag gac 966 Leu Lys Lys Val Arg Arg Lys Ile Arg Asn Lys Gln Ser Ala Gln Asp 220 225 230 agt cgg cgg cgg aag aag gag tac att gat ggg ctg gag agc agg gtg 1014 Ser Arg Arg Arg Lys Lys Glu Tyr Ile Asp Gly Leu Glu Ser Arg Val 235 240 245 gca gcc tgt tct gca cag aac caa gaa tta cag aaa aaa gtc cag gag 1062 Ala Ala Cys Ser Ala Gln Asn Gln Glu Leu Gln Lys Lys Val Gln Glu 250 255 260 265 ctg gag agg cac aac atc tcc ttg gta gct cag ctc cgc cag ctg cag 1110 Leu Glu Arg His Asn Ile Ser Leu Val Ala Gln Leu Arg Gln Leu Gln 270 275 280 acg cta att gct caa act tcc aac aaa gct gcc cag acc agc act tgt 1158 Thr Leu Ile Ala Gln Thr Ser Asn Lys Ala Ala Gln Thr Ser Thr Cys 285 290 295 gtt ttg att ctt ctt ttt tcc ctg gct ctc atc atc ctg ccc agc ttc 1206 Val Leu Ile Leu Leu Phe Ser Leu Ala Leu Ile Ile Leu Pro Ser Phe 300 305 310 agt cca ttc cag agt cga cca gaa gct ggg tct gag gat tac cag cct 1254 Ser Pro Phe Gln Ser Arg Pro Glu Ala Gly Ser Glu Asp Tyr Gln Pro 315 320 325 cac gga gtg act tcc aga aat atc ctg acc cac aag gac gta aca gaa 1302 His Gly Val Thr Ser Arg Asn Ile Leu Thr His Lys Asp Val Thr Glu 330 335 340 345 aat ctg gag acc caa gtg gta gag tcc aga ctg agg gag cca cct gga 1350 Asn Leu Glu Thr Gln Val Val Glu Ser Arg Leu Arg Glu Pro Pro Gly 350 355 360 gcc aag gat gca aat ggc tca aca agg aca ctg ctt gag aag atg gga 1398 Ala Lys Asp Ala Asn Gly Ser Thr Arg Thr Leu Leu Glu Lys Met Gly 365 370 375 ggg aag cca aga ccc agt ggg cgc atc cgg tcc gtg ctg cat gca gat 1446 Gly Lys Pro Arg Pro Ser Gly Arg Ile Arg Ser Val Leu His Ala Asp 380 385 390 gag atg tga gctggaacag accttcctgg cccacttcct gatcacaagg 1495 Glu Met 395 aatcctgggc ttccttatgg ctttgcttcc cactgggatt cctacttagg tgtctgccct 1555 caggggtcca aatcacttca ggacacccca agagatgtcc tttagtctct gcctgaggcc 1615 tagtctgcat ttgtttgcat atatgagagg gtacctcaaa tacttctgtt atgtatctgt 1675 gattttattt cttctttggg tatagggttg aggggaaata agttttgagt gagaaataaa 1735 cgttttagct gaaattgt 1753 <210> SEQ ID NO 124 <211> LENGTH: 395 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 124 Met Asp Leu Gly Ile Pro Asp Leu Leu Asp Ala Trp Leu Glu Pro Pro 1 5 10 15 Glu Asp Ile Phe Ser Thr Gly Ser Val Leu Glu Leu Gly Leu His Cys 20 25 30 Pro Pro Pro Glu Val Pro Val Thr Arg Leu Gln Glu Gln Gly Leu Gln 35 40 45 Gly Trp Lys Ser Gly Gly Asp Arg Gly Cys Gly Leu Gln Glu Ser Glu 50 55 60 Pro Glu Asp Phe Leu Lys Leu Phe Ile Asp Pro Asn Glu Val Tyr Cys 65 70 75 80 Ser Glu Ala Ser Pro Gly Ser Asp Ser Gly Ile Ser Glu Asp Pro Cys 85 90 95 His Pro Asp Ser Pro Pro Ala Pro Arg Ala Thr Ser Ser Pro Met Leu 100 105 110 Tyr Glu Val Val Tyr Glu Ala Gly Ala Leu Glu Arg Met Gln Gly Glu 115 120 125 Thr Gly Pro Asn Val Gly Leu Ile Ser Ile Gln Leu Asp Gln Trp Ser 130 135 140 Pro Ala Phe Met Val Pro Asp Ser Cys Met Val Ser Glu Leu Pro Phe 145 150 155 160 Asp Ala His Ala His Ile Leu Pro Arg Ala Gly Thr Val Ala Pro Val 165 170 175 Pro Cys Thr Thr Leu Leu Pro Cys Gln Thr Leu Phe Leu Thr Asp Glu 180 185 190 Glu Lys Arg Leu Leu Gly Gln Glu Gly Val Ser Leu Pro Ser His Leu 195 200 205 Pro Leu Thr Lys Ala Glu Glu Arg Val Leu Lys Lys Val Arg Arg Lys 210 215 220 Ile Arg Asn Lys Gln Ser Ala Gln Asp Ser Arg Arg Arg Lys Lys Glu 225 230 235 240 Tyr Ile Asp Gly Leu Glu Ser Arg Val Ala Ala Cys Ser Ala Gln Asn 245 250 255 Gln Glu Leu Gln Lys Lys Val Gln Glu Leu Glu Arg His Asn Ile Ser 260 265 270 Leu Val Ala Gln Leu Arg Gln Leu Gln Thr Leu Ile Ala Gln Thr Ser 275 280 285 Asn Lys Ala Ala Gln Thr Ser Thr Cys Val Leu Ile Leu Leu Phe Ser 290 295 300 Leu Ala Leu Ile Ile Leu Pro Ser Phe Ser Pro Phe Gln Ser Arg Pro 305 310 315 320 Glu Ala Gly Ser Glu Asp Tyr Gln Pro His Gly Val Thr Ser Arg Asn 325 330 335 Ile Leu Thr His Lys Asp Val Thr Glu Asn Leu Glu Thr Gln Val Val 340 345 350 Glu Ser Arg Leu Arg Glu Pro Pro Gly Ala Lys Asp Ala Asn Gly Ser 355 360 365 Thr Arg Thr Leu Leu Glu Lys Met Gly Gly Lys Pro Arg Pro Ser Gly 370 375 380 Arg Ile Arg Ser Val Leu His Ala Asp Glu Met 385 390 395 <210> SEQ ID NO 125 <211> LENGTH: 668 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (54)..(122) <400> SEQUENCE: 125 ctttcttcct tttggtgcga gcttgctgtg gtttttgctc tgggtcctct ggg atg 56 Met 1 gcg cct ggc tgt ggc cgc gtg gtc tct cac gca ggg gcg ccg ggc ggg 104 Ala Pro Gly Cys Gly Arg Val Val Ser His Ala Gly Ala Pro Gly Gly 5 10 15 gga acg cgg cca ccc tga gtctggtgag tcgactgcgg cggcctgtgt 152 Gly Thr Arg Pro Pro 20 ccgaagtgtc cggggccgtg aacaagggca gcggcctggc ctcaggcctg cgttcccacg 212 tttggaaacg gggagcttcg tcgattttgt ttacatcatc gactatgcca gggagttctc 272 cagataagcc tggttttatt ttcgtcagtg aaaaggcctt accgtataac tgactttatg 332 cttgccctgc ccccgtataa aataacttaa aagcagcgtg cctggttaca gctgtttcca 392 cgtgcggtgc tcgtcgggag tgatcaccta ccctacaggt ggaagatgga tgcctgaagt 452 gtagactgct gctagctgaa taccatctgg gagcataaag gtgacctgaa ggatgtcctt 512 ggtgaggatt ttgaaaattt gatcttcaca agagttgcct ggatcatttg aaatttctgg 572 gagtctgagg agtactgaca taattacctg ctggagtctg taaatacaca tttaagacag 632 tgaggatgtg aataaatata ttaatgcaaa aaaaac 668 <210> SEQ ID NO 126 <211> LENGTH: 22 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 126 Met Ala Pro Gly Cys Gly Arg Val Val Ser His Ala Gly Ala Pro Gly 1 5 10 15 Gly Gly Thr Arg Pro Pro 20 <210> SEQ ID NO 127 <211> LENGTH: 279 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (27)..(239) <400> SEQUENCE: 127 atccctctcc acgacctcgg tcgagc atg ttc acc agg gcc cag gtg aga cgg 53 Met Phe Thr Arg Ala Gln Val Arg Arg 1 5 att ctg cag cgg gtg ccc ggg aag cag cga ttt ggc atc tac cgg ttc 101 Ile Leu Gln Arg Val Pro Gly Lys Gln Arg Phe Gly Ile Tyr Arg Phe 10 15 20 25 ctg ccc ttc ttt ttt gtc ctg gga gga acg atg gag tgg atc atg att 149 Leu Pro Phe Phe Phe Val Leu Gly Gly Thr Met Glu Trp Ile Met Ile 30 35 40 aaa gtg cgc gtg ggc cag gag acc ttc tat gat gtc tac cgt aga aaa 197 Lys Val Arg Val Gly Gln Glu Thr Phe Tyr Asp Val Tyr Arg Arg Lys 45 50 55 gcc tca gaa aga cag tat cag aga agg ctg gaa gat gaa tga 239 Ala Ser Glu Arg Gln Tyr Gln Arg Arg Leu Glu Asp Glu 60 65 70 gactgaactt cagcagtcaa taaagtcaat atgaattttt 279 <210> SEQ ID NO 128 <211> LENGTH: 70 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 128 Met Phe Thr Arg Ala Gln Val Arg Arg Ile Leu Gln Arg Val Pro Gly 1 5 10 15 Lys Gln Arg Phe Gly Ile Tyr Arg Phe Leu Pro Phe Phe Phe Val Leu 20 25 30 Gly Gly Thr Met Glu Trp Ile Met Ile Lys Val Arg Val Gly Gln Glu 35 40 45 Thr Phe Tyr Asp Val Tyr Arg Arg Lys Ala Ser Glu Arg Gln Tyr Gln 50 55 60 Arg Arg Leu Glu Asp Glu 65 70 <210> SEQ ID NO 129 <211> LENGTH: 3367 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (91)..(2178) <400> SEQUENCE: 129 cagatatact gagtgagccc tgagaagcag tctcagatcc tgacggtgca gcagcccgca 60 gcctcagcca gggagtccca gccgctttca atg gag gag aag ccc ggc cag cca 114 Met Glu Glu Lys Pro Gly Gln Pro 1 5 cag cct cag cac cat cac agc cac cac cat ccg cac cat cac cct cag 162 Gln Pro Gln His His His Ser His His His Pro His His His Pro Gln 10 15 20 cag cag cag cag cag ccg cac cac cac cac cat tat tat ttc tac aac 210 Gln Gln Gln Gln Gln Pro His His His His His Tyr Tyr Phe Tyr Asn 25 30 35 40 cac agc cac aac cac cac cac cac cat cat cac cag cag cct cac caa 258 His Ser His Asn His His His His His His His Gln Gln Pro His Gln 45 50 55 tac ctg cag cat gga gcc gag ggc agc ccc aag gcc cag cca aag ccg 306 Tyr Leu Gln His Gly Ala Glu Gly Ser Pro Lys Ala Gln Pro Lys Pro 60 65 70 ctg aaa cat gag cag aaa cac acc ctc cag cag cac cag gaa acg ccg 354 Leu Lys His Glu Gln Lys His Thr Leu Gln Gln His Gln Glu Thr Pro 75 80 85 aag aag aaa aca ggc tat ggt gaa cta aac ggt aat gct gga gaa aga 402 Lys Lys Lys Thr Gly Tyr Gly Glu Leu Asn Gly Asn Ala Gly Glu Arg 90 95 100 gaa ata tct tta aag aac ctg agt tct gat gaa gcc acc aac cct att 450 Glu Ile Ser Leu Lys Asn Leu Ser Ser Asp Glu Ala Thr Asn Pro Ile 105 110 115 120 tcc agg gtc ctc aat ggc aac cag caa gtt gta gac act agc ctg aag 498 Ser Arg Val Leu Asn Gly Asn Gln Gln Val Val Asp Thr Ser Leu Lys 125 130 135 cag act gta aag gcc aac acc ttt ggg aaa gca gga att aaa acc aag 546 Gln Thr Val Lys Ala Asn Thr Phe Gly Lys Ala Gly Ile Lys Thr Lys 140 145 150 aat ttc att cag aaa aac agt atg gac aaa aag aat ggg aag tct tat 594 Asn Phe Ile Gln Lys Asn Ser Met Asp Lys Lys Asn Gly Lys Ser Tyr 155 160 165 gaa aat aaa tct gga gag aat cag tct gta gat aag tct gat act ata 642 Glu Asn Lys Ser Gly Glu Asn Gln Ser Val Asp Lys Ser Asp Thr Ile 170 175 180 cca att cca aat ggt gtg gta aca aat aat tct ggt tat att act aat 690 Pro Ile Pro Asn Gly Val Val Thr Asn Asn Ser Gly Tyr Ile Thr Asn 185 190 195 200 ggt tat atg agt aaa gga gca gat aat gat ggt agt gga tct gag agc 738 Gly Tyr Met Ser Lys Gly Ala Asp Asn Asp Gly Ser Gly Ser Glu Ser 205 210 215 gga tat aca act cct aaa aaa agg aaa gct agg cgc aat agt gcc aag 786 Gly Tyr Thr Thr Pro Lys Lys Arg Lys Ala Arg Arg Asn Ser Ala Lys 220 225 230 ggt tgt gaa aac ctt aat ata gtg cag gac aaa ata atg caa caa gag 834 Gly Cys Glu Asn Leu Asn Ile Val Gln Asp Lys Ile Met Gln Gln Glu 235 240 245 acc agt gtc cca acc tta aaa cag gga ctt gaa act ttc aag cct gac 882 Thr Ser Val Pro Thr Leu Lys Gln Gly Leu Glu Thr Phe Lys Pro Asp 250 255 260 tat agt gaa caa aag gga aat cga gta gat ggt tcg aag ccc att tgg 930 Tyr Ser Glu Gln Lys Gly Asn Arg Val Asp Gly Ser Lys Pro Ile Trp 265 270 275 280 aag tat gaa act ggg cct gga gga aca agt cga gga aaa cct gct gtg 978 Lys Tyr Glu Thr Gly Pro Gly Gly Thr Ser Arg Gly Lys Pro Ala Val 285 290 295 ggt gat atg ctt cgg aaa agc tca gat agt aaa cct ggt gtg agc agc 1026 Gly Asp Met Leu Arg Lys Ser Ser Asp Ser Lys Pro Gly Val Ser Ser 300 305 310 aaa aag ttt gat gat cgg ccc aaa gga aag cat gct tca gct gtt gcc 1074 Lys Lys Phe Asp Asp Arg Pro Lys Gly Lys His Ala Ser Ala Val Ala 315 320 325 tcc aaa gag gac tcg tgg acc cta ttt aaa cca ccc cca gtt ttt cca 1122 Ser Lys Glu Asp Ser Trp Thr Leu Phe Lys Pro Pro Pro Val Phe Pro 330 335 340 gtg gac aat agc agt gct aaa ata gtt cct aaa ata agt tat gca agc 1170 Val Asp Asn Ser Ser Ala Lys Ile Val Pro Lys Ile Ser Tyr Ala Ser 345 350 355 360 aaa gtt aag gaa aac ctc aac aaa act ata cag aac tct tct gtg tca 1218 Lys Val Lys Glu Asn Leu Asn Lys Thr Ile Gln Asn Ser Ser Val Ser 365 370 375 cca act tca tct tca tca tct tca tca tct acc ggg gaa act cag acc 1266 Pro Thr Ser Ser Ser Ser Ser Ser Ser Ser Thr Gly Glu Thr Gln Thr 380 385 390 caa tca tca agt cgc tta tcc cag gtc cct atg tca gcg ctg aaa tct 1314 Gln Ser Ser Ser Arg Leu Ser Gln Val Pro Met Ser Ala Leu Lys Ser 395 400 405 gtt act tct gcc aac ttt tct aat ggg cct gtt tta gca ggg act gat 1362 Val Thr Ser Ala Asn Phe Ser Asn Gly Pro Val Leu Ala Gly Thr Asp 410 415 420 gga aat gtt tat cct cca ggg ggt cag cca ctg cta act act gct gct 1410 Gly Asn Val Tyr Pro Pro Gly Gly Gln Pro Leu Leu Thr Thr Ala Ala 425 430 435 440 aat act cta aca ccc atc tct tct ggg aca gat tca gtt ctc cag gac 1458 Asn Thr Leu Thr Pro Ile Ser Ser Gly Thr Asp Ser Val Leu Gln Asp 445 450 455 atg agt cta act tca gca gct gtt gaa caa att aag act agc ctt ttt 1506 Met Ser Leu Thr Ser Ala Ala Val Glu Gln Ile Lys Thr Ser Leu Phe 460 465 470 atc tat cct tca aat atg caa act atg ctg ttg agc aca gca caa gtg 1554 Ile Tyr Pro Ser Asn Met Gln Thr Met Leu Leu Ser Thr Ala Gln Val 475 480 485 gat ctg ccc tct cag aca gat cag caa aac ctg ggg gat atc ttc cag 1602 Asp Leu Pro Ser Gln Thr Asp Gln Gln Asn Leu Gly Asp Ile Phe Gln 490 495 500 aat cag tgg ggt tta tca ttt ata aat gag ccc agt gct ggc cct gag 1650 Asn Gln Trp Gly Leu Ser Phe Ile Asn Glu Pro Ser Ala Gly Pro Glu 505 510 515 520 act gtt act ggg aag tca tca gag cat aaa gtg atg gag gtg aca ttt 1698 Thr Val Thr Gly Lys Ser Ser Glu His Lys Val Met Glu Val Thr Phe 525 530 535 caa gga gaa tat cct gct act ttg gtt tca cag ggt gct gaa ata att 1746 Gln Gly Glu Tyr Pro Ala Thr Leu Val Ser Gln Gly Ala Glu Ile Ile 540 545 550 ccc tca gga act gag cat cct gtg ttt ccc aag gct tac gag ctg gag 1794 Pro Ser Gly Thr Glu His Pro Val Phe Pro Lys Ala Tyr Glu Leu Glu 555 560 565 aaa cgg act agt cct caa gtt ctg ggt agc att cta aaa tct ggg act 1842 Lys Arg Thr Ser Pro Gln Val Leu Gly Ser Ile Leu Lys Ser Gly Thr 570 575 580 act agt gag agt gga gcc tta tcc ttg gaa ccc agt cat ata ggt gac 1890 Thr Ser Glu Ser Gly Ala Leu Ser Leu Glu Pro Ser His Ile Gly Asp 585 590 595 600 ctg cag aaa gca gac acc agt agt caa ggt gct tta gtg ttt ctc tca 1938 Leu Gln Lys Ala Asp Thr Ser Ser Gln Gly Ala Leu Val Phe Leu Ser 605 610 615 aag gac tac gag ata gaa agt caa aat cct ctg gcc tct cct acg aac 1986 Lys Asp Tyr Glu Ile Glu Ser Gln Asn Pro Leu Ala Ser Pro Thr Asn 620 625 630 act ttg tta ggc tct gcc aaa gaa cag aga tac cag aga ggc cta gaa 2034 Thr Leu Leu Gly Ser Ala Lys Glu Gln Arg Tyr Gln Arg Gly Leu Glu 635 640 645 agg aat gat agc tgg ggt tct ttt gac ctg agg gct gct att gta tat 2082 Arg Asn Asp Ser Trp Gly Ser Phe Asp Leu Arg Ala Ala Ile Val Tyr 650 655 660 cac act aaa gaa atg gaa tct att tgg aat ttg cag aag caa gat ccc 2130 His Thr Lys Glu Met Glu Ser Ile Trp Asn Leu Gln Lys Gln Asp Pro 665 670 675 680 aaa agg ata atc act tac aat gaa gcc atg gat agt cca gat caa tga 2178 Lys Arg Ile Ile Thr Tyr Asn Glu Ala Met Asp Ser Pro Asp Gln 685 690 695 aggaccagac tgcctattcg taacctttct gcagcattag agccatcgtt catgggggac 2238 acaaggcttt tatgctccta gatcttcaac gcagcagagg aaccataagt agaatcacag 2298 gataatatat acaaatatat atatatacat atatatatat atagttattt aaaaaaggca 2358 actgaaagta attagacttc ttaaggaatc aaatttattt caagagacta cacatggtta 2418 tttaatctcc ggtactgaat aggttttttt tcttctgtta gtttttgttt ttaagtgtga 2478 atgcaagtga ttaatgaata cagacttaac aagtgtggtt ctaaagttcc tgctgtcatc 2538 aacttgggca acaaatgacc cactggaaag gcaaatccac ttaaaagatc tctgtatctt 2598 gttctgtgac tgaagtgata cactaatcac ggggaaccca gaatgattca acattttccc 2658 cccactcctc ccttgatctt tttggtttta ctttaattaa gccctgcgag aatgctggat 2718 aaatgccttg aagttagcag ggtgtatttt tttagcgaat atgatttgca tgtcttgcca 2778 ggagttaagc ggcctctggg gtgttgggga aatactttat ttctttccat ttattttttg 2838 tggggcgggg ataggggagg gcattgaagt tctacaattc tggaatagtt agttgatggt 2898 acatagttaa cttggcttcg gttacatatt ggactttaac aactgaagaa tctatgcgtg 2958 tcatttaaag aaaagttgca gaacaagcaa ttggcttaga tatacaatct ggaaaaatat 3018 tcctgtgccc atattttaat gtaattgtat aactgggagc aaaaatatat tctgcttttc 3078 aactgtaggt gctccagact tgctctccgt cactaacact aaatgtgctg ttttccttgt 3138 ttttcatcaa acatttaaga caaacttaga cctttctgta aattatcttt taatttctca 3198 gcaaaatcta aaaggggaag aaaaaagtcc atgaaaacta aaacttttca tgtttttagc 3258 cagtgagaag ataataaacc ctgactgtag aaggtgtgtt ttcatgcaaa ctatacttct 3318 gagcttgtta gcttctaatt atatcttaat aaatatattt tattactag 3367 <210> SEQ ID NO 130 <211> LENGTH: 695 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 130 Met Glu Glu Lys Pro Gly Gln Pro Gln Pro Gln His His His Ser His 1 5 10 15 His His Pro His His His Pro Gln Gln Gln Gln Gln Gln Pro His His 20 25 30 His His His Tyr Tyr Phe Tyr Asn His Ser His Asn His His His His 35 40 45 His His His Gln Gln Pro His Gln Tyr Leu Gln His Gly Ala Glu Gly 50 55 60 Ser Pro Lys Ala Gln Pro Lys Pro Leu Lys His Glu Gln Lys His Thr 65 70 75 80 Leu Gln Gln His Gln Glu Thr Pro Lys Lys Lys Thr Gly Tyr Gly Glu 85 90 95 Leu Asn Gly Asn Ala Gly Glu Arg Glu Ile Ser Leu Lys Asn Leu Ser 100 105 110 Ser Asp Glu Ala Thr Asn Pro Ile Ser Arg Val Leu Asn Gly Asn Gln 115 120 125 Gln Val Val Asp Thr Ser Leu Lys Gln Thr Val Lys Ala Asn Thr Phe 130 135 140 Gly Lys Ala Gly Ile Lys Thr Lys Asn Phe Ile Gln Lys Asn Ser Met 145 150 155 160 Asp Lys Lys Asn Gly Lys Ser Tyr Glu Asn Lys Ser Gly Glu Asn Gln 165 170 175 Ser Val Asp Lys Ser Asp Thr Ile Pro Ile Pro Asn Gly Val Val Thr 180 185 190 Asn Asn Ser Gly Tyr Ile Thr Asn Gly Tyr Met Ser Lys Gly Ala Asp 195 200 205 Asn Asp Gly Ser Gly Ser Glu Ser Gly Tyr Thr Thr Pro Lys Lys Arg 210 215 220 Lys Ala Arg Arg Asn Ser Ala Lys Gly Cys Glu Asn Leu Asn Ile Val 225 230 235 240 Gln Asp Lys Ile Met Gln Gln Glu Thr Ser Val Pro Thr Leu Lys Gln 245 250 255 Gly Leu Glu Thr Phe Lys Pro Asp Tyr Ser Glu Gln Lys Gly Asn Arg 260 265 270 Val Asp Gly Ser Lys Pro Ile Trp Lys Tyr Glu Thr Gly Pro Gly Gly 275 280 285 Thr Ser Arg Gly Lys Pro Ala Val Gly Asp Met Leu Arg Lys Ser Ser 290 295 300 Asp Ser Lys Pro Gly Val Ser Ser Lys Lys Phe Asp Asp Arg Pro Lys 305 310 315 320 Gly Lys His Ala Ser Ala Val Ala Ser Lys Glu Asp Ser Trp Thr Leu 325 330 335 Phe Lys Pro Pro Pro Val Phe Pro Val Asp Asn Ser Ser Ala Lys Ile 340 345 350 Val Pro Lys Ile Ser Tyr Ala Ser Lys Val Lys Glu Asn Leu Asn Lys 355 360 365 Thr Ile Gln Asn Ser Ser Val Ser Pro Thr Ser Ser Ser Ser Ser Ser 370 375 380 Ser Ser Thr Gly Glu Thr Gln Thr Gln Ser Ser Ser Arg Leu Ser Gln 385 390 395 400 Val Pro Met Ser Ala Leu Lys Ser Val Thr Ser Ala Asn Phe Ser Asn 405 410 415 Gly Pro Val Leu Ala Gly Thr Asp Gly Asn Val Tyr Pro Pro Gly Gly 420 425 430 Gln Pro Leu Leu Thr Thr Ala Ala Asn Thr Leu Thr Pro Ile Ser Ser 435 440 445 Gly Thr Asp Ser Val Leu Gln Asp Met Ser Leu Thr Ser Ala Ala Val 450 455 460 Glu Gln Ile Lys Thr Ser Leu Phe Ile Tyr Pro Ser Asn Met Gln Thr 465 470 475 480 Met Leu Leu Ser Thr Ala Gln Val Asp Leu Pro Ser Gln Thr Asp Gln 485 490 495 Gln Asn Leu Gly Asp Ile Phe Gln Asn Gln Trp Gly Leu Ser Phe Ile 500 505 510 Asn Glu Pro Ser Ala Gly Pro Glu Thr Val Thr Gly Lys Ser Ser Glu 515 520 525 His Lys Val Met Glu Val Thr Phe Gln Gly Glu Tyr Pro Ala Thr Leu 530 535 540 Val Ser Gln Gly Ala Glu Ile Ile Pro Ser Gly Thr Glu His Pro Val 545 550 555 560 Phe Pro Lys Ala Tyr Glu Leu Glu Lys Arg Thr Ser Pro Gln Val Leu 565 570 575 Gly Ser Ile Leu Lys Ser Gly Thr Thr Ser Glu Ser Gly Ala Leu Ser 580 585 590 Leu Glu Pro Ser His Ile Gly Asp Leu Gln Lys Ala Asp Thr Ser Ser 595 600 605 Gln Gly Ala Leu Val Phe Leu Ser Lys Asp Tyr Glu Ile Glu Ser Gln 610 615 620 Asn Pro Leu Ala Ser Pro Thr Asn Thr Leu Leu Gly Ser Ala Lys Glu 625 630 635 640 Gln Arg Tyr Gln Arg Gly Leu Glu Arg Asn Asp Ser Trp Gly Ser Phe 645 650 655 Asp Leu Arg Ala Ala Ile Val Tyr His Thr Lys Glu Met Glu Ser Ile 660 665 670 Trp Asn Leu Gln Lys Gln Asp Pro Lys Arg Ile Ile Thr Tyr Asn Glu 675 680 685 Ala Met Asp Ser Pro Asp Gln 690 695 <210> SEQ ID NO 131 <211> LENGTH: 1290 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (100)..(699) <400> SEQUENCE: 131 aaaaacaaag gagcggcggc cgggagcgga cttaccttac cttctctgcc ttcggcgcgc 60 ttctcagccg ggccgccgac ccaaaggagc cgtccgact atg tct aac atg gag 114 Met Ser Asn Met Glu 1 5 aaa cac ctg ttc aac ctg aag ttc gcg gcc aaa gaa ctg agt agg agt 162 Lys His Leu Phe Asn Leu Lys Phe Ala Ala Lys Glu Leu Ser Arg Ser 10 15 20 gcc aaa aaa tgc gat aag gag gaa aag gcc gaa aag gcc aaa att aaa 210 Ala Lys Lys Cys Asp Lys Glu Glu Lys Ala Glu Lys Ala Lys Ile Lys 25 30 35 aag gcc att cag aag ggc aac atg gaa gtt gcg agg ata cac gcc gaa 258 Lys Ala Ile Gln Lys Gly Asn Met Glu Val Ala Arg Ile His Ala Glu 40 45 50 aat gcc atc cgc cag aag aac cag gcg gtg aat ttc ttg aga atg agt 306 Asn Ala Ile Arg Gln Lys Asn Gln Ala Val Asn Phe Leu Arg Met Ser 55 60 65 gcg cga gtc gat gca gtg gct gcc agg gtc cag acg gcg gtg acg atg 354 Ala Arg Val Asp Ala Val Ala Ala Arg Val Gln Thr Ala Val Thr Met 70 75 80 85 ggc aag gtg acc aag tcg atg gct ggt gtg gtt aag tcg atg gat gcg 402 Gly Lys Val Thr Lys Ser Met Ala Gly Val Val Lys Ser Met Asp Ala 90 95 100 aca ttg aag acc atg aat ctg gag aag att tct gct ttg atg gac aaa 450 Thr Leu Lys Thr Met Asn Leu Glu Lys Ile Ser Ala Leu Met Asp Lys 105 110 115 ttc gag cac cag ttt gag act ctg gac gtc cag acg cag caa atg gaa 498 Phe Glu His Gln Phe Glu Thr Leu Asp Val Gln Thr Gln Gln Met Glu 120 125 130 gac acg atg agc agc acg acg acg ctc acc act ccc cag aac caa gtg 546 Asp Thr Met Ser Ser Thr Thr Thr Leu Thr Thr Pro Gln Asn Gln Val 135 140 145 gat atg ctg ctc cag gaa atg gca gat gag gcg ggc ctc gac ctc aac 594 Asp Met Leu Leu Gln Glu Met Ala Asp Glu Ala Gly Leu Asp Leu Asn 150 155 160 165 atg gag ctg ccg cag ggc cag acc ggc tcc gtg ggc acg agc gtg gct 642 Met Glu Leu Pro Gln Gly Gln Thr Gly Ser Val Gly Thr Ser Val Ala 170 175 180 tcg gcg gag cag gat gaa ctg tct cag aga ctg gcc cgc ctt cgg gat 690 Ser Ala Glu Gln Asp Glu Leu Ser Gln Arg Leu Ala Arg Leu Arg Asp 185 190 195 caa gtg tga cggcagaacc cgctctgagg tttcctggcc atagccaccc 739 Gln Val tttgaaatgc tctctgtgtg ttagagagat actataccct agaaactctg aacacgccag 799 aatgctgaaa tgcccttcta cctttgggtt tacagccccc tccacataaa ttaagaaatt 859 cagtatttct gcactcttag ctggattcta aagttctgta tagctcgtaa tgatggtatt 919 tttatagcag ccttttaaca gaactagtta atttcgtgta tatgaatctt tctcgaagat 979 ctggtcaaaa ctgtattcag tttcctgccc agaatgatca gattgaaggt ggttggtttt 1039 tattattatt tagtgtgatt gatagtatct agaatggcag gtggtgcata aaagttaaag 1099 agaggggaaa gattacttag tttggttata cagttataaa caccatgcag tgtattcggt 1159 ggactgtgct atttctgttt atcctttggg ttttggtttt tgtttttttt ttttgccttc 1219 acagtgagac tgcaaatgat tgttctcata acgtatatta ttaataaatg tggtcctata 1279 atttatactg g 1290 <210> SEQ ID NO 132 <211> LENGTH: 199 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 132 Met Ser Asn Met Glu Lys His Leu Phe Asn Leu Lys Phe Ala Ala Lys 1 5 10 15 Glu Leu Ser Arg Ser Ala Lys Lys Cys Asp Lys Glu Glu Lys Ala Glu 20 25 30 Lys Ala Lys Ile Lys Lys Ala Ile Gln Lys Gly Asn Met Glu Val Ala 35 40 45 Arg Ile His Ala Glu Asn Ala Ile Arg Gln Lys Asn Gln Ala Val Asn 50 55 60 Phe Leu Arg Met Ser Ala Arg Val Asp Ala Val Ala Ala Arg Val Gln 65 70 75 80 Thr Ala Val Thr Met Gly Lys Val Thr Lys Ser Met Ala Gly Val Val 85 90 95 Lys Ser Met Asp Ala Thr Leu Lys Thr Met Asn Leu Glu Lys Ile Ser 100 105 110 Ala Leu Met Asp Lys Phe Glu His Gln Phe Glu Thr Leu Asp Val Gln 115 120 125 Thr Gln Gln Met Glu Asp Thr Met Ser Ser Thr Thr Thr Leu Thr Thr 130 135 140 Pro Gln Asn Gln Val Asp Met Leu Leu Gln Glu Met Ala Asp Glu Ala 145 150 155 160 Gly Leu Asp Leu Asn Met Glu Leu Pro Gln Gly Gln Thr Gly Ser Val 165 170 175 Gly Thr Ser Val Ala Ser Ala Glu Gln Asp Glu Leu Ser Gln Arg Leu 180 185 190 Ala Arg Leu Arg Asp Gln Val 195 <210> SEQ ID NO 133 <211> LENGTH: 564 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (24)..(380) <400> SEQUENCE: 133 gcctgccggg agcttggtgc gct atg gcg aca ccc agc ctg cgg ggt cgt ctg 53 Met Ala Thr Pro Ser Leu Arg Gly Arg Leu 1 5 10 gcg cgg ttt ggg aac ccg cgg aag cct gtg ctg aag ccc aat aaa cct 101 Ala Arg Phe Gly Asn Pro Arg Lys Pro Val Leu Lys Pro Asn Lys Pro 15 20 25 ctc att cta gct aac cgc gtc ggg gag cgg cgc cgg gag aag ggc gag 149 Leu Ile Leu Ala Asn Arg Val Gly Glu Arg Arg Arg Glu Lys Gly Glu 30 35 40 gcg act tgc atc acg gag atg tcg gtg atg atg gct tgc tgg aag cag 197 Ala Thr Cys Ile Thr Glu Met Ser Val Met Met Ala Cys Trp Lys Gln 45 50 55 aat gaa ttc cgc gac gat gcg tgc aga aaa gag atc cag ggc ttc ctc 245 Asn Glu Phe Arg Asp Asp Ala Cys Arg Lys Glu Ile Gln Gly Phe Leu 60 65 70 gat tgt gcc gcg agg gct cag gaa gcc cga aag atg aga tca ata cag 293 Asp Cys Ala Ala Arg Ala Gln Glu Ala Arg Lys Met Arg Ser Ile Gln 75 80 85 90 gaa acc ctg gga gag tct ggg agt tta ctt cca aat aaa ttg aat aag 341 Glu Thr Leu Gly Glu Ser Gly Ser Leu Leu Pro Asn Lys Leu Asn Lys 95 100 105 ttg tta cag agg ttt cct aac aaa cct tac ctc agc tga aaatggacaa 390 Leu Leu Gln Arg Phe Pro Asn Lys Pro Tyr Leu Ser 110 115 gtattttcaa tgactgaaat atagcttctg acaactatgc agaggcattt tagagacatt 450 ggcattgcca tgccctcttt ggagggtaga agaggcaaaa cacttttttc accctttgga 510 atcatagtat gggtagaagt tatgatttat cttgaaataa aatcctctga acag 564 <210> SEQ ID NO 134 <211> LENGTH: 118 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 134 Met Ala Thr Pro Ser Leu Arg Gly Arg Leu Ala Arg Phe Gly Asn Pro 1 5 10 15 Arg Lys Pro Val Leu Lys Pro Asn Lys Pro Leu Ile Leu Ala Asn Arg 20 25 30 Val Gly Glu Arg Arg Arg Glu Lys Gly Glu Ala Thr Cys Ile Thr Glu 35 40 45 Met Ser Val Met Met Ala Cys Trp Lys Gln Asn Glu Phe Arg Asp Asp 50 55 60 Ala Cys Arg Lys Glu Ile Gln Gly Phe Leu Asp Cys Ala Ala Arg Ala 65 70 75 80 Gln Glu Ala Arg Lys Met Arg Ser Ile Gln Glu Thr Leu Gly Glu Ser 85 90 95 Gly Ser Leu Leu Pro Asn Lys Leu Asn Lys Leu Leu Gln Arg Phe Pro 100 105 110 Asn Lys Pro Tyr Leu Ser 115 <210> SEQ ID NO 135 <211> LENGTH: 904 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (467)..(811) <400> SEQUENCE: 135 actctgcgtg cgccggaggc tgccgtggcg ggtgggccgc ctgacttctc ctcccggcca 60 gttctcgagc gcctcaccgg gcctcgccct gcagcctcgc tctcgctggc gctgcgcggc 120 ctaggggact gggctgctgg cctccgggtg cggggtgggg gcaggctccg acctggggcg 180 tcctggccgc gcgagccgcg ggatgggggc ccgggccgcg gaggaggcgc cgctggtgtg 240 tcccttggtg gagagggcgc tgccggccct gcgcggtttc cagccaggaa gcttcgggaa 300 gcctggacgt ctgctcactg gagatgacac gtgcgtgggg tgttggcatt cttgttattt 360 aacacgggaa ggaggtgact tcgcctgtga tggacttcca gtgtgagcac tggccagagt 420 gaccaggctg accagcacca gccctgatcc agatgcagag gccagg atg tgg gcc 475 Met Trp Ala 1 cag ccc tgt gcc agg agg ctg gct gga ata aag gta cag ata gag gcc 523 Gln Pro Cys Ala Arg Arg Leu Ala Gly Ile Lys Val Gln Ile Glu Ala 5 10 15 tca ccc cct ctg gga cca ctg gca ctc agg gtg ttt gca gcc tca gag 571 Ser Pro Pro Leu Gly Pro Leu Ala Leu Arg Val Phe Ala Ala Ser Glu 20 25 30 35 ccc acc tgc ccc cag ggc cac agc tgc atc tcc tgc cct gct gtc att 619 Pro Thr Cys Pro Gln Gly His Ser Cys Ile Ser Cys Pro Ala Val Ile 40 45 50 aca ggg atg ggc agg ctg gca tgg ggg cac ccg ctg ccc ctg cct ggg 667 Thr Gly Met Gly Arg Leu Ala Trp Gly His Pro Leu Pro Leu Pro Gly 55 60 65 tgt tgc tgt gta ttc ctg ccg gcc agg ggc cac tgc cag gac cac gcc 715 Cys Cys Cys Val Phe Leu Pro Ala Arg Gly His Cys Gln Asp His Ala 70 75 80 tcc ctt ttc ata tcc cga ttc tta agt tct gct att gtg gta ttc tgg 763 Ser Leu Phe Ile Ser Arg Phe Leu Ser Ser Ala Ile Val Val Phe Trp 85 90 95 tgg aga aaa aag aac cgc gtg gct gtt ttt gaa ctg cct gga acc taa 811 Trp Arg Lys Lys Asn Arg Val Ala Val Phe Glu Leu Pro Gly Thr 100 105 110 gaccctgaat tcttttcccc cccaagggga aaatctatat ggaaaacatt tattttaaaa 871 tacaggatga agtgaattaa aagatttaaa tgc 904 <210> SEQ ID NO 136 <211> LENGTH: 114 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 136 Met Trp Ala Gln Pro Cys Ala Arg Arg Leu Ala Gly Ile Lys Val Gln 1 5 10 15 Ile Glu Ala Ser Pro Pro Leu Gly Pro Leu Ala Leu Arg Val Phe Ala 20 25 30 Ala Ser Glu Pro Thr Cys Pro Gln Gly His Ser Cys Ile Ser Cys Pro 35 40 45 Ala Val Ile Thr Gly Met Gly Arg Leu Ala Trp Gly His Pro Leu Pro 50 55 60 Leu Pro Gly Cys Cys Cys Val Phe Leu Pro Ala Arg Gly His Cys Gln 65 70 75 80 Asp His Ala Ser Leu Phe Ile Ser Arg Phe Leu Ser Ser Ala Ile Val 85 90 95 Val Phe Trp Trp Arg Lys Lys Asn Arg Val Ala Val Phe Glu Leu Pro 100 105 110 Gly Thr <210> SEQ ID NO 137 <211> LENGTH: 472 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (90)..(353) <400> SEQUENCE: 137 aatttccgct tccggtagtg agaacccttc cggtgggcta ggtactgagc gcgcgaggct 60 ctacagagtg aaggtttaaa tccaaggtc atg gca aaa cat ctg aag ttc atc 113 Met Ala Lys His Leu Lys Phe Ile 1 5 gcc agg act gtg atg gta cag gaa ggg aac gtg gaa agc gca tac agg 161 Ala Arg Thr Val Met Val Gln Glu Gly Asn Val Glu Ser Ala Tyr Arg 10 15 20 acc cta aac aga atc ctc act atg gat ggg ctc att gag gac att aag 209 Thr Leu Asn Arg Ile Leu Thr Met Asp Gly Leu Ile Glu Asp Ile Lys 25 30 35 40 cat cgg cgg tat tat gag aag cca tgc cgc cgg cga cag agg gaa agc 257 His Arg Arg Tyr Tyr Glu Lys Pro Cys Arg Arg Arg Gln Arg Glu Ser 45 50 55 tat gaa agg tgc cgg cgg atc tac aac atg gaa atg gct cgc aag atc 305 Tyr Glu Arg Cys Arg Arg Ile Tyr Asn Met Glu Met Ala Arg Lys Ile 60 65 70 aac ttc ttg atg cga aag aat cgg gca gat ccg tgg cag ggc tgc tga 353 Asn Phe Leu Met Arg Lys Asn Arg Ala Asp Pro Trp Gln Gly Cys 75 80 85 ggcctgtggg tgggacaccc agtgcgaaac cctcatccag ttttctctcc atctcttttc 413 tttgtacaat cccatttcct attaccattc tctgcaataa actcaaatca catgtctgc 472 <210> SEQ ID NO 138 <211> LENGTH: 87 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 138 Met Ala Lys His Leu Lys Phe Ile Ala Arg Thr Val Met Val Gln Glu 1 5 10 15 Gly Asn Val Glu Ser Ala Tyr Arg Thr Leu Asn Arg Ile Leu Thr Met 20 25 30 Asp Gly Leu Ile Glu Asp Ile Lys His Arg Arg Tyr Tyr Glu Lys Pro 35 40 45 Cys Arg Arg Arg Gln Arg Glu Ser Tyr Glu Arg Cys Arg Arg Ile Tyr 50 55 60 Asn Met Glu Met Ala Arg Lys Ile Asn Phe Leu Met Arg Lys Asn Arg 65 70 75 80 Ala Asp Pro Trp Gln Gly Cys 85 <210> SEQ ID NO 139 <211> LENGTH: 180 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (49)..(168) <400> SEQUENCE: 139 attatatatg aattccattc aaatcgttcc tttttgttaa caaggggc atg ggg agg 57 Met Gly Arg 1 ggt ggg ggt ggg ggg gca gag gcg tct gac ccc agg aac ctg cag ggc 105 Gly Gly Gly Gly Gly Ala Glu Ala Ser Asp Pro Arg Asn Leu Gln Gly 5 10 15 ggg gct ggg tcg gtg ccc tct aag gac aat ttt gac ctt gtt caa cct 153 Gly Ala Gly Ser Val Pro Ser Lys Asp Asn Phe Asp Leu Val Gln Pro 20 25 30 35 ttc cac aaa gaa taa attgtgtttc ac 180 Phe His Lys Glu <210> SEQ ID NO 140 <211> LENGTH: 39 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 140 Met Gly Arg Gly Gly Gly Gly Gly Ala Glu Ala Ser Asp Pro Arg Asn 1 5 10 15 Leu Gln Gly Gly Ala Gly Ser Val Pro Ser Lys Asp Asn Phe Asp Leu 20 25 30 Val Gln Pro Phe His Lys Glu 35 <210> SEQ ID NO 141 <211> LENGTH: 473 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (35)..(343) <400> SEQUENCE: 141 gagacgcaga gtcttgagca gcgcggcagg cacc atg ttc ctg act gcg ctc ctc 55 Met Phe Leu Thr Ala Leu Leu 1 5 tgg cgc ggc cgc att ccc ggc cgt cag tgg atc ggg aag cac cgg cgg 103 Trp Arg Gly Arg Ile Pro Gly Arg Gln Trp Ile Gly Lys His Arg Arg 10 15 20 ccg cgg ttc gtg tcg ttg cgc gcc aag cag aac atg atc cgc cgc ctg 151 Pro Arg Phe Val Ser Leu Arg Ala Lys Gln Asn Met Ile Arg Arg Leu 25 30 35 gag atc gag gcg gag aac cat tac tgg ctg agc atg ccc tac atg acc 199 Glu Ile Glu Ala Glu Asn His Tyr Trp Leu Ser Met Pro Tyr Met Thr 40 45 50 55 cgg gag cag gag cgc ggc cac gcc gcg gtg cgc agg agg gag gcc ttc 247 Arg Glu Gln Glu Arg Gly His Ala Ala Val Arg Arg Arg Glu Ala Phe 60 65 70 gag gcc ata aag gcg gcc gcc act tcc aag ttc ccc ccg cat aga ttc 295 Glu Ala Ile Lys Ala Ala Ala Thr Ser Lys Phe Pro Pro His Arg Phe 75 80 85 att gcg gac cag ctc gac cat ctc aat gtc acc aag aaa tgg tcc taa 343 Ile Ala Asp Gln Leu Asp His Leu Asn Val Thr Lys Lys Trp Ser 90 95 100 tcctgagtcg tcacccttgg attttatgga tcacggagct gaccatcttt acctggtcct 403 ggaactgaaa aactgtagct tgtgtgaaaa tgagcctttg gaccagtctt tattaaaaca 463 aacaaacatg 473 <210> SEQ ID NO 142 <211> LENGTH: 102 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 142 Met Phe Leu Thr Ala Leu Leu Trp Arg Gly Arg Ile Pro Gly Arg Gln 1 5 10 15 Trp Ile Gly Lys His Arg Arg Pro Arg Phe Val Ser Leu Arg Ala Lys 20 25 30 Gln Asn Met Ile Arg Arg Leu Glu Ile Glu Ala Glu Asn His Tyr Trp 35 40 45 Leu Ser Met Pro Tyr Met Thr Arg Glu Gln Glu Arg Gly His Ala Ala 50 55 60 Val Arg Arg Arg Glu Ala Phe Glu Ala Ile Lys Ala Ala Ala Thr Ser 65 70 75 80 Lys Phe Pro Pro His Arg Phe Ile Ala Asp Gln Leu Asp His Leu Asn 85 90 95 Val Thr Lys Lys Trp Ser 100 <210> SEQ ID NO 143 <211> LENGTH: 1664 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (106)..(1131) <400> SEQUENCE: 143 tctggcactg aggccctcgc cacctgcctc gccacctggc gaccctgacc ccaccacact 60 gccttgagag tcgctcaaaa gtagggcccc agggctcgca gcagc atg ggc acc gag 117 Met Gly Thr Glu 1 aaa gaa agc cca gag ccc gac tgc cag aaa cag ttc cag gct gca gtg 165 Lys Glu Ser Pro Glu Pro Asp Cys Gln Lys Gln Phe Gln Ala Ala Val 5 10 15 20 agc gtc atc cag aac ctg ccc aag aac ggt tct tac cgc ccc tcc tat 213 Ser Val Ile Gln Asn Leu Pro Lys Asn Gly Ser Tyr Arg Pro Ser Tyr 25 30 35 gaa gag atg ctg cga ttc tac agt tac tac aag cag gcc acc atg ggg 261 Glu Glu Met Leu Arg Phe Tyr Ser Tyr Tyr Lys Gln Ala Thr Met Gly 40 45 50 ccc tgc ctg gtc ccc cgg ccc ggg ttc tgg gac ccc att gga cga tat 309 Pro Cys Leu Val Pro Arg Pro Gly Phe Trp Asp Pro Ile Gly Arg Tyr 55 60 65 aag tgg gac gcc tgg aac agt ctg ggc aag atg agc agg gag gag gcc 357 Lys Trp Asp Ala Trp Asn Ser Leu Gly Lys Met Ser Arg Glu Glu Ala 70 75 80 atg tct gcc tac atc act gaa atg aaa ctg gtg gca cag aag gtg atc 405 Met Ser Ala Tyr Ile Thr Glu Met Lys Leu Val Ala Gln Lys Val Ile 85 90 95 100 gac aca gtg ccc ctg ggt gag gtg gca gag gac atg ttt ggt tac ttc 453 Asp Thr Val Pro Leu Gly Glu Val Ala Glu Asp Met Phe Gly Tyr Phe 105 110 115 gag ccc ctg tac cag gtg atc cct gac atg ccg agg ccc cca gag acc 501 Glu Pro Leu Tyr Gln Val Ile Pro Asp Met Pro Arg Pro Pro Glu Thr 120 125 130 ttc ctg aga agg gtc aca ggt tgg aaa gag cag gtt gtg aat gga gat 549 Phe Leu Arg Arg Val Thr Gly Trp Lys Glu Gln Val Val Asn Gly Asp 135 140 145 gtt ggg gct gtt tca gag cct ccc tgc ctc ccc aag gaa ccg gca ccc 597 Val Gly Ala Val Ser Glu Pro Pro Cys Leu Pro Lys Glu Pro Ala Pro 150 155 160 cca agc cca gct tcc ctc tgg gca gta act cta cca acc cct cca cag 645 Pro Ser Pro Ala Ser Leu Trp Ala Val Thr Leu Pro Thr Pro Pro Gln 165 170 175 180 agt ccc att cac cca ggg acc tgg act ccg agg ttt tct gtg att ccc 693 Ser Pro Ile His Pro Gly Thr Trp Thr Pro Arg Phe Ser Val Ile Pro 185 190 195 tgg agc agc tgg agc ctg agc tgg ttt gga cag agc agc ggg cag cat 741 Trp Ser Ser Trp Ser Leu Ser Trp Phe Gly Gln Ser Ser Gly Gln His 200 205 210 ctg gag gaa agc gtg atc cca gga aca gcc ccg tgc ccc cca caa aga 789 Leu Glu Glu Ser Val Ile Pro Gly Thr Ala Pro Cys Pro Pro Gln Arg 215 220 225 aag agg ggt tgc ggg gca gcc cgc cgg ggc ccc agg agt tgg acg tgt 837 Lys Arg Gly Cys Gly Ala Ala Arg Arg Gly Pro Arg Ser Trp Thr Cys 230 235 240 ggc tgc tgg gga cag ttc gag cac tac agg aga gca tgc agg agg tgc 885 Gly Cys Trp Gly Gln Phe Glu His Tyr Arg Arg Ala Cys Arg Arg Cys 245 250 255 260 agg cga ggg tgc aga gcc tgg aga gca tgc ccc ggc ccc ctg agc aga 933 Arg Arg Gly Cys Arg Ala Trp Arg Ala Cys Pro Gly Pro Leu Ser Arg 265 270 275 ggc cgc agc cca ggc cca gtg ctc ggc cat ggc ccc ttg ggc tcc cgg 981 Gly Arg Ser Pro Gly Pro Val Leu Gly His Gly Pro Leu Gly Ser Arg 280 285 290 ggc ccg cgc tgc tct tct tcc tcc tgt ggc cct tcg tcg tcc agt ggc 1029 Gly Pro Arg Cys Ser Ser Ser Ser Cys Gly Pro Ser Ser Ser Ser Gly 295 300 305 tct tcc gaa tgt ttc gga ccc aaa aga ggt gac tgt cag tgg agg ggt 1077 Ser Ser Glu Cys Phe Gly Pro Lys Arg Gly Asp Cys Gln Trp Arg Gly 310 315 320 ctc tgc agc caa ctg aga cta tct tgc tgt gcc ctg agc ctt cct agg 1125 Leu Cys Ser Gln Leu Arg Leu Ser Cys Cys Ala Leu Ser Leu Pro Arg 325 330 335 340 gtt tag aagaacagca ttcaaaattc cccgtcctgt cagtgtttgc cttcgcacct 1181 Val cctcccctaa agcagcgcgg ggggcaaata agaccccacc cctccctgca gcttcacagg 1241 gacgcttcct tccctccccg caaccacccc aggctcccct gggaggctgc agttgtggta 1301 cacgtccccg gtgctgggtt ggccgtgact cgggggcggg gcgatcgggt ctcagcccct 1361 gccttcccca gtctctgggt cacccgaatt ttcccacccc tgcttctccc cgaggaggtt 1421 gagctcttga gcaagttggg acttgggccg gggcctggaa gaatgattgg ctgggaggcc 1481 gcgggaggga ggccaggagg cccggaccag ttgggaggag tgagcaggcc ccgggggagg 1541 gggatgagcg cagtttgctc gctttcctcc cctgccggcc ccctccgccc ccacacacac 1601 tcgggacgtc ttcattgaag attcacttac aaaggaatgt ttcactaaat aaaagaaaac 1661 cag 1664 <210> SEQ ID NO 144 <211> LENGTH: 341 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 144 Met Gly Thr Glu Lys Glu Ser Pro Glu Pro Asp Cys Gln Lys Gln Phe 1 5 10 15 Gln Ala Ala Val Ser Val Ile Gln Asn Leu Pro Lys Asn Gly Ser Tyr 20 25 30 Arg Pro Ser Tyr Glu Glu Met Leu Arg Phe Tyr Ser Tyr Tyr Lys Gln 35 40 45 Ala Thr Met Gly Pro Cys Leu Val Pro Arg Pro Gly Phe Trp Asp Pro 50 55 60 Ile Gly Arg Tyr Lys Trp Asp Ala Trp Asn Ser Leu Gly Lys Met Ser 65 70 75 80 Arg Glu Glu Ala Met Ser Ala Tyr Ile Thr Glu Met Lys Leu Val Ala 85 90 95 Gln Lys Val Ile Asp Thr Val Pro Leu Gly Glu Val Ala Glu Asp Met 100 105 110 Phe Gly Tyr Phe Glu Pro Leu Tyr Gln Val Ile Pro Asp Met Pro Arg 115 120 125 Pro Pro Glu Thr Phe Leu Arg Arg Val Thr Gly Trp Lys Glu Gln Val 130 135 140 Val Asn Gly Asp Val Gly Ala Val Ser Glu Pro Pro Cys Leu Pro Lys 145 150 155 160 Glu Pro Ala Pro Pro Ser Pro Ala Ser Leu Trp Ala Val Thr Leu Pro 165 170 175 Thr Pro Pro Gln Ser Pro Ile His Pro Gly Thr Trp Thr Pro Arg Phe 180 185 190 Ser Val Ile Pro Trp Ser Ser Trp Ser Leu Ser Trp Phe Gly Gln Ser 195 200 205 Ser Gly Gln His Leu Glu Glu Ser Val Ile Pro Gly Thr Ala Pro Cys 210 215 220 Pro Pro Gln Arg Lys Arg Gly Cys Gly Ala Ala Arg Arg Gly Pro Arg 225 230 235 240 Ser Trp Thr Cys Gly Cys Trp Gly Gln Phe Glu His Tyr Arg Arg Ala 245 250 255 Cys Arg Arg Cys Arg Arg Gly Cys Arg Ala Trp Arg Ala Cys Pro Gly 260 265 270 Pro Leu Ser Arg Gly Arg Ser Pro Gly Pro Val Leu Gly His Gly Pro 275 280 285 Leu Gly Ser Arg Gly Pro Arg Cys Ser Ser Ser Ser Cys Gly Pro Ser 290 295 300 Ser Ser Ser Gly Ser Ser Glu Cys Phe Gly Pro Lys Arg Gly Asp Cys 305 310 315 320 Gln Trp Arg Gly Leu Cys Ser Gln Leu Arg Leu Ser Cys Cys Ala Leu 325 330 335 Ser Leu Pro Arg Val 340 <210> SEQ ID NO 145 <211> LENGTH: 835 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (90)..(740) <400> SEQUENCE: 145 aaaaatccga agtgccgcgg aaagtggaga gctgacaagg aaggtttcga gcgttttgct 60 ggcaaaggga tttcttacaa cctccaggc atg cgt ctt tct gcc ctg ctg gcc 113 Met Arg Leu Ser Ala Leu Leu Ala 1 5 ttg gca tcc aag gtc act ctg ccc ccc cat tac cgc tat ggg atg agc 161 Leu Ala Ser Lys Val Thr Leu Pro Pro His Tyr Arg Tyr Gly Met Ser 10 15 20 ccc cca ggc tct gtt gca gac aag agg aag aac ccc cca tgg atc agg 209 Pro Pro Gly Ser Val Ala Asp Lys Arg Lys Asn Pro Pro Trp Ile Arg 25 30 35 40 cgg cgc cca gtg gtt gtg gaa ccc atc tct gat gaa gac tgg tat ctg 257 Arg Arg Pro Val Val Val Glu Pro Ile Ser Asp Glu Asp Trp Tyr Leu 45 50 55 ttc tgt ggg gac acg gtg gag atc cta gaa ggc aag gat gcc ggg aag 305 Phe Cys Gly Asp Thr Val Glu Ile Leu Glu Gly Lys Asp Ala Gly Lys 60 65 70 cag ggc aaa gtg gtt caa gtt atc cgg cag cga aac tgg gtg gtc gtg 353 Gln Gly Lys Val Val Gln Val Ile Arg Gln Arg Asn Trp Val Val Val 75 80 85 gga ggg ctg aac aca cat tac cgc tac att ggc aag acc atg gat tac 401 Gly Gly Leu Asn Thr His Tyr Arg Tyr Ile Gly Lys Thr Met Asp Tyr 90 95 100 cgg gga acc atg atc cct agt gaa gcc ccc ttg ctc cac cgc cag gtc 449 Arg Gly Thr Met Ile Pro Ser Glu Ala Pro Leu Leu His Arg Gln Val 105 110 115 120 aaa ctt gtg gat cct atg gac agg aaa ccc act gag atc gag tgg aga 497 Lys Leu Val Asp Pro Met Asp Arg Lys Pro Thr Glu Ile Glu Trp Arg 125 130 135 ttt act gaa gca gga gag cgg gta cga gtc tcc aca cga tca ggg aga 545 Phe Thr Glu Ala Gly Glu Arg Val Arg Val Ser Thr Arg Ser Gly Arg 140 145 150 att atc cct aaa ccc gaa ttt ccc aga gct gat ggc atc gtc cct gaa 593 Ile Ile Pro Lys Pro Glu Phe Pro Arg Ala Asp Gly Ile Val Pro Glu 155 160 165 acg tgg att gat ggc ccc aaa gac aca tca gtg gaa gat gct tta gaa 641 Thr Trp Ile Asp Gly Pro Lys Asp Thr Ser Val Glu Asp Ala Leu Glu 170 175 180 aga acc tat gtg ccc tgt cta aag aca ctg cag gag gag gtg atg gag 689 Arg Thr Tyr Val Pro Cys Leu Lys Thr Leu Gln Glu Glu Val Met Glu 185 190 195 200 gcc atg ggg atc aag gag acc cgg aaa tac aag aag gtc tat tgg tat 737 Ala Met Gly Ile Lys Glu Thr Arg Lys Tyr Lys Lys Val Tyr Trp Tyr 205 210 215 tga gcctggggca gagcagctcc tccccaactt ctgtcccagc cttgaaggct 790 gaggcacttc tttttcagat gccaataaag agcactttat gagtc 835 <210> SEQ ID NO 146 <211> LENGTH: 216 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 146 Met Arg Leu Ser Ala Leu Leu Ala Leu Ala Ser Lys Val Thr Leu Pro 1 5 10 15 Pro His Tyr Arg Tyr Gly Met Ser Pro Pro Gly Ser Val Ala Asp Lys 20 25 30 Arg Lys Asn Pro Pro Trp Ile Arg Arg Arg Pro Val Val Val Glu Pro 35 40 45 Ile Ser Asp Glu Asp Trp Tyr Leu Phe Cys Gly Asp Thr Val Glu Ile 50 55 60 Leu Glu Gly Lys Asp Ala Gly Lys Gln Gly Lys Val Val Gln Val Ile 65 70 75 80 Arg Gln Arg Asn Trp Val Val Val Gly Gly Leu Asn Thr His Tyr Arg 85 90 95 Tyr Ile Gly Lys Thr Met Asp Tyr Arg Gly Thr Met Ile Pro Ser Glu 100 105 110 Ala Pro Leu Leu His Arg Gln Val Lys Leu Val Asp Pro Met Asp Arg 115 120 125 Lys Pro Thr Glu Ile Glu Trp Arg Phe Thr Glu Ala Gly Glu Arg Val 130 135 140 Arg Val Ser Thr Arg Ser Gly Arg Ile Ile Pro Lys Pro Glu Phe Pro 145 150 155 160 Arg Ala Asp Gly Ile Val Pro Glu Thr Trp Ile Asp Gly Pro Lys Asp 165 170 175 Thr Ser Val Glu Asp Ala Leu Glu Arg Thr Tyr Val Pro Cys Leu Lys 180 185 190 Thr Leu Gln Glu Glu Val Met Glu Ala Met Gly Ile Lys Glu Thr Arg 195 200 205 Lys Tyr Lys Lys Val Tyr Trp Tyr 210 215 <210> SEQ ID NO 147 <211> LENGTH: 2465 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (71)..(1261) <400> SEQUENCE: 147 aaactcgtca tttcctccag ctagaggagc tcaactgatc tgttttcttt cgcccagcca 60 aaatcacaga atg aag gcg gtg aag agc gaa cgg gag cga ggg agc cgg 109 Met Lys Ala Val Lys Ser Glu Arg Glu Arg Gly Ser Arg 1 5 10 cga aga cac cgg gac ggg gac gtg gtg ctg ccg gcg ggg gtg gtg gtg 157 Arg Arg His Arg Asp Gly Asp Val Val Leu Pro Ala Gly Val Val Val 15 20 25 aag cag gag cgt ctc agc cca gaa gtc gca cct ccc gcc cac cgc cgt 205 Lys Gln Glu Arg Leu Ser Pro Glu Val Ala Pro Pro Ala His Arg Arg 30 35 40 45 ccg gac cac tcc ggt ggt agc ccg tct ccg ccg acc agc gag ccg gcc 253 Pro Asp His Ser Gly Gly Ser Pro Ser Pro Pro Thr Ser Glu Pro Ala 50 55 60 cgc tcg ggc cac cgc ggg aac cga gcc cga gga gtt agc cgg tcc cca 301 Arg Ser Gly His Arg Gly Asn Arg Ala Arg Gly Val Ser Arg Ser Pro 65 70 75 ccc aaa aag aaa aac aag gcc tca ggg aga aga agc aag tct cct cgc 349 Pro Lys Lys Lys Asn Lys Ala Ser Gly Arg Arg Ser Lys Ser Pro Arg 80 85 90 agt aag aga aac cga agt cct cac cac tca aca gtc aaa gtg aag cag 397 Ser Lys Arg Asn Arg Ser Pro His His Ser Thr Val Lys Val Lys Gln 95 100 105 gag cgt gag gat cat ccc cgg aga gga cgg gag gat cgg cag cac agg 445 Glu Arg Glu Asp His Pro Arg Arg Gly Arg Glu Asp Arg Gln His Arg 110 115 120 125 gaa cca tca gaa cag gaa cac agg aga gct agg aac agt gac cgg gac 493 Glu Pro Ser Glu Gln Glu His Arg Arg Ala Arg Asn Ser Asp Arg Asp 130 135 140 aga cac cgg ggc cat tcc cac caa agg aga acg tct aac gag agg cct 541 Arg His Arg Gly His Ser His Gln Arg Arg Thr Ser Asn Glu Arg Pro 145 150 155 ggg agt ggg cag ggt cag gga cgg gat cga gac act cag aac ctg cag 589 Gly Ser Gly Gln Gly Gln Gly Arg Asp Arg Asp Thr Gln Asn Leu Gln 160 165 170 gct cag gaa gaa gag cgg gag ttt tat aat gcc agg cga cgg gag cat 637 Ala Gln Glu Glu Glu Arg Glu Phe Tyr Asn Ala Arg Arg Arg Glu His 175 180 185 cgc cag agg aat gac gtt ggt ggt ggc ggc agt gag tct cag gag ttg 685 Arg Gln Arg Asn Asp Val Gly Gly Gly Gly Ser Glu Ser Gln Glu Leu 190 195 200 205 gtt cct cgg cct ggt ggc aac aac aaa gaa aaa gag gtg ccc gct aaa 733 Val Pro Arg Pro Gly Gly Asn Asn Lys Glu Lys Glu Val Pro Ala Lys 210 215 220 gaa aaa cca agc ttt gaa ctt tct ggg gca ctt ctt gag gac acc aac 781 Glu Lys Pro Ser Phe Glu Leu Ser Gly Ala Leu Leu Glu Asp Thr Asn 225 230 235 act ttc cgg ggt gta gtc att aaa tat agt gag ccc cca gaa gca cgt 829 Thr Phe Arg Gly Val Val Ile Lys Tyr Ser Glu Pro Pro Glu Ala Arg 240 245 250 atc ccc aaa aaa cgg tgg cgt ctc tac cca ttt aaa aat gat gag gtg 877 Ile Pro Lys Lys Arg Trp Arg Leu Tyr Pro Phe Lys Asn Asp Glu Val 255 260 265 ctt cca gtc atg tac ata cat cga cag agt gcg tac cta ctg ggt cga 925 Leu Pro Val Met Tyr Ile His Arg Gln Ser Ala Tyr Leu Leu Gly Arg 270 275 280 285 cac cgc cgc att gca gac att cca att gat cac ccg tct tgt tca aag 973 His Arg Arg Ile Ala Asp Ile Pro Ile Asp His Pro Ser Cys Ser Lys 290 295 300 cag cat gcg gtc ttt caa tat cgg ctt gtg gaa tat acc cgt gct gat 1021 Gln His Ala Val Phe Gln Tyr Arg Leu Val Glu Tyr Thr Arg Ala Asp 305 310 315 ggc aca gtt ggc cga aga gtg aag ccc tac atc att gac ctt ggc tca 1069 Gly Thr Val Gly Arg Arg Val Lys Pro Tyr Ile Ile Asp Leu Gly Ser 320 325 330 ggc aat gga acc ttc tta aac aac aaa cgt att gag cca cag aga tac 1117 Gly Asn Gly Thr Phe Leu Asn Asn Lys Arg Ile Glu Pro Gln Arg Tyr 335 340 345 tat gaa cta aaa gaa aag gat gta ctc aaa ttt gga ttc agt agc aga 1165 Tyr Glu Leu Lys Glu Lys Asp Val Leu Lys Phe Gly Phe Ser Ser Arg 350 355 360 365 gaa tac gtc ttg ctc cat gag tcg tcg gac act tct gaa ata gac agg 1213 Glu Tyr Val Leu Leu His Glu Ser Ser Asp Thr Ser Glu Ile Asp Arg 370 375 380 aaa gat gac gag gat gag gag gag gag gaa gaa gtg tct gac agc tag 1261 Lys Asp Asp Glu Asp Glu Glu Glu Glu Glu Glu Val Ser Asp Ser 385 390 395 caaactaaga acccaaacta ttgatacacg gtttccttct tggaagtctt tgattgactc 1321 agagagcact atggtggtgg gtccagcact atggtgctct ctgtaatgcc tcttactgcc 1381 ttaagtcttt cctctgttgc tgaccagatt gtgttaccat ttgaatacac tgactaatgt 1441 ttgttaaact ttttctgtgg caccttggcc acatgcctgc aggcatttgt tttcagaaca 1501 gtctcaccaa ttacaacaca ccgtgtttta gtagaagtgt tgtggtttta gttggtgctt 1561 tcagaactgc tgcctaggaa actataaacc cttggttaag gggaaatcat ggcttgttct 1621 ctttgtacag ttactttatt tatataggtg ttaagctttg tggaccaggt gtttttcttt 1681 tggggcgaac ccctgagcag agaatcttac taggctttgg ttatcaccaa aacaacctcc 1741 agtatatacc aaagctttga cttgtttgag ctcttgagct tagaagttga ttttgcactt 1801 atttttttgg ggggtgggaa tgtactgcag tcagtaaaca ttattgactg tttaacttaa 1861 acagatgctt tatggcacct gctcaagccc gtgactgtac agaaggatcc tggttgctac 1921 cagtgggtgc tgattcagca tcacaagtga ctgaaattgg ctgtggatct gttctttgtg 1981 aaagaattcc tgatttctcc atggagcatg tacacaacaa ttttgatcat attaactgta 2041 cttcagtttt gcatttttat tcaaatgtta tctctttttt tctttgagaa ataaactgtc 2101 actgatgtga cagcgttctt tctttattct aataacatgt atagatctaa agcaggttgt 2161 gttgtttaca tgtttctaca catttcatcc tttaaaaagt tgttgagaga ggttgtattt 2221 accttcccaa ggttggaaag caggggaatt tcccagtgtc ctagttttcc accagaggaa 2281 tatgtgtaag tagcaaagta tttgctgctt acatatagtg tgtatgtatg tatatatgta 2341 aattgtgtgt taaagagctg atactgattt tcatatgaca atgttaggca aaggcctccc 2401 tgcatttgaa gagcaggttt tcatttatat gtatttttgg gataaaaaaa taaatttgta 2461 atat 2465 <210> SEQ ID NO 148 <211> LENGTH: 396 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 148 Met Lys Ala Val Lys Ser Glu Arg Glu Arg Gly Ser Arg Arg Arg His 1 5 10 15 Arg Asp Gly Asp Val Val Leu Pro Ala Gly Val Val Val Lys Gln Glu 20 25 30 Arg Leu Ser Pro Glu Val Ala Pro Pro Ala His Arg Arg Pro Asp His 35 40 45 Ser Gly Gly Ser Pro Ser Pro Pro Thr Ser Glu Pro Ala Arg Ser Gly 50 55 60 His Arg Gly Asn Arg Ala Arg Gly Val Ser Arg Ser Pro Pro Lys Lys 65 70 75 80 Lys Asn Lys Ala Ser Gly Arg Arg Ser Lys Ser Pro Arg Ser Lys Arg 85 90 95 Asn Arg Ser Pro His His Ser Thr Val Lys Val Lys Gln Glu Arg Glu 100 105 110 Asp His Pro Arg Arg Gly Arg Glu Asp Arg Gln His Arg Glu Pro Ser 115 120 125 Glu Gln Glu His Arg Arg Ala Arg Asn Ser Asp Arg Asp Arg His Arg 130 135 140 Gly His Ser His Gln Arg Arg Thr Ser Asn Glu Arg Pro Gly Ser Gly 145 150 155 160 Gln Gly Gln Gly Arg Asp Arg Asp Thr Gln Asn Leu Gln Ala Gln Glu 165 170 175 Glu Glu Arg Glu Phe Tyr Asn Ala Arg Arg Arg Glu His Arg Gln Arg 180 185 190 Asn Asp Val Gly Gly Gly Gly Ser Glu Ser Gln Glu Leu Val Pro Arg 195 200 205 Pro Gly Gly Asn Asn Lys Glu Lys Glu Val Pro Ala Lys Glu Lys Pro 210 215 220 Ser Phe Glu Leu Ser Gly Ala Leu Leu Glu Asp Thr Asn Thr Phe Arg 225 230 235 240 Gly Val Val Ile Lys Tyr Ser Glu Pro Pro Glu Ala Arg Ile Pro Lys 245 250 255 Lys Arg Trp Arg Leu Tyr Pro Phe Lys Asn Asp Glu Val Leu Pro Val 260 265 270 Met Tyr Ile His Arg Gln Ser Ala Tyr Leu Leu Gly Arg His Arg Arg 275 280 285 Ile Ala Asp Ile Pro Ile Asp His Pro Ser Cys Ser Lys Gln His Ala 290 295 300 Val Phe Gln Tyr Arg Leu Val Glu Tyr Thr Arg Ala Asp Gly Thr Val 305 310 315 320 Gly Arg Arg Val Lys Pro Tyr Ile Ile Asp Leu Gly Ser Gly Asn Gly 325 330 335 Thr Phe Leu Asn Asn Lys Arg Ile Glu Pro Gln Arg Tyr Tyr Glu Leu 340 345 350 Lys Glu Lys Asp Val Leu Lys Phe Gly Phe Ser Ser Arg Glu Tyr Val 355 360 365 Leu Leu His Glu Ser Ser Asp Thr Ser Glu Ile Asp Arg Lys Asp Asp 370 375 380 Glu Asp Glu Glu Glu Glu Glu Glu Val Ser Asp Ser 385 390 395 <210> SEQ ID NO 149 <211> LENGTH: 3600 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (149)..(1504) <400> SEQUENCE: 149 aatccagcgc agccgggaga cagatgcgag gcggcggtca gcaggtgccg aacccacggc 60 caggcttccg tggccagcag ccctagagga atggccatcc tgtccctgcg agcccctggg 120 ccctggcagg cgatgcaggt gggatgct atg gaa tat gat gag aag ctg gcc 172 Met Glu Tyr Asp Glu Lys Leu Ala 1 5 cgt ttc cgg cag gcc cac ctc aac ccc ttc aac aag cag tct ggg ccg 220 Arg Phe Arg Gln Ala His Leu Asn Pro Phe Asn Lys Gln Ser Gly Pro 10 15 20 aga cag cat gag cag ggc cct ggg gag gag gtc ccg gac gtc act cct 268 Arg Gln His Glu Gln Gly Pro Gly Glu Glu Val Pro Asp Val Thr Pro 25 30 35 40 gaa gag gcc ctg cct gag ctg ccc cct ggg gag ccg gaa ttc cgc tgc 316 Glu Glu Ala Leu Pro Glu Leu Pro Pro Gly Glu Pro Glu Phe Arg Cys 45 50 55 cct gaa cgc gtg atg gat ctc ggc ctg tct gag gac cac ttc tcc cgc 364 Pro Glu Arg Val Met Asp Leu Gly Leu Ser Glu Asp His Phe Ser Arg 60 65 70 cct gtg ggt ctg ttc ctg gcc tct gac gtc cag cag ctg cgg cag gcg 412 Pro Val Gly Leu Phe Leu Ala Ser Asp Val Gln Gln Leu Arg Gln Ala 75 80 85 atc gag gag tgc aag cag gtg att ctg gag ctg ccc gag cag tcg gag 460 Ile Glu Glu Cys Lys Gln Val Ile Leu Glu Leu Pro Glu Gln Ser Glu 90 95 100 aag cag aag gat gcc gtg gtg cga ctc atc cac ctc cgg ctg aag ctc 508 Lys Gln Lys Asp Ala Val Val Arg Leu Ile His Leu Arg Leu Lys Leu 105 110 115 120 cag gag ctg aag gac ccc aat gag gat gag cca aac atc cga gtg ctc 556 Gln Glu Leu Lys Asp Pro Asn Glu Asp Glu Pro Asn Ile Arg Val Leu 125 130 135 ctt gag cac cgc ttt tac aag gag aag agc aag agc gtc aag cag acc 604 Leu Glu His Arg Phe Tyr Lys Glu Lys Ser Lys Ser Val Lys Gln Thr 140 145 150 tgt gac aag tgt aac acc atc atc tgg ggg ctc att cag acc tgg tac 652 Cys Asp Lys Cys Asn Thr Ile Ile Trp Gly Leu Ile Gln Thr Trp Tyr 155 160 165 acc tgc aca ggg tgt tat tac cgc tgt cac agt aag tgc ttg aac ctc 700 Thr Cys Thr Gly Cys Tyr Tyr Arg Cys His Ser Lys Cys Leu Asn Leu 170 175 180 atc tcc aag ccc tgt gtg agc tcc aaa gtc agc cac caa gct gaa tac 748 Ile Ser Lys Pro Cys Val Ser Ser Lys Val Ser His Gln Ala Glu Tyr 185 190 195 200 gaa ctg aac atc tgc cct gag aca ggg ctg gac agc cag gat tac cgc 796 Glu Leu Asn Ile Cys Pro Glu Thr Gly Leu Asp Ser Gln Asp Tyr Arg 205 210 215 tgt gcc gag tgc cgg gcg ccc atc tct ctg cgg ggt gtg ccc agt gag 844 Cys Ala Glu Cys Arg Ala Pro Ile Ser Leu Arg Gly Val Pro Ser Glu 220 225 230 gcc agg cag tgc gac tac acc ggc cag tac tac tgc agc cac tgc cac 892 Ala Arg Gln Cys Asp Tyr Thr Gly Gln Tyr Tyr Cys Ser His Cys His 235 240 245 tgg aac gac ctg gct gtg atc cct gca cgc gtt gta cac aac tgg gac 940 Trp Asn Asp Leu Ala Val Ile Pro Ala Arg Val Val His Asn Trp Asp 250 255 260 ttt gag cct cga aag gtt tct cgc tgc agc atg cgc tac ctg gcg ctg 988 Phe Glu Pro Arg Lys Val Ser Arg Cys Ser Met Arg Tyr Leu Ala Leu 265 270 275 280 atg gtg tct cgg ccc gta ctc agg ctc cgg gag atc aac cct ctg ctg 1036 Met Val Ser Arg Pro Val Leu Arg Leu Arg Glu Ile Asn Pro Leu Leu 285 290 295 ttc agc tac gtg gag gag ctg gtg gag att cgc aag ctg cgc cag gac 1084 Phe Ser Tyr Val Glu Glu Leu Val Glu Ile Arg Lys Leu Arg Gln Asp 300 305 310 atc ctg ctc atg aag ccg tac ttc atc acc tgc agg gag gcc atg gag 1132 Ile Leu Leu Met Lys Pro Tyr Phe Ile Thr Cys Arg Glu Ala Met Glu 315 320 325 gct cgt ctg ctg ctg cag ctc cag gat cgg cag cat ttt gtg gag aac 1180 Ala Arg Leu Leu Leu Gln Leu Gln Asp Arg Gln His Phe Val Glu Asn 330 335 340 gac gag atg tac tct gtc cag gac ctc ctg gac gtg cat gcc ggc cgc 1228 Asp Glu Met Tyr Ser Val Gln Asp Leu Leu Asp Val His Ala Gly Arg 345 350 355 360 ctg ggc tgc tcg ctc acc gag atc cac acg ctc ttc gcc aag cac atc 1276 Leu Gly Cys Ser Leu Thr Glu Ile His Thr Leu Phe Ala Lys His Ile 365 370 375 aag ctg gac tgc gag cgg tgc cag gcc aag ggc ttc gtg tgt gag ctc 1324 Lys Leu Asp Cys Glu Arg Cys Gln Ala Lys Gly Phe Val Cys Glu Leu 380 385 390 tgc aga gag ggc gac gtg ctg ttc ccg ttc gac agc cac acg tct gtg 1372 Cys Arg Glu Gly Asp Val Leu Phe Pro Phe Asp Ser His Thr Ser Val 395 400 405 tgc gcc gac tgc tcc gcg gtc ttc cac agg gac tgc tac tac gac aac 1420 Cys Ala Asp Cys Ser Ala Val Phe His Arg Asp Cys Tyr Tyr Asp Asn 410 415 420 tcc acc act tgt ccc aag tgt gcc cgg ctc agc ctg agg aag cag tcg 1468 Ser Thr Thr Cys Pro Lys Cys Ala Arg Leu Ser Leu Arg Lys Gln Ser 425 430 435 440 ctc ttc cag gag cca ggt ccc gat gtg gag gcc tag cgccgaggaa 1514 Leu Phe Gln Glu Pro Gly Pro Asp Val Glu Ala 445 450 cagtgctggg caccccgcct ggcccgccag gacccaccct gccaacatca agttgttcct 1574 tctgctccgg agacccctgg ggtgcggccc tggccccctc cacccctgct gggccagagc 1634 gggtgggcag tgtcaaggcc cgctgtctcc caggtgcttg ctgggactcg gggcggctgc 1694 acctggctgt cacctgggtg tgctgctgtg aggggtcctt gcgtggcccc catccttccc 1754 ccaatgcaga actccatggg cagggagctg gggggacatc tcacctcccc catggcacag 1814 agccctccac acccctggac cagggcatcc gggccctaga aattccacag ctcccgtcct 1874 ggccaccctg gaagctcatc aggccaagac ccggacagag cttcagagga gtgttgagtg 1934 acacctgagg atgcggctgc acacactcag ccaagggccg agtctcacct gcggtggggt 1994 ttcggctctg cctgggggct ccatcccttt cagccactcg tggccttggg gatttctggt 2054 tgtccccagc tgggactgtt cacagttgtc acctgcagac ctgcctctcc ctggcctgag 2114 gttcaaaggc ctcatcggat ggtcagtaca gtggggtcac ctgttgtttc tatacaacag 2174 cagggaaggg gccatggagc ttttccctgc tgggtgctcc tgctttggcc cagcccacct 2234 ttcctggtgc tccaagctag gaggctgtgg ccccagcctg aggagggtgt cctggcctcc 2294 aggtgtgcag caggggctgt gtgctggggg aggttccagt taggcgatgg gatcctgcag 2354 tggtctggtg gcatttcttg gaaccagatt tacctgagga gctctgtcct gctccctgtg 2414 gagggctcca gatagctcag aaatgaccag ccaatggcct tttgtttggg ggcctgaggt 2474 caagagagct gagagtattc gctcgactga gcacattcag gaagatcagg gcaggcgtgt 2534 gggaggtccc tcactccacg ggacagaggc ccctggacag cagaggaaac ctacagctct 2594 gggtgagggg acacttggct ttggtgtttg cactttacag atcctgcggt ccacgagggg 2654 cctcaggaga ggacgtgtca ggacgtggct tcccagcctt ctgccttggg cagtgggggt 2714 gctcctgtct gtccttttcc cccacaccct ggactgtgct tggctgttgg tgcacatggt 2774 tggcacacgg tgggcagagg gcagagaatg ccactgcttg gttattggtc ccctttgacc 2834 aggaaaccca agaggagaca cctcagtcag cagaaaggcc acctggctca ctggctcatt 2894 ccaggagtgg gagagacggc agggtctcct ctttgtcctc cggcatcagg aaggggatgg 2954 tgtccactcc ccactgtggt ggctttaggc aaggttctta ttgtctgctc tgcctcggtt 3014 tccccatctg gaaaatgggg gcaggggtcc tgacctacct caggtggaac ggtgagcagg 3074 gaacatgtcg gagtccttca gagaatgtga tgtgaggttg gatcaacagt gtgggttcct 3134 gtcctgtttc cccttcctct ttggggctga ggaggaggtt aaaggccaaa tgctgtttcc 3194 caacacccca aagtctgcac acgtctcatg aatgcatcac atttctgtca tatggatatt 3254 agccattccg aaatctgtgt aatcaacttc acattattca agttacaaat cactgtgtcc 3314 atagaaaaac tgtgctggta tttgctggac aaagggttgg gcccctttta tttttacctg 3374 ccacccagca tctcccccac ctgccccttc tgggtgacac agccggtaaa cggaatcacg 3434 tatggttctt tctgtgggtc tgtggcacag caggaagagc ccggtgccgc cagcaccttg 3494 tggaagacca cacatgggtg gtcccacagc atgggaccag gctggcctga gggatgccca 3554 gttgtaacaa tgctgctgtc actgtctcat taaatataca tccttt 3600 <210> SEQ ID NO 150 <211> LENGTH: 451 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 150 Met Glu Tyr Asp Glu Lys Leu Ala Arg Phe Arg Gln Ala His Leu Asn 1 5 10 15 Pro Phe Asn Lys Gln Ser Gly Pro Arg Gln His Glu Gln Gly Pro Gly 20 25 30 Glu Glu Val Pro Asp Val Thr Pro Glu Glu Ala Leu Pro Glu Leu Pro 35 40 45 Pro Gly Glu Pro Glu Phe Arg Cys Pro Glu Arg Val Met Asp Leu Gly 50 55 60 Leu Ser Glu Asp His Phe Ser Arg Pro Val Gly Leu Phe Leu Ala Ser 65 70 75 80 Asp Val Gln Gln Leu Arg Gln Ala Ile Glu Glu Cys Lys Gln Val Ile 85 90 95 Leu Glu Leu Pro Glu Gln Ser Glu Lys Gln Lys Asp Ala Val Val Arg 100 105 110 Leu Ile His Leu Arg Leu Lys Leu Gln Glu Leu Lys Asp Pro Asn Glu 115 120 125 Asp Glu Pro Asn Ile Arg Val Leu Leu Glu His Arg Phe Tyr Lys Glu 130 135 140 Lys Ser Lys Ser Val Lys Gln Thr Cys Asp Lys Cys Asn Thr Ile Ile 145 150 155 160 Trp Gly Leu Ile Gln Thr Trp Tyr Thr Cys Thr Gly Cys Tyr Tyr Arg 165 170 175 Cys His Ser Lys Cys Leu Asn Leu Ile Ser Lys Pro Cys Val Ser Ser 180 185 190 Lys Val Ser His Gln Ala Glu Tyr Glu Leu Asn Ile Cys Pro Glu Thr 195 200 205 Gly Leu Asp Ser Gln Asp Tyr Arg Cys Ala Glu Cys Arg Ala Pro Ile 210 215 220 Ser Leu Arg Gly Val Pro Ser Glu Ala Arg Gln Cys Asp Tyr Thr Gly 225 230 235 240 Gln Tyr Tyr Cys Ser His Cys His Trp Asn Asp Leu Ala Val Ile Pro 245 250 255 Ala Arg Val Val His Asn Trp Asp Phe Glu Pro Arg Lys Val Ser Arg 260 265 270 Cys Ser Met Arg Tyr Leu Ala Leu Met Val Ser Arg Pro Val Leu Arg 275 280 285 Leu Arg Glu Ile Asn Pro Leu Leu Phe Ser Tyr Val Glu Glu Leu Val 290 295 300 Glu Ile Arg Lys Leu Arg Gln Asp Ile Leu Leu Met Lys Pro Tyr Phe 305 310 315 320 Ile Thr Cys Arg Glu Ala Met Glu Ala Arg Leu Leu Leu Gln Leu Gln 325 330 335 Asp Arg Gln His Phe Val Glu Asn Asp Glu Met Tyr Ser Val Gln Asp 340 345 350 Leu Leu Asp Val His Ala Gly Arg Leu Gly Cys Ser Leu Thr Glu Ile 355 360 365 His Thr Leu Phe Ala Lys His Ile Lys Leu Asp Cys Glu Arg Cys Gln 370 375 380 Ala Lys Gly Phe Val Cys Glu Leu Cys Arg Glu Gly Asp Val Leu Phe 385 390 395 400 Pro Phe Asp Ser His Thr Ser Val Cys Ala Asp Cys Ser Ala Val Phe 405 410 415 His Arg Asp Cys Tyr Tyr Asp Asn Ser Thr Thr Cys Pro Lys Cys Ala 420 425 430 Arg Leu Ser Leu Arg Lys Gln Ser Leu Phe Gln Glu Pro Gly Pro Asp 435 440 445 Val Glu Ala 450 <210> SEQ ID NO 151 <211> LENGTH: 442 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (12)..(353) <400> SEQUENCE: 151 gttctacagc t atg gcc ggg cca gct gca gct ttc cgc cgc ttg ggc gcc 50 Met Ala Gly Pro Ala Ala Ala Phe Arg Arg Leu Gly Ala 1 5 10 ttg tcc gga gct gcg gcc tta ggc ttc gct tcc tac ggg gcg cac ggc 98 Leu Ser Gly Ala Ala Ala Leu Gly Phe Ala Ser Tyr Gly Ala His Gly 15 20 25 gcc caa ttc cca gat gcc tac ggg aag gag ctg ttt gac aag gcc aac 146 Ala Gln Phe Pro Asp Ala Tyr Gly Lys Glu Leu Phe Asp Lys Ala Asn 30 35 40 45 aaa cac cac ttc tta cac agc ctg gcc ctg tta ggg gtg ccc cat tgc 194 Lys His His Phe Leu His Ser Leu Ala Leu Leu Gly Val Pro His Cys 50 55 60 aga aag cca ctc tgg gct ggg tta ttg cta gct tcc gga acg acc tta 242 Arg Lys Pro Leu Trp Ala Gly Leu Leu Leu Ala Ser Gly Thr Thr Leu 65 70 75 ttc tgc acc agc ttt tac tac cag gct ctg agt gga gac ccc agc atc 290 Phe Cys Thr Ser Phe Tyr Tyr Gln Ala Leu Ser Gly Asp Pro Ser Ile 80 85 90 cag act ttg gcc cct gcg gga ggg acc ctg cta ctc ttg ggc tgg ctt 338 Gln Thr Leu Ala Pro Ala Gly Gly Thr Leu Leu Leu Leu Gly Trp Leu 95 100 105 gcc ttg gct ctt tga gctccctttt gcttaattac tgggttttct gggcagtttt 393 Ala Leu Ala Leu 110 tttttttaaa gagttggagt aagaagagga ttaaaaagga aaggcaaat 442 <210> SEQ ID NO 152 <211> LENGTH: 113 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 152 Met Ala Gly Pro Ala Ala Ala Phe Arg Arg Leu Gly Ala Leu Ser Gly 1 5 10 15 Ala Ala Ala Leu Gly Phe Ala Ser Tyr Gly Ala His Gly Ala Gln Phe 20 25 30 Pro Asp Ala Tyr Gly Lys Glu Leu Phe Asp Lys Ala Asn Lys His His 35 40 45 Phe Leu His Ser Leu Ala Leu Leu Gly Val Pro His Cys Arg Lys Pro 50 55 60 Leu Trp Ala Gly Leu Leu Leu Ala Ser Gly Thr Thr Leu Phe Cys Thr 65 70 75 80 Ser Phe Tyr Tyr Gln Ala Leu Ser Gly Asp Pro Ser Ile Gln Thr Leu 85 90 95 Ala Pro Ala Gly Gly Thr Leu Leu Leu Leu Gly Trp Leu Ala Leu Ala 100 105 110 Leu <210> SEQ ID NO 153 <211> LENGTH: 726 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (12)..(680) <400> SEQUENCE: 153 gcacagccaa g atg gcg gcg tcc gtg cga cag gca cgc agc cta cta ggt 50 Met Ala Ala Ser Val Arg Gln Ala Arg Ser Leu Leu Gly 1 5 10 gtg gcg gcg acc ctg gcc ccg ggt tcc cgt ggc tac cgg gcg cgg ccg 98 Val Ala Ala Thr Leu Ala Pro Gly Ser Arg Gly Tyr Arg Ala Arg Pro 15 20 25 ccc ccg cgc cgc agg ccg gga ccc cgg tgg cca gac ccc gag gac ctc 146 Pro Pro Arg Arg Arg Pro Gly Pro Arg Trp Pro Asp Pro Glu Asp Leu 30 35 40 45 ctg acc ccg cgg tgg cag ctg gga ccg cgc tac gcg gct aag cag ttc 194 Leu Thr Pro Arg Trp Gln Leu Gly Pro Arg Tyr Ala Ala Lys Gln Phe 50 55 60 gcg cgt tac ggc gcc gcc tcc ggg gtg gtc ccc ggt tcg tta tgg ccg 242 Ala Arg Tyr Gly Ala Ala Ser Gly Val Val Pro Gly Ser Leu Trp Pro 65 70 75 tcg ccg gag cag ctg cgg gag ctg gag gcc gaa gaa cgc gaa tgg tac 290 Ser Pro Glu Gln Leu Arg Glu Leu Glu Ala Glu Glu Arg Glu Trp Tyr 80 85 90 ccg agc ctg gcg acc atg cag gag tcg ctg cgg gtg aag cag ctg gcc 338 Pro Ser Leu Ala Thr Met Gln Glu Ser Leu Arg Val Lys Gln Leu Ala 95 100 105 gaa gag cag aag cgt cgg gag agg gag cag cac atc gca gag tgc atg 386 Glu Glu Gln Lys Arg Arg Glu Arg Glu Gln His Ile Ala Glu Cys Met 110 115 120 125 gcc aag atg cca cag atg att gtg aac tgg cag cag cag cag cgg gag 434 Ala Lys Met Pro Gln Met Ile Val Asn Trp Gln Gln Gln Gln Arg Glu 130 135 140 aac tgg gag aag gcc cag gct gac aag gag agg agg gcc cga ctg cag 482 Asn Trp Glu Lys Ala Gln Ala Asp Lys Glu Arg Arg Ala Arg Leu Gln 145 150 155 gct gag gcc cag gag ctc ctg ggc tac cag gtg gac cca agg agt gcc 530 Ala Glu Ala Gln Glu Leu Leu Gly Tyr Gln Val Asp Pro Arg Ser Ala 160 165 170 cgc ttc cag gag ctg ctc cag gac cta gag aag aag gag cgc aag cgc 578 Arg Phe Gln Glu Leu Leu Gln Asp Leu Glu Lys Lys Glu Arg Lys Arg 175 180 185 ctc aag gag gaa aaa cag aaa cgg aag aag gag gcg cga gct gct gca 626 Leu Lys Glu Glu Lys Gln Lys Arg Lys Lys Glu Ala Arg Ala Ala Ala 190 195 200 205 ttg gct gca gct gtg gct caa gac cca gca gcc tct ggg gca ccc agc 674 Leu Ala Ala Ala Val Ala Gln Asp Pro Ala Ala Ser Gly Ala Pro Ser 210 215 220 tcc tga ggctttgtcc cttcccaata aagcctgcta cctggcagta cccctg 726 Ser <210> SEQ ID NO 154 <211> LENGTH: 222 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 154 Met Ala Ala Ser Val Arg Gln Ala Arg Ser Leu Leu Gly Val Ala Ala 1 5 10 15 Thr Leu Ala Pro Gly Ser Arg Gly Tyr Arg Ala Arg Pro Pro Pro Arg 20 25 30 Arg Arg Pro Gly Pro Arg Trp Pro Asp Pro Glu Asp Leu Leu Thr Pro 35 40 45 Arg Trp Gln Leu Gly Pro Arg Tyr Ala Ala Lys Gln Phe Ala Arg Tyr 50 55 60 Gly Ala Ala Ser Gly Val Val Pro Gly Ser Leu Trp Pro Ser Pro Glu 65 70 75 80 Gln Leu Arg Glu Leu Glu Ala Glu Glu Arg Glu Trp Tyr Pro Ser Leu 85 90 95 Ala Thr Met Gln Glu Ser Leu Arg Val Lys Gln Leu Ala Glu Glu Gln 100 105 110 Lys Arg Arg Glu Arg Glu Gln His Ile Ala Glu Cys Met Ala Lys Met 115 120 125 Pro Gln Met Ile Val Asn Trp Gln Gln Gln Gln Arg Glu Asn Trp Glu 130 135 140 Lys Ala Gln Ala Asp Lys Glu Arg Arg Ala Arg Leu Gln Ala Glu Ala 145 150 155 160 Gln Glu Leu Leu Gly Tyr Gln Val Asp Pro Arg Ser Ala Arg Phe Gln 165 170 175 Glu Leu Leu Gln Asp Leu Glu Lys Lys Glu Arg Lys Arg Leu Lys Glu 180 185 190 Glu Lys Gln Lys Arg Lys Lys Glu Ala Arg Ala Ala Ala Leu Ala Ala 195 200 205 Ala Val Ala Gln Asp Pro Ala Ala Ser Gly Ala Pro Ser Ser 210 215 220 <210> SEQ ID NO 155 <211> LENGTH: 1120 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (208)..(1044) <400> SEQUENCE: 155 ccttttcttc cgcacggttg gaggaggtcg gctggttatc gggagttgga gggctgaggt 60 cgggagggtg gtgtgtacag agctctagga ctcacgcacc aggccagtcg cgggttttgg 120 gccgaggcct gggttacaag cagcaagtgc gcggttgggg ccactgcgag gccgttttag 180 aaaactgttt aaaacaaaga gcaattg atg gat aaa tca gga ata gat tct ctt 234 Met Asp Lys Ser Gly Ile Asp Ser Leu 1 5 gac cat gtg aca tct gat gct gtg gaa ctt gca aat cga agt gat aac 282 Asp His Val Thr Ser Asp Ala Val Glu Leu Ala Asn Arg Ser Asp Asn 10 15 20 25 tct tct gat agc agc tta ttt aaa act cag tgt atc cct tac tca cct 330 Ser Ser Asp Ser Ser Leu Phe Lys Thr Gln Cys Ile Pro Tyr Ser Pro 30 35 40 aaa ggg gag aaa aga aac ccc att cga aaa ttt gtt cgt aca cct gaa 378 Lys Gly Glu Lys Arg Asn Pro Ile Arg Lys Phe Val Arg Thr Pro Glu 45 50 55 agt gtt cac gca agt gat tca tca agt gac tca tct ttt gaa cca ata 426 Ser Val His Ala Ser Asp Ser Ser Ser Asp Ser Ser Phe Glu Pro Ile 60 65 70 cca ttg act ata aaa gct att ttt gaa aga ttc aag aac agg aaa aag 474 Pro Leu Thr Ile Lys Ala Ile Phe Glu Arg Phe Lys Asn Arg Lys Lys 75 80 85 aga tat aaa aaa aag aaa aag agg agg tac cag cca aca gga aga cca 522 Arg Tyr Lys Lys Lys Lys Lys Arg Arg Tyr Gln Pro Thr Gly Arg Pro 90 95 100 105 cgg gga aga cca gaa gga agg aga aat cct ata tac tca cta ata gat 570 Arg Gly Arg Pro Glu Gly Arg Arg Asn Pro Ile Tyr Ser Leu Ile Asp 110 115 120 aag aag aaa caa ttt aga agc aga gga tct ggc ttc cca ttt tta gaa 618 Lys Lys Lys Gln Phe Arg Ser Arg Gly Ser Gly Phe Pro Phe Leu Glu 125 130 135 tca gag aat gaa aaa aac gca cct tgg aga aaa att tta acg ttt gag 666 Ser Glu Asn Glu Lys Asn Ala Pro Trp Arg Lys Ile Leu Thr Phe Glu 140 145 150 caa gct gtt gca aga gga ttt ttt aac tat att gaa aaa ctg aag tat 714 Gln Ala Val Ala Arg Gly Phe Phe Asn Tyr Ile Glu Lys Leu Lys Tyr 155 160 165 gaa cac cac ctg aaa gaa tca ttg aag caa atg aat gtt ggt gaa gat 762 Glu His His Leu Lys Glu Ser Leu Lys Gln Met Asn Val Gly Glu Asp 170 175 180 185 tta gaa aat gaa gat ttt gac agt cgt aga tac aaa ttt ttg gat gat 810 Leu Glu Asn Glu Asp Phe Asp Ser Arg Arg Tyr Lys Phe Leu Asp Asp 190 195 200 gat gga tcc att tct cct att gag gag tca aca gca gag gat gag gat 858 Asp Gly Ser Ile Ser Pro Ile Glu Glu Ser Thr Ala Glu Asp Glu Asp 205 210 215 gca aca cat ctt gaa gat aac gaa tgt gat atc aaa ttg gca ggg gat 906 Ala Thr His Leu Glu Asp Asn Glu Cys Asp Ile Lys Leu Ala Gly Asp 220 225 230 agt ttc ata gta agt tct gaa ttc cct gta aga ctg agt gta tac tta 954 Ser Phe Ile Val Ser Ser Glu Phe Pro Val Arg Leu Ser Val Tyr Leu 235 240 245 gaa gaa gag gat att act gaa gaa gct gct ttg tct aaa aag aga gct 1002 Glu Glu Glu Asp Ile Thr Glu Glu Ala Ala Leu Ser Lys Lys Arg Ala 250 255 260 265 aca aaa gcc aaa aat act gga cag aga ggc ctg aaa atg tga 1044 Thr Lys Ala Lys Asn Thr Gly Gln Arg Gly Leu Lys Met 270 275 caggatcatg aatgtcaaag gtgaagcata tagaaaaaac gacttcatag aaatgaataa 1104 agataaatgt ggatat 1120 <210> SEQ ID NO 156 <211> LENGTH: 278 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 156 Met Asp Lys Ser Gly Ile Asp Ser Leu Asp His Val Thr Ser Asp Ala 1 5 10 15 Val Glu Leu Ala Asn Arg Ser Asp Asn Ser Ser Asp Ser Ser Leu Phe 20 25 30 Lys Thr Gln Cys Ile Pro Tyr Ser Pro Lys Gly Glu Lys Arg Asn Pro 35 40 45 Ile Arg Lys Phe Val Arg Thr Pro Glu Ser Val His Ala Ser Asp Ser 50 55 60 Ser Ser Asp Ser Ser Phe Glu Pro Ile Pro Leu Thr Ile Lys Ala Ile 65 70 75 80 Phe Glu Arg Phe Lys Asn Arg Lys Lys Arg Tyr Lys Lys Lys Lys Lys 85 90 95 Arg Arg Tyr Gln Pro Thr Gly Arg Pro Arg Gly Arg Pro Glu Gly Arg 100 105 110 Arg Asn Pro Ile Tyr Ser Leu Ile Asp Lys Lys Lys Gln Phe Arg Ser 115 120 125 Arg Gly Ser Gly Phe Pro Phe Leu Glu Ser Glu Asn Glu Lys Asn Ala 130 135 140 Pro Trp Arg Lys Ile Leu Thr Phe Glu Gln Ala Val Ala Arg Gly Phe 145 150 155 160 Phe Asn Tyr Ile Glu Lys Leu Lys Tyr Glu His His Leu Lys Glu Ser 165 170 175 Leu Lys Gln Met Asn Val Gly Glu Asp Leu Glu Asn Glu Asp Phe Asp 180 185 190 Ser Arg Arg Tyr Lys Phe Leu Asp Asp Asp Gly Ser Ile Ser Pro Ile 195 200 205 Glu Glu Ser Thr Ala Glu Asp Glu Asp Ala Thr His Leu Glu Asp Asn 210 215 220 Glu Cys Asp Ile Lys Leu Ala Gly Asp Ser Phe Ile Val Ser Ser Glu 225 230 235 240 Phe Pro Val Arg Leu Ser Val Tyr Leu Glu Glu Glu Asp Ile Thr Glu 245 250 255 Glu Ala Ala Leu Ser Lys Lys Arg Ala Thr Lys Ala Lys Asn Thr Gly 260 265 270 Gln Arg Gly Leu Lys Met 275 <210> SEQ ID NO 157 <211> LENGTH: 747 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (27)..(692) <400> SEQUENCE: 157 ctctctcatg accccgctcc gggatt atg gcc ggg act ggg ctg ctg gcg ctg 53 Met Ala Gly Thr Gly Leu Leu Ala Leu 1 5 cgg acg ctg cca ggg ccc agc tgg gtg cga ggc tcg ggc cct tcc gtg 101 Arg Thr Leu Pro Gly Pro Ser Trp Val Arg Gly Ser Gly Pro Ser Val 10 15 20 25 ctg agc cgc ctg cag gac gcg gcc gtg gtg cgg cct ggc ttc ctg agc 149 Leu Ser Arg Leu Gln Asp Ala Ala Val Val Arg Pro Gly Phe Leu Ser 30 35 40 acg gca gag gag gag acg ctg agc cga gaa ctg gag ccc gag ctg cgc 197 Thr Ala Glu Glu Glu Thr Leu Ser Arg Glu Leu Glu Pro Glu Leu Arg 45 50 55 cgc cgc cgc tac gaa tac gat cac tgg gac gcg gcc atc cac ggc ttc 245 Arg Arg Arg Tyr Glu Tyr Asp His Trp Asp Ala Ala Ile His Gly Phe 60 65 70 cga gag aca gag aag tcg cgc tgg tca gaa gcc agc cgg gcc atc ctg 293 Arg Glu Thr Glu Lys Ser Arg Trp Ser Glu Ala Ser Arg Ala Ile Leu 75 80 85 cag cgc gtg cag gcg gcc gcc ttt ggc ccc ggc cag acc ctg ctc tcc 341 Gln Arg Val Gln Ala Ala Ala Phe Gly Pro Gly Gln Thr Leu Leu Ser 90 95 100 105 tcc gtg cac gtg ctg gac ctg gaa gcc cgc ggc tac atc aag ccc cac 389 Ser Val His Val Leu Asp Leu Glu Ala Arg Gly Tyr Ile Lys Pro His 110 115 120 gtg gac agc atc aag ttc tgc ggg gcc acc atc gcc ggc ctg tct ctc 437 Val Asp Ser Ile Lys Phe Cys Gly Ala Thr Ile Ala Gly Leu Ser Leu 125 130 135 ctg tct ccc agc gtt atg cgg ctg gtg cac acc cag gag ccg ggg gag 485 Leu Ser Pro Ser Val Met Arg Leu Val His Thr Gln Glu Pro Gly Glu 140 145 150 tgg ctg gaa ctc ttg ctg gag ccg ggc tcc ctc tac atc ctt agg ggc 533 Trp Leu Glu Leu Leu Leu Glu Pro Gly Ser Leu Tyr Ile Leu Arg Gly 155 160 165 tca gcc cgt tat gac ttc tcc cat gag atc ctt cgg gat gaa gag tcc 581 Ser Ala Arg Tyr Asp Phe Ser His Glu Ile Leu Arg Asp Glu Glu Ser 170 175 180 185 ttc ttt ggg gaa cgc cgg att ccc cgg ggc cgg cgc atc tcc gtg atc 629 Phe Phe Gly Glu Arg Arg Ile Pro Arg Gly Arg Arg Ile Ser Val Ile 190 195 200 tgc cgc tcc ctc cct gag ggc atg ggg cca ggg gag tct gga cag ccg 677 Cys Arg Ser Leu Pro Glu Gly Met Gly Pro Gly Glu Ser Gly Gln Pro 205 210 215 ccc cca gcc tgc tga cccccagctt tctacagaca ccagatttgt gaataaagtt 732 Pro Pro Ala Cys 220 ggggaatgga cagcc 747 <210> SEQ ID NO 158 <211> LENGTH: 221 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 158 Met Ala Gly Thr Gly Leu Leu Ala Leu Arg Thr Leu Pro Gly Pro Ser 1 5 10 15 Trp Val Arg Gly Ser Gly Pro Ser Val Leu Ser Arg Leu Gln Asp Ala 20 25 30 Ala Val Val Arg Pro Gly Phe Leu Ser Thr Ala Glu Glu Glu Thr Leu 35 40 45 Ser Arg Glu Leu Glu Pro Glu Leu Arg Arg Arg Arg Tyr Glu Tyr Asp 50 55 60 His Trp Asp Ala Ala Ile His Gly Phe Arg Glu Thr Glu Lys Ser Arg 65 70 75 80 Trp Ser Glu Ala Ser Arg Ala Ile Leu Gln Arg Val Gln Ala Ala Ala 85 90 95 Phe Gly Pro Gly Gln Thr Leu Leu Ser Ser Val His Val Leu Asp Leu 100 105 110 Glu Ala Arg Gly Tyr Ile Lys Pro His Val Asp Ser Ile Lys Phe Cys 115 120 125 Gly Ala Thr Ile Ala Gly Leu Ser Leu Leu Ser Pro Ser Val Met Arg 130 135 140 Leu Val His Thr Gln Glu Pro Gly Glu Trp Leu Glu Leu Leu Leu Glu 145 150 155 160 Pro Gly Ser Leu Tyr Ile Leu Arg Gly Ser Ala Arg Tyr Asp Phe Ser 165 170 175 His Glu Ile Leu Arg Asp Glu Glu Ser Phe Phe Gly Glu Arg Arg Ile 180 185 190 Pro Arg Gly Arg Arg Ile Ser Val Ile Cys Arg Ser Leu Pro Glu Gly 195 200 205 Met Gly Pro Gly Glu Ser Gly Gln Pro Pro Pro Ala Cys 210 215 220 <210> SEQ ID NO 159 <211> LENGTH: 1441 <212> TYPE: DNA <213> ORGANISM: Homo sapiens <220> FEATURE: <221> NAME/KEY: CDS <222> LOCATION: (95)..(1420) <400> SEQUENCE: 159 atattccggt ggctggtctc cggcggcccc gtccccgact gggccccgtg cccccccgcc 60 cccgcggccc cccgccgccg ggccagccgc cacc atg aag aaa ttc ttt cag gag 115 Met Lys Lys Phe Phe Gln Glu 1 5 ttc aag gcc gac atc aag ttc aaa agc gcg gga ccc ggt cag aag ctc 163 Phe Lys Ala Asp Ile Lys Phe Lys Ser Ala Gly Pro Gly Gln Lys Leu 10 15 20 aaa gag tcc gtg ggg gaa aag gcc cac aaa gag aag ccc aac cag cca 211 Lys Glu Ser Val Gly Glu Lys Ala His Lys Glu Lys Pro Asn Gln Pro 25 30 35 gcc ccc agg ccg ccc cgc cag gga ccc acc aat gag gca cag atg gca 259 Ala Pro Arg Pro Pro Arg Gln Gly Pro Thr Asn Glu Ala Gln Met Ala 40 45 50 55 gcc gct gcc gcc cta gcc cgg ctg gag cag aag cag tcc cgg gcc tgg 307 Ala Ala Ala Ala Leu Ala Arg Leu Glu Gln Lys Gln Ser Arg Ala Trp 60 65 70 ggc ccc aca tcg cag gac acc atc cga aac cag gtg aga aag gaa ctt 355 Gly Pro Thr Ser Gln Asp Thr Ile Arg Asn Gln Val Arg Lys Glu Leu 75 80 85 caa gcc gaa gcc acc gtc agc ggg agc ccc gag gcc cca ggg acc aac 403 Gln Ala Glu Ala Thr Val Ser Gly Ser Pro Glu Ala Pro Gly Thr Asn 90 95 100 gtg gta tct gag ccc aga gag gaa ggc tct gcc cac ctg gct gtg cct 451 Val Val Ser Glu Pro Arg Glu Glu Gly Ser Ala His Leu Ala Val Pro 105 110 115 ggc gtg tac ttc acc tgt ccg ctc act ggg gcc acc ctg agg aag gac 499 Gly Val Tyr Phe Thr Cys Pro Leu Thr Gly Ala Thr Leu Arg Lys Asp 120 125 130 135 cag cgg gac gcc tgc atc aag gag gcc att ctc ttg cac ttc tcc acc 547 Gln Arg Asp Ala Cys Ile Lys Glu Ala Ile Leu Leu His Phe Ser Thr 140 145 150 gac cca gtg gcc gcc tcc atc atg aag atc tac acg ttc aac aaa gac 595 Asp Pro Val Ala Ala Ser Ile Met Lys Ile Tyr Thr Phe Asn Lys Asp 155 160 165 cag gac cgg gtg aag ctg ggt gtg gac acc att gcc aag tac ctg gac 643 Gln Asp Arg Val Lys Leu Gly Val Asp Thr Ile Ala Lys Tyr Leu Asp 170 175 180 aac atc cac ctg cac ccc gag gag gag aag tac cgg aag atc aag ctg 691 Asn Ile His Leu His Pro Glu Glu Glu Lys Tyr Arg Lys Ile Lys Leu 185 190 195 cag aac aag gtg ttt cag gag cgc att aac tgc ctg gaa ggg acc cac 739 Gln Asn Lys Val Phe Gln Glu Arg Ile Asn Cys Leu Glu Gly Thr His 200 205 210 215 gag ttt ttt gag gcc att ggg ttc cag aag gtg ttg ctt ccc gcc cag 787 Glu Phe Phe Glu Ala Ile Gly Phe Gln Lys Val Leu Leu Pro Ala Gln 220 225 230 gat cag gag gac ccc gag gag ttc tac gtg ctg agc gag acc acc ttg 835 Asp Gln Glu Asp Pro Glu Glu Phe Tyr Val Leu Ser Glu Thr Thr Leu 235 240 245 gcc cag ccc cag agc ctg gag agg cac aag gaa cag ctg ctg gct gcg 883 Ala Gln Pro Gln Ser Leu Glu Arg His Lys Glu Gln Leu Leu Ala Ala 250 255 260 gag ccc gtg cgc gcc aag ctg gac agg cag cgc cgc gtc ttc cag ccc 931 Glu Pro Val Arg Ala Lys Leu Asp Arg Gln Arg Arg Val Phe Gln Pro 265 270 275 tcg ccc ctg gcc tcg cag ttc gaa ctg cct ggg gac ttc ttc aac ctc 979 Ser Pro Leu Ala Ser Gln Phe Glu Leu Pro Gly Asp Phe Phe Asn Leu 280 285 290 295 aca gca gag gag atc aag cgg gag cag agg ctc agg tcc gag gcg gtg 1027 Thr Ala Glu Glu Ile Lys Arg Glu Gln Arg Leu Arg Ser Glu Ala Val 300 305 310 gag cgg ctg agc gtg ctg cgg acc aag gcc atg cgg gag aag gag gag 1075 Glu Arg Leu Ser Val Leu Arg Thr Lys Ala Met Arg Glu Lys Glu Glu 315 320 325 cag cgg ggg ctg cgc aag tac aac tac acg ctg ctg cgc gtg cgc ctc 1123 Gln Arg Gly Leu Arg Lys Tyr Asn Tyr Thr Leu Leu Arg Val Arg Leu 330 335 340 ccc gat ggc tgc ctc ctg cag ggc act ttc tac gct cgg gag cgg ctg 1171 Pro Asp Gly Cys Leu Leu Gln Gly Thr Phe Tyr Ala Arg Glu Arg Leu 345 350 355 ggg gcg gtg tac ggg ttc gtc cgg gag gcc ctg cag agc gac tgg ctg 1219 Gly Ala Val Tyr Gly Phe Val Arg Glu Ala Leu Gln Ser Asp Trp Leu 360 365 370 375 cct ttt gag ctg ctg gcc tcg gga ggg cag aag ctg tcc gag gac gag 1267 Pro Phe Glu Leu Leu Ala Ser Gly Gly Gln Lys Leu Ser Glu Asp Glu 380 385 390 aac ctg gcc ttg aac gag tgc ggg ctg gtg ccc tct gcc ctc ctg acc 1315 Asn Leu Ala Leu Asn Glu Cys Gly Leu Val Pro Ser Ala Leu Leu Thr 395 400 405 ttc tcg tgg gac atg gct gtg ctg gag gac atc aag gcc gcg ggg gcc 1363 Phe Ser Trp Asp Met Ala Val Leu Glu Asp Ile Lys Ala Ala Gly Ala 410 415 420 gag ccg gac tcc atc ctg aaa ccc gag ctc ctg tca gcc atc gag aag 1411 Glu Pro Asp Ser Ile Leu Lys Pro Glu Leu Leu Ser Ala Ile Glu Lys 425 430 435 ctc ttg tga aataaaagca gggttggcct c 1441 Leu Leu 440 <210> SEQ ID NO 160 <211> LENGTH: 441 <212> TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 160 Met Lys Lys Phe Phe Gln Glu Phe Lys Ala Asp Ile Lys Phe Lys Ser 1 5 10 15 Ala Gly Pro Gly Gln Lys Leu Lys Glu Ser Val Gly Glu Lys Ala His 20 25 30 Lys Glu Lys Pro Asn Gln Pro Ala Pro Arg Pro Pro Arg Gln Gly Pro 35 40 45 Thr Asn Glu Ala Gln Met Ala Ala Ala Ala Ala Leu Ala Arg Leu Glu 50 55 60 Gln Lys Gln Ser Arg Ala Trp Gly Pro Thr Ser Gln Asp Thr Ile Arg 65 70 75 80 Asn Gln Val Arg Lys Glu Leu Gln Ala Glu Ala Thr Val Ser Gly Ser 85 90 95 Pro Glu Ala Pro Gly Thr Asn Val Val Ser Glu Pro Arg Glu Glu Gly 100 105 110 Ser Ala His Leu Ala Val Pro Gly Val Tyr Phe Thr Cys Pro Leu Thr 115 120 125 Gly Ala Thr Leu Arg Lys Asp Gln Arg Asp Ala Cys Ile Lys Glu Ala 130 135 140 Ile Leu Leu His Phe Ser Thr Asp Pro Val Ala Ala Ser Ile Met Lys 145 150 155 160 Ile Tyr Thr Phe Asn Lys Asp Gln Asp Arg Val Lys Leu Gly Val Asp 165 170 175 Thr Ile Ala Lys Tyr Leu Asp Asn Ile His Leu His Pro Glu Glu Glu 180 185 190 Lys Tyr Arg Lys Ile Lys Leu Gln Asn Lys Val Phe Gln Glu Arg Ile 195 200 205 Asn Cys Leu Glu Gly Thr His Glu Phe Phe Glu Ala Ile Gly Phe Gln 210 215 220 Lys Val Leu Leu Pro Ala Gln Asp Gln Glu Asp Pro Glu Glu Phe Tyr 225 230 235 240 Val Leu Ser Glu Thr Thr Leu Ala Gln Pro Gln Ser Leu Glu Arg His 245 250 255 Lys Glu Gln Leu Leu Ala Ala Glu Pro Val Arg Ala Lys Leu Asp Arg 260 265 270 Gln Arg Arg Val Phe Gln Pro Ser Pro Leu Ala Ser Gln Phe Glu Leu 275 280 285 Pro Gly Asp Phe Phe Asn Leu Thr Ala Glu Glu Ile Lys Arg Glu Gln 290 295 300 Arg Leu Arg Ser Glu Ala Val Glu Arg Leu Ser Val Leu Arg Thr Lys 305 310 315 320 Ala Met Arg Glu Lys Glu Glu Gln Arg Gly Leu Arg Lys Tyr Asn Tyr 325 330 335 Thr Leu Leu Arg Val Arg Leu Pro Asp Gly Cys Leu Leu Gln Gly Thr 340 345 350 Phe Tyr Ala Arg Glu Arg Leu Gly Ala Val Tyr Gly Phe Val Arg Glu 355 360 365 Ala Leu Gln Ser Asp Trp Leu Pro Phe Glu Leu Leu Ala Ser Gly Gly 370 375 380 Gln Lys Leu Ser Glu Asp Glu Asn Leu Ala Leu Asn Glu Cys Gly Leu 385 390 395 400 Val Pro Ser Ala Leu Leu Thr Phe Ser Trp Asp Met Ala Val Leu Glu 405 410 415 Asp Ile Lys Ala Ala Gly Ala Glu Pro Asp Ser Ile Leu Lys Pro Glu 420 425 430 Leu Leu Ser Ala Ile Glu Lys Leu Leu 435 440 

1. A purified human proteins having any one of the amino acid sequences of SEQ ID No: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158 or
 160. 2. A DNA fragment encoding the protein of claim
 1. 3. A DNA fragment having the base sequence of the translated region in SEQ ID No: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157 or 159, which is human cDNA encoding the protein of claim
 1. 4. The DNA fragment of claim 3, which consists of any one of the base sequences of SEQ ID No: 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157 or
 159. 5. An expression vector, which is capable of expressing any one of the DNA fragments of claims 2 to 4 by in vitro translation or within host cell.
 6. The expression vector of claim 5, which is capable of expressing a fused DNA fragment of the DNA fragment of any one of claims 2 to 4 and the DNA fragment encoding a fluorescent protein.
 7. A fluorescent protein-fused protein, which is an expression product of the expression vector of claim
 6. 8. A cell transformed with the expression vector of claim 5 or 6, which is capable of producing the protein of claim 1 or the fluorescent protein-fused protein of claim
 7. 9. An antibody against the protein of claim
 1. 